Compounds and methods of modulating protein degradation

ABSTRACT

Disclosed herein are protein-probe adducts and synthetic ligands that inhibit protein-probe adduct formation, in which the protein is part of the E3 ligase complex and the protein is modified to alter the substrate recognition of the E3 ligase complex. In some instances, also provided herein are protein-probe adducts and synthetic ligands that inhibit protein-probe adduct formation, in which the protein is modified or tagged for degradation. In some instances, additionally provided herein are cysteine-containing protein binding domains that interact with a probe and/or a ligand described herein.

CROSS-REFERENCE

This application claims the benefit of U.S. Provisional Application No. 62/564,184, filed Sep. 27, 2017, which application is incorporated herein by reference in its entirety.

BACKGROUND OF THE DISCLOSURE

Protein biosynthesis and degradation is a dynamic process which sustains normal cell metabolism. In some instances, production of new proteins modulate proliferation and differentiation of cells and upon completion, these protein are degraded through one of two proteolytic mechanisms, the lysosome degradation system or the ubiquitin proteasome pathway. In some cases, a majority of cellular proteins are degraded by the proteasome pathway, and the process is initiated via tagging of a ubiquitin.

SUMMARY OF THE DISCLOSURE

In certain embodiments, described herein are compositions that comprise cysteine-containing proteins that are conjugated with a probe of Formula (I) or with a ligand disclosed herein. In some embodiments, disclosed herein is a protein-probe adduct wherein the probe binds to a cysteine residue illustrated in Table 1A or Table 2A; wherein the probe has a structure represented by Formula (I):

wherein,

-   -   n is 0-8.

In some embodiments, disclosed herein is a synthetic ligand that inhibits a covalent interaction between a protein and a probe, wherein in the absence of the synthetic ligand, the probe binds to a cysteine residue illustrated in Table 1A or Table 2A; and wherein the probe has a structure represented by Formula (I):

wherein,

-   -   n is 0-8.

In some embodiments, disclosed herein is a protein binding domain wherein said protein binding domain comprises a cysteine residue illustrated in Table 1A or Table 2A, wherein said cysteine forms an adduct with a compound of Formula I,

-   -   and wherein a compound of Formula IIA or Formula IIB interferes         with the formation of the cysteine adduct by the compound of         Formula I, wherein Formula (IIA) or Formula (IIB) have the         structure:

-   -   wherein,     -   each R^(A) and R^(B) is independently selected from the group         consisting of H, D, substituted or unsubstituted C₁-C₆alkyl,         substituted or unsubstituted C₁-C₆fluoroalkyl, substituted or         unsubstituted C₁-C₆heteroalkyl, substituted or unsubstituted         C₃-C₈cycloalkyl, substituted or unsubstituted         C₂-C₇heterocycloalkyl, substituted or unsubstituted aryl,         substituted or unsubstituted C₁-C₃alkylene-aryl, substituted or         unsubstituted heteroaryl, and substituted or unsubstituted         C₁-C₃alkylene-heteroaryl; or     -   or R^(A) and R^(B) together with the nitrogen to which they are         attached form a 5, 6, 7 or 8-membered heterocyclic ring A,         optionally having one additional heteroatom moiety independently         selected from NR¹, O, or S; wherein A is optionally substituted;         and     -   R¹ is independently H, D, substituted or unsubstituted         C₁-C₆alkyl, substituted or unsubstituted C₁-C₆fluoroalkyl,         substituted or unsubstituted C₁-C₆heteroalkyl, substituted or         unsubstituted aryl, or substituted or unsubstituted heteroaryl.

DETAILED DESCRIPTION OF THE DISCLOSURE

Ubiquitin-proteasome system is characterized by the E1, E2, and E3 enzyme. First, a ubiquitin molecule is chemically activated in an ATP-dependent manner by an E1-activating enzyme forming a thioester bond between the C-terminal glycine residue of ubiquitin and a conserved cysteine residue of the E1. Then, ubiquitin is transferred on to an E2-conjugated enzyme via a trans-thiolation reaction. Next, an isopeptide bond between the ε-amino group of a substrate lysine residue and the C-terminal glycine residue of ubiquitin is formed via E3 ligase-mediated catalysis and then between ubiquitin molecules to form poly-ubiquitin chains. Upon completion of the ubiquination process, the tagged substrate is subsequently recognized and degraded by the 26S proteasome in an ATP-dependent manner.

In some cases, the E3 ubiquitin ligase family is divided into three families, the HECT (homologous with E6-associated protein C-terminus) family, the RING finger family, and the RBR (RING-between RING_RING) family. HECT E3 enzyme forms a covalent thioester intermediate by accepting a ubiquitin molecule from the E2-ubiquitin via a conserved cysteine residue prior to transferring the ubiquitin molecule to a substrate. RING E3 enzyme directly transfers a ubiquitin molecule to a substrate by bringing both the E2-ubiquitin and the substrate in close proximity to each other. The RBR family recruit E3-ubiquitin conjugated by an N-terminal RING domain and then transfer ubiquitin on to a HECT-type C-terminal catalytic cysteine residue of the E3 before transferring on to the substrate.

In some instances, the RING finger family is further categorized into two subgroups, CRL and APC/C (anaphase-promoting complex/cyclosome). In some cases, the CRL and APC/C subfamilies comprise multi-subunit complexes comprising an adaptor, a substrate receptor subunit, a Cullin scaffold, and a RING-box subunit.

In some embodiments, the CUL4-RBX1-DDB1-CRBN complex (CRL4^(CRBN)) is an E3 ligase that falls under the CRL subgroup of the RING finger family. The CRL4^(CRBN) complex comprises the adaptor protein DDB1, which connects the substrate receptor cereblon (CRBN) to the Cullin 4 (CUL4) scaffold. The Cullin 4 scaffold further binds to RBX1. Upon substrate binding, the CUL4-RBX1-DDB1-CRBN complex bridges the substrate to the E2-ubiquitin to initiate a direct transfer of ubiquitin molecule onto the substrate.

In some instances, thalidomide and related immunomodulatory (IMiD) compounds such as lenalidomide and pomalidomide promote and modulate cereblon recruitment of neosubstrates. For example, a cereblon modulator CC-220 has been shown to improve degradation of Ikaros and Aiolos, two zinc finger transcription factors that have been implicated in lymphoid development and differentiation (Matyskiela, et al., “A cereblon modulator (CC-220) with improved degradation of Ikaros and Aiolos,” J Med Chem. Apr. 20, 2017). Further, dBET1, a bifunctional phthalimide-conjugated ligand which is a substrate for cereblon, selectively targets BRD4, a transcriptional coactivator, for degradation.

In some embodiments, provided herein are protein-probe adducts and synthetic ligands that inhibit protein-probe adduct formation, in which the protein is part of the E3 ligase complex and the protein is modified to alter the substrate recognition of the E3 ligase complex. In some instances, also provided herein are protein-probe adducts and synthetic ligands that inhibit protein-probe adduct formation, in which the protein is modified or tagged for degradation. In some instances, additionally provided herein are cysteine-containing protein binding domains that interact with a probe and/or a ligand described herein.

In some embodiments, provided herein are protein-probe adducts illustrated in Table 2B, wherein the percent inhibition is greater than 98%. In some embodiments, provided herein are protein-probe adducts illustrated in Table 2B, wherein the percent inhibition is greater than 97%. In some embodiments, provided herein are protein-probe adducts illustrated in Table 2B, wherein the percent inhibition is greater than 96%. In some embodiments, provided herein are protein-probe adducts illustrated in Table 2B, wherein the percent inhibition is greater than 95%. In some embodiments, provided herein are protein-probe adducts illustrated in Table 2B, wherein the percent inhibition is greater than 94%. In some embodiments, provided herein are protein-probe adducts illustrated in Table 2B, wherein the percent inhibition is greater than 93%. In some embodiments, provided herein are protein-probe adducts illustrated in Table 2B, wherein the percent inhibition is greater than 92%. In some embodiments, provided herein are protein-probe adducts illustrated in Table 2B, wherein the percent inhibition is greater than 91%. In some embodiments, provided herein are protein-probe adducts illustrated in Table 2B, wherein the percent inhibition is greater than 90%. In some embodiments, provided herein are protein-probe adducts illustrated in Table 2B, wherein the percent inhibition is greater than 85%. In some embodiments, provided herein are protein-probe adducts illustrated in Table 2B, wherein the percent inhibition is greater than 80%. In some embodiments, provided herein are protein-probe adducts illustrated in Table 2B, wherein the percent inhibition is greater than 75%. In some embodiments, provided herein are protein-probe adducts illustrated in Table 2B, wherein the percent inhibition is greater than 70%. In some embodiments, provided herein are protein-probe adducts illustrated in Table 2B, wherein the percent inhibition is greater than 65%.

In some embodiments, further described herein is a method of modulating or altering recruitment of neosubstrates to the ubiquitin proteasome pathway. In some instances, the method comprises covalent binding of a reactive residue on one or more proteins described below for modulation of substrate interaction. In some cases, the method comprises covalent binding of a reactive cysteine residue on one or more proteins described below for substrate modulation.

Cysteine-Containing Proteins and Protein Conjugates

In some embodiments, described herein are cysteine-containing proteins that upon interaction with a probe or a ligand described herein, alters the recruitment of neosubstrates to the ubiquitin proteasome pathway. In some instance, the cysteine-containing protein is a member of the E3 ubiquitin ligase family. In other instances, the cysteine-containing protein is a member of the E3 ligase complex, such as for example, an adaptor, a substrate receptor subunit, a Cullin scaffold, or a RING-box subunit protein. In additional instances, the cysteine-containing protein is a target to be recruited by the ubiquitin proteasome pathway as a neosubstrate.

In some embodiments, the cysteine-containing protein is a protein illustrated in Table 1 (e.g., Table 1A). In some embodiments, Table 1 further illustrates one or more cysteine residues for interaction with a probe and/or a ligand described herein. In some cases, the cysteine residue number of a cysteine-containing protein is in reference to the respective UNIPROT identifier.

In some embodiments, the cysteine-containing protein is a protein illustrated in Table 2 (e.g., Table 2A). In some embodiments, Table 2 further illustrates one or more cysteine residues for interaction with a probe and/or a ligand described herein. In some cases, the cysteine residue number of a cysteine-containing protein is in reference to the respective UNIPROT identifier.

In some instances, a cysteine residue illustrated in Table 1 (e.g, Table 1A) or Table 2 (e.g., Table 2A) is located from 10 Å to 60 Å away from an active site residue of the respective cysteine-containing protein. In some instances, the cysteine residue is located at least 10 Å, 12 Å, 15 Å, 20 Å, 25 Å, 30 Å, 35 Å, 40 Å, 45 Å, or 50 Å away from an active site residue of the respective cysteine-containing protein. In some instances, the cysteine residue is located about 10 Å, 12 Å, 15 Å, 20 Å, 25 Å, 30 Å, 35 Å, 40 Å, 45 Å, or 50 Å away from an active site residue of the respective cysteine-containing protein.

In some instances, the probe binds to a cysteine residue of a member of the E3 ligase complex. In some cases, the probe binds to a cysteine residue of Anaphase-promoting complex subunit 16, Anaphase-promoting complex subunit 7, Apoptosis-resistant E3 ubiquitin protein ligase 1, Transcription regulator protein BACH1, Transcription regulator protein BACH2, Baculoviral IAP repeat-containing protein 2, Baculoviral IAP repeat-containing protein 3, DDB1- and CUL4-associated factor 17, Denticleless protein homolog, F-box only protein 11, F-box only protein 30, E3 ubiquitin-protein ligase HECTD1, Probable E3 ubiquitin-protein ligase HERC1, Probable E3 ubiquitin-protein ligase HERC4, E3 ISG15-protein ligase HERC5, E3 ubiquitin-protein ligase HUWE1, Kelch repeat and BTB domain-containing protein 8, Kelch-like ECH-associated protein 1, MYCBP2 Probable E3 ubiquitin-protein ligase MYCBP2, E3 ubiquitin-protein ligase MYCBP2, Polycomb group RING finger protein 2, E3 SUMO-protein ligase PIAS4, Protein PML, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase RNF213, RING finger protein 214, E3 ubiquitin-protein ligase RNF25, E3 ubiquitin-protein ligase BRE1B, RING-box protein 2, Tumor necrosis factor alpha-induced protein 3, E3 ubiquitin-protein ligase TRIM33, E3 ubiquitin-protein ligase TRIM56, Tripartite motif-containing protein 65, E3 ubiquitin-protein ligase TRIM71, E3 ubiquitin-protein ligase TRIP12, (E3-independent) E2 ubiquitin-conjugating enzyme, UBE4A Ubiquitin conjugation factor E4 A, Ubiquitin conjugation factor E4 A, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UBR4, E3 ubiquitin-protein ligase UBR5, Protein VPRBP, Vacuolar protein sorting-associated protein 18 homolog, or Nuclear-interacting partner of ALK.

In some instances, the protein is Ankyrin repeat and BTB/POZ domain-containing protein 1, Ankyrin repeat and BTB/POZ domain-containing protein 2, Activating molecule in BECN1-regulated autophagy protein 1, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 15, Anaphase-promoting complex subunit 16, Anaphase-promoting complex subunit 2, Anaphase-promoting complex subunit 7, Rabankyrin-5, Ankyrin repeat and IBR domain-containing protein 1, Amyloid protein-binding protein 2, Apoptosis-resistant E3 ubiquitin protein ligase 1, E3 ubiquitin-protein ligase ARIH1, E3 ubiquitin-protein ligase ARIH2, Armadillo repeat-containing protein 5, Ankyrin repeat and SOCS box protein 2, Ankyrin repeat and SOCS box protein 6, Transcriptional regulator ATRX, Transcription regulator protein BACH1, Transcription regulator protein BACH2, Baculoviral IAP repeat-containing protein 2, Baculoviral IAP repeat-containing protein 3, Baculoviral IAP repeat-containing protein 6, Breast cancer type 1 susceptibility protein, F-box/WD repeat-containing protein 1A, Cullin-associated NEDD8-dissociated protein 1, Cullin-associated NEDD8-dissociated protein 2, E3 ubiquitin-protein ligase CBL, E3 ubiquitin-protein ligase CBL-B, E3 ubiquitin-protein ligase CBL-C, Cyclin-F, Cell division cycle protein 20 homolog, Cell division cycle protein 23 homolog, Cell division cycle protein 27 homolog, Cell growth regulator with RING finger domain protein 1, E3 ubiquitin-protein ligase CHFR, Clusterin, CCR4-NOT transcription complex subunit 4, COMM domain-containing protein 2, COMM domain-containing protein 9, Cullin-4A, Cullin-5, Cullin-7, Cullin-9, DDB1- and CUL4-associated factor 1, DDB1- and CUL4-associated factor 10, DDB1- and CUL4-associated factor 13, DDB1- and CUL4-associated factor 16, DDB1- and CUL4-associated factor 17, DDB1- and CUL4-associated factor 5, DDB1- and CUL4-associated factor 6, DDB1- and CUL4-associated factor 7, DNA damage-binding protein 2, Zinc finger protein neuro-d4, Denticleless protein homolog, E3 ubiquitin-protein ligase DTX1, Probable E3 ubiquitin-protein ligase DTX3, E3 ubiquitin-protein ligase DTX3L, E3 SUMO-protein ligase EGR2, Ectoderm-neural cortex protein 1, DNA excision repair protein ERCC-8, E3 ubiquitin-protein ligase FANCL, F-box DNA helicase 1, F-box/LRR-repeat protein 12, F-box/LRR-repeat protein 17, F-box/LRR-repeat protein 18, F-box/LRR-repeat protein 20, F-box/LRR-repeat protein 3, F-box/LRR-repeat protein 6, F-box only protein 11, F-box only protein 30, F-box only protein 31, F-box only protein 38, F-box only protein 42, F-box/SPRY domain-containing protein 1, F-box only protein 5, F-box only protein 7, F-box only protein 9, F-box/WD repeat-containing protein 11, F-box/WD repeat-containing protein 4, F-box/WD repeat-containing protein 8, F-box/WD repeat-containing protein 9, Protein fem-1 homolog A, Protein fem-1 homolog B, Gigaxonin, General transcription factor IIH subunit 2, E3 ubiquitin-protein ligase HACE1, E3 ubiquitin-protein ligase HECTD1, Probable E3 ubiquitin-protein ligase HECTD4, E3 ubiquitin-protein ligase HECW1, E3 ubiquitin-protein ligase HECW2, Probable E3 ubiquitin-protein ligase HERC1, E3 ubiquitin-protein ligase HERC2, Probable E3 ubiquitin-protein ligase HERC3, Probable E3 ubiquitin-protein ligase HERC4, E3 ISG15-protein ligase HERC5, Helicase-like transcription factor, E3 ubiquitin-protein ligase HUWE1, Actin-binding protein IPP, Interferon regulatory factor 2-binding protein 1, Interferon regulatory factor 2-binding protein 2, Interferon regulatory factor 2-binding protein-like, E3 ubiquitin-protein ligase Itchy homolog, Influenza virus NS1A-binding protein, Kelch repeat and BTB domain-containing protein 11, Kelch repeat and BTB domain-containing protein 4, Kelch repeat and BTB domain-containing protein 6, Kelch repeat and BTB domain-containing protein 7, Kelch repeat and BTB domain-containing protein 8, E3 ubiquitin-protein ligase KCMF1, BTB/POZ domain-containing protein KCTD3, BTB/POZ domain-containing protein KCTD7, Kelch-like ECH-associated protein 1, Kelch domain-containing protein 10, Kelch domain-containing protein 3, Kelch-like protein 20, Kelch-like protein 24, Kelch-like protein 26, Kelch-like protein 36, E3 ubiquitin-protein ligase LNX, LON peptidase N-terminal domain and RING finger protein 2, Leucine-rich repeat protein 1, Leucine-rich repeat-containing protein 41, E3 ubiquitin-protein ligase LRSAM1, E3 ubiquitin-protein ligase listerin, E3 ubiquitin-protein ligase MARCH1, E3 ubiquitin-protein ligase MARCH3, E3 ubiquitin-protein ligase MARCH5, E3 ubiquitin-protein ligase MARCH6, E3 ubiquitin-protein ligase MARCH7, E3 ubiquitin-protein ligase Mdm2, E3 ubiquitin-protein ligase MGRN1, E3 ubiquitin-protein ligase MIB2, Probable E3 ubiquitin-protein ligase MID2, E3 ubiquitin-protein ligase makorin-1, Probable E3 ubiquitin-protein ligase makorin-2, Male-specific lethal 1 homolog, E3 ubiquitin-protein ligase MYCBP2, E3 ubiquitin-protein ligase NEDD4, E3 ubiquitin-protein ligase NEDD4-like, Transcriptional repressor NF-X1, NF-X1-type zinc finger protein NFXL1, Nitric oxide synthase-interacting protein, Histone-lysine N-methyltransferase NSD2, OTU domain-containing protein 7B, POZ-, AT hook-, and zinc finger-containing protein 1, Polycomb group RING finger protein 2, E3 ubiquitin-protein ligase PDZRN3, E3 ubiquitin-protein ligase pellino homolog 1, E3 ubiquitin-protein ligase pellino homolog 2, Peroxisome biogenesis factor 10, PHD and RING finger domain-containing protein 1, E3 SUMO-protein ligase PIAS2, E3 SUMO-protein ligase PIAS4, E3 ubiquitin-protein ligase Praja-2, Protein PML, RING-type E3 ubiquitin-protein ligase PPIL2, E3 ubiquitin-protein ligase parkin, Pre-mRNA-processing factor 19, E3 SUMO-protein ligase RanBP2, E3 ubiquitin-protein ligase RBX1, RCC1 and BTB domain-containing protein 1, RING finger and CHY zinc finger domain-containing protein 1, E3 ubiquitin-protein ligase RFWD3, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RLIM, RING finger protein 10, E3 ubiquitin-protein ligase RNF114, E3 ubiquitin-protein ligase RNF126, E3 ubiquitin-protein ligase RNF128, E3 ubiquitin-protein ligase RNF135, E3 ubiquitin-protein ligase RNF14, E3 ubiquitin-protein ligase RNF144B, RING finger protein 148, E3 ubiquitin-protein ligase RNF149, RING finger protein 150, E3 ubiquitin ligase RNF157, E3 ubiquitin-protein ligase RNF168, E3 ubiquitin-protein ligase RNF187, E3 ubiquitin-protein ligase RNF19B, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase RNF213, RING finger protein 214, E3 ubiquitin-protein ligase RNF216, Probable E3 ubiquitin-protein ligase RNF217, RING finger protein 219, E3 ubiquitin-protein ligase RNF25, E3 ubiquitin-protein ligase RNF31, E3 ubiquitin-protein ligase BRE1B, E3 ubiquitin-protein ligase RNF43, E3 ubiquitin-protein ligase RNF5, RING-box protein 2, E3 ubiquitin-protein ligase RNF8, RUN and FYVE domain-containing protein 1, E3 ubiquitin-protein ligase SH3RF2, SH3KBP1-binding protein 1, Structure-specific endonuclease subunit SLX4, E3 ubiquitin-protein ligase SMURF1, E3 ubiquitin-protein ligase SMURF2, Suppressor of cytokine signaling 2, Suppressor of cytokine signaling 3, Suppressor of cytokine signaling 6, Suppressor of cytokine signaling 7, Speckle-type POZ protein, Tumor necrosis factor alpha-induced protein 3, E3 ubiquitin-protein ligase Topors, TNF receptor-associated factor 1, TNF receptor-associated factor 2, TNF receptor-associated factor 3, E3 ubiquitin-protein ligase TRIM11, E3 ubiquitin-protein ligase TRIM22, E3 ubiquitin/ISG15 ligase TRIM25, Transcription intermediary factor 1-beta, Tripartite motif-containing protein 3, E3 ubiquitin-protein ligase TRIM32, E3 ubiquitin-protein ligase TRIM33, E3 ubiquitin-protein ligase TRIM36, E3 ubiquitin-protein ligase TRIM4, Tripartite motif-containing protein 47, E3 ubiquitin-protein ligase TRIM56, Tripartite motif-containing protein 59, Tripartite motif-containing protein 65, E3 ubiquitin-protein ligase TRIM7, E3 ubiquitin-protein ligase TRIM71, Tripartite motif-containing protein 72, E3 ubiquitin-protein ligase TRIM8, E3 ubiquitin-protein ligase TRIP12, Short transient receptor potential channel 4-associated protein, E3 ubiquitin-protein ligase TTC3, (E3-independent) E2 ubiquitin-conjugating enzyme, Ubiquitin-protein ligase E3 Å, Ubiquitin-protein ligase E3B, Ubiquitin-protein ligase E3C, E3 ubiquitin-protein ligase E3D, Ubiquitin conjugation factor E4 A, Ubiquitin conjugation factor E4 B, E3 ubiquitin-protein ligase UBR1, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UBR3, E3 ubiquitin-protein ligase UBR4, E3 ubiquitin-protein ligase UBR5, Putative E3 ubiquitin-protein ligase UBR7, RING finger protein unkempt homolog, Putative E3 ubiquitin-protein ligase UNKL, Vacuolar protein sorting-associated protein 11 homolog, Vacuolar protein sorting-associated protein 18 homolog, Vacuolar protein sorting-associated protein 41 homolog, Vacuolar protein sorting-associated protein 8 homolog, WD repeat-containing protein 26, WD and tetratricopeptide repeats protein 1, NEDD4-like E3 ubiquitin-protein ligase WWP1, NEDD4-like E3 ubiquitin-protein ligase WWP2, Nuclear-interacting partner of ALK, Zinc finger protein-like 1, E3 ubiquitin-protein ligase ZNF598, E3 ubiquitin-protein ligase ZNRF3.

In some embodiments, the cysteine-containing protein is a member of the E3-RING family. In some instances, the probe binds to a cysteine residue of a member of the E3-RING family. In some instances, the members comprise Polycomb group RING finger protein 6, E3 ubiquitin-protein ligase CBL-B, F-box only protein 22, Elongin-B, Elongin-C, Kelch repeat and BTB domain domain-containing protein 4, Kelch-like ECH-associated protein 1, E3 ubiquitin-protein ligase pellino homolog 1, E3 ubiquitin-protein ligase RNF128, and TNF receptor-associated factor 6. In some cases, the probe binds to a cysteine residue of Polycomb group RING finger protein 6, E3 ubiquitin-protein ligase CBL-B, F-box only protein 22, Elongin-B, Elongin-C, Kelch repeat and BTB domain domain-containing protein 4, Kelch-like ECH-associated protein 1, E3 ubiquitin-protein ligase pellino homolog 1, E3 ubiquitin-protein ligase RNF128, or TNF receptor-associated factor 6.

In some instances, the cysteine-containing protein is a member of the Cullin RING ligase (CRL) family. In some cases, the members comprise Elongin-B and Elongin-C. In some cases, the probe binds to a cysteine residue of Elongin-B or Elongin-C.

In some instances, the cysteine-containing protein is B-cell lymphoma 6 protein. In some cases, the probe binds to a cysteine residue of B-cell lymphoma 6 protein.

In some instances, the cysteine-containing protein is (E3-independent) E2 ubiquitin-conjugating enzyme. In some cases, the probe binds to a cysteine residue of (E3-independent) E2 ubiquitin-conjugating enzyme.

In some embodiments, described herein include a protein-probe adduct wherein the probe binds to a cysteine residue illustrated in Table 1A or Table 2A; wherein the probe has a structure represented by Formula (I):

wherein,

n is 0-8.

In some instances, n is 0, 1, 2, 3, 4, 5, 6, 7, or 8. In some instances, n is 1. In some instances, n is 2. In some instances, n is 3. In some instances, n is 4. In some instances, n is 5. In some instances, n is 6. In some instances, n is 7. In some instances, n is 8.

In some instances, the protein is Ankyrin repeat and BTB/POZ domain-containing protein 1, Ankyrin repeat and BTB/POZ domain-containing protein 2, Activating molecule in BECN1-regulated autophagy protein 1, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 15, Anaphase-promoting complex subunit 16, Anaphase-promoting complex subunit 2, Anaphase-promoting complex subunit 7, Rabankyrin-5, Ankyrin repeat and IBR domain-containing protein 1, Amyloid protein-binding protein 2, Apoptosis-resistant E3 ubiquitin protein ligase 1, E3 ubiquitin-protein ligase ARIH1, E3 ubiquitin-protein ligase ARIH2, Armadillo repeat-containing protein 5, Ankyrin repeat and SOCS box protein 2, Ankyrin repeat and SOCS box protein 6, Transcriptional regulator ATRX, Transcription regulator protein BACH1, Transcription regulator protein BACH2, Baculoviral IAP repeat-containing protein 2, Baculoviral IAP repeat-containing protein 3, Baculoviral IAP repeat-containing protein 6, Breast cancer type 1 susceptibility protein, F-box/WD repeat-containing protein 1A, Cullin-associated NEDD8-dissociated protein 1, Cullin-associated NEDD8-dissociated protein 2, E3 ubiquitin-protein ligase CBL, E3 ubiquitin-protein ligase CBL-B, E3 ubiquitin-protein ligase CBL-C, Cyclin-F, Cell division cycle protein 20 homolog, Cell division cycle protein 23 homolog, Cell division cycle protein 27 homolog, Cell growth regulator with RING finger domain protein 1, E3 ubiquitin-protein ligase CHFR, Clusterin, CCR4-NOT transcription complex subunit 4, COMM domain-containing protein 2, COMM domain-containing protein 9, Cullin-4A, Cullin-5, Cullin-7, Cullin-9, DDB1- and CUL4-associated factor 1, DDB1- and CUL4-associated factor 10, DDB1- and CUL4-associated factor 13, DDB1- and CUL4-associated factor 16, DDB1- and CUL4-associated factor 17, DDB1- and CUL4-associated factor 5, DDB1- and CUL4-associated factor 6, DDB1- and CUL4-associated factor 7, DNA damage-binding protein 2, Zinc finger protein neuro-d4, Denticleless protein homolog, E3 ubiquitin-protein ligase DTX1, Probable E3 ubiquitin-protein ligase DTX3, E3 ubiquitin-protein ligase DTX3L, E3 SUMO-protein ligase EGR2, Ectoderm-neural cortex protein 1, DNA excision repair protein ERCC-8, E3 ubiquitin-protein ligase FANCL, F-box DNA helicase 1, F-box/LRR-repeat protein 12, F-box/LRR-repeat protein 17, F-box/LRR-repeat protein 18, F-box/LRR-repeat protein 20, F-box/LRR-repeat protein 3, F-box/LRR-repeat protein 6, F-box only protein 11, F-box only protein 30, F-box only protein 31, F-box only protein 38, F-box only protein 42, F-box/SPRY domain-containing protein 1, F-box only protein 5, F-box only protein 7, F-box only protein 9, F-box/WD repeat-containing protein 11, F-box/WD repeat-containing protein 4, F-box/WD repeat-containing protein 8, F-box/WD repeat-containing protein 9, Protein fem-1 homolog A, Protein fem-1 homolog B, Gigaxonin, General transcription factor IIH subunit 2, E3 ubiquitin-protein ligase HACE1, E3 ubiquitin-protein ligase HECTD1, Probable E3 ubiquitin-protein ligase HECTD4, E3 ubiquitin-protein ligase HECW1, E3 ubiquitin-protein ligase HECW2, Probable E3 ubiquitin-protein ligase HERC1, E3 ubiquitin-protein ligase HERC2, Probable E3 ubiquitin-protein ligase HERC3, Probable E3 ubiquitin-protein ligase HERC4, E3 ISG15-protein ligase HERC5, Helicase-like transcription factor, E3 ubiquitin-protein ligase HUWE1, Actin-binding protein IPP, Interferon regulatory factor 2-binding protein 1, Interferon regulatory factor 2-binding protein 2, Interferon regulatory factor 2-binding protein-like, E3 ubiquitin-protein ligase Itchy homolog, Influenza virus NS1A-binding protein, Kelch repeat and BTB domain-containing protein 11, Kelch repeat and BTB domain-containing protein 4, Kelch repeat and BTB domain-containing protein 6, Kelch repeat and BTB domain-containing protein 7, Kelch repeat and BTB domain-containing protein 8, E3 ubiquitin-protein ligase KCMF1, BTB/POZ domain-containing protein KCTD3, BTB/POZ domain-containing protein KCTD7, Kelch-like ECH-associated protein 1, Kelch domain-containing protein 10, Kelch domain-containing protein 3, Kelch-like protein 20, Kelch-like protein 24, Kelch-like protein 26, Kelch-like protein 36, E3 ubiquitin-protein ligase LNX, LON peptidase N-terminal domain and RING finger protein 2, Leucine-rich repeat protein 1, Leucine-rich repeat-containing protein 41, E3 ubiquitin-protein ligase LRSAM1, E3 ubiquitin-protein ligase listerin, E3 ubiquitin-protein ligase MARCH1, E3 ubiquitin-protein ligase MARCH3, E3 ubiquitin-protein ligase MARCH5, E3 ubiquitin-protein ligase MARCH6, E3 ubiquitin-protein ligase MARCH7, E3 ubiquitin-protein ligase Mdm2, E3 ubiquitin-protein ligase MGRN1, E3 ubiquitin-protein ligase MIB2, Probable E3 ubiquitin-protein ligase MID2, E3 ubiquitin-protein ligase makorin-1, Probable E3 ubiquitin-protein ligase makorin-2, Male-specific lethal 1 homolog, E3 ubiquitin-protein ligase MYCBP2, E3 ubiquitin-protein ligase NEDD4, E3 ubiquitin-protein ligase NEDD4-like, Transcriptional repressor NF-X1, NF-X1-type zinc finger protein NFXL1, Nitric oxide synthase-interacting protein, Histone-lysine N-methyltransferase NSD2, OTU domain-containing protein 7B, POZ-, AT hook-, and zinc finger-containing protein 1, Polycomb group RING finger protein 2, E3 ubiquitin-protein ligase PDZRN3, E3 ubiquitin-protein ligase pellino homolog 1, E3 ubiquitin-protein ligase pellino homolog 2, Peroxisome biogenesis factor 10, PHD and RING finger domain-containing protein 1, E3 SUMO-protein ligase PIAS2, E3 SUMO-protein ligase PIAS4, E3 ubiquitin-protein ligase Praja-2, Protein PML, RING-type E3 ubiquitin-protein ligase PPIL2, E3 ubiquitin-protein ligase parkin, Pre-mRNA-processing factor 19, E3 SUMO-protein ligase RanBP2, E3 ubiquitin-protein ligase RBX1, RCC1 and BTB domain-containing protein 1, RING finger and CHY zinc finger domain-containing protein 1, E3 ubiquitin-protein ligase RFWD3, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RLIM, RING finger protein 10, E3 ubiquitin-protein ligase RNF114, E3 ubiquitin-protein ligase RNF126, E3 ubiquitin-protein ligase RNF128, E3 ubiquitin-protein ligase RNF135, E3 ubiquitin-protein ligase RNF14, E3 ubiquitin-protein ligase RNF144B, RING finger protein 148, E3 ubiquitin-protein ligase RNF149, RING finger protein 150, E3 ubiquitin ligase RNF157, E3 ubiquitin-protein ligase RNF168, E3 ubiquitin-protein ligase RNF187, E3 ubiquitin-protein ligase RNF19B, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase RNF213, RING finger protein 214, E3 ubiquitin-protein ligase RNF216, Probable E3 ubiquitin-protein ligase RNF217, RING finger protein 219, E3 ubiquitin-protein ligase RNF25, E3 ubiquitin-protein ligase RNF31, E3 ubiquitin-protein ligase BRE1B, E3 ubiquitin-protein ligase RNF43, E3 ubiquitin-protein ligase RNF5, RING-box protein 2, E3 ubiquitin-protein ligase RNF8, RUN and FYVE domain-containing protein 1, E3 ubiquitin-protein ligase SH3RF2, SH3KBP1-binding protein 1, Structure-specific endonuclease subunit SLX4, E3 ubiquitin-protein ligase SMURF1, E3 ubiquitin-protein ligase SMURF2, Suppressor of cytokine signaling 2, Suppressor of cytokine signaling 3, Suppressor of cytokine signaling 6, Suppressor of cytokine signaling 7, Speckle-type POZ protein, Tumor necrosis factor alpha-induced protein 3, E3 ubiquitin-protein ligase Topors, TNF receptor-associated factor 1, TNF receptor-associated factor 2, TNF receptor-associated factor 3, E3 ubiquitin-protein ligase TRIM11, E3 ubiquitin-protein ligase TRIM22, E3 ubiquitin/ISG15 ligase TRIM25, Transcription intermediary factor 1-beta, Tripartite motif-containing protein 3, E3 ubiquitin-protein ligase TRIM32, E3 ubiquitin-protein ligase TRIM33, E3 ubiquitin-protein ligase TRIM36, E3 ubiquitin-protein ligase TRIM4, Tripartite motif-containing protein 47, E3 ubiquitin-protein ligase TRIM56, Tripartite motif-containing protein 59, Tripartite motif-containing protein 65, E3 ubiquitin-protein ligase TRIM7, E3 ubiquitin-protein ligase TRIM71, Tripartite motif-containing protein 72, E3 ubiquitin-protein ligase TRIM8, E3 ubiquitin-protein ligase TRIP12, Short transient receptor potential channel 4-associated protein, E3 ubiquitin-protein ligase TTC3, (E3-independent) E2 ubiquitin-conjugating enzyme, Ubiquitin-protein ligase E3A, Ubiquitin-protein ligase E3B, Ubiquitin-protein ligase E3C, E3 ubiquitin-protein ligase E3D, Ubiquitin conjugation factor E4 A, Ubiquitin conjugation factor E4 B, E3 ubiquitin-protein ligase UBR1, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UBR3, E3 ubiquitin-protein ligase UBR4, E3 ubiquitin-protein ligase UBR5, Putative E3 ubiquitin-protein ligase UBR7, RING finger protein unkempt homolog, Putative E3 ubiquitin-protein ligase UNKL, Vacuolar protein sorting-associated protein 11 homolog, Vacuolar protein sorting-associated protein 18 homolog, Vacuolar protein sorting-associated protein 41 homolog, Vacuolar protein sorting-associated protein 8 homolog, WD repeat-containing protein 26, WD and tetratricopeptide repeats protein 1, NEDD4-like E3 ubiquitin-protein ligase WWP1, NEDD4-like E3 ubiquitin-protein ligase WWP2, Nuclear-interacting partner of ALK, Zinc finger protein-like 1, E3 ubiquitin-protein ligase ZNF598, E3 ubiquitin-protein ligase ZNRF3.

In some embodiments, the probe with a structure represented by Formula (I) binds to a cysteine residue of a member of the E3-RING family. In some instances, the members comprise Polycomb group RING finger protein 6, E3 ubiquitin-protein ligase CBL-B, F-box only protein 22, Elongin-B, Elongin-C, Kelch repeat and BTB domain domain-containing protein 4, Kelch-like ECH-associated protein 1, E3 ubiquitin-protein ligase pellino homolog 1, E3 ubiquitin-protein ligase RNF128, and TNF receptor-associated factor 6. In some cases, the probe with a structure represented by Formula (I) binds to a cysteine residue of Polycomb group RING finger protein 6, E3 ubiquitin-protein ligase CBL-B, F-box only protein 22, Elongin-B, Elongin-C, Kelch repeat and BTB domain domain-containing protein 4, Kelch-like ECH-associated protein 1, E3 ubiquitin-protein ligase pellino homolog 1, E3 ubiquitin-protein ligase RNF128, or TNF receptor-associated factor 6.

In some instances, the probe with a structure represented by Formula (I) binds to a cysteine residue of Elongin-B or Elongin-C.

In some instances, the probe with a structure represented by Formula (I) binds to a cysteine residue of B-cell lymphoma 6 protein.

In some instances, the probe with a structure represented by Formula (I) binds to a cysteine residue of (E3-independent) E2 ubiquitin-conjugating enzyme.

In some instances, the protein is E3 ubiquitin-protein ligase TRIP12 (TRIP12). In some cases, the cysteine residue is C1959, wherein the numberings of the amino acid positions correspond to the amino acid positions with the UniProt Identifier Q14669. In some cases, the probe binds to C1959 of TRIP12.

In some instances, the protein is anaphase-promoting complex subunit 16 (ANAPC16). In some cases, the cysteine residue is C55, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96DE5. In some cases, the probe binds to C55 of ANAPC16.

In some instances, the protein is probable E3 ubiquitin-protein ligase MYCBP2 (MYCBP2). In some cases, the cysteine residue is C1131 or C3152, wherein the numberings of the amino acid positions correspond to the amino acid positions with the UniProt Identifier 075592. In some cases, the probe binds to C1131 or C3152 of MYCBP2.

In some instances, the protein is ubiquitin conjugation factor E4A (UBE4A). In some cases, the cysteine residue is C79, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14139. In some cases, the probe binds to C79 of UBE4A.

In some instances, the protein is autophagy-related protein 16-1 (ATG16L1). In some cases, the cysteine residue is C145, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q676U5. In some cases, the probe binds to C145 of ATG16L1.

In some instances, the protein is protein arginine N-methyltransferase 5 (PRMT5). In some cases, the cysteine residue is C278, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier 014744. In some cases, the probe binds to C278 of PRMT5.

In some instances, the protein is isocitrate dehydrogenase (IDH2). In some cases, the cysteine residue is C154, wherein the numberings of the amino acid positions correspond to the amino acid positions with the UniProt Identifier P48735. In some cases, the probe binds to C154 of IDH2.

In some instances, the protein is antigen peptide transporter 2 (TAP2). In some cases, the cysteine residue is C641, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q03519. In some cases, the probe binds to C641 of TAP2.

In some instances, the protein is tapasin (TAPBP). In some cases, the cysteine residue is C440, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier O15533. In some cases, the probe binds to C440 of TAPBP.

In some instances, the protein is protein unc-93 homolog B1 (UNC93B1). In some cases, the cysteine residue is C583, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9H1C4. In some cases, the probe binds to C583 of UNC93B1.

In some instances, the protein is probable ATP-dependent RNA helicase DDX60 (DDX60). In some cases, the cysteine residue is C1051, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q81Y21. In some cases, the probe binds to C1051 of DDX60.

In some embodiments, the protein is B-cell lymphoma 6 protein (BCL6) and the cysteine residue is C121, C175, C232, C254, C296, C339, C348, C354, C414, C548, or C663, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182. In some cases, the probe binds to C121, C175, C232, C254, C296, C339, C348, C354, C414, C548, or C663 of BCL6.

In some instances, the protein is B-cell lymphoma 6 protein. In some cases, the cysteine residue is C121, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182. In some cases, the probe binds to C121 of BCL6.

In some instances, the protein is B-cell lymphoma 6 protein. In some cases, the cysteine residue is C175, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182. In some cases, the probe binds to C175 of BCL6.

In some instances, the protein is B-cell lymphoma 6 protein. In some cases, the cysteine residue is C232, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182. In some cases, the probe binds to C232 of BCL6.

In some instances, the protein is B-cell lymphoma 6 protein. In some cases, the cysteine residue is C254, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182. In some cases, the probe binds to C254 of BCL6.

In some instances, the protein is B-cell lymphoma 6 protein. In some cases, the cysteine residue is C296, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182. In some cases, the probe binds to C296 of BCL6.

In some instances, the protein is B-cell lymphoma 6 protein. In some cases, the cysteine residue is C339, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182. In some cases, the probe binds to C339 of BCL6.

In some instances, the protein is B-cell lymphoma 6 protein. In some cases, the cysteine residue is C348, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182. In some cases, the probe binds to C348 of BCL6.

In some instances, the protein is B-cell lymphoma 6 protein. In some cases, the cysteine residue is C354, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182. In some cases, the probe binds to C354 of BCL6.

In some instances, the protein is B-cell lymphoma 6 protein. In some cases, the cysteine residue is C414, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182. In some cases, the probe binds to C414 of BCL6.

In some instances, the protein is B-cell lymphoma 6 protein. In some cases, the cysteine residue is C548, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182. In some cases, the probe binds to C548 of BCL6.

In some instances, the protein is B-cell lymphoma 6 protein. In some cases, the cysteine residue is C663, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182. In some cases, the probe binds to C663 of BCL6.

In some embodiments, the protein is Polycomb group RING finger protein 6 (PCGF6) and the cysteine residue is C56, C137, or C155, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9BYE7. In some cases, the probe binds to C56, C137, or C155 of PCGF6.

In some instances, the protein is Polycomb group RING finger protein 6. In some cases, the cysteine residue is C56, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9BYE7. In some cases, the probe binds to C56 of PCGF6.

In some instances, the protein is Polycomb group RING finger protein 6. In some cases, the cysteine residue is C137, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9BYE7. In some cases, the probe binds to C137 of PCGF6.

In some instances, the protein is Polycomb group RING finger protein 6. In some cases, the cysteine residue is C155, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9BYE7. In some cases, the probe binds to C155 of PCGF6.

In some embodiments, the protein is E3 ubiquitin-protein ligase CBL-B (CBLB) and the cysteine residue is C60, C345, C376, C435, C436, C470, C523, C535, C594, C607, C686, C741, or C895, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the probe binds to C60, C345, C376, C435, C436, C470, C523, C535, C594, C607, C686, C741, or C895 of CBLB.

In some instances, the protein is E3 ubiquitin-protein ligase CBL-B. In some cases, the cysteine residue is C60, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the probe binds to C60 of CBLB.

In some instances, the protein is E3 ubiquitin-protein ligase CBL-B. In some cases, the cysteine residue is C345, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the probe binds to C345 of CBLB.

In some instances, the protein is E3 ubiquitin-protein ligase CBL-B. In some cases, the cysteine residue is C376, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the probe binds to C376 of CBLB.

In some instances, the protein is E3 ubiquitin-protein ligase CBL-B. In some cases, the cysteine residue is C435, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the probe binds to C435 of CBLB.

In some instances, the protein is E3 ubiquitin-protein ligase CBL-B. In some cases, the cysteine residue is C436, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the probe binds to C436 of CBLB.

In some instances, the protein is E3 ubiquitin-protein ligase CBL-B. In some cases, the cysteine residue is C470, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the probe binds to C470 of CBLB.

In some instances, the protein is E3 ubiquitin-protein ligase CBL-B. In some cases, the cysteine residue is C523, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the probe binds to C523 of CBLB.

In some instances, the protein is E3 ubiquitin-protein ligase CBL-B. In some cases, the cysteine residue is C535, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the probe binds to C535 of CBLB.

In some instances, the protein is E3 ubiquitin-protein ligase CBL-B. In some cases, the cysteine residue is C594, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the probe binds to C594 of CBLB.

In some instances, the protein is E3 ubiquitin-protein ligase CBL-B. In some cases, the cysteine residue is C607, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the probe binds to C607 of CBLB.

In some instances, the protein is E3 ubiquitin-protein ligase CBL-B. In some cases, the cysteine residue is C686, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the probe binds to C686 of CBLB.

In some instances, the protein is E3 ubiquitin-protein ligase CBL-B. In some cases, the cysteine residue is C741, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the probe binds to C741 of CBLB.

In some instances, the protein is E3 ubiquitin-protein ligase CBL-B. In some cases, the cysteine residue is C895, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the probe binds to C895 of CBLB.

In some embodiments, the protein is Elongin-B (ELOB) and the cysteine residue is C60 or C89, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q15370. In some cases, the probe binds to C60 or C89 of ELOB.

In some instances, the protein is Elongin-B. In some cases, the cysteine residue is C60, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q15370. In some cases, the probe binds to C60 of ELOB.

In some instances, the protein is Elongin-B. In some cases, the cysteine residue is C89, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q15370. In some cases, the probe binds to 89C of ELOB.

In some embodiments, the protein is Elongin-C (ELOC) and the cysteine residue is C11 or C74, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q15369. In some cases, the probe binds to C11 or C74 of ELOC.

In some instances, the protein is Elongin-C. In some cases, the cysteine residue is C11, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q15369. In some cases, the probe binds to C11 of ELOC.

In some instances, the protein is Elongin-C. In some cases, the cysteine residue is C74, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q15369. In some cases, the probe binds to C74 of ELOC.

In some embodiments, the protein is F-box only protein 22 (FBXO22) and the cysteine residue is C47, C117, C227, C228, or C378, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8NEZ5. In some cases, the probe binds to C47, C117, C227, C228, or C378 of FBXO22.

In some instances, the protein is F-box only protein 22. In some cases, the cysteine residue is C47, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8NEZ5. In some cases, the probe binds to C47 of FBXO22.

In some instances, the protein is F-box only protein 22. In some cases, the cysteine residue is C117, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8NEZ5. In some cases, the probe binds to C117 of FBXO22.

In some instances, the protein is F-box only protein 22. In some cases, the cysteine residue is C227, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8NEZ5. In some cases, the probe binds to C227 of FBXO22.

In some instances, the protein is F-box only protein 22. In some cases, the cysteine residue is C228, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8NEZ5. In some cases, the probe binds to C228 of FBXO22.

In some instances, the protein is F-box only protein 22. In some cases, the cysteine residue is C378, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8NEZ5. In some cases, the probe binds to C378 of FBXO22.

In some embodiments, the protein is Kelch repeat and BTB domain-containing protein 4 (KBTBD4) and the cysteine residue is C68, C201, C274, C301, C455, or C472, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7. In some cases, the probe binds to C68, C201, C274, C301, C455, or C472 of KBTBD4.

In some instances, the protein is Kelch repeat and BTB domain-containing protein 4. In some cases, the cysteine residue is C68, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7. In some cases, the probe binds to C68 of KBTBD4.

In some instances, the protein is Kelch repeat and BTB domain-containing protein 4. In some cases, the cysteine residue is C201, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7. In some cases, the probe binds to C201 of KBTBD4.

In some instances, the protein is Kelch repeat and BTB domain-containing protein 4. In some cases, the cysteine residue is C274, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7. In some cases, the probe binds to C274 of KBTBD4.

In some instances, the protein is Kelch repeat and BTB domain-containing protein 4. In some cases, the cysteine residue is C301, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7. In some cases, the probe binds to C301 of KBTBD4.

In some instances, the protein is Kelch repeat and BTB domain-containing protein 4. In some cases, the cysteine residue is C455, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7. In some cases, the probe binds to C455 of KBTBD4.

In some instances, the protein is Kelch repeat and BTB domain-containing protein 4. In some cases, the cysteine residue is C472, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7. In some cases, the probe binds to C472 of KBTBD4.

In some embodiments, the protein is Kelch-like ECH-associated protein 1 (KEAP1) and the cysteine residue is C23, C38, C151, C226, C241, C257, C288, C297, C319, C434, C613, C622, or C624 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the probe binds to C23, C38, C151, C226, C241, C257, C288, C297, C319, C434, C613, C622, or C624 of KEAP1.

In some instances, the protein is Kelch-like ECH-associated protein 1. In some cases, the cysteine residue is C23, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the probe binds to C23 of KEAP1.

In some instances, the protein is Kelch-like ECH-associated protein 1. In some cases, the cysteine residue is C38, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the probe binds to C38 of KEAP1.

In some instances, the protein is Kelch-like ECH-associated protein 1. In some cases, the cysteine residue is C151, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the probe binds to C151 of KEAP1.

In some instances, the protein is Kelch-like ECH-associated protein 1. In some cases, the cysteine residue is C226, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the probe binds to C226 of KEAP1.

In some instances, the protein is Kelch-like ECH-associated protein 1. In some cases, the cysteine residue is C241, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the probe binds to C241 of KEAP1.

In some instances, the protein is Kelch-like ECH-associated protein 1. In some cases, the cysteine residue is C257, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the probe binds to C257 of KEAP1.

In some instances, the protein is Kelch-like ECH-associated protein 1. In some cases, the cysteine residue is C288, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the probe binds to C288 of KEAP1.

In some instances, the protein is Kelch-like ECH-associated protein 1. In some cases, the cysteine residue is C297, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the probe binds to C297 of KEAP1.

In some instances, the protein is Kelch-like ECH-associated protein 1. In some cases, the cysteine residue is C319, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the probe binds to C319 of KEAP1.

In some instances, the protein is Kelch-like ECH-associated protein 1. In some cases, the cysteine residue is C434, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the probe binds to C434 of KEAP1.

In some instances, the protein is Kelch-like ECH-associated protein 1. In some cases, the cysteine residue is C613, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the probe binds to C613 of KEAP1.

In some instances, the protein is Kelch-like ECH-associated protein 1. In some cases, the cysteine residue is C624 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the probe binds to C622 of KEAP1.

In some instances, the protein is Kelch-like ECH-associated protein 1. In some cases, the cysteine residue is C624 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the probe binds to C624 of KEAP1.

In some embodiments, the protein is E3 ubiquitin-protein ligase pellino homolog 11 (PELI1) and the cysteine residue is C61, C212, or C282 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96FA3. In some cases, the probe binds to C61, C212, or C282 of PELI1.

In some instances, the protein is E3 ubiquitin-protein ligase pellino homolog 11. In some cases, the cysteine residue is C61, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96FA3. In some cases, the probe binds to C61 of PELI1.

In some instances, the protein is E3 ubiquitin-protein ligase pellino homolog 11. In some cases, the cysteine residue is C212 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96FA3. In some cases, the probe binds to C212 of PELI1.

In some instances, the protein is E3 ubiquitin-protein ligase pellino homolog 11. In some cases, the cysteine residue is C282 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96FA3. In some cases, the probe binds to C282 of PELI1.

In some embodiments, the protein is E3 ubiquitin-protein ligase RNF128 (RNF128) and the cysteine residue is C295, C303, C314, or C317 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8TEB7. In some cases, the probe binds to C295, C303, C314, or C317 of RNF128.

In some instances, the protein is E3 ubiquitin-protein ligase RNF128. In some cases, the cysteine residue is C295, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8TEB7. In some cases, the probe binds to C295 of RNF128.

In some instances, the protein is E3 ubiquitin-protein ligase RNF128. In some cases, the cysteine residue is C303, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8TEB7. In some cases, the probe binds to C303 of RNF128.

In some instances, the protein is E3 ubiquitin-protein ligase RNF128. In some cases, the cysteine residue is C314 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8TEB7. In some cases, the probe binds to C314 of RNF128.

In some instances, the protein is E3 ubiquitin-protein ligase RNF128. In some cases, the cysteine residue is C317 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8TEB7. In some cases, the probe binds to C317 of RNF128.

In some embodiments, the protein is TNF receptor-associated factor 6 (TRAF6) and the cysteine residue is C85, C105, C134, C139, C182, C235, C349, or C366, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9Y4K3. In some cases, the probe binds to C85, C105, C134, C139, C182, C235, C349, or C366 of TRAF6.

In some instances, the protein is TNF receptor-associated factor 6. In some cases, the cysteine residue is C85, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9Y4K3. In some cases, the probe binds to C85 of TRAF6.

In some instances, the protein is TNF receptor-associated factor 6. In some cases, the cysteine residue is C105, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9Y4K3. In some cases, the probe binds to C105 of TRAF6.

In some instances, the protein is TNF receptor-associated factor 6. In some cases, the cysteine residue is C134, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9Y4K3. In some cases, the probe binds to C134 of TRAF6.

In some instances, the protein is TNF receptor-associated factor 6. In some cases, the cysteine residue is C139, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9Y4K3. In some cases, the probe binds to C139 of TRAF6.

In some instances, the protein is TNF receptor-associated factor 6. In some cases, the cysteine residue is C182, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9Y4K3. In some cases, the probe binds to C182 of TRAF6.

In some instances, the protein is TNF receptor-associated factor 6. In some cases, the cysteine residue is C235, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9Y4K3. In some cases, the probe binds to C235 of TRAF6.

In some instances, the protein is TNF receptor-associated factor 6. In some cases, the cysteine residue is C349, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9Y4K3. In some cases, the probe binds to C349 of TRAF6.

In some instances, the protein is TNF receptor-associated factor 6. In some cases, the cysteine residue is C366, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9Y4K3. In some cases, the probe binds to C366 of TRAF6.

In some embodiments, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme (UBE20) and the cysteine residue is C101, C182, C208, C230, C244, C314, C341, C370, C375, C400, C406, C585, C598, C910, C913, C1040, C1099, or C1288, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C101, C182, C208, C230, C244, C314, C341, C370, C375, C400, C406, C585, C598, C910, C913, C1040, C1099, or C1288 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C101, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C101 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C182, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C182 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C208, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C208 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C230, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C230 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C244, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C244 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C314, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C314 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C341, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C341 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C370, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C370 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C375, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C375 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C400, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C400 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C406, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C406 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C585, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C585 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C598, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C598 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C910, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C910 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C913, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C913 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C1040, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C1040 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C1099, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C1099 of UBE20.

In some instances, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C1288, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the probe binds to C1288 of UBE20.

In some embodiments, also described herein include a synthetic ligand that inhibits a covalent interaction between a protein and a probe, wherein in the absence of the synthetic ligand, the probe binds to a cysteine residue illustrated in Table 1A or Table 2A; and wherein the probe has a structure represented by Formula (I):

wherein,

-   -   n is 0-8.

In some instances, n is 0, 1, 2, 3, 4, 5, 6, 7, or 8. In some instances, n is 1. In some instances, n is 2. In some instances, n is 3. In some instances, n is 4. In some instances, n is 5. In some instances, n is 6. In some instances, n is 7. In some instances, n is 8.

In some instances, the synthetic ligand comprises a structure represented by Formula II:

wherein,

-   -   CRG-L is optional, and when present is a covalent reactive group         comprising a Michael acceptor moiety, a leaving group moiety, or         a moiety capable of forming a covalent bond to the thiol group         of a cysteine residue, and L is a linker;

MRE is a molecular recognition element that is capable of interacting with the protein; and R^(M) is optional, and when present comprises a binding element that binds to a second protein or another compound.

In some cases, the Michael acceptor moiety comprises an alkene or an alkyne moiety. In some cases, the Michael acceptor moiety comprises an alkene moiety. In some cases, the Michael acceptor moiety comprises an alkyne moiety.

In some instances, L is a cleavable linker. In other instances, L is a non-cleavable linker.

In some cases, MRE comprises a small molecule compound, a polynucleotide, a polypeptide or fragments thereof, or a peptidomimetic. In some embodiments, MRE is a small molecule compound. In some embodiments, MRE is a polynucleotide. In some embodiments, MRE is a polypeptide or fragments thereof. In some embodiments, MRE is a peptidomimetic.

In some embodiments, the synthetic ligand has a structure represented by Formula (IIA) or Formula (IIB):

wherein,

-   -   each R^(A) and R^(B) is independently selected from the group         consisting of H, D, substituted or unsubstituted C₁-C₆alkyl,         substituted or unsubstituted C₁-C₆fluoroalkyl, substituted or         unsubstituted C₁-C₆heteroalkyl, substituted or unsubstituted         C₃-C₈cycloalkyl, substituted or unsubstituted         C₂-C₇heterocycloalkyl, substituted or unsubstituted aryl,         substituted or unsubstituted C₁-C₃alkylene-aryl, substituted or         unsubstituted heteroaryl, and substituted or unsubstituted         C₁-C₃alkylene-heteroaryl; or     -   R^(A) and R^(B) together with the nitrogen to which they are         attached form a substituted or unsubstituted 5, 6, 7 or         8-membered heterocyclic ring A, optionally having one additional         heteroatom moiety independently selected from NR¹, O, or S; and     -   R¹ is H, D, substituted or unsubstituted C₁-C₆alkyl, substituted         or unsubstituted C₁-C₆fluoroalkyl, substituted or unsubstituted         C₁-C₆heteroalkyl, substituted or unsubstituted aryl, or         substituted or unsubstituted heteroaryl.

In some embodiments, R^(A) is H or D.

In some embodiments, R^(B) is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl. In some embodiments, R^(B) is substituted or unsubstituted aryl. In some embodiments, R^(B) is substituted or unsubstituted heteroaryl.

In some embodiments, R^(B) is substituted aryl. In some embodiments, R^(B) is aryl, substituted with one or more substituents selected from the group consisting of halogen, C₁-C₄fluoroalkyl, —CN, and —NO₂.

In some embodiments, R^(A) and R^(B) together with the nitrogen to which they are attached form a substituted or unsubstituted 6 or 7-membered heterocyclic ring A. In some embodiments, ring A is a 6-membered heterocyclic ring. In some embodiments, In some embodiments, ring A is 6-membered heterocyclic ring substituted with substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl. In some embodiments, ring A is 6-membered heterocyclic ring fused with substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl.

In some cases, the synthetic ligand is

In some cases, the synthetic ligand is:

In some cases, the synthetic ligand is:

In some cases, the synthetic ligand is:

In some cases, the synthetic ligand is:

In some instances, the protein is Anaphase-promoting complex subunit 16, Anaphase-promoting complex subunit 7, Apoptosis-resistant E3 ubiquitin protein ligase 1, Transcription regulator protein BACH1, Transcription regulator protein BACH2, Baculoviral IAP repeat-containing protein 2, Baculoviral IAP repeat-containing protein 3, DDB1- and CUL4-associated factor 17, Denticleless protein homolog, F-box only protein 11, F-box only protein 30, E3 ubiquitin-protein ligase HECTD1, Probable E3 ubiquitin-protein ligase HERC1, Probable E3 ubiquitin-protein ligase HERC4, E3 ISG15-protein ligase HERC5, E3 ubiquitin-protein ligase HUWE1, Kelch repeat and BTB domain-containing protein 8, Kelch-like ECH-associated protein 1, MYCBP2 Probable E3 ubiquitin-protein ligase MYCBP2, E3 ubiquitin-protein ligase MYCBP2, Polycomb group RING finger protein 2, E3 SUMO-protein ligase PIAS4, Protein PML, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase RNF213, RING finger protein 214, E3 ubiquitin-protein ligase RNF25, E3 ubiquitin-protein ligase BRE1B, RING-box protein 2, Tumor necrosis factor alpha-induced protein 3, E3 ubiquitin-protein ligase TRIM33, E3 ubiquitin-protein ligase TRIM56, Tripartite motif-containing protein 65, E3 ubiquitin-protein ligase TRIM71, E3 ubiquitin-protein ligase TRIP12, (E3-independent) E2 ubiquitin-conjugating enzyme, UBE4A Ubiquitin conjugation factor E4 A, Ubiquitin conjugation factor E4 A, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UBR4, E3 ubiquitin-protein ligase UBR5, Protein VPRBP, Vacuolar protein sorting-associated protein 18 homolog, or Nuclear-interacting partner of ALK.

In some embodiments, the cysteine-containing protein is a member of the E3-RING family. In some instances, the probe binds to a cysteine residue of a member of the E3-RING family. In some instances, the members comprise Polycomb group RING finger protein 6, E3 ubiquitin-protein ligase CBL-B, F-box only protein 22, Elongin-B, Elongin-C, Kelch repeat and BTB domain domain-containing protein 4, Kelch-like ECH-associated protein 1, E3 ubiquitin-protein ligase pellino homolog 1, E3 ubiquitin-protein ligase RNF128, and TNF receptor-associated factor 6. In some cases, the probe binds to a cysteine residue of Polycomb group RING finger protein 6, E3 ubiquitin-protein ligase CBL-B, F-box only protein 22, Elongin-B, Elongin-C, Kelch repeat and BTB domain domain-containing protein 4, Kelch-like ECH-associated protein 1, E3 ubiquitin-protein ligase pellino homolog 1, E3 ubiquitin-protein ligase RNF128, or TNF receptor-associated factor 6.

In some instances, the cysteine-containing protein is a member of the Cullin RING ligase (CRL) family. In some cases, the members comprise Elongin-B and Elongin-C. In some cases, the probe binds to a cysteine residue of Elongin-B or Elongin-C.

In some instances, the cysteine-containing protein is B-cell lymphoma 6 protein. In some cases, the probe binds to a cysteine residue of B-cell lymphoma 6 protein.

In some instances, the cysteine-containing protein is (E3-independent) E2 ubiquitin-conjugating enzyme. In some cases, the probe binds to a cysteine residue of (E3-independent) E2 ubiquitin-conjugating enzyme.

In some embodiments, the protein is B-cell lymphoma 6 protein (BCL6) and the cysteine residue is C121, C175, C232, C254, C296, C339, C348, C354, C414, C548, or C663, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182. In some cases, the synthetic ligand inhibits a covalent interaction between C121, C175, C232, C254, C296, C339, C348, C354, C414, C548, or C663 of BCL6 and the probe.

In some embodiments, the protein is Polycomb group RING finger protein 6 (PCGF6) and the cysteine residue is C56, C137, or C155, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9BYE7. In some cases, the synthetic ligand inhibits a covalent interaction between C56, C137, or C155 of PCGF6 and the probe.

In some embodiments, the protein is E3 ubiquitin-protein ligase CBL-B (CBLB) and the cysteine residue is C60, C345, C376, C435, C436, C470, C523, C535, C594, C607, C686, C741, or C895, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the synthetic ligand inhibits a covalent interaction between C60, C345, C376, C435, C436, C470, C523, C535, C594, C607, C686, C741, or C895 of CBLB and the probe.

In some embodiments, the protein is E3 ubiquitin-protein ligase CBL-B (CBLB) and the cysteine residue is C607, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the synthetic ligand inhibits a covalent interaction between C607 of CBLB and the probe.

In some embodiments, the protein is Elongin-B (ELOB) and the cysteine residue is C60 or C89, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q15370. In some cases, the synthetic ligand inhibits a covalent interaction between C60 or C89 of ELOB and the probe.

In some embodiments, the protein is Elongin-C (ELOC) and the cysteine residue is C11 or C74, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q15369. In some cases, the synthetic ligand inhibits a covalent interaction between C11 or C74 of ELOC and the probe.

In some embodiments, the protein is F-box only protein 22 (FBXO22) and the cysteine residue is C47, C117, C227, C228, or C378, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8NEZ5. In some cases, the synthetic ligand inhibits a covalent interaction between C47, C117, C227, C228, or C378 of FBXO22 and the probe.

In some embodiments, the protein is Kelch repeat and BTB domain-containing protein 4 (KBTBD4) and the cysteine residue is C68, C201, C274, C301, C455, or C472, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7.

In some cases, the synthetic ligand inhibits a covalent interaction between C68, C201, C274, C301, C455, or C472 of KBTBD4 and the probe.

In some embodiments, the protein is Kelch repeat and BTB domain-containing protein 4 and the cysteine residue is C68, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7. In some cases, the synthetic ligand inhibits a covalent interaction between C68 of KBTBD4 and the probe.

In some embodiments, the protein is Kelch-like ECH-associated protein 1 (KEAP1) and the cysteine residue is C23, C38, C151, C226, C241, C257, C288, C297, C319, C434, C613, C622, or C624 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the synthetic ligand inhibits a covalent interaction between C23, C38, C151, C226, C241, C257, C288, C297, C319, C434, C613, C622, or C624 of KEAP1 and the probe.

In some embodiments, the protein is Kelch-like ECH-associated protein 1 and the cysteine residue is C23, C38, C151, C241, C257, C288, C297, C319, C613, or C624, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the synthetic ligand inhibits a covalent interaction between C23, C38, C151, C241, C257, C288, C297, C319, C613, or C624 of KEAP1 and the probe.

In some embodiments, the protein is E3 ubiquitin-protein ligase pellino homolog 11 (PELI1) and the cysteine residue is C61, C212, or C282 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96FA3. In some cases, the synthetic ligand inhibits a covalent interaction between C61, C212, or C282 of PELI1 and the probe.

In some embodiments, the protein is E3 ubiquitin-protein ligase pellino homolog 1 and the cysteine residue is C282, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96FA3. In some cases, the synthetic ligand inhibits a covalent interaction between C282 of PELI1 and the probe.

In some embodiments, the protein is E3 ubiquitin-protein ligase RNF128 (RNF128) and the cysteine residue is C295, C303, C314, or C317 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8TEB7. In some cases, the synthetic ligand inhibits a covalent interaction between C295, C303, C314, or C317 of RNF128 and the probe.

In some embodiments, the protein is E3 ubiquitin-protein ligase RNF128 and the cysteine residue is C317, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8TEB7. In some cases, the synthetic ligand inhibits a covalent interaction between C317 of RNF128 and the probe.

In some embodiments, the protein is TNF receptor-associated factor 6 (TRAF6) and the cysteine residue is C85, C105, C134, C139, C182, C235, C349, or C366, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9Y4K3. In some cases, the synthetic ligand inhibits a covalent interaction between C85, C105, C134, C139, C182, C235, C349, or C366 of TRAF6 and the probe.

In some embodiments, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme (UBE20) and the cysteine residue is C101, C182, C208, C230, C244, C314, C341, C370, C375, C400, C406, C585, C598, C910, C913, C1040, C1099, or C1288, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the synthetic ligand inhibits a covalent interaction between C101, C182, C208, C230, C244, C314, C341, C370, C375, C400, C406, C585, C598, C910, C913, C1040, C1099, or C1288 of UBE20 and the probe.

In some embodiments, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C370, C400, C910, or C913, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the synthetic ligand inhibits a covalent interaction between C370, C400, C910, or C913 of UBE20 and the probe.

In some instances, the protein is E3 ubiquitin-protein ligase TRIP12 (TRIP12) and the cysteine residue is C1959, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14669. In some cases, the synthetic ligand inhibits a covalent interaction between C1959 of TRIP12 and the probe.

In some instances, the protein is anaphase-promoting complex subunit 16 (ANAPC16) and the cysteine residue is C55, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96DE5. In some cases, the synthetic ligand inhibits a covalent interaction between C55 of ANAPC16 and the probe.

In some instances, the protein is probable E3 ubiquitin-protein ligase MYCBP2 (MYCBP2) and the cysteine residue is C3152, wherein the numberings of the amino acid positions correspond to the amino acid positions with the UniProt Identifier 075592. In some cases, the synthetic ligand inhibits a covalent interaction between C3152 of MYCBP2 and the probe.

In some instances, the protein is ubiquitin conjugation factor E4 A (UBE4A) and the cysteine residue is C79, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14139. In some cases, the synthetic ligand inhibits a covalent interaction between C79 of UBE4A and the probe.

In some instances, the protein is autophagy-related protein 16-1 (ATG16L1) and the cysteine residue is C145, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q676U5. In some cases, the synthetic ligand inhibits a covalent interaction between C145 of ATG16L1 and the probe.

In some instances, the protein is protein arginine N-methyltransferase 5 (PRMT5) and the cysteine residue is C278, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier 014744. In some cases, the synthetic ligand inhibits a covalent interaction between C278 of PRMT5 and the probe.

In some instances, the protein is isocitrate dehydrogenase (IDH2) and the cysteine residue is C154, wherein the numberings of the amino acid positions correspond to the amino acid positions with the UniProt Identifier P48735. In some cases, the synthetic ligand inhibits a covalent interaction between C154 of IDH2 and the probe.

In some instances, the protein is antigen peptide transporter 2 (TAP2) and the cysteine residue is C641, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q03519. In some cases, the synthetic ligand inhibits a covalent interaction between C641 of TAP2 and the probe.

In some instances, the protein is tapasin (TAPBP) and the cysteine residue is C440, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier O15533. In some cases, the synthetic ligand inhibits a covalent interaction between C440 of TAPBP and the probe.

In some instances, the protein is protein unc-93 homolog B1 (UNC93B1) and the cysteine residue is C583, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9H1C4. In some cases, the synthetic ligand inhibits a covalent interaction between C583 of UNC93B1 and the probe.

In some instances, the protein is probable ATP-dependent RNA helicase DDX60 (DDX60) and the cysteine residue is C1051, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q81Y21. In some cases, the synthetic ligand inhibits a covalent interaction between C1051 of DDX60 and the probe.

In some instances, the synthetic ligand further comprises a second moiety that interacts with a second protein. In some cases, the second protein is not a protein illustrated in Table 1A or Table 2A.

In some embodiments, additionally described herein include a protein binding domain wherein said protein binding domain comprises a cysteine residue illustrated in Table 1A or Table 2A, wherein said cysteine forms an adduct with a compound of Formula I,

-   -   and wherein a compound of Formula IIA or Formula IIB interferes         with the formation of the cysteine adduct by the compound of         Formula I, wherein Formula (IIA) or Formula (IIB) have the         structure:

-   -   wherein,     -   each R^(A) and R^(B) is independently selected from the group         consisting of H, D, substituted or unsubstituted C₁-C₆alkyl,         substituted or unsubstituted C₁-C₆fluoroalkyl, substituted or         unsubstituted C₁-C₆heteroalkyl, substituted or unsubstituted         C₃-C₈cycloalkyl, substituted or unsubstituted         C₂-C₇heterocycloalkyl, substituted or unsubstituted aryl,         substituted or unsubstituted C₁-C₃alkylene-aryl, substituted or         unsubstituted heteroaryl, and substituted or unsubstituted         C₁-C₃alkylene-heteroaryl; or     -   or R^(A) and R^(B) together with the nitrogen to which they are         attached form a 5, 6, 7 or 8-membered heterocyclic ring A,         optionally having one additional heteroatom moiety independently         selected from NR¹, O, or S; wherein A is optionally substituted;         and     -   R¹ is independently H, D, substituted or unsubstituted         C₁-C₆alkyl, substituted or unsubstituted C₁-C₆fluoroalkyl,         substituted or unsubstituted C₁-C₆heteroalkyl, substituted or         unsubstituted aryl, or substituted or unsubstituted heteroaryl

In some instances, n is 0, 1, 2, 3, 4, 5, 6, 7, or 8. In some instances, n is 1. In some instances, n is 2. In some instances, n is 3. In some instances, n is 4. In some instances, n is 5. In some instances, n is 6. In some instances, n is 7. In some instances, n is 8.

In some instances, the protein is Anaphase-promoting complex subunit 16, Anaphase-promoting complex subunit 7, Apoptosis-resistant E3 ubiquitin protein ligase 1, Transcription regulator protein BACH1, Transcription regulator protein BACH2, Baculoviral IAP repeat-containing protein 2, Baculoviral IAP repeat-containing protein 3, DDB1- and CUL4-associated factor 17, Denticleless protein homolog, F-box only protein 11, F-box only protein 30, E3 ubiquitin-protein ligase HECTD1, Probable E3 ubiquitin-protein ligase HERC1, Probable E3 ubiquitin-protein ligase HERC4, E3 ISG15-protein ligase HERC5, E3 ubiquitin-protein ligase HUWE1, Kelch repeat and BTB domain-containing protein 8, Kelch-like ECH-associated protein 1, MYCBP2 Probable E3 ubiquitin-protein ligase MYCBP2, E3 ubiquitin-protein ligase MYCBP2, Polycomb group RING finger protein 2, E3 SUMO-protein ligase PIAS4, Protein PML, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase RNF213, RING finger protein 214, E3 ubiquitin-protein ligase RNF25, E3 ubiquitin-protein ligase BRE1B, RING-box protein 2, Tumor necrosis factor alpha-induced protein 3, E3 ubiquitin-protein ligase TRIM33, E3 ubiquitin-protein ligase TRIM56, Tripartite motif-containing protein 65, E3 ubiquitin-protein ligase TRIM71, E3 ubiquitin-protein ligase TRIP12, (E3-independent) E2 ubiquitin-conjugating enzyme, UBE4A Ubiquitin conjugation factor E4 A, Ubiquitin conjugation factor E4 A, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UBR4, E3 ubiquitin-protein ligase UBR5, Protein VPRBP, Vacuolar protein sorting-associated protein 18 homolog, or Nuclear-interacting partner of ALK.

In some embodiments, the cysteine-containing protein is a member of the E3-RING family. In some instances, the probe binds to a cysteine residue of a member of the E3-RING family. In some instances, the members comprise Polycomb group RING finger protein 6, E3 ubiquitin-protein ligase CBL-B, F-box only protein 22, Elongin-B, Elongin-C, Kelch repeat and BTB domain domain-containing protein 4, Kelch-like ECH-associated protein 1, E3 ubiquitin-protein ligase pellino homolog 1, E3 ubiquitin-protein ligase RNF128, and TNF receptor-associated factor 6. In some cases, the probe binds to a cysteine residue of Polycomb group RING finger protein 6, E3 ubiquitin-protein ligase CBL-B, F-box only protein 22, Elongin-B, Elongin-C, Kelch repeat and BTB domain domain-containing protein 4, Kelch-like ECH-associated protein 1, E3 ubiquitin-protein ligase pellino homolog 1, E3 ubiquitin-protein ligase RNF128, or TNF receptor-associated factor 6.

In some instances, the cysteine-containing protein is a member of the Cullin RING ligase (CRL) family. In some cases, the members comprise Elongin-B and Elongin-C. In some cases, the probe binds to a cysteine residue of Elongin-B or Elongin-C.

In some instances, the cysteine-containing protein is B-cell lymphoma 6 protein. In some cases, the probe binds to a cysteine residue of B-cell lymphoma 6 protein.

In some instances, the cysteine-containing protein is (E3-independent) E2 ubiquitin-conjugating enzyme. In some cases, the probe binds to a cysteine residue of (E3-independent) E2 ubiquitin-conjugating enzyme.

In some embodiments, the protein is B-cell lymphoma 6 protein (BCL6) and the cysteine residue is C121, C175, C232, C254, C296, C339, C348, C354, C414, C548, or C663, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182. In some cases, the protein binding domain comprises C121, C175, C232, C254, C296, C339, C348, C354, C414, C548, or C663.

In some embodiments, the protein is Polycomb group RING finger protein 6 (PCGF6) and the cysteine residue is C56, C137, or C155, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9BYE7. In some cases, the protein binding domain comprises C56, C137, or C155.

In some embodiments, the protein is E3 ubiquitin-protein ligase CBL-B (CBLB) and the cysteine residue is C60, C345, C376, C435, C436, C470, C523, C535, C594, C607, C686, C741, or C895, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the protein binding domain comprises C60, C345, C376, C435, C436, C470, C523, C535, C594, C607, C686, C741, or C895.

In some embodiments, the protein is E3 ubiquitin-protein ligase CBL-B (CBLB) and the cysteine residue is C607, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191. In some cases, the protein binding domain comprises C607.

In some embodiments, the protein is Elongin-B (ELOB) and the cysteine residue is C60 or C89, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q15370. In some cases, the protein binding domain comprises C60 or C89.

In some embodiments, the protein is Elongin-C (ELOC) and the cysteine residue is C11 or C74, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q15369. In some cases, the protein binding domain comprises C11 or C74.

In some embodiments, the protein is F-box only protein 22 (FBXO22) and the cysteine residue is C47, C117, C227, C228, or C378, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8NEZ5. In some cases, the protein binding domain comprises C47, C117, C227, C228, or C378.

In some embodiments, the protein is Kelch repeat and BTB domain-containing protein 4 (KBTBD4) and the cysteine residue is C68, C201, C274, C301, C455, or C472, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7. In some cases, the protein binding domain comprises C68, C201, C274, C301, C455, or C472.

In some embodiments, the protein is Kelch repeat and BTB domain-containing protein 4 and the cysteine residue is C68, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7. In some cases, the protein binding domain comprises C68.

In some embodiments, the protein is Kelch-like ECH-associated protein 1 (KEAP1) and the cysteine residue is C23, C38, C151, C226, C241, C257, C288, C297, C319, C434, C613, C622, or C624 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the protein binding domain comprises C23, C38, C151, C226, C241, C257, C288, C297, C319, C434, C613, C622, or C624.

In some embodiments, the protein is Kelch-like ECH-associated protein 1 and the cysteine residue is C23, C38, C151, C241, C257, C288, C297, C319, C613, or C624, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145. In some cases, the protein binding domain comprises C23, C38, C151, C241, C257, C288, C297, C319, C613, or C624.

In some embodiments, the protein is E3 ubiquitin-protein ligase pellino homolog 11 (PELI1) and the cysteine residue is C61, C212, or C282 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96FA3. In some cases, the protein binding domain comprises C61, C212, or C282.

In some embodiments, the protein is E3 ubiquitin-protein ligase pellino homolog 1 and the cysteine residue is C282, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96FA3. In some cases, the protein binding domain comprises C282.

In some embodiments, the protein is E3 ubiquitin-protein ligase RNF128 (RNF128) and the cysteine residue is C295, C303, C314, or C317 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8TEB7. In some cases, the protein binding domain comprises C295, C303, C314, or C317.

In some embodiments, the protein is E3 ubiquitin-protein ligase RNF128 and the cysteine residue is C317, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8TEB7. In some cases, the protein binding domain comprises C317.

In some embodiments, the protein is TNF receptor-associated factor 6 (TRAF6) and the cysteine residue is C85, C105, C134, C139, C182, C235, C349, or C366, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9Y4K3. In some cases, the protein binding domain comprises C85, C105, C134, C139, C182, C235, C349, or C366.

In some embodiments, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme (UBE20) and the cysteine residue is C101, C182, C208, C230, C244, C314, C341, C370, C375, C400, C406, C585, C598, C910, C913, C1040, C1099, or C1288, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the protein binding domain comprises C101, C182, C208, C230, C244, C314, C341, C370, C375, C400, C406, C585, C598, C910, C913, C1040, C1099, or C1288.

In some embodiments, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C370, C400, C910, or C913, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. In some cases, the protein binding domain comprises C370, C400, C910, or C913.

In some instances, the protein is E3 ubiquitin-protein ligase TRIP12 (TRIP12) and the cysteine residue is C1959, wherein the numberings of the amino acid positions correspond to the amino acid positions with the UniProt Identifier Q14669. In some cases, the protein binding domain comprises C1959.

In some instances, the protein is anaphase-promoting complex subunit 16 (ANAPC16) and the cysteine residue is C55, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96DE5. In some cases, the protein binding domain comprises C55.

In some instances, the protein is probable E3 ubiquitin-protein ligase MYCBP2 (MYCBP2) and the cysteine residue is C3152, wherein the numberings of the amino acid positions correspond to the amino acid positions with the UniProt Identifier 075592. In some cases, the protein binding domain comprises C3152.

In some instances, the protein is ubiquitin conjugation factor E4 A (UBE4A) and the cysteine residue is C79, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14139. In some cases, the protein binding domain comprises C79.

In some instances, the protein is autophagy-related protein 16-1 (ATG16L1) and the cysteine residue is C145, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q676U5. In some cases, the protein binding domain comprises C145.

In some instances, the protein is protein arginine N-methyltransferase 5 (PRMT5) and the cysteine residue is C278, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier 014744. In some cases, the protein binding domain comprises C278.

In some instances, the protein is isocitrate dehydrogenase (IDH2) and the cysteine residue is C154, wherein the numberings of the amino acid positions correspond to the amino acid positions with the UniProt Identifier P48735. In some cases, the protein binding domain comprises C154.

In some instances, the protein is antigen peptide transporter 2 (TAP2) and the cysteine residue is C641, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q03519. In some cases, the protein binding domain comprises C641.

In some instances, the protein is tapasin (TAPBP) and the cysteine residue is C440, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier O15533. In some cases, the protein binding domain comprises C440.

In some instances, the protein is protein unc-93 homolog B1 (UNC93B1) and the cysteine residue is C583, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9H1C4. In some cases, the protein binding domain comprises C583.

In some instances, the protein is probable ATP-dependent RNA helicase DDX60 (DDX60) and the cysteine residue is C1051, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q81Y21. In some cases, the protein binding domain comprises C1051.

In some embodiments, further disclosed herein is a method for identifying a synthetic ligand that interacts with a protein comprising a cysteine residue illustrated in Table 1A or Table 2A, comprising exposing, in a reaction vessel, the protein to the synthetic ligand and a probe that has a structure represented by Formula (I):

wherein

-   -   n is 0-8; and     -   measuring the amount of the probe that has covalently bound to         the cysteine residue relative to the amount of probe that has         covalently bound to the same cysteine residue in the absence of         the synthetic ligand.

In some instances, the protein is Anaphase-promoting complex subunit 16, Anaphase-promoting complex subunit 7, Apoptosis-resistant E3 ubiquitin protein ligase 1, Transcription regulator protein BACH1, Transcription regulator protein BACH2, Baculoviral IAP repeat-containing protein 2, Baculoviral IAP repeat-containing protein 3, DDB1- and CUL4-associated factor 17, Denticleless protein homolog, F-box only protein 11, F-box only protein 30, E3 ubiquitin-protein ligase HECTD1, Probable E3 ubiquitin-protein ligase HERC1, Probable E3 ubiquitin-protein ligase HERC4, E3 ISG15-protein ligase HERC5, E3 ubiquitin-protein ligase HUWE1, Kelch repeat and BTB domain-containing protein 8, Kelch-like ECH-associated protein 1, MYCBP2 Probable E3 ubiquitin-protein ligase MYCBP2, E3 ubiquitin-protein ligase MYCBP2, Polycomb group RING finger protein 2, E3 SUMO-protein ligase PIAS4, Protein PML, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase RNF213, RING finger protein 214, E3 ubiquitin-protein ligase RNF25, E3 ubiquitin-protein ligase BRE1B, RING-box protein 2, Tumor necrosis factor alpha-induced protein 3, E3 ubiquitin-protein ligase TRIM33, E3 ubiquitin-protein ligase TRIM56, Tripartite motif-containing protein 65, E3 ubiquitin-protein ligase TRIM71, E3 ubiquitin-protein ligase TRIP12, (E3-independent) E2 ubiquitin-conjugating enzyme, UBE4A Ubiquitin conjugation factor E4 A, Ubiquitin conjugation factor E4 A, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UBR4, E3 ubiquitin-protein ligase UBR5, Protein VPRBP, Vacuolar protein sorting-associated protein 18 homolog, or Nuclear-interacting partner of ALK.

In some embodiments, the cysteine-containing protein is a member of the E3-RING family. In some instances, the probe binds to a cysteine residue of a member of the E3-RING family. In some instances, the members comprise Polycomb group RING finger protein 6, E3 ubiquitin-protein ligase CBL-B, F-box only protein 22, Elongin-B, Elongin-C, Kelch repeat and BTB domain domain-containing protein 4, Kelch-like ECH-associated protein 1, E3 ubiquitin-protein ligase pellino homolog 1, E3 ubiquitin-protein ligase RNF128, and TNF receptor-associated factor 6. In some cases, the probe binds to a cysteine residue of Polycomb group RING finger protein 6, E3 ubiquitin-protein ligase CBL-B, F-box only protein 22, Elongin-B, Elongin-C, Kelch repeat and BTB domain domain-containing protein 4, Kelch-like ECH-associated protein 1, E3 ubiquitin-protein ligase pellino homolog 1, E3 ubiquitin-protein ligase RNF128, or TNF receptor-associated factor 6.

In some instances, the cysteine-containing protein is a member of the Cullin RING ligase (CRL) family. In some cases, the members comprise Elongin-B and Elongin-C. In some cases, the probe binds to a cysteine residue of Elongin-B or Elongin-C.

In some instances, the cysteine-containing protein is B-cell lymphoma 6 protein. In some cases, the probe binds to a cysteine residue of B-cell lymphoma 6 protein.

In some instances, the cysteine-containing protein is (E3-independent) E2 ubiquitin-conjugating enzyme. In some cases, the probe binds to a cysteine residue of (E3-independent) E2 ubiquitin-conjugating enzyme.

In some embodiments, the protein is B-cell lymphoma 6 protein (BCL6) and the cysteine residue is C121, C175, C232, C254, C296, C339, C348, C354, C414, C548, or C663, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182.

In some embodiments, the protein is Polycomb group RING finger protein 6 (PCGF6) and the cysteine residue is C56, C137, or C155, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9BYE7.

In some embodiments, the protein is E3 ubiquitin-protein ligase CBL-B (CBLB) and the cysteine residue is C60, C345, C376, C435, C436, C470, C523, C535, C594, C607, C686, C741, or C895, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191.

In some embodiments, the protein is E3 ubiquitin-protein ligase CBL-B (CBLB) and the cysteine residue is C607, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191.

In some embodiments, the protein is Elongin-B (ELOB) and the cysteine residue is C60 or C89, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q15370.

In some embodiments, the protein is Elongin-C (ELOC) and the cysteine residue is C11 or C74, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q15369.

In some embodiments, the protein is F-box only protein 22 (FBXO22) and the cysteine residue is C47, C117, C227, C228, or C378, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8NEZ5.

In some embodiments, the protein is Kelch repeat and BTB domain-containing protein 4 (KBTBD4) and the cysteine residue is C68, C201, C274, C301, C455, or C472, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7.

In some embodiments, the protein is Kelch repeat and BTB domain-containing protein 4 and the cysteine residue is C68, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7.

In some embodiments, the protein is Kelch-like ECH-associated protein 1 (KEAP1) and the cysteine residue is C23, C38, C151, C226, C241, C257, C288, C297, C319, C434, C613, C622, or C624 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145.

In some embodiments, the protein is Kelch-like ECH-associated protein 1 and the cysteine residue is C23, C38, C151, C241, C257, C288, C297, C319, C613, or C624, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145.

In some embodiments, the protein is E3 ubiquitin-protein ligase pellino homolog 11 (PELI1) and the cysteine residue is C61, C212, or C282 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96FA3.

In some embodiments, the protein is E3 ubiquitin-protein ligase pellino homolog 1 and the cysteine residue is C282, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96FA3.

In some embodiments, the protein is E3 ubiquitin-protein ligase RNF128 (RNF128) and the cysteine residue is C295, C303, C314, or C317 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8TEB7.

In some embodiments, the protein is E3 ubiquitin-protein ligase RNF128 and the cysteine residue is C317, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8TEB7.

In some embodiments, the protein is TNF receptor-associated factor 6 (TRAF6) and the cysteine residue is C85, C105, C134, C139, C182, C235, C349, or C366, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9Y4K3.

In some embodiments, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme (UBE20) and the cysteine residue is C101, C182, C208, C230, C244, C314, C341, C370, C375, C400, C406, C585, C598, C910, C913, C1040, C1099, or C1288, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9.

In some embodiments, the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C370, C400, C910, or C913, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9.

In some instances, the protein is E3 ubiquitin-protein ligase TRIP12 (TRIP12) and the cysteine residue is C1959, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14669. In some cases, the synthetic ligand inhibits a covalent interaction between C1959 of TRIP12 and the probe.

In some instances, the protein is anaphase-promoting complex subunit 16 (ANAPC16) and the cysteine residue is C55, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96DE5. In some cases, the synthetic ligand inhibits a covalent interaction between C55 of ANAPC16 and the probe.

In some instances, the protein is probable E3 ubiquitin-protein ligase MYCBP2 (MYCBP2) and the cysteine residue is C3152, wherein the numberings of the amino acid positions correspond to the amino acid positions with the UniProt Identifier 075592. In some cases, the synthetic ligand inhibits a covalent interaction between C3152 of MYCBP2 and the probe.

In some instances, the protein is ubiquitin conjugation factor E4 A (UBE4A) and the cysteine residue is C79, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14139. In some cases, the synthetic ligand inhibits a covalent interaction between C79 of UBE4A and the probe.

In some instances, the protein is autophagy-related protein 16-1 (ATG16L1) and the cysteine residue is C145, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q676U5. In some cases, the synthetic ligand inhibits a covalent interaction between C145 of ATG16L1 and the probe.

In some instances, the protein is protein arginine N-methyltransferase 5 (PRMT5) and the cysteine residue is C278, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier 014744. In some cases, the synthetic ligand inhibits a covalent interaction between C278 of PRMT5 and the probe.

In some instances, the protein is isocitrate dehydrogenase (IDH2) and the cysteine residue is C154, wherein the numberings of the amino acid positions correspond to the amino acid positions with the UniProt Identifier P48735. In some cases, the synthetic ligand inhibits a covalent interaction between C154 of IDH2 and the probe.

In some instances, the protein is antigen peptide transporter 2 (TAP2) and the cysteine residue is C641, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q03519. In some cases, the synthetic ligand inhibits a covalent interaction between C641 of TAP2 and the probe.

In some instances, the protein is tapasin (TAPBP) and the cysteine residue is C440, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier O15533. In some cases, the synthetic ligand inhibits a covalent interaction between C440 of TAPBP and the probe.

In some instances, the protein is protein unc-93 homolog B1 (UNC93B1) and the cysteine residue is C583, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9H1C4. In some cases, the synthetic ligand inhibits a covalent interaction between C583 of UNC93B1 and the probe.

In some instances, the protein is probable ATP-dependent RNA helicase DDX60 (DDX60) and the cysteine residue is C1051, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q81Y21. In some cases, the synthetic ligand inhibits a covalent interaction between C1051 of DDX60 and the probe.

Further Forms of Compounds

In one aspect, the compound of Formula (II), Formula (IIA), or Formula (IIB) possesses one or more stereocenters and each stereocenter exists independently in either the R or S configuration. The compounds presented herein include all diastereomeric, enantiomeric, and epimeric forms as well as the appropriate mixtures thereof. The compounds and methods provided herein include all cis, trans, syn, anti, entgegen (E), and zusammen (Z) isomers as well as the appropriate mixtures thereof. In certain embodiments, compounds described herein are prepared as their individual stereoisomers by reacting a racemic mixture of the compound with an optically active resolving agent to form a pair of diastereoisomeric compounds/salts, separating the diastereomers and recovering the optically pure enantiomers. In some embodiments, resolution of enantiomers is carried out using covalent diastereomeric derivatives of the compounds described herein. In another embodiment, diastereomers are separated by separation/resolution techniques based upon differences in solubility. In other embodiments, separation of stereoisomers is performed by chromatography or by the forming diastereomeric salts and separation by recrystallization, or chromatography, or any combination thereof. Jean Jacques, Andre Collet, Samuel H. Wilen, “Enantiomers, Racemates and Resolutions”, John Wiley And Sons, Inc., 1981. In one aspect, stereoisomers are obtained by stereoselective synthesis.

In another embodiment, the compounds described herein are labeled isotopically (e.g. with a radioisotope) or by another other means, including, but not limited to, the use of chromophores or fluorescent moieties, bioluminescent labels, or chemiluminescent labels.

Compounds described herein include isotopically-labeled compounds, which are identical to those recited in the various formulae and structures presented herein, but for the fact that one or more atoms are replaced by an atom having an atomic mass or mass number different from the atomic mass or mass number usually found in nature. Examples of isotopes that can be incorporated into the present compounds include isotopes of hydrogen, carbon, nitrogen, oxygen, sulfur, fluorine and chlorine, such as, for example, ²H, ³H, ¹³C, ¹⁴C, ¹⁵N, ¹⁸O, ¹⁷O, ³⁵S, ¹⁸F, ³⁶Cl. In one aspect, isotopically-labeled compounds described herein, for example those into which radioactive isotopes such as ³H and ¹⁴C are incorporated, are useful in drug and/or substrate tissue distribution assays. In one aspect, substitution with isotopes such as deuterium affords certain therapeutic advantages resulting from greater metabolic stability, such as, for example, increased in vivo half-life or reduced dosage requirements.

Compounds described herein may be formed as, and/or used as, acceptable salts. The type of acceptable salts, include, but are not limited to: (1) acid addition salts, formed by reacting the free base form of the compound with an acceptable: inorganic acid, such as, for example, hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, metaphosphoric acid, and the like; or with an organic acid, such as, for example, acetic acid, propionic acid, hexanoic acid, cyclopentanepropionic acid, glycolic acid, pyruvic acid, lactic acid, malonic acid, succinic acid, malic acid, maleic acid, fumaric acid, trifluoroacetic acid, tartaric acid, citric acid, benzoic acid, 3-(4-hydroxybenzoyl)benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, 1,2-ethanedisulfonic acid, 2-hydroxyethanesulfonic acid, benzenesulfonic acid, toluenesulfonic acid, 2-naphthalenesulfonic acid, 4-methylbicyclo-[2.2.2]oct-2-ene-1-carboxylic acid, glucoheptonic acid, 4,4′-methylenebis-(3-hydroxy-2-ene-1-carboxylic acid), 3-phenylpropionic acid, trimethylacetic acid, tertiary butylacetic acid, lauryl sulfuric acid, gluconic acid, glutamic acid, hydroxynaphthoic acid, salicylic acid, stearic acid, muconic acid, butyric acid, phenylacetic acid, phenylbutyric acid, valproic acid, and the like; (2) salts formed when an acidic proton present in the parent compound is replaced by a metal ion, e.g., an alkali metal ion (e.g. lithium, sodium, potassium), an alkaline earth ion (e.g. magnesium, or calcium), or an aluminum ion. In some cases, compounds described herein may coordinate with an organic base, such as, but not limited to, ethanolamine, diethanolamine, triethanolamine, tromethamine, N-methylglucamine, dicyclohexylamine, tris(hydroxymethyl)methylamine. In other cases, compounds described herein may form salts with amino acids such as, but not limited to, arginine, lysine, and the like. Acceptable inorganic bases used to form salts with compounds that include an acidic proton, include, but are not limited to, aluminum hydroxide, calcium hydroxide, potassium hydroxide, sodium carbonate, sodium hydroxide, and the like.

It should be understood that a reference to a pharmaceutically acceptable salt includes the solvent addition forms, particularly solvates. Solvates contain either stoichiometric or non-stoichiometric amounts of a solvent, and may be formed during the process of crystallization with pharmaceutically acceptable solvents such as water, ethanol, and the like. Hydrates are formed when the solvent is water, or alcoholates are formed when the solvent is alcohol. Solvates of compounds described herein can be conveniently prepared or formed during the processes described herein. In addition, the compounds provided herein can exist in unsolvated as well as solvated forms. In general, the solvated forms are considered equivalent to the unsolvated forms for the purposes of the compounds and methods provided herein.

Synthesis of Compounds

In some embodiments, the synthesis of compounds described herein are accomplished using means described in the chemical literature, using the methods described herein, or by a combination thereof. In addition, solvents, temperatures and other reaction conditions presented herein may vary.

In other embodiments, the starting materials and reagents used for the synthesis of the compounds described herein are synthesized or are obtained from commercial sources, such as, but not limited to, Sigma-Aldrich, Fisher Scientific (Fisher Chemicals), and Acros Organics.

In further embodiments, the compounds described herein, and other related compounds having different substituents are synthesized using techniques and materials described herein as well as those that are recognized in the field, such as described, for example, in Fieser and Fieser's Reagents for Organic Synthesis, Volumes 1-17 (John Wiley and Sons, 1991); Rodd's Chemistry of Carbon Compounds, Volumes 1-5 and Supplementals (Elsevier Science Publishers, 1989); Organic Reactions, Volumes 1-40 (John Wiley and Sons, 1991), Larock's Comprehensive Organic Transformations (VCH Publishers Inc., 1989), March, Advanced Organic Chemistry 4^(th) Ed., (Wiley 1992); Carey and Sundberg, Advanced Organic Chemistry 4^(th) Ed., Vols. A and B (Plenum 2000, 2001), and Green and Wuts, Protective Groups in Organic Synthesis 3^(rd) Ed., (Wiley 1999) (all of which are incorporated by reference for such disclosure). General methods for the preparation of compounds as disclosed herein may be derived from reactions and the reactions may be modified by the use of appropriate reagents and conditions, for the introduction of the various moieties found in the formulae as provided herein. As a guide the following synthetic methods may be utilized.

In the reactions described, it may be necessary to protect reactive functional groups, for example hydroxy, amino, imino, thio or carboxy groups, where these are desired in the final product, in order to avoid their unwanted participation in reactions. A detailed description of techniques applicable to the creation of protecting groups and their removal are described in Greene and Wuts, Protective Groups in Organic Synthesis, 3rd Ed., John Wiley & Sons, New York, N.Y., 1999, and Kocienski, Protective Groups, Thieme Verlag, New York, N.Y., 1994, which are incorporated herein by reference for such disclosure).

In some embodiments, the compounds of Formula (I), Formula (II), Formula (IIA), and Formula (IIB) are purchased from a variety of vendors, including Sigma Aldrich, Acros, Fisher, Fluka, Santa Cruz, CombiBlocks, BioBlocks, and Matrix Scientific.

Cells, Analytical Techniques, and Instrumentation

In certain embodiments, also described herein are methods for profiling a protein described above to determine a reactive or ligandable cysteine residue. In some instances, the methods comprising profiling a cell sample or a cell lysate sample. In some embodiments, the cell sample or cell lysate sample is obtained from cells of an animal. In some instances, the animal cell includes a cell from a marine invertebrate, fish, insects, amphibian, reptile, or mammal. In some instances, the mammalian cell is a primate, ape, equine, bovine, porcine, canine, feline, or rodent. In some instances, the mammal is a primate, ape, dog, cat, rabbit, ferret, or the like. In some cases, the rodent is a mouse, rat, hamster, gerbil, hamster, chinchilla, or guinea pig. In some embodiments, the bird cell is from a canary, parakeet or parrots. In some embodiments, the reptile cell is from a turtles, lizard or snake. In some cases, the fish cell is from a tropical fish. In some cases, the fish cell is from a zebrafish (e.g. Danino rerio). In some cases, the worm cell is from a nematode (e.g. C. elegans). In some cases, the amphibian cell is from a frog. In some embodiments, the arthropod cell is from a tarantula or hermit crab.

In some embodiments, the cell sample or cell lysate sample is obtained from a mammalian cell. In some instances, the mammalian cell is an epithelial cell, connective tissue cell, hormone secreting cell, a nerve cell, a skeletal muscle cell, a blood cell, or an immune system cell.

Exemplary mammalian cells include, but are not limited to, 293A cell line, 293FT cell line, 293F cells, 293 H cells, HEK 293 cells, CHO DG44 cells, CHO-S cells, CHO-K1 cells, Expi293F™ cells, Flp-In™ T-REx™ 293 cell line, Flp-In™-293 cell line, Flp-In™-3T3 cell line, Flp-In™-BHK cell line, Flp-In™-CHO cell line, Flp-In™-CV-1 cell line, Flp-In™-Jurkat cell line, FreeStyle™ 293-F cells, FreeStyle™ CHO-S cells, GripTite™ 293 MSR cell line, GS-CHO cell line, HepaRG™ cells, T-REx™ Jurkat cell line, Per.C6 cells, T-REx™-293 cell line, T-REx™-CHO cell line, T-REx™-HeLa cell line, NC-HIMT cell line, and PC12 cell line.

In some instances, the cell sample or cell lysate sample is obtained from cells of a tumor cell line. In some instances, the cell sample or cell lysate sample is obtained from cells of a solid tumor cell line. In some instances, the solid tumor cell line is a sarcoma cell line. In some instances, the solid tumor cell line is a carcinoma cell line. In some embodiments, the sarcoma cell line is obtained from a cell line of alveolar rhabdomyosarcoma, alveolar soft part sarcoma, ameloblastoma, angiosarcoma, chondrosarcoma, chordoma, clear cell sarcoma of soft tissue, dedifferentiated liposarcoma, desmoid, desmoplastic small round cell tumor, embryonal rhabdomyosarcoma, epithelioid fibrosarcoma, epithelioid hemangioendothelioma, epithelioid sarcoma, esthesioneuroblastoma, Ewing sarcoma, extrarenal rhabdoid tumor, extraskeletal myxoid chondrosarcoma, extraskeletal osteosarcoma, fibrosarcoma, giant cell tumor, hemangiopericytoma, infantile fibrosarcoma, inflammatory myofibroblastic tumor, Kaposi sarcoma, leiomyosarcoma of bone, liposarcoma, liposarcoma of bone, malignant fibrous histiocytoma (MFH), malignant fibrous histiocytoma (MFH) of bone, malignant mesenchymoma, malignant peripheral nerve sheath tumor, mesenchymal chondrosarcoma, myxofibrosarcoma, myxoid liposarcoma, myxoinflammatory fibroblastic sarcoma, neoplasms with perivascular epitheioid cell differentiation, osteosarcoma, parosteal osteosarcoma, neoplasm with perivascular epitheioid cell differentiation, periosteal osteosarcoma, pleomorphic liposarcoma, pleomorphic rhabdomyosarcoma, PNET/extraskeletal Ewing tumor, rhabdomyosarcoma, round cell liposarcoma, small cell osteosarcoma, solitary fibrous tumor, synovial sarcoma, telangiectatic osteosarcoma.

In some embodiments, the carcinoma cell line is obtained from a cell line of adenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma, anaplastic carcinoma, large cell carcinoma, small cell carcinoma, anal cancer, appendix cancer, bile duct cancer (i.e., cholangiocarcinoma), bladder cancer, brain tumor, breast cancer, cervical cancer, colon cancer, cancer of Unknown Primary (CUP), esophageal cancer, eye cancer, fallopian tube cancer, gastroenterological cancer, kidney cancer, liver cancer, lung cancer, medulloblastoma, melanoma, oral cancer, ovarian cancer, pancreatic cancer, parathyroid disease, penile cancer, pituitary tumor, prostate cancer, rectal cancer, skin cancer, stomach cancer, testicular cancer, throat cancer, thyroid cancer, uterine cancer, vaginal cancer, or vulvar cancer.

In some instances, the cell sample or cell lysate sample is obtained from cells of a hematologic malignant cell line. In some instances, the hematologic malignant cell line is a T-cell cell line. In some instances, B-cell cell line. In some instances, the hematologic malignant cell line is obtained from a T-cell cell line of: peripheral T-cell lymphoma not otherwise specified (PTCL-NOS), anaplastic large cell lymphoma, angioimmunoblastic lymphoma, cutaneous T-cell lymphoma, adult T-cell leukemia/lymphoma (ATLL), blastic NK-cell lymphoma, enteropathy-type T-cell lymphoma, hematosplenic gamma-delta T-cell lymphoma, lymphoblastic lymphoma, nasal NK/T-cell lymphomas, or treatment-related T-cell lymphomas.

In some instances, the hematologic malignant cell line is obtained from a B-cell cell line of: acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), acute monocytic leukemia (AMoL), chronic lymphocytic leukemia (CLL), high-risk chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), high-risk small lymphocytic lymphoma (SLL), follicular lymphoma (FL), mantle cell lymphoma (MCL), Waldenstrom's macroglobulinemia, multiple myeloma, extranodal marginal zone B cell lymphoma, nodal marginal zone B cell lymphoma, Burkitt's lymphoma, non-Burkitt high grade B cell lymphoma, primary mediastinal B-cell lymphoma (PMBL), immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, B cell prolymphocytic leukemia, lymphoplasmacytic lymphoma, splenic marginal zone lymphoma, plasma cell myeloma, plasmacytoma, mediastinal (thymic) large B cell lymphoma, intravascular large B cell lymphoma, primary effusion lymphoma, or lymphomatoid granulomatosis.

In some embodiments, the cell sample or cell lysate sample is obtained from a tumor cell line. Exemplary tumor cell line includes, but is not limited to, 600MPE, AU565, BT-20, BT-474, BT-483, BT-549, Evsa-T, Hs578T, MCF-7, MDA-MB-231, SkBr3, T-47D, HeLa, DU145, PC3, LNCaP, A549, H1299, NCI-H460, A2780, SKOV-3/Luc, Neuro2a, RKO, RKO-AS45-1, HT-29, SW1417, SW948, DLD-1, SW480, Capan-1, MC/9, B72.3, B25.2, B6.2, B38.1, DMS 153, SU.86.86, SNU-182, SNU-423, SNU-449, SNU-475, SNU-387, Hs 817.T, LMH, LMH/2A, SNU-398, PLHC-1, HepG2/SF, OCI-Ly1, OCI-Ly2, OCI-Ly3, OCI-Ly4, OCI-Ly6, OCI-Ly7, OCI-Ly10, OCI-Ly18, OCI-Ly19, U2932, DB, HBL-1, RIVA, SUDHL2, TMD8, MEC1, MEC2, 8E5, CCRF-CEM, MOLT-3, TALL-104, AML-193, THP-1, BDCM, HL-60, Jurkat, RPMI 8226, MOLT-4, RS4, K-562, KASUMI-1, Daudi, GA-10, Raji, JeKo-1, NK-92, and Mino.

In some embodiments, the cell sample or cell lysate sample is from any tissue or fluid from an individual. Samples include, but are not limited to, tissue (e.g. connective tissue, muscle tissue, nervous tissue, or epithelial tissue), whole blood, dissociated bone marrow, bone marrow aspirate, pleural fluid, peritoneal fluid, central spinal fluid, abdominal fluid, pancreatic fluid, cerebrospinal fluid, brain fluid, ascites, pericardial fluid, urine, saliva, bronchial lavage, sweat, tears, ear flow, sputum, hydrocele fluid, semen, vaginal flow, milk, amniotic fluid, and secretions of respiratory, intestinal or genitourinary tract.

In some embodiments, the cell sample or cell lysate sample is a tissue sample, such as a sample obtained from a biopsy or a tumor tissue sample. In some embodiments, the cell sample or cell lysate sample is a blood serum sample. In some embodiments, the cell sample or cell lysate sample is a blood cell sample containing one or more peripheral blood mononuclear cells (PBMCs). In some embodiments, the cell sample or cell lysate sample contains one or more circulating tumor cells (CTCs). In some embodiments, the cell sample or cell lysate sample contains one or more disseminated tumor cells (DTC, e.g., in a bone marrow aspirate sample).

In some embodiments, the cell sample or cell lysate sample is obtained from the individual by any suitable means of obtaining the sample using well-known and routine clinical methods. Procedures for obtaining tissue samples from an individual are well known. For example, procedures for drawing and processing tissue sample such as from a needle aspiration biopsy is well-known and is employed to obtain a sample for use in the methods provided. Typically, for collection of such a tissue sample, a thin hollow needle is inserted into a mass such as a tumor mass for sampling of cells that, after being stained, will be examined under a microscope.

Sample Preparation and Analysis

In some embodiments, a sample solution comprises a cell sample, a cell lysate sample, or a sample comprising isolated proteins. In some instances, the sample solution comprises a solution such as a buffer (e.g. phosphate buffered saline) or a media. In some embodiments, the media is an isotopically labeled media. In some instances, the sample solution is a cell solution.

In some embodiments, the solution sample (e.g., cell sample, cell lysate sample, or comprising isolated proteins) is incubated with a compound of Formula (I) for analysis of protein-probe interactions. In some instances, the solution sample (e.g., cell sample, cell lysate sample, or comprising isolated proteins) is further incubated in the presence of an additional compound probe prior to addition of the compound of Formula (I). In other instances, the solution sample (e.g., cell sample, cell lysate sample, or comprising isolated proteins) is further incubated with a ligand, in which the ligand does not contain a photoreactive moiety and/or an alkyne group. In such instances, the solution sample is incubated with a probe and a ligand for competitive protein profiling analysis.

In some cases, the cell sample or the cell lysate sample is compared with a control. In some cases, a difference is observed between a set of probe protein interactions between the sample and the control. In some instances, the difference correlates to the interaction between the small molecule fragment and the proteins.

In some embodiments, one or more methods are utilized for labeling a solution sample (e.g. cell sample, cell lysate sample, or comprising isolated proteins) for analysis of probe protein interactions. In some instances, a method comprises labeling the sample (e.g. cell sample, cell lysate sample, or comprising isolated proteins) with an enriched media. In some cases, the sample (e.g. cell sample, cell lysate sample, or comprising isolated proteins) is labeled with isotope-labeled amino acids, such as ¹³C or ¹⁵N-labeled amino acids. In some cases, the labeled sample is further compared with a non-labeled sample to detect differences in probe protein interactions between the two samples. In some instances, this difference is a difference of a target protein and its interaction with a small molecule ligand in the labeled sample versus the non-labeled sample. In some instances, the difference is an increase, decrease or a lack of protein-probe interaction in the two samples. In some instances, the isotope-labeled method is termed SILAC, stable isotope labeling using amino acids in cell culture.

In some embodiments, a method comprises incubating a solution sample (e.g. cell sample, cell lysate sample, or comprising isolated proteins) with a labeling group (e.g., an isotopically labeled labeling group) to tag one or more proteins of interest for further analysis. In such cases, the labeling group comprises a biotin, a streptavidin, bead, resin, a solid support, or a combination thereof, and further comprises a linker that is optionally isotopically labeled. As described above, the linker can be about 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 or more residues in length and might further comprise a cleavage site, such as a protease cleavage site (e.g., TEV cleavage site). In some cases, the labeling group is a biotin-linker moiety, which is optionally isotopically labeled with ¹³C and ¹⁵N atoms at one or more amino acid residue positions within the linker. In some cases, the biotin-linker moiety is a isotopically-labeled TEV-tag as described in Weerapana, et al., “Quantitative reactivity profiling predicts functional cysteines in proteomes,” Nature 468(7325): 790-795.

In some embodiments, an isotopic reductive dimethylation (ReDi) method is utilized for processing a sample. In some cases, the ReDi labeling method involves reacting peptides with formaldehyde to form a Schiff base, which is then reduced by cyanoborohydride. This reaction dimethylates free amino groups on N-termini and lysine side chains and monomethylates N-terminal prolines. In some cases, the ReDi labeling method comprises methylating peptides from a first processed sample with a “light” label using reagents with hydrogen atoms in their natural isotopic distribution and peptides from a second processed sample with a “heavy” label using deuterated formaldehyde and cyanoborohydride. Subsequent proteomic analysis (e.g., mass spectrometry analysis) based on a relative peptide abundance between the heavy and light peptide version might be used for analysis of probe-protein interactions.

In some embodiments, isobaric tags for relative and absolute quantitation (iTRAQ) method is utilized for processing a sample. In some cases, the iTRAQ method is based on the covalent labeling of the N-terminus and side chain amines of peptides from a processed sample. In some cases, reagent such as 4-plex or 8-plex is used for labeling the peptides.

In some embodiments, the probe-protein complex is further conjugated to a chromophore, such as a fluorophore. In some instances, the probe-protein complex is separated and visualized utilizing an electrophoresis system, such as through a gel electrophoresis, or a capillary electrophoresis. Exemplary gel electrophoresis includes agarose based gels, polyacrylamide based gels, or starch based gels. In some instances, the probe-protein is subjected to a native electrophoresis condition. In some instances, the probe-protein is subjected to a denaturing electrophoresis condition.

In some instances, the probe-protein after harvesting is further fragmentized to generate protein fragments. In some instances, fragmentation is generated through mechanical stress, pressure, or chemical means. In some instances, the protein from the probe-protein complexes is fragmented by a chemical means. In some embodiments, the chemical means is a protease. Exemplary proteases include, but are not limited to, serine proteases such as chymotrypsin A, penicillin G acylase precursor, dipeptidase E, DmpA aminopeptidase, subtilisin, prolyl oligopeptidase, D-Ala-D-Ala peptidase C, signal peptidase I, cytomegalovirus assemblin, Lon-A peptidase, peptidase Clp, Escherichia coli phage K1F endosialidase CIMCD self-cleaving protein, nucleoporin 145, lactoferrin, murein tetrapeptidase LD-carboxypeptidase, or rhomboid-1; threonine proteases such as ornithine acetyltransferase; cysteine proteases such as TEV protease, amidophosphoribosyltransferase precursor, gamma-glutamyl hydrolase (Rattus norvegicus), hedgehog protein, DmpA aminopeptidase, papain, bromelain, cathepsin K, calpain, caspase-1, separase, adenain, pyroglutamyl-peptidase I, sortase A, hepatitis C virus peptidase 2, sindbis virus-type nsP2 peptidase, dipeptidyl-peptidase VI, or DeSI-1 peptidase; aspartate proteases such as beta-secretase 1 (BACE1), beta-secretase 2 (BACE2), cathepsin D, cathepsin E, chymosin, napsin-A, nepenthesin, pepsin, plasmepsin, presenilin, or renin; glutamic acid proteases such as AfuGprA; and metalloproteases such as peptidase_M48.

In some instances, the fragmentation is a random fragmentation. In some instances, the fragmentation generates specific lengths of protein fragments, or the shearing occurs at particular sequence of amino acid regions.

In some instances, the protein fragments are further analyzed by a proteomic method such as by liquid chromatography (LC) (e.g. high performance liquid chromatography), liquid chromatography-mass spectrometry (LC-MS), matrix-assisted laser desorption/ionization (MALDI-TOF), gas chromatography-mass spectrometry (GC-MS), capillary electrophoresis-mass spectrometry (CE-MS), or nuclear magnetic resonance imaging (NMR).

In some embodiments, the LC method is any suitable LC methods well known in the art, for separation of a sample into its individual parts. This separation occurs based on the interaction of the sample with the mobile and stationary phases. Since there are many stationary/mobile phase combinations that are employed when separating a mixture, there are several different types of chromatography that are classified based on the physical states of those phases. In some embodiments, the LC is further classified as normal-phase chromatography, reverse-phase chromatography, size-exclusion chromatography, ion-exchange chromatography, affinity chromatography, displacement chromatography, partition chromatography, flash chromatography, chiral chromatography, and aqueous normal-phase chromatography.

In some embodiments, the LC method is a high performance liquid chromatography (HPLC) method. In some embodiments, the HPLC method is further categorized as normal-phase chromatography, reverse-phase chromatography, size-exclusion chromatography, ion-exchange chromatography, affinity chromatography, displacement chromatography, partition chromatography, chiral chromatography, and aqueous normal-phase chromatography.

In some embodiments, the HPLC method of the present disclosure is performed by any standard techniques well known in the art. Exemplary HPLC methods include hydrophilic interaction liquid chromatography (HILIC), electrostatic repulsion-hydrophilic interaction liquid chromatography (ERLIC) and reverse phase liquid chromatography (RPLC).

In some embodiments, the LC is coupled to a mass spectroscopy as a LC-MS method. In some embodiments, the LC-MS method includes ultra-performance liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOF-MS), ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS), reverse phase liquid chromatography-mass spectrometry (RPLC-MS), hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS), hydrophilic interaction liquid chromatography-triple quadrupole tandem mass spectrometry (HILIC-QQQ), electrostatic repulsion-hydrophilic interaction liquid chromatography-mass spectrometry (ERLIC-MS), liquid chromatography time-of-flight mass spectrometry (LC-QTOF-MS), liquid chromatography-tandem mass spectrometry (LC-MS/MS), multidimensional liquid chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS). In some instances, the LC-MS method is LC/LC-MS/MS. In some embodiments, the LC-MS methods of the present disclosure are performed by standard techniques well known in the art.

In some embodiments, the GC is coupled to a mass spectroscopy as a GC-MS method. In some embodiments, the GC-MS method includes two-dimensional gas chromatography time-of-flight mass spectrometry (GC*GC-TOFMS), gas chromatography time-of-flight mass spectrometry (GC-QTOF-MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS).

In some embodiments, CE is coupled to a mass spectroscopy as a CE-MS method. In some embodiments, the CE-MS method includes capillary electrophoresis-negative electrospray ionization-mass spectrometry (CE-ESI-MS), capillary electrophoresis-negative electrospray ionization-quadrupole time of flight-mass spectrometry (CE-ESI-QTOF-MS) and capillary electrophoresis-quadrupole time of flight-mass spectrometry (CE-QTOF-MS).

In some embodiments, the nuclear magnetic resonance (NMR) method is any suitable method well known in the art for the detection of one or more cysteine binding proteins or protein fragments disclosed herein. In some embodiments, the NMR method includes one dimensional (1D) NMR methods, two dimensional (2D) NMR methods, solid state NMR methods and NMR chromatography. Exemplary 1D NMR methods include ¹Hydrogen, ¹³Carbon, ¹⁵Nitrogen, ¹⁷Oxygen, ¹⁹Fluorine, ³¹Phosphorus, ³⁹Potassium, ²³Sodium, ³³Sulfur, ⁸⁷Strontium, ²⁷Aluminium, ⁴³Calcium, ³⁵Chlorine, ³⁷Chlorine, ⁶³Copper, ⁶⁵Copper, ⁵⁷Iron, ²⁵Magnesium, ¹⁹⁹Mercury or ⁶⁷Zinc NMR method, distortionless enhancement by polarization transfer (DEPT) method, attached proton test (APT) method and 1D-incredible natural abundance double quantum transition experiment (INADEQUATE) method. Exemplary 2D NMR methods include correlation spectroscopy (COSY), total correlation spectroscopy (TOCSY), 2D-INADEQUATE, 2D-adequate double quantum transfer experiment (ADEQUATE), nuclear overhauser effect spectroscopy (NOSEY), rotating-frame NOE spectroscopy (ROESY), heteronuclear multiple-quantum correlation spectroscopy (HMQC), heteronuclear single quantum coherence spectroscopy (HSQC), short range coupling and long range coupling methods. Exemplary solid state NMR method include solid state ¹³Carbon NMR, high resolution magic angle spinning (HR-MAS) and cross polarization magic angle spinning (CP-MAS) NMR methods. Exemplary NMR techniques include diffusion ordered spectroscopy (DOSY), DOSY-TOCSY and DOSY-HSQC.

In some embodiments, the protein fragments are analyzed by method as described in Weerapana et al., “Quantitative reactivity profiling predicts functional cysteines in proteomes,” Nature, 468:790-795 (2010).

In some embodiments, the results from the mass spectroscopy method are analyzed by an algorithm for protein identification. In some embodiments, the algorithm combines the results from the mass spectroscopy method with a protein sequence database for protein identification. In some embodiments, the algorithm comprises ProLuCID algorithm, Probity, Scaffold, SEQUEST, or Mascot.

In some embodiments, a value is assigned to each of the protein from the probe-protein complex. In some embodiments, the value assigned to each of the protein from the probe-protein complex is obtained from the mass spectroscopy analysis. In some instances, the value is the area-under-the curve from a plot of signal intensity as a function of mass-to-charge ratio. In some instances, the value correlates with the reactivity of a Cys residue within a protein. In some instances, the value correlates with the reactivity of a Lys residue within a protein.

In some instances, a ratio between a first value obtained from a first protein sample and a second value obtained from a second protein sample is calculated. In some instances, the ratio is greater than 2.5, 3, 3.5, 4, 4.5, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20. In some cases, the ratio is at most 20.

In some instances, the ratio is calculated based on averaged values. In some instances, the averaged value is an average of at least two, three, or four values of the protein from each cell solution, or that the protein is observed at least two, three, or four times in each cell solution and a value is assigned to each observed time. In some instances, the ratio further has a standard deviation of less than 12, 10, or 8.

In some instances, a value is not an averaged value. In some instances, the ratio is calculated based on value of a protein observed only once in a cell population. In some instances, the ratio is assigned with a value of 20.

Kits/Article of Manufacture

Disclosed herein, in certain embodiments, are kits and articles of manufacture for use to generate a protein-probe adduct or with one or more methods described herein. In some embodiments, described herein is a kit for detecting protein ligand interaction. In some embodiments, such kit includes small molecule ligands described herein, small molecule fragments or libraries, compound probes described herein, and/or controls, and reagents suitable for carrying out one or more of the methods described herein. In some instances, the kit further comprises samples, such as a cell sample, and suitable solutions such as buffers or media. In some embodiments, the kit further comprises recombinant cereblon protein for use in one or more of the methods described herein. In some embodiments, additional components of the kit comprises a carrier, package, or container that is compartmentalized to receive one or more containers such as vials, tubes, and the like, each of the container(s) comprising one of the separate elements to be used in a method described herein. Suitable containers include, for example, bottles, vials, plates, syringes, and test tubes. In one embodiment, the containers are formed from a variety of materials such as glass or plastic.

The articles of manufacture provided herein contain packaging materials. Examples of pharmaceutical packaging materials include, but are not limited to, bottles, tubes, bags, containers, and any packaging material suitable for a selected formulation and intended mode of use.

For example, the container(s) include probes, test compounds, and one or more reagents for use in a method disclosed herein. Such kits optionally include an identifying description or label or instructions relating to its use in the methods described herein.

A kit typically includes labels listing contents and/or instructions for use, and package inserts with instructions for use. A set of instructions will also typically be included.

In one embodiment, a label is on or associated with the container. In one embodiment, a label is on a container when letters, numbers or other characters forming the label are attached, molded or etched into the container itself; a label is associated with a container when it is present within a receptacle or carrier that also holds the container, e.g., as a package insert. In one embodiment, a label is used to indicate that the contents are to be used for a specific therapeutic application. The label also indicates directions for use of the contents, such as in the methods described herein.

Certain Terminology

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of skill in the art to which the claimed subject matter belongs. It is to be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of any subject matter claimed. In this application, the use of the singular includes the plural unless specifically stated otherwise. It must be noted that, as used in the specification and the appended claims, the singular forms “a,” “an” and “the” include plural referents unless the context clearly dictates otherwise. In this application, the use of “or” means “and/or” unless stated otherwise. Furthermore, use of the term “including” as well as other forms, such as “include”, “includes,” and “included,” is not limiting.

As used herein, ranges and amounts can be expressed as “about” a particular value or range. About also includes the exact amount. Hence “about 5 μL” means “about 5 μL” and also “5 μL.” Generally, the term “about” includes an amount that would be expected to be within experimental error.

“Alkyl” refers to a straight or branched hydrocarbon chain radical, having from one to twenty carbon atoms, and which is attached to the rest of the molecule by a single bond. An alkyl comprising up to 10 carbon atoms is referred to as a C₁-C₁₀ alkyl, likewise, for example, an alkyl comprising up to 6 carbon atoms is a C₁-C₆ alkyl. Alkyls (and other moieties defined herein) comprising other numbers of carbon atoms are represented similarly. Alkyl groups include, but are not limited to, C₁-C₁₀ alkyl, C₁-C₉ alkyl, C₁-C₈ alkyl, C₁-C₇ alkyl, C₁-C₆ alkyl, C₁-C₅ alkyl, C₁-C₄ alkyl, C₁-C₃ alkyl, C₁-C₂ alkyl, C₂-C₈ alkyl, C₃-C₈ alkyl and C₄-C₈ alkyl. Representative alkyl groups include, but are not limited to, methyl, ethyl, n-propyl, 1-methylethyl (i-propyl), n-butyl, i-butyl, s-butyl, n-pentyl, 1,1-dimethylethyl (t-butyl), 3-methylhexyl, 2-methylhexyl, 1-ethyl-propyl, and the like. In some embodiments, the alkyl is methyl or ethyl. In some embodiments, the alkyl is —CH(CH₃)₂ or —C(CH₃)₃. Unless stated otherwise specifically in the specification, an alkyl group may be optionally substituted as described below. “Alkylene” or “alkylene chain” refers to a straight or branched divalent hydrocarbon chain linking the rest of the molecule to a radical group. In some embodiments, the alkylene is —CH₂—, —CH₂CH₂—, or —CH₂CH₂CH₂—. In some embodiments, the alkylene is —CH₂—. In some embodiments, the alkylene is —CH₂CH₂—. In some embodiments, the alkylene is —CH₂CH₂CH₂—.

“Alkoxy” refers to a radical of the formula —OR where R is an alkyl radical as defined. Unless stated otherwise specifically in the specification, an alkoxy group may be optionally substituted as described below. Representative alkoxy groups include, but are not limited to, methoxy, ethoxy, propoxy, butoxy, pentoxy. In some embodiments, the alkoxy is methoxy. In some embodiments, the alkoxy is ethoxy.

“Heteroalkylene” refers to an alkyl radical as described above where one or more carbon atoms of the alkyl is replaced with a O, N or S atom. “Heteroalkylene” or “heteroalkylene chain” refers to a straight or branched divalent heteroalkyl chain linking the rest of the molecule to a radical group. Unless stated otherwise specifically in the specification, the heteroalkyl or heteroalkylene group may be optionally substituted as described below. Representative heteroalkyl groups include, but are not limited to —OCH₂OMe, —OCH₂CH₂OMe, or —OCH₂CH₂OCH₂CH₂NH₂. Representative heteroalkylene groups include, but are not limited to —OCH₂CH₂O—, —OCH₂CH₂OCH₂CH₂O—, or —OCH₂CH₂OCH₂CH₂OCH₂CH₂O—.

“Alkylamino” refers to a radical of the formula —NHR or —NRR where each R is, independently, an alkyl radical as defined above. Unless stated otherwise specifically in the specification, an alkylamino group may be optionally substituted as described below.

The term “aromatic” refers to a planar ring having a delocalized π-electron system containing 4n+2 π electrons, where n is an integer. Aromatics can be optionally substituted. The term “aromatic” includes both aryl groups (e.g., phenyl, naphthalenyl) and heteroaryl groups (e.g., pyridinyl, quinolinyl).

“Aryl” refers to an aromatic ring wherein each of the atoms forming the ring is a carbon atom. Aryl groups can be optionally substituted. Examples of aryl groups include, but are not limited to phenyl, and naphthyl. In some embodiments, the aryl is phenyl. Depending on the structure, an aryl group can be a monoradical or a diradical (i.e., an arylene group). Unless stated otherwise specifically in the specification, the term “aryl” or the prefix “ar-” (such as in “aralkyl”) is meant to include aryl radicals that are optionally substituted.

“Carboxy” refers to —CO₂H. In some embodiments, carboxy moieties may be replaced with a “carboxylic acid bioisostere”, which refers to a functional group or moiety that exhibits similar physical and/or chemical properties as a carboxylic acid moiety. A carboxylic acid bioisostere has similar biological properties to that of a carboxylic acid group. A compound with a carboxylic acid moiety can have the carboxylic acid moiety exchanged with a carboxylic acid bioisostere and have similar physical and/or biological properties when compared to the carboxylic acid-containing compound. For example, in one embodiment, a carboxylic acid bioisostere would ionize at physiological pH to roughly the same extent as a carboxylic acid group. Examples of bioisosteres of a carboxylic acid include, but are not limited to:

and the like.

“Cycloalkyl” refers to a monocyclic or polycyclic non-aromatic radical, wherein each of the atoms forming the ring (i.e. skeletal atoms) is a carbon atom. Cycloalkyls may be saturated, or partially unsaturated. Cycloalkyls may be fused with an aromatic ring (in which case the cycloalkyl is bonded through a non-aromatic ring carbon atom). Cycloalkyl groups include groups having from 3 to 10 ring atoms. Representative cycloalkyls include, but are not limited to, cycloalkyls having from three to ten carbon atoms, from three to eight carbon atoms, from three to six carbon atoms, or from three to five carbon atoms. Monocyclic cyclcoalkyl radicals include, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. In some embodiments, the monocyclic cyclcoalkyl is cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl. In some embodiments, the monocyclic cyclcoalkyl is cyclopentyl. Polycyclic radicals include, for example, adamantyl, norbornyl, decalinyl, and 3,4-dihydronaphthalen-1(2H)-one. Unless otherwise stated specifically in the specification, a cycloalkyl group may be optionally substituted.

“Fused” refers to any ring structure described herein which is fused to an existing ring structure. When the fused ring is a heterocyclyl ring or a heteroaryl ring, any carbon atom on the existing ring structure which becomes part of the fused heterocyclyl ring or the fused heteroaryl ring may be replaced with a nitrogen atom.

“Halo” or “halogen” refers to bromo, chloro, fluoro or iodo.

“Haloalkyl” refers to an alkyl radical, as defined above, that is substituted by one or more halo radicals, as defined above, e.g., trifluoromethyl, difluoromethyl, fluoromethyl, trichloromethyl, 2,2,2-trifluoroethyl, 1,2-difluoroethyl, 3-bromo-2-fluoropropyl, 1,2-dibromoethyl, and the like. Unless stated otherwise specifically in the specification, a haloalkyl group may be optionally substituted.

“Haloalkoxy” refers to an alkoxy radical, as defined above, that is substituted by one or more halo radicals, as defined above, e.g., trifluoromethoxy, difluoromethoxy, fluoromethoxy, trichloromethoxy, 2,2,2-trifluoroethoxy, 1,2-difluoroethoxy, 3-bromo-2-fluoropropoxy, 1,2-dibromoethoxy, and the like. Unless stated otherwise specifically in the specification, a haloalkoxy group may be optionally substituted.

“Heterocycloalkyl” or “heterocyclyl” or “heterocyclic ring” refers to a stable 3- to 14-membered non-aromatic ring radical comprising 2 to 10 carbon atoms and from one to 4 heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur. Unless stated otherwise specifically in the specification, the heterocycloalkyl radical may be a monocyclic, or bicyclic ring system, which may include fused (when fused with an aryl or a heteroaryl ring, the heterocycloalkyl is bonded through a non-aromatic ring atom) or bridged ring systems. The nitrogen, carbon or sulfur atoms in the heterocyclyl radical may be optionally oxidized. The nitrogen atom may be optionally quaternized. The heterocycloalkyl radical is partially or fully saturated. Examples of such heterocycloalkyl radicals include, but are not limited to, dioxolanyl, thienyl[1,3]dithianyl, decahydroisoquinolyl, imidazolinyl, imidazolidinyl, isothiazolidinyl, isoxazolidinyl, morpholinyl, octahydroindolyl, octahydroisoindolyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, oxazolidinyl, piperidinyl, piperazinyl, 4-piperidonyl, pyrrolidinyl, pyrazolidinyl, quinuclidinyl, thiazolidinyl, tetrahydrofuryl, trithianyl, tetrahydropyranyl, thiomorpholinyl, thiamorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxo-thiomorpholinyl. The term heterocycloalkyl also includes all ring forms of carbohydrates, including but not limited to monosaccharides, disaccharides and oligosaccharides. Unless otherwise noted, heterocycloalkyls have from 2 to 10 carbons in the ring. In some embodiments, heterocycloalkyls have from 2 to 8 carbons in the ring. In some embodiments, heterocycloalkyls have from 2 to 8 carbons in the ring and 1 or 2 N atoms. In some embodiments, heterocycloalkyls have from 2 to 10 carbons, 0-2 N atoms, 0-2 O atoms, and 0-1 S atoms in the ring. In some embodiments, heterocycloalkyls have from 2 to 10 carbons, 1-2 N atoms, 0-1 O atoms, and 0-1 S atoms in the ring. It is understood that when referring to the number of carbon atoms in a heterocycloalkyl, the number of carbon atoms in the heterocycloalkyl is not the same as the total number of atoms (including the heteroatoms) that make up the heterocycloalkyl (i.e. skeletal atoms of the heterocycloalkyl ring). Unless stated otherwise specifically in the specification, a heterocycloalkyl group may be optionally substituted.

“Heteroaryl” refers to an aryl group that includes one or more ring heteroatoms selected from nitrogen, oxygen and sulfur. The heteroaryl is monocyclic or bicyclic. Illustrative examples of monocyclic heteroaryls include pyridinyl, imidazolyl, pyrimidinyl, pyrazolyl, triazolyl, pyrazinyl, tetrazolyl, furyl, thienyl, isoxazolyl, thiazolyl, oxazolyl, isothiazolyl, pyrrolyl, pyridazinyl, triazinyl, oxadiazolyl, thiadiazolyl, furazanyl, indolizine, indole, benzofuran, benzothiophene, indazole, benzimidazole, purine, quinolizine, quinoline, isoquinoline, cinnoline, phthalazine, quinazoline, quinoxaline, 1,8-naphthyridine, and pteridine. Illustrative examples of monocyclic heteroaryls include pyridinyl, imidazolyl, pyrimidinyl, pyrazolyl, triazolyl, pyrazinyl, tetrazolyl, furyl, thienyl, isoxazolyl, thiazolyl, oxazolyl, isothiazolyl, pyrrolyl, pyridazinyl, triazinyl, oxadiazolyl, thiadiazolyl, and furazanyl. Illustrative examples of bicyclic heteroaryls include indolizine, indole, benzofuran, benzothiophene, indazole, benzimidazole, purine, quinolizine, quinoline, isoquinoline, cinnoline, phthalazine, quinazoline, quinoxaline, 1,8-naphthyridine, and pteridine. In some embodiments, heteroaryl is pyridinyl, pyrazinyl, pyrimidinyl, thiazolyl, thienyl, thiadiazolyl or furyl. In some embodiments, a heteroaryl contains 0-4 N atoms in the ring. In some embodiments, a heteroaryl contains 1-4 N atoms in the ring. In some embodiments, a heteroaryl contains 0-4 N atoms, 0-1 O atoms, and 0-1 S atoms in the ring. In some embodiments, a heteroaryl contains 1-4 N atoms, 0-1 O atoms, and 0-1 S atoms in the ring. In some embodiments, heteroaryl is a C₁-C₉heteroaryl. In some embodiments, monocyclic heteroaryl is a C₁-C₅heteroaryl. In some embodiments, monocyclic heteroaryl is a 5-membered or 6-membered heteroaryl. In some embodiments, a bicyclic heteroaryl is a C₆-C₉heteroaryl.

The term “optionally substituted” or “substituted” means that the referenced group may be substituted with one or more additional group(s) individually and independently selected from alkyl, haloalkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, —OH, alkoxy, aryloxy, alkylthio, arylthio, alkylsulfoxide, arylsulfoxide, alkylsulfone, arylsulfone, —CN, alkyne, C₁-C₆alkylalkyne, halogen, acyl, acyloxy, —CO₂H, —CO₂alkyl, nitro, and amino, including mono- and di-substituted amino groups (e.g. —NH₂, —NHR, —N(R)₂), and the protected derivatives thereof. In some embodiments, optional substituents are independently selected from alkyl, alkoxy, haloalkyl, cycloalkyl, halogen, —CN, —NH₂, —NH(CH₃), —N(CH₃)₂, —OH, —CO₂H, and —CO₂alkyl. In some embodiments, optional substituents are independently selected from fluoro, chloro, bromo, iodo, —CH₃, —CH₂CH₃, —CF₃, —OCH₃, and —OCF₃. In some embodiments, substituted groups are substituted with one or two of the preceding groups. In some embodiments, an optional substituent on an aliphatic carbon atom (acyclic or cyclic, saturated or unsaturated carbon atoms, excluding aromatic carbon atoms) includes oxo (═O).

The section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described.

EXAMPLES

These examples are provided for illustrative purposes only and not to limit the scope of the claims provided herein.

Example 1

Table 1A and Table 1B illustrate exemplary proteins and cysteine site residues described herein.

TABLE 1A KB02 KBO3 uniprot Res# Symbol Description E3? Liganded Liganded Q96DE5 55 ANAPC16 ANAPC16 Anaphase-promoting yes YES complex subunit 16 Q96DE5 55 ANAPC16 Anaphase-promoting complex subunit 16 Yes YES Q9UJX3 329 ANAPC7 Anaphase-promoting complex subunit 7 Yes YES O15033 382 AREL1 Apoptosis-resistant E3 ubiquitin protein Yes YES ligase 1 O14867 224 BACH1 Transcription regulator protein BACH1 Yes YES YES Q9BYV9 370 BACH2 Transcription regulator protein BACH2 Yes YES Q13490 45 BIRC2 Baculoviral IAP repeat-containing Yes YES YES protein 2 Q13489 28 BIRC3 Baculoviral IAP repeat-containing Yes YES protein 3 Q5H9S7 20 DCAF17 DDB1- and CUL4-associated factor 17 Yes YES Q9NZJ0 141 DTL Denticleless protein homolog Yes YES Q9NZJ0 136 DTL Denticleless protein homolog Yes YES Q86XK2 581 FBXO11 F-box only protein 11 Yes YES Q8TB52 725 FBXO30 F-box only protein 30 Yes YES Q9ULT8 1855 HECTD1 E3 ubiquitin-protein ligase HECTD1 Yes YES Q15751 56 HERC1 Probable E3 ubiquitin-protein ligase Yes YES HERC1 Q15751 1941 HERC1 Probable E3 ubiquitin-protein ligase Yes YES HERC1 Q5GLZ8 60 HERC4 Probable E3 ubiquitin-protein ligase Yes YES HERC4 Q9UII4 994 HERC5 E3 ISG15--protein ligase HERC5 Yes YES YES Q7Z6Z7 2181 HUWE1 E3 ubiquitin-protein ligase HUWE1 Yes YES Q8NFY9 181 KBTBD8 Kelch repeat and BTB domain- Yes YES containing protein 8 Q14145 288 KEAP1 Kelch-like ECH-associated protein 1 Yes YES O75592 3152 MYCBP2 MYCBP2 Probable E3 ubiquitin-protein yes YES ligase MYCBP2 O75592 1131 MYCBP2 E3 ubiquitin-protein ligase MYCBP2 Yes YES O75592 3152 MYCBP2 E3 ubiquitin-protein ligase MYCBP2 Yes YES P35227 233 PCGF2 Polycomb group RING finger protein 2 Yes YES Q8N2W9 326 PIAS4 E3 SUMO-protein ligase PIAS4 Yes YES YES P29590 484 PML Protein PML Yes YES P29590 479 PML Protein PML Yes YES Q06587 72 RING1 E3 ubiquitin-protein ligase RING1 Yes YES YES Q06587 51 RING1 E3 ubiquitin-protein ligase RING1 Yes YES Q99496 54 RNF2 E3 ubiquitin-protein ligase RING2 Yes YES Q5VTR2 383 RNF20 E3 ubiquitin-protein ligase BRE1A Yes YES Q63HN8 1510 RNF213 E3 ubiquitin-protein ligase RNF213 Yes YES Q63HN8 4407 RNF213 E3 ubiquitin-protein ligase RNF213 Yes YES Q63HN8 4258 RNF213 E3 ubiquitin-protein ligase RNF213 Yes YES Q8ND24 655 RNF214 RING finger protein 214 Yes YES YES Q96BH1 417 RNF25 E3 ubiquitin-protein ligase RNF25 Yes YES O75150 890 RNF40 E3 ubiquitin-protein ligase BRE1B Yes YES Q9UBF6 88 RNF7 RING-box protein 2 Yes YES P21580 579 TNFAIP3 Tumor necrosis factor alpha-induced Yes YES protein 3 P21580 54 TNFAIP3 Tumor necrosis factor alpha-induced Yes YES YES protein 3 P21580 536 TNFAIP3 Tumor necrosis factor alpha-induced Yes YES protein 3 Q9UPN9 153 TRIM33 E3 ubiquitin-protein ligase TRIM33 Yes YES Q9UPN9 582 TRIM33 E3 ubiquitin-protein ligase TRIM33 Yes YES Q9BRZ2 338 TRIM56 E3 ubiquitin-protein ligase TRIM56 Yes YES Q9BRZ2 36 TRIM56 E3 ubiquitin-protein ligase TRIM56 Yes YES Q6PJ69 320 TRIM65 Tripartite motif-containing protein 65 Yes YES Q2Q1W2 636 TRIM71 E3 ubiquitin-protein ligase TRIM71 Yes YES Q14669 1959 TRIP12 TRIP12 E3 ubiquitin-protein ligase yes YES TRIP12 Q14669 1959 TRIP12 E3 ubiquitin-protein ligase TRIP12 Yes YES Q9C0C9 370 UBE2O (E3-independent) E2 ubiquitin- Yes YES YES conjugating enzyme Q9C0C9 910 UBE2O (E3-independent) E2 ubiquitin- Yes YES conjugating enzyme Q9C0C9 913 UBE2O (E3-independent) E2 ubiquitin- Yes YES conjugating enzyme Q9C0C9 400 UBE2O (E3-independent) E2 ubiquitin- Yes YES conjugating enzyme Q14139 79 UBE4A UBE4A Ubiquitin conjugation factor E4 A yes YES Q14139 79 UBE4A Ubiquitin conjugation factor E4 A Yes YES Q8IWV8 1717 UBR2 E3 ubiquitin-protein ligase UBR2 Yes YES Q5T4S7 4049 UBR4 E3 ubiquitin-protein ligase UBR4 Yes YES O95071 2314 UBR5 E3 ubiquitin-protein ligase UBR5 Yes YES Q9Y4B6 69 VPRBP Protein VPRBP Yes YES Q9Y4B6 967 VPRBP Protein VPRBP Yes YES Q9P253 806 VPS18 Vacuolar protein sorting-associated Yes YES protein 18 homolog Q86WB0 406 ZC3HC1 Nuclear-interacting partner of ALK Yes YES P28288 472 ABCD3 ABCD3 ATP-binding cassette sub-family D YES member 3 P28288 477 ABCD3 ABCD3 ATP-binding cassette sub-family D YES member 3 P42765 382 ACAA2 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial YES Q86UL3 325 AGPAT6 AGPAT6 Glycerol-3-phosphate acyltransferase 4 YES YES Q92667 376 AKAP1 AKAP1 A-kinase anchor protein 1, mitochondrial YES P54886 612 ALDH18A1 ALDH18A1 Delta-1-pyrroline-5-carboxylate YES synthase Q3SY69 707 ALDH1L2 ALDH1L2 Mitochondrial 10- YES formyltetrahydrofolate dehydrogen Q6DCA0 153 AMMECR1L AMMECR1L AMMECR1-like protein YES Q6NXT1 230 ANKRD54 ANKRD54 Ankyrin repeat domain-containing YES protein 54 Q676U5 145 ATG16L1 ATG16L1 Autophagy-related protein 16-1 YES P38606 277 ATP6V1A ATP6V1A V-type proton ATPase catalytic YES YES subunit A Q00536 206 CDK16 CDK16 Cyclin-dependent kinase 16 YES YES Q00537 233 CDK17 CDK17 Cyclin-dependent kinase 17 YES YES Q07002 183 CDK18 CDK18 Cyclin-dependent kinase 18 YES YES Q9C0F1 28 CEP44 CEP44 Centrosomal protein of 44 kDa YES P12277 283 CKB CKB Creatine kinase B-type YES P12532 316 CKMT1B CKMT1B Creatine kinase U-type, mitochondrial YES YES P53634 258 CTSC CTSC Dipeptidyl peptidase 1 YES Q9UHI6 577 DDX20 DDX20 Probable ATP-dependent RNA helicase YES DDX20 Q9BQ39 603 DDX50 DDX50 ATP-dependent RNA helicase DDX50 YES Q8IY21 1051 DDX60 DDX60 Probable ATP-dependent RNA helicase YES DDX60 Q9NUI1 120 DECR2 DECR2 Peroxisomal 2,4-dienoyl-CoA reductase YES YES Q14689 6 DIP2A DIP2A Disco-interacting protein 2 homolog A YES YES P68104 370 EEF1A1 EEF1A1 Elongation factor 1-alpha 1 YES YES P68104 363 EEF1A1 EEF1A1 Elongation factor 1-alpha 1 YES YES Q9NZB2 919 FAM120A FAM120A Constitutive coactivator of PPAR- YES gamma-like protei P49327 161 FASN FASN Fatty acid synthase YES Q7L8L6 670 FASTKD5 FASTKD5 FAST kinase domain-containing YES protein 5 P37268 6 FDFT1 FDFT1 Squalene synthase YES Q96CP2 64 FLYWCH2 FLYWCH2 FLYWCH family member 2 YES Q14353 91 GAMT GAMT Guanidinoacetate N-methyltransferase YES Q92616 648 GCN1L1 GCN1L1 Translational activator GCN1 YES Q96RP9 146 GFM1 GFM1 Elongation factor G, mitochondrial YES Q08379 794 GOLGA2 GOLGA2 Golgin subfamily A member 2 YES P55084 458 HADHB HADHB Trifunctional enzyme subunit beta, YES mitochondrial P68431 111 HIST1H3J HIST1H3J Histone H3.1 YES YES P30519 265 HMOX2 HMOX2 Heme oxygenase 2 YES YES Q8WVV9 464 HNRPLL HNRPLL Heterogeneous nuclear YES ribonucleoprotein L-like P48735 154 IDH2 IDH2 Isocitrate dehydrogenase YES Q8N201 1534 INTS1 INTS1 Integrator complex subunit 1 YES Q06136 121 KDSR KDSR 3-ketodihydrosphingosine reductase YES Q86YS7 867 KIAA0528 KIAA0528 Uncharacterized protein KIAA0528 YES O75153 333 KIAA0664 KIAA0664 Clustered mitochondria protein YES homolog Q9H9P8 187 L2HGDH L2HGDH L-2-hydroxyglutarate dehydrogenase, YES mitochondrial Q96JM7 233 L3MBTL3 L3MBTL3 Lethal(3)malignant brain tumor-like YES protein 3 Q99538 50 LGMN LGMN Legumain YES P46821 382 MAP1B MAP1B Microtubule-associated protein 1B YES P53779 283 MAPK10 MAPK10 Mitogen-activated protein kinase 10 YES P45983 245 MAPK8 MAPK8 Mitogen-activated protein kinase 8 YES P03915 518 MT-ND5 MT-ND5 NADH-ubiquinone oxidoreductase YES YES chain 5 Q9BXJ9 817 NAA15 NAA15 N-alpha-acetyltransferase 15, NatA YES auxiliary subun Q8TD19 260 NEK9 NEK9 Serine/threonine-protein kinase Nek9 YES Q9Y3T9 585 NOC2L NOC2L Nucleolar complex protein 2 homolog YES O00567 211 NOP56 NOP56 Nucleolar protein 56 YES Q9H857 504 NT5DC2 NT5DC2 5-nucleotidase domain-containing YES protein 2 Q9H857 507 NT5DC2 NT5DC2 5-nucleotidase domain-containing YES protein 2 P53384 31 NUBP1 NUBP1 Cytosolic Fe—S cluster assembly factor YES YES NUBP1 Q14690 361 PDCD11 PDCD11 Protein RRP5 homolog YES Q7Z3K3 547 POGZ POGZ Pogo transposable element with ZNF YES domain Q96CD2 173 PPCDC PPCDC Phosphopantothenoylcysteine YES decarboxylase O14744 278 PRMT5 PRMT5 Protein arginine N-methyltransferase 5 YES P04843 477 RPN1 RPN1 Dolichyl-diphosphooligosaccharide-- YES protein glycosy Q15418 223 RPS6KA1 RPS6KA1 Ribosomal protein S6 kinase alpha-1 YES P51812 229 RPS6KA3 RPS6KA3 Ribosomal protein S6 kinase alpha-3 YES Q6P087 147 RPUSD3 RPUSD3 RNA pseudouridylate synthase domain- YES containing pro Q14684 155 RRP1B RRP1B Ribosomal RNA processing protein 1 YES homolog B O43159 451 RRP8 RRP8 Ribosomal RNA-processing protein 8 YES Q9UGP8 295 SEC63 SEC63 Translocation protein SEC63 homolog YES O15047 1648 SETD1A SETD1A Histone-lysine N-methyltransferase YES SETD1A Q9Y5X2 200 SNX8 SNX8 Sorting nexin-8 YES Q96R06 382 SPAG5 SPAG5 Sperm-associated antigen 5 YES YES Q13501 131 SQSTM1 SQSTM1 Sequestosome-1 YES Q9UQ35 1029 SRRM2 SRRM2 Serine/arginine repetitive matrix protein 2 YES Q9UQ35 1036 SRRM2 SRRM2 Serine/arginine repetitive matrix protein 2 YES P28290 901 SSFA2 SSFA2 Sperm-specific antigen 2 YES Q03519 641 TAP2 TAP2 Antigen peptide transporter 2 YES YES O15533 440 TAPBP TAPBP Tapasin YES Q8TC07 24 TBC1D15 TBC1D15 TBC1 domain family member 15 YES Q7Z2T5 239 TRMT1L TRMT1L TRMT1-like protein YES Q13748 4 TUBA3D TUBA3D Tubulin alpha-3C/D chain YES YES Q13748 20 TUBA3D TUBA3D Tubulin alpha-3C/D chain YES YES Q9H1C4 583 UNC93B1 UNC93B1 Protein unc-93 homolog B1 YES P45880 227 VDAC2 VDAC2 Voltage-dependent anion-selective YES YES channel protein P45880 210 VDAC2 VDAC2 Voltage-dependent anion-selective YES YES channel protein Q9Y277 229 VDAC3 VDAC3 Voltage-dependent anion-selective YES channel protein Q8IV63 191 VRK3 VRK3 Inactive serine/threonine-protein kinase YES VRK3 Q5VUA4 1681 ZNF318 ZNF318 Zinc finger protein 318 YES Q14966 1023 ZNF638 ZNF638 Zinc finger protein 638 YES Q14966 1026 ZNF638 ZNF638 Zinc finger protein 638 YES Q14966 1023 ZNF638 ZNF638 Zinc finger protein 638 YES Q9H582 507 ZNF644 ZNF644 Zinc finger protein 644 YES

TABLE 1B uniprot KB02¹ KB02² KB02³ KB02⁴ KB03⁵ KB03⁶ KB03⁷ KB03⁸ Q96DE5 75.05 34.265 75.46 46.17 28.34 −0.24 36.5 20.4 Q96DE5 75.1 34.3 75.5 46.2 28.3 −0.2 36.5 20.4 Q9UJX3 77.1 51.2 77.1 58.1 68.4 47.5 73.4 60.9 O15033 77.2 77.2 55.1 49.1 55.1 56.8 O14867 87.8 61.6 87.8 61.6 85.3 53.8 85.3 53.8 Q9BYV9 77.6 40.9 77.6 42.2 62.8 17.2 62.8 25.4 Q13490 95.7 84.9 98.1 92.3 85.9 41.4 92.0 47.9 Q13489 76.9 25.8 76.9 27.2 18.7 −2.6 18.7 1.3 Q5H9S7 91.7 40.3 91.7 60.8 −21.2 −21.2 Q9NZJ0 93.6 85.0 93.6 85.0 70.5 36.7 70.5 36.7 Q9NZJ0 77.3 33.7 77.3 33.7 69.3 29.9 69.3 29.9 Q86XK2 83.2 43.1 98.3 63.5 20.3 −20.1 28.6 −13.9 Q8TB52 54.1 35.6 80.1 56.3 25.0 4.3 39.5 10.4 Q9ULT8 87.1 29.5 87.1 43.3 72.6 0.1 72.6 1.2 Q15751 90.7 45.6 91.8 62.8 58.0 8.9 68.4 20.5 Q15751 63.2 77.7 2.0 2.9 Q5GLZ8 79.8 32.6 82.2 40.3 58.8 15.4 62.3 42.0 Q9UII4 85.3 18.9 85.3 18.9 96.8 83.4 96.8 83.4 Q7Z6Z7 76.4 76.4 9.7 9.7 Q8NFY9 79.2 36.7 79.2 38.4 21.5 −7.4 21.5 5.3 Q14145 82.3 37.7 82.3 37.7 O75592 71.85 20.98 76.84 28.88 25.92 −7.46 28.63 4.67 O75592 82.8 42.5 82.8 55.0 30.7 −12.9 30.7 0.0 O75592 71.9 21.0 76.8 28.9 25.9 −7.5 28.6 4.7 P35227 79.2 35.2 80.1 41.7 35.9 −4.4 49.9 5.9 Q8N2W9 96.5 91.8 96.5 96.0 75.4 30.1 87.0 35.5 P29590 75.5 26.1 84.7 44.1 65.9 0.4 65.9 10.2 P29590 72.4 33.3 79.4 58.9 44.4 −3.1 60.8 15.3 Q06587 83.1 50.3 83.1 50.3 83.4 32.4 83.4 32.4 Q06587 24.0 −2.4 24.0 4.8 76.8 0.5 76.8 18.1 Q99496 24.0 −2.4 24.0 4.8 76.8 0.5 76.8 18.1 Q5VTR2 86.1 57.7 94.1 62.1 32.6 0.6 37.3 11.0 Q63HN8 93.0 79.9 96.5 88.1 58.4 5.6 66.6 15.3 Q63HN8 87.1 56.7 87.1 68.4 39.2 −21.4 39.2 −15.8 Q63HN8 70.3 74.7 26.0 −9.8 26.0 −1.2 Q8ND24 74.8 45.8 83.2 50.3 65.9 24.8 96.4 35.5 Q96BH1 77.7 33.5 77.7 33.5 62.0 14.3 62.0 14.3 O75150 91.8 56.5 93.4 79.4 24.5 −9.9 29.2 −5.2 Q9UBF6 75.2 75.2 20.4 20.4 P21580 99.8 99.2 99.8 99.8 56.8 28.1 56.8 52.6 P21580 98.9 83.8 99.6 90.4 99.3 97.1 99.3 98.2 P21580 86.6 47.0 86.6 53.4 46.1 28.5 46.1 31.2 Q9UPN9 33.1 4.4 51.7 30.1 56.8 10.3 85.7 86.6 Q9UPN9 81.0 24.1 84.6 43.7 57.4 1.1 70.5 22.0 Q9BRZ2 87.7 40.3 88.3 54.3 11.8 25.9 Q9BRZ2 37.9 6.0 48.6 18.4 78.3 24.0 78.3 32.2 Q6PJ69 87.6 45.8 87.7 58.0 60.2 19.4 70.9 35.1 Q2Q1W2 87.2 33.5 87.2 33.5 64.2 17.2 64.2 17.2 Q14669 75.47 20.33 75.47 24.93 48.04 0.28 48.04 6.39 Q14669 75.5 20.3 75.5 24.9 48.0 0.3 48.0 6.4 Q9C0C9 74.3 21.4 89.5 49.4 53.0 2.0 76.5 30.4 Q9C0C9 83.8 34.8 83.8 34.8 34.3 35.7 34.3 35.7 Q9C0C9 77.5 19.1 77.5 19.1 30.1 16.7 30.1 16.7 Q9C0C9 76.2 49.9 76.2 49.9 59.4 23.1 59.4 23.1 Q14139 90.45 9.64 90.45 16.75 19.24 2.64 24.72 10.39 Q14139 90.5 9.6 90.5 16.8 19.2 2.6 24.7 10.4 Q8IWV8 90.9 60.0 92.7 72.1 60.0 8.3 65.9 18.5 Q5T4S7 71.9 18.6 82.0 24.0 29.3 −4.9 49.5 13.1 O95071 66.6 17.3 76.2 19.3 26.8 −2.4 33.0 9.2 Q9Y4B6 84.1 52.4 84.1 56.8 59.5 30.2 59.5 61.2 Q9Y4B6 77.3 30.3 77.3 30.3 28.2 −0.9 28.2 −0.9 Q9P253 85.0 35.2 85.0 45.1 47.0 16.2 47.0 19.6 Q86WB0 65.5 13.9 77.7 34.0 34.6 −8.7 53.8 6.3 P28288 84.24 10.775 84.24 30.56 34.93 −5.085 34.93 3.18 P28288 86.86 29.54 87.59 43.9 35.18 −12.80 39.85 −0.23 P42765 94.11 92.98 94.11 92.98 −0.69 3.45 −0.69 3.45 Q86UL3 93.71 72.63 93.71 88.26 85.19 65.705 85.19 66.91 Q92667 84.17 22.975 84.17 43.22 45.04 −0.33 57.81 18.92 P54886 80.12 34.8575 80.76 40.24 66.23 13.91 66.31 34.21 Q3SY69 35.43 −9.84 35.43 −9.84 77.55 52.7 77.55 52.7 Q6DCA0 85.74 91.46 85.74 91.46 Q6NXT1 75.08 28.77 77.15 46.44 44.21 −0.72 45.29 7.02 Q676U5 80 16.2813 80 16.28 18.73 −47.09 18.73 −47.09 P38606 84.565 56.1875 86.62 67.33 69.985 18.165 76.55 27.98 Q00536 88.13 48.8275 90.78 69.25 79.225 28.2075 80.44 50.67 Q00537 88.13 48.8275 90.78 69.25 79.225 28.2075 80.44 50.67 Q07002 88.13 48.8275 90.78 69.25 79.225 28.2075 80.44 50.67 Q9C0F1 78.74 16.65 78.74 16.65 69.9 14.85 69.9 14.85 P12277 95.3 84.26 95.3 85.17 71.73 15.155 71.73 23.24 P12532 91.53 80.325 96.43 96.46 81.71 29.59 86.19 42.35 P53634 50.925 36.695 64.88 62.83 95.44 76.05 95.44 76.05 Q9UHI6 74.765 21.5175 85.27 39.22 31.49 −6.7225 37.31 0.85 Q9BQ39 91.56 41.415 95.81 60.06 22.82 −13.925 28.63 −9.62 Q8IY21 98.68 88.54 98.68 93.26 73.07 19.7 73.07 29.56 Q9NUI1 55.92 76.8 55.92 76.8 85 66.9 85 66.9 Q14689 85.31 24.24 85.31 24.24 91.21 39.34 91.21 39.34 P68104 79.795 31.885 86.92 48.77 74.35 24 87.08 46.21 P68104 78.125 36.0625 87.29 50.66 86.19 21.28333 86.19 43.3 Q9NZB2 82.72 2.92 82.72 8.53 55.62 −8.925 55.62 13.09 P49327 90.93 90.93 −26.25 −26.25 Q7L8L6 75.66 38.15 75.66 38.15 45.06 14.55 57.23 14.75 P37268 69.42 19.56 69.42 30.82 82.93 37.70333 82.93 59.08 Q96CP2 79.89 18.1 79.89 25.4 41.635 2.25 41.66 12.97 Q14353 87.425 41.34 88.2 46.77 6.05 −25.93 16.85 −9.9 Q92616 55.68 11.47 57.17 30.58 78.745 25.61 80.3 28.59 Q96RP9 80.72 34.48 80.72 34.48 Q08379 85.65 30.41 85.65 30.41 54.38 1.85 54.38 1.85 P55084 91.7 71.865 94.32 80.88 60.9 15.245 64.33 26.24 P68431 86.28 27.43 86.28 47.9 79.39 22.28 79.39 50.87 P30519 93.98 74.475 98.47 89.99 88.6 81.435 98.54 93.81 Q8WVV9 90.12 39.085 90.12 49.46 61.83 3.35 61.83 4.14 P48735 37.86 20.30 75.27 54.11 70.11 43.06 73.43 63.35 Q8N201 24.155 −2.61 26.58 3.23 70.05 36.495 77.65 51.25 Q06136 79.49 79.49 −22.72 −22.72 Q86YS7 71.91 20.55 76.77 29.09 33.415 −6.4125 46.81 7.23 O75153 86.65 15.665 86.65 29.11 51.405 9.323333 73.65 23.11 Q9H9P8 73.53 34.0075 75.71 40.09 67.435 26.9925 70.21 39.03 Q96JM7 77.37 24.805 77.37 32.93 57.17 10.83 57.17 16.63 Q99538 78.38 20.31 78.38 33.6 60.93 0.755 60.93 12.45 P46821 71.07 27.9 71.07 27.9 75.17 37.5 75.17 37.5 P53779 76.89 26.11 78.63 44.42 40.875 12.33 44.06 17.22 P45983 76.89 26.11 78.63 44.42 40.875 12.33 44.06 17.22 P03915 88.34 88.34 83.61 83.61 Q9BXJ9 87.75 14.80 87.75 30.16 14.66 −31.6767 14.66 −21.23 Q8TD19 79.22 30.62 79.22 30.62 56.18 9.47 56.18 9.47 Q9Y3T9 93.26 39.755 95.32 48.21 56.82 7.195 59.2 29.97 O00567 75.79 14.04 75.79 36.67 68.12 27.36 68.12 51.21 Q9H857 79.98 9.89 79.98 9.89 66.1 10.83 66.1 10.83 Q9H857 77.1 28.22 77.1 31.68 65.33 9.86 65.33 18.84 P53384 63.785 25.0375 76.77 44.6 55.66 7.3775 75.8 28.64 Q14690 85.92 39.81 85.92 50.22 46.645 3.78 49.26 19.85 Q7Z3K3 88.955 43.4525 89.05 62.36 13.995 −8.9575 15.64 2.21 Q96CD2 87.25 35.095 87.25 46.12 71.73 13.215 71.73 23.85 O14744 91.94 33.17 91.94 33.17 45.47 16.62 45.47 16.62 P04843 89.175 36.5375 92.37 47.76 23.85 −5.035 28.71 9.24 Q15418 75.6 39.63 75.6 39.63 30.61 1.03 30.61 1.03 P51812 75.6 21.44 75.6 39.63 30.61 −4.76667 30.61 1.03 Q6P087 95.86 70.79 95.86 79.96 49.47 9.07 49.47 14.63 Q14684 76.37 29.87 80.26 42.52 66.05 18.31333 70.79 27.08 O43159 84.6 27.285 85.51 39.05 48.93 −3.99 57.64 14.62 Q9UGP8 86.655 37.09 91.28 44.36 48.96 4.99 55.53 17.92 O15047 72.83 36.6275 76.52 54.8 38.365 −0.4575 40.15 15.12 Q9Y5X2 75.58 75.58 36.21 36.21 Q96R06 84.21 58.18 84.21 58.18 86.56 53.77 86.56 53.77 Q13501 80.385 22.825 80.81 41.08 54.29 −14.15 56.86 11.89 Q9UQ35 72.45 31.6 88.59 39.96 33.105 0.7 55.3 1.76 Q9UQ35 87.74 18.93 87.74 39.43 53.28 −5.29333 53.28 5.78 P28290 65.99 22.48 65.99 22.48 76.66 34.29 76.66 34.29 Q03519 99.1948 85.26225 99.1948 88.9828 94.0932 70.56835 94.0932 71.9622 O15533 99.1316 98.8859 99.1316 99.1295 68.7451 28.53795 68.7451 31.4264 Q8TC07 86.57 22.025 86.57 30.32 47.51 0.88 47.51 7.83 Q7Z2T5 65.645 5.516667 75.12 12.37 36.38 −17.83 36.38 −4.62 Q13748 84.97 9.925 84.97 25.78 77.83 15.975 77.83 49.24 Q13748 90.9 9.25 90.9 30.23 91.98 14.425 91.98 42.36 Q9H1C4 89.88683 35.09511 92.03 59.48 70.38475 13.00236 72.3195 29.9385 P45880 84.085 53.2675 93.19 72.22 79.44 73.7325 94.31 85.47 P45880 92.73 54.92 92.73 54.92 95.08 92.99 95.08 92.99 Q9Y277 74.03 23.8025 75.01 33.34 44.31 4.9525 51.97 21.56 Q8IV63 82.09 19.46 82.09 25.34 14.41 −10.03 14.41 −8.38 Q5VUA4 71.6 32.505 77.86 38.01 40.555 −8.115 55.07 −1.63 Q14966 62.76 10.52 91.48 18.82 58.34 −4.38 58.34 −4.38 Q14966 75.07 33.24 75.07 33.24 63.04 17.48 63.04 17.48 Q14966 62.76 10.52 91.48 18.82 58.34 −4.38 58.34 −4.38 Q9H582 79.04 37.4675 82.24 63 67.685 11.2825 72.77 24.53 ¹KB02_500 ave; ²KB02_100 ave; ³KB02_500 Max; ⁴KB02_100 Max; ⁵KB03_500 ave; ⁶KB03_100 ave; ⁷KB03_500 Max: ⁸KB03_100 Max;

Table 2A and illustrate additional exemplary proteins and cysteine site residues described herein.

TABLE 2A UniProt Description Symbol Residue Q969K4 Ankyrin repeat and BTB/POZ domain-containing protein 1 ABTB1 62 Q969K4 Ankyrin repeat and BTB/POZ domain-containing protein 1 ABTB1 72 Q969K4 Ankyrin repeat and BTB/POZ domain-containing protein 1 ABTB1 95 Q969K4 Ankyrin repeat and BTB/POZ domain-containing protein 1 ABTB1 222 Q969K4 Ankyrin repeat and BTB/POZ domain-containing protein 1 ABTB1 285 Q8N961 Ankyrin repeat and BTB/POZ domain-containing protein 2 ABTB2 27 Q8N961 Ankyrin repeat and BTB/POZ domain-containing protein 2 ABTB2 361 Q8N961 Ankyrin repeat and BTB/POZ domain-containing protein 2 ABTB2 393 Q8N961 Ankyrin repeat and BTB/POZ domain-containing protein 2 ABTB2 460 Q8N961 Ankyrin repeat and BTB/POZ domain-containing protein 2 ABTB2 470 Q8N961 Ankyrin repeat and BTB/POZ domain-containing protein 2 ABTB2 497 Q9C0C7 Activating molecule in BECN1-regulated autophagy protein 1 AMBRA1 87 Q9C0C7 Activating molecule in BECN1-regulated autophagy protein l AMBRA1 301 Q9C0C7 Activating molecule in BECN1-regulated autophagy protein 1 AMBRA1 302 Q9C0C7 Activating molecule in BECN1-regulated autophagy protein 1 AMBRA1 501 Q9C0C7 Activating molecule in BECN1-regulated autophagy protein 1 AMBRA1 571 Q9C0C7 Activating molecule in BECN1-regulated autophagy protein 1 AMBRA1 1270 Q9UKV5 E3 ubiquitin-protein ligase AMFR AMFR 364 Q9H1A4 Anaphase-promoting complex subunit 1 ANAPC1 28 Q9H1A4 Anaphase-promoting complex subunit 1 ANAPC1 437 Q9H1A4 Anaphase-promoting complex subunit 1 ANAPC1 575 Q9H1A4 Anaphase-promoting complex subunit 1 ANAPC1 962 Q9H1A4 Anaphase-promoting complex subunit 1 ANAPC1 988 Q9H1A4 Anaphase-promoting complex subunit 1 ANAPC1 1074 Q9UM13 Anaphase-promoting complex subunit 10 ANAPC10 173 Q9NYG5 Anaphase-promoting complex subunit 11 ANAPC11 7 Q9NYG5 Anaphase-promoting complex subunit 11 ANAPC11 34 Q9NYG5 Anaphase-promoting complex subunit 11 ANAPC11 73 Q9NYG5 Anaphase-promoting complex subunit 11 ANAPC11 76 P60006 Anaphase-promoting complex subunit 15 ANAPC15 24 Q96DE5 Anaphase-promoting complex subunit 16 ANAPC16 55 Q9UJX6 Anaphase-promoting complex subunit 2 ANAPC2 179 Q9UJX6 Anaphase-promoting complex subunit 2 ANAPC2 221 Q9UJX6 Anaphase-promoting complex subunit 2 ANAPC2 224 Q9UJX6 Anaphase-promoting complex subunit 2 ANAPC2 231 Q9UJX6 Anaphase-promoting complex subunit 2 ANAPC2 233 Q9UJX6 Anaphase-promoting complex subunit 2 ANAPC2 394 Q9UJX6 Anaphase-promoting complex subunit 2 ANAPC2 557 Q9UJX5 Anaphase-promoting complex subunit 4 ANAPC4 7 Q9UJX4 Anaphase-promoting complex subunit 5 ANAPC5 86 Q9UJX4 Anaphase-promoting complex subunit 5 ANAPC5 203 Q9UJX4 Anaphase-promoting complex subunit 5 ANAPC5 312 Q9UJX4 Anaphase-promoting complex subunit 5 ANAPC5 339 Q9UJX4 Anaphase-promoting complex subunit 5 ANAPC5 571 Q9UJX4 Anaphase-promoting complex subunit 5 ANAPC5 670 Q9UJX4 Anaphase-promoting complex subunit 5 ANAPC5 733 Q9UJX3 Anaphase-promoting complex subunit 7 ANAPC7 131 Q9UJX3 Anaphase-promoting complex subunit 7 ANAPC7 145 Q9UJX3 Anaphase-promoting complex subunit 7 ANAPC7 199 Q9UJX3 Anaphase-promoting complex subunit 7 ANAPC7 259 Q9UJX3 Anaphase-promoting complex subunit 7 ANAPC7 329 Q9UJX3 Anaphase-promoting complex subunit 7 ANAPC7 347 Q9UJX3 Anaphase-promoting complex subunit 7 ANAPC7 405 Q9UJX3 Anaphase-promoting complex subunit 7 ANAPC7 409 Q9UJX3 Anaphase-promoting complex subunit 7 ANAPC7 451 Q9UJX3 Anaphase-promoting complex subunit 7 ANAPC7 509 Q9P2R3 Rabankyrin-5 ANKFY1 34 Q9P2R3 Rabankyrin-5 ANKFY1 389 Q9P2R3 Rabankyrin-5 ANKFY1 460 Q9P2R3 Rabankyrin-5 ANKFY1 499 Q9P2R3 Rabankyrin-5 ANKFY1 675 Q9P2R3 Rabankyrin-5 ANKFY1 712 Q9P2R3 Rabankyrin-5 ANKFY1 716 Q9P2R3 Rabankyrin-5 ANKFY1 724 Q9P2R3 Rabankyrin-5 ANKFY1 742 Q9P2R3 Rabankyrin-5 ANKFY1 749 Q9P2R3 Rabankyrin-5 ANKFY1 843 Q9P2R3 Rabankyrin-5 ANKFY1 995 Q9P2R3 Rabankyrin-5 ANKFY1 1060 Q9P2R3 Rabankyrin-5 ANKFY1 1105 Q9P2R3 Rabankyrin-5 ANKFY1 1110 Q9P2R3 Rabankyrin-5 ANKFY1 1113 Q9P2R3 Rabankyrin-5 ANKFY1 1156 Q9P2R3 Rabankyrin-5 ANKFY1 1159 Q9P2G1 Ankyrin repeat and IBR domain-containing protein 1 ANKIB1 116 Q9P2G1 Ankyrin repeat and IBR domain-containing protein 1 ANKIB1 160 Q9P2G1 Ankyrin repeat and IBR domain-containing protein 1 ANKIB1 184 Q9P2G1 Ankyrin repeat and IBR domain-containing protein 1 ANKIB1 280 Q9P2G1 Ankyrin repeat and IBR domain-containing protein 1 ANKIB1 359 Q9P2G1 Ankyrin repeat and IBR domain-containing protein 1 ANKIB1 468 Q9P2G1 Ankyrin repeat and IBR domain-containing protein 1 ANKIB1 519 Q9P2G1 Ankyrin repeat and IBR domain-containing protein 1 ANKIB1 532 Q9P2G1 Ankyrin repeat and IBR domain-containing protein 1 ANKIB1 640 Q9P2G1 Ankyrin repeat and IBR domain-containing protein 1 ANKIB1 715 Q92624 Amyloid protein-binding protein 2 APPBP2 54 Q92624 Amyloid protein-binding protein 2 APPBP2 393 O15033 Apoptosis-resistant E3 ubiquitin protein ligase 1 AREL1 382 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 161 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 186 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 189 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 203 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 208 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 211 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 269 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 276 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 281 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 304 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 307 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 317 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 327 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 357 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 372 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 375 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 389 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 ARIH1 418 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 142 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 156 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 161 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 164 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 169 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 183 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 188 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 228 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 233 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 249 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 252 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 257 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 270 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 280 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 300 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 303 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 310 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 318 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 323 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 326 O95376 E3 ubiquitin-protein ligase ARIH2 ARIH2 340 Q96C12 Armadillo repeat-containing protein 5 ARMC5 273 Q96C12 Armadillo repeat-containing protein 5 ARMC5 579 Q96C12 Armadillo repeat-containing protein 5 ARMC5 665 Q96C12 Armadillo repeat-containing protein 5 ARMC5 884 Q96C12 Armadillo repeat-containing protein 5 ARMC5 894 Q9Y576 Ankyrin repeat and SOCS box protein 1 ASB1 29 Q9Y576 Ankyrin repeat and SOCS box protein 1 ASB1 36 Q9Y576 Ankyrin repeat and SOCS box protein 1 ASB1 73 Q9Y576 Ankyrin repeat and SOCS box protein 1 ASB1 79 Q9Y576 Ankyrin repeat and SOCS box protein 1 ASB1 93 Q9Y576 Ankyrin repeat and SOCS box protein 1 ASB1 301 Q8WXK3 Ankyrin repeat and SOCS box protein 13 ASB13 9 Q8WXK3 Ankyrin repeat and SOCS box protein 13 ASB13 90 Q8WXK3 Ankyrin repeat and SOCS box protein 13 ASB13 148 Q8WXK3 Ankyrin repeat and SOCS box protein 13 ASB13 165 Q8WXK3 Ankyrin repeat and SOCS box protein 13 ASB13 231 Q96Q27 Ankyrin repeat and SOCS box protein 2 ASB2 133 Q96Q27 Ankyrin repeat and SOCS box protein 2 ASB2 440 Q96Q27 Ankyrin repeat and SOCS box protein 2 ASB2 493 Q96Q27 Ankyrin repeat and SOCS box protein 2 ASB2 552 Q9NWX5 Ankyrin repeat and SOCS box protein 6 ASB6 153 Q9NWX5 Ankyrin repeat and SOCS box protein 6 ASB6 256 Q9NWX5 Ankyrin repeat and SOCS box protein 6 ASB6 266 Q9NWX5 Ankyrin repeat and SOCS box protein 6 ASB6 313 Q9H765 Ankyrin repeat and SOCS box protein 8 ASB8 237 Q96DX5 Ankyrin repeat and SOCS box protein 9 ASB9 175 Q96DX5 Ankyrin repeat and SOCS box protein 9 ASB9 216 Q96DX5 Ankyrin repeat and SOCS box protein 9 ASB9 269 P46100 Transcriptional regulator ATRX ATRX 174 P46100 Transcriptional regulator ATRX ATRX 197 P46100 Transcriptional regulator ATRX ATRX 220 P46100 Transcriptional regulator ATRX ATRX 223 P46100 Transcriptional regulator ATRX ATRX 231 P46100 Transcriptional regulator ATRX ATRX 232 P46100 Transcriptional regulator ATRX ATRX 235 P46100 Transcriptional regulator ATRX ATRX 240 P46100 Transcriptional regulator ATRX ATRX 324 P46100 Transcriptional regulator ATRX ATRX 335 P46100 Transcriptional regulator ATRX ATRX 450 P46100 Transcriptional regulator ATRX ATRX 605 P46100 Transcriptional regulator ATRX ATRX 618 P46100 Transcriptional regulator ATRX ATRX 681 P46100 Transcriptional regulator ATRX ATRX 954 P46100 Transcriptional regulator ATRX ATRX 1026 P46100 Transcriptional regulator ATRX ATRX 1074 P46100 Transcriptional regulator ATRX ATRX 1094 P46100 Transcriptional regulator ATRX ATRX 1107 P46100 Transcriptional regulator ATRX ATRX 1242 P46100 Transcriptional regulator ATRX ATRX 1531 P46100 Transcriptional regulator ATRX ATRX 1574 P46100 Transcriptional regulator ATRX ATRX 1575 P46100 Transcriptional regulator ATRX ATRX 1576 P46100 Transcriptional regulator ATRX ATRX 1590 P46100 Transcriptional regulator ATRX ATRX 1595 P46100 Transcriptional regulator ATRX ATRX 1718 P46100 Transcriptional regulator ATRX ATRX 1760 P46100 Transcriptional regulator ATRX ATRX 1789 P46100 Transcriptional regulator ATRX ATRX 1814 P46100 Transcriptional regulator ATRX ATRX 1888 P46100 Transcriptional regulator ATRX ATRX 2404 Q9NXR7 BRISC and BRCA1-A complex member 2 BABAM2 34 Q9NXR7 BRISC and BRCA1-A complex member 2 BABAM2 44 Q9NXR7 BRISC and BRCA1-A complex member 2 BABAM2 53 Q9NXR7 BRISC and BRCA1-A complex member 2 BABAM2 129 Q9NXR7 BRISC and BRCA1-A complex member 2 BABAM2 245 Q9NXR7 BRISC and BRCA1-A complex member 2 BABAM2 254 O14867 Transcription regulator protein BACH1 BACH1 140 O14867 Transcription regulator protein BACH1 BACH1 145 O14867 Transcription regulator protein BACH1 BACH1 150 O14867 Transcription regulator protein BACH1 BACH1 184 O14867 Transcription regulator protein BACH1 BACH1 224 O14867 Transcription regulator protein BACH1 BACH1 263 O14867 Transcription regulator protein BACH1 BACH1 270 O14867 Transcription regulator protein BACH1 BACH1 299 O14867 Transcription regulator protein BACH1 BACH1 406 O14867 Transcription regulator protein BACH1 BACH1 412 O14867 Transcription regulator protein BACH1 BACH1 435 O14867 Transcription regulator protein BACH1 BACH1 522 O14867 Transcription regulator protein BACH1 BACH1 557 O14867 Transcription regulator protein BACH1 BACH1 581 O14867 Transcription regulator protein BACH1 BACH1 621 O14867 Transcription regulator protein BACH1 BACH1 646 O14867 Transcription regulator protein BACH1 BACH1 683 O14867 Transcription regulator protein BACH1 BACH1 715 Q9BYV9 Transcription regulator protein BACH2 BACH2 149 Q9BYV9 Transcription regulator protein BACH2 BACH2 156 Q9BYV9 Transcription regulator protein BACH2 BACH2 238 Q9BYV9 Transcription regulator protein BACH2 BACH2 328 Q9BYV9 Transcription regulator protein BACH2 BACH2 340 Q9BYV9 Transcription regulator protein BACH2 BACH2 370 Q9BYV9 Transcription regulator protein BACH2 BACH2 420 Q9BYV9 Transcription regulator protein BACH2 BACH2 500 Q9BYV9 Transcription regulator protein BACH2 BACH2 507 Q9BYV9 Transcription regulator protein BACH2 BACH2 670 Q9BYV9 Transcription regulator protein BACH2 BACH2 676 Q9BYV9 Transcription regulator protein BACH2 BACH2 683 Q9BYV9 Transcription regulator protein BACH2 BACH2 698 Q9BYV9 Transcription regulator protein BACH2 BACH2 714 Q9BYV9 Transcription regulator protein BACH2 BACH2 823 Q9BYV9 Transcription regulator protein BACH2 BACH2 830 Q99728 BRCA1-associated RING domain protein 1 BARD1 108 Q99728 BRCA1-associated RING domain protein 1 BARD1 304 Q99728 BRCA1-associated RING domain protein 1 BARD1 362 Q99728 BRCA1-associated RING domain protein 1 BARD1 368 Q99728 BRCA1-associated RING domain protein 1 BARD1 557 Q99728 BRCA1-associated RING domain protein 1 BARD1 743 P41182 B-cell lymphoma 6 protein BCL6 121 P41182 B-cell lymphoma 6 protein BCL6 175 P41182 B-cell lymphoma 6 protein BCL6 232 P41182 B-cell lymphoma 6 protein BCL6 254 P41182 B-cell lymphoma 6 protein BCL6 296 P41182 B-cell lymphoma 6 protein BCL6 339 P41182 B-cell lymphoma 6 protein BCL6 348 P41182 B-cell lymphoma 6 protein BCL6 354 P41182 B-cell lymphoma 6 protein BCL6 414 P41182 B-cell lymphoma 6 protein BCL6 548 P41182 B-cell lymphoma 6 protein BCL6 663 Q13490 Baculoviral IAP repeat-containing protein 2 BIRC2 45 Q13490 Baculoviral IAP repeat-containing protein 2 BIRC2 83 Q13490 Baculoviral IAP repeat-containing protein 2 BIRC2 85 Q13490 Baculoviral IAP repeat-containing protein 2 BIRC2 220 Q13490 Baculoviral IAP repeat-containing protein 2 BIRC2 247 Q13490 Baculoviral IAP repeat-containing protein 2 BIRC2 308 Q13490 Baculoviral IAP repeat-containing protein 2 BIRC2 315 Q13490 Baculoviral IAP repeat-containing protein 2 BIRC2 474 Q13490 Baculoviral IAP repeat-containing protein 2 BIRC2 602 Q13490 Baculoviral IAP repeat-containing protein 2 BIRC2 605 Q13489 Baculoviral IAP repeat-containing protein 3 BIRC3 28 Q13489 Baculoviral IAP repeat-containing protein 3 BIRC3 66 Q13489 Baculoviral IAP repeat-containing protein 3 BIRC3 68 Q13489 Baculoviral IAP repeat-containing protein 3 BIRC3 93 Q13489 Baculoviral IAP repeat-containing protein 3 BIRC3 164 Q13489 Baculoviral IAP repeat-containing protein 3 BIRC3 205 Q13489 Baculoviral IAP repeat-containing protein 3 BIRC3 232 Q13489 Baculoviral IAP repeat-containing protein 3 BIRC3 294 Q13489 Baculoviral IAP repeat-containing protein 3 BIRC3 301 Q13489 Baculoviral IAP repeat-containing protein 3 BIRC3 581 Q13489 Baculoviral IAP repeat-containing protein 3 BIRC3 588 Q13489 Baculoviral IAP repeat-containing protein 3 BIRC3 591 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 62 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 65 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 136 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 355 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 381 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 390 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 396 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 410 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 463 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 543 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 613 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 752 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 777 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 946 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 970 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 1045 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 1099 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 1236 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 1319 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 1417 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 1420 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 1517 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 1547 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 1926 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 1932 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 2123 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 2892 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 2910 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 3075 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 3404 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 3673 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 3786 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 3830 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 4183 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 4443 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 4750 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 4813 Q9NR09 Baculoviral IAP repeat-containing protein 6 BIRC6 4828 Q96P09 Baculoviral IAP repeat-containing protein 8 BIRC8 66 Q7Z569 BRCA1-associated protein BRAP 47 Q7Z569 BRCA1-associated protein BRAP 110 Q7Z569 BRCA1-associated protein BRAP 221 Q7Z569 BRCA1-associated protein BRAP 264 Q7Z569 BRCA1-associated protein BRAP 267 Q7Z569 BRCA1-associated protein BRAP 283 Q7Z569 BRCA1-associated protein BRAP 291 Q7Z569 BRCA1-associated protein BRAP 300 Q7Z569 BRCA1-associated protein BRAP 306 Q7Z569 BRCA1-associated protein BRAP 452 Q7Z569 BRCA1-associated protein BRAP 473 Q7Z569 BRCA1-associated protein BRAP 519 P38398 Breast cancer type 1 susceptibility protein BRCA1 24 P38398 Breast cancer type 1 susceptibility protein BRCA1 27 P38398 Breast cancer type 1 susceptibility protein BRCA1 39 P38398 Breast cancer type 1 susceptibility protein BRCA1 44 P38398 Breast cancer type 1 susceptibility protein BRCA1 61 P38398 Breast cancer type 1 susceptibility protein BRCA1 64 P38398 Breast cancer type 1 susceptibility protein BRCA1 197 P38398 Breast cancer type 1 susceptibility protein BRCA1 226 P38398 Breast cancer type 1 susceptibility protein BRCA1 274 P38398 Breast cancer type 1 susceptibility protein BRCA1 305 P38398 Breast cancer type 1 susceptibility protein BRCA1 328 P38398 Breast cancer type 1 susceptibility protein BRCA1 348 P38398 Breast cancer type 1 susceptibility protein BRCA1 360 P38398 Breast cancer type 1 susceptibility protein BRCA1 442 P38398 Breast cancer type 1 susceptibility protein BRCA1 636 P38398 Breast cancer type 1 susceptibility protein BRCA1 644 P38398 Breast cancer type 1 susceptibility protein BRCA1 712 P38398 Breast cancer type 1 susceptibility protein BRCA1 801 P38398 Breast cancer type 1 susceptibility protein BRCA1 805 P38398 Breast cancer type 1 susceptibility protein BRCA1 818 P38398 Breast cancer type 1 susceptibility protein BRCA1 882 P38398 Breast cancer type 1 susceptibility protein BRCA1 903 P38398 Breast cancer type 1 susceptibility protein BRCA1 953 P38398 Breast cancer type 1 susceptibility protein BRCA1 1103 P38398 Breast cancer type 1 susceptibility protein BRCA1 1225 P38398 Breast cancer type 1 susceptibility protein BRCA1 1251 P38398 Breast cancer type 1 susceptibility protein BRCA1 1270 P38398 Breast cancer type 1 susceptibility protein BRCA1 1291 P38398 Breast cancer type 1 susceptibility protein BRCA1 1300 P38398 Breast cancer type 1 susceptibility protein BRCA1 1513 Q9H0C5 BTB/POZ domain-containing protein 1 BTBD1 167 Q9H0C5 BTB/POZ domain-containing protein 1 BTBD1 252 Q9H0C5 BTB/POZ domain-containing protein 1 BTBD1 422 Q9BSF8 BTB/POZ domain-containing protein 10 BTBD10 86 Q9BSF8 BTB/POZ domain-containing protein 10 BTBD10 143 Q9BSF8 BTB/POZ domain-containing protein 10 BTBD10 419 A6QL63 Ankyrin repeat and BTB/POZ domain-containing protein BTBD11 261 BTBD11 A6QL63 Ankyrin repeat and BTB/POZ domain-containing protein BTBD11 552 BTBD11 A6QL63 Ankyrin repeat and BTB/POZ domain-containing protein BTBD11 554 BTBD11 A6QL63 Ankyrin repeat and BTB/POZ domain-containing protein BTBD11 579 BTBD11 A6QL63 Ankyrin repeat and BTB/POZ domain-containing protein BTBD11 844 BTBD11 Q9BX70 BTB/POZ domain-containing protein 2 BTBD2 372 Q9P203 BTB/POZ domain-containing protein 7 BTBD7 827 Q9P203 BTB/POZ domain-containing protein 7 BTBD7 953 Q5XKL5 BTB/POZ domain-containing protein 8 BTBD8 4 Q5XKL5 BTB/POZ domain-containing protein 8 BTBD8 31 Q96Q07 BTB/POZ domain-containing protein 9 BTBD9 159 Q96Q07 BTB/POZ domain-containing protein 9 BTBD9 318 Q9Y297 F-box/WD repeat-containing protein 1A BTRC 83 Q9Y297 F-box/WD repeat-containing protein 1A BTRC 87 Q9Y297 F-box/WD repeat-containing protein 1A BTRC 105 Q9Y297 F-box/WD repeat-containing protein 1A BTRC 335 Q9Y297 F-box/WD repeat-containing protein 1A BTRC 471 Q9Y297 F-box/WD repeat-containing protein 1A BTRC 495 Q9Y297 F-box/WD repeat-containing protein 1A BTRC 498 Q9Y297 F-box/WD repeat-containing protein 1A BTRC 547 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 71 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 92 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 131 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 179 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 237 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 301 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 356 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 413 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 453 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 454 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 571 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 592 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 802 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 940 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 942 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 954 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 1007 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 1134 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 1153 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 92 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 131 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 179 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 206 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 240 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 304 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 358 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 375 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 594 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 807 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 815 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 828 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 945 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 959 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 1139 O75155 Cullin-associated NEDD8-dissociated protein 2 CAND2 1158 P22681 E3 ubiquitin-protein ligase CBL CBL 70 P22681 E3 ubiquitin-protein ligase CBL CBL 353 P22681 E3 ubiquitin-protein ligase CBL CBL 384 P22681 E3 ubiquitin-protein ligase CBL CBL 421 P22681 E3 ubiquitin-protein ligase CBL CBL 508 P22681 E3 ubiquitin-protein ligase CBL CBL 567 P22681 E3 ubiquitin-protein ligase CBL CBL 572 P22681 E3 ubiquitin-protein ligase CBL CBL 659 P22681 E3 ubiquitin-protein ligase CBL CBL 840 Q13191 E3 ubiquitin-protein ligase CBL-B CBLB 60 Q13191 E3 ubiquitin-protein ligase CBL-B CBLB 345 Q13191 E3 ubiquitin-protein ligase CBL-B CBLB 376 Q13191 E3 ubiquitin-protein ligase CBL-B CBLB 435 Q13191 E3 ubiquitin-protein ligase CBL-B CBLB 436 Q13191 E3 ubiquitin-protein ligase CBL-B CBLB 470 Q13191 E3 ubiquitin-protein ligase CBL-B CBLB 523 Q13191 E3 ubiquitin-protein ligase CBL-B CBLB 535 Q13191 E3 ubiquitin-protein ligase CBL-B CBLB 594 Q13191 E3 ubiquitin-protein ligase CBL-B CBLB 607 Q13191 E3 ubiquitin-protein ligase CBL-B CBLB 686 Q13191 E3 ubiquitin-protein ligase CBL-B CBLB 741 Q13191 E3 ubiquitin-protein ligase CBL-B CBLB 895 Q9ULV8 E3 ubiquitin-protein ligase CBL-C CBLC 168 Q9ULV8 E3 ubiquitin-protein ligase CBL-C CBLC 182 Q9ULV8 E3 ubiquitin-protein ligase CBL-C CBLC 189 Q9ULV8 E3 ubiquitin-protein ligase CBL-C CBLC 267 Q9ULV8 E3 ubiquitin-protein ligase CBL-C CBLC 354 Q75N03 E3 ubiquitin-protein ligase Hakai CBLL1 73 Q75N03 E3 ubiquitin-protein ligase Hakai CBLL1 112 Q75N03 E3 ubiquitin-protein ligase Hakai CBLL1 130 Q75N03 E3 ubiquitin-protein ligase Hakai CBLL1 133 Q75N03 E3 ubiquitin-protein ligase Hakai CBLL1 145 Q75N03 E3 ubiquitin-protein ligase Hakai CBLL1 148 Q75N03 E3 ubiquitin-protein ligase Hakai CBLL1 158 Q75N03 E3 ubiquitin-protein ligase Hakai CBLL1 172 O00257 E3 SUMO-protein ligase CBX4 CBX4 185 O00257 E3 SUMO-protein ligase CBX4 CBX4 413 O00257 E3 SUMO-protein ligase CBX4 CBX4 424 O00257 E3 SUMO-protein ligase CBX4 CBX4 438 O60826 Coiled-coil domain-containing protein 22 CCDC22 215 O60826 Coiled-coil domain-containing protein 22 CCDC22 369 O60826 Coiled-coil domain-containing protein 22 CCDC22 441 P55774 C-C motif chemokine 18 CCL18 18 P55774 C-C motif chemokine 18 CCL18 20 P41002 Cyclin-F CCNF 176 P41002 Cyclin-F CCNF 240 P41002 Cyclin-F CCNF 255 Q13042 Cell division cycle protein 16 homolog CDC16 79 Q13042 Cell division cycle protein 16 homolog CDC16 133 Q13042 Cell division cycle protein 16 homolog CDC16 194 Q13042 Cell division cycle protein 16 homolog CDC16 245 Q13042 Cell division cycle protein 16 homolog CDC16 367 Q13042 Cell division cycle protein 16 homolog CDC16 455 Q13042 Cell division cycle protein 16 homolog CDC16 544 Q12834 Cell division cycle protein 20 homolog CDC20 313 Q12834 Cell division cycle protein 20 homolog CDC20 364 Q12834 Cell division cycle protein 20 homolog CDC20 388 Q12834 Cell division cycle protein 20 homolog CDC20 472 Q9UJX2 Cell division cycle protein 23 homolog CDC23 109 Q9UJX2 Cell division cycle protein 23 homolog CDC23 324 Q9UJX2 Cell division cycle protein 23 homolog CDC23 442 Q9UJX2 Cell division cycle protein 23 homolog CDC23 489 Q9UJX2 Cell division cycle protein 23 homolog CDC23 500 Q9UJX2 Cell division cycle protein 23 homolog CDC23 523 Q9UJX2 Cell division cycle protein 23 homolog CDC23 532 Q9UJX2 Cell division cycle protein 23 homolog CDC23 536 Q9UJX2 Cell division cycle protein 23 homolog CDC23 537 P30260 Cell division cycle protein 27 homolog CDC27 66 P30260 Cell division cycle protein 27 homolog CDC27 71 P30260 Cell division cycle protein 27 homolog CDC27 78 P30260 Cell division cycle protein 27 homolog CDC27 115 P30260 Cell division cycle protein 27 homolog CDC27 137 P30260 Cell division cycle protein 27 homolog CDC27 156 P30260 Cell division cycle protein 27 homolog CDC27 179 P30260 Cell division cycle protein 27 homolog CDC27 184 P30260 Cell division cycle protein 27 homolog CDC27 477 P30260 Cell division cycle protein 27 homolog CDC27 481 P30260 Cell division cycle protein 27 homolog CDC27 576 P30260 Cell division cycle protein 27 homolog CDC27 623 P30260 Cell division cycle protein 27 homolog CDC27 673 P30260 Cell division cycle protein 27 homolog CDC27 705 Q6P1J9 Parafibromin CDC73 145 Q6P1J9 Parafibromin CDC73 397 Q99675 Cell growth regulator with RING finger domain protein 1 CGRRF1 117 Q99675 Cell growth regulator with RING finger domain protein 1 CGRRF1 277 Q99675 Cell growth regulator with RING finger domain protein 1 CGRRF1 293 Q99675 Cell growth regulator with RING finger domain protein 1 CGRRF1 295 Q99675 Cell growth regulator with RING finger domain protein 1 CGRRF1 298 Q99675 Cell growth regulator with RING finger domain protein 1 CGRRF1 319 Q96EP1 E3 ubiquitin-protein ligase CHFR CHFR 46 Q96EP1 E3 ubiquitin-protein ligase CHFR CHFR 61 Q96EP1 E3 ubiquitin-protein ligase CHFR CHFR 95 Q96EP1 E3 ubiquitin-protein ligase CHFR CHFR 206 Q96EP1 E3 ubiquitin-protein ligase CHFR CHFR 431 Q96EP1 E3 ubiquitin-protein ligase CHFR CHFR 513 Q96EP1 E3 ubiquitin-protein ligase CHFR CHFR 529 Q96EP1 E3 ubiquitin-protein ligase CHFR CHFR 601 Q96EP1 E3 ubiquitin-protein ligase CHFR CHFR 603 Q96EP1 E3 ubiquitin-protein ligase CHFR CHFR 604 Q96EP1 E3 ubiquitin-protein ligase CHFR CHFR 635 Q96EP1 E3 ubiquitin-protein ligase CHFR CHFR 657 Q9NSE2 Cytokine-inducible SH2-containing protein CISH 69 Q9NSE2 Cytokine-inducible SH2-containing protein CISH 144 Q9NSE2 Cytokine-inducible SH2-containing protein CISH 167 Q9NSE2 Cytokine-inducible SH2-containing protein CISH 227 P10909 Clusterin CLU 102 P10909 Clusterin CLU 285 P10909 Clusterin CLU 295 P10909 Clusterin CLU 302 P10909 Clusterin CLU 313 O95628 CCR4-NOT transcription complex subunit 4 CNOT4 53 O95628 CCR4-NOT transcription complex subunit 4 CNOT4 56 O95628 CCR4-NOT transcription complex subunit 4 CNOT4 175 O95628 CCR4-NOT transcription complex subunit 4 CNOT4 196 O95628 CCR4-NOT transcription complex subunit 4 CNOT4 210 Q86X83 COMM domain-containing protein 2 COMMD2 191 Q9UBI1 COMM domain-containing protein 3 COMMD3 90 Q9UBI1 COMM domain-containing protein 3 COMMD3 101 Q9GZQ3 COMM domain-containing protein 5 COMMD5 64 Q7Z4G1 COMM domain-containing protein 6 COMMD6 35 Q7Z4G1 COMM domain-containing protein 6 COMMD6 60 Q9P000 COMM domain-containing protein 9 COMMD9 147 Q9P000 COMM domain-containing protein 9 COMMD9 160 Q8NHY2 E3 ubiquitin-protein ligase COP1 COP1 91 Q8NHY2 E3 ubiquitin-protein ligase COP1 COP1 120 Q8NHY2 E3 ubiquitin-protein ligase COP1 COP1 136 Q8NHY2 E3 ubiquitin-protein ligase COP1 COP1 151 Q8NHY2 E3 ubiquitin-protein ligase COP1 COP1 156 Q8NHY2 E3 ubiquitin-protein ligase COP1 COP1 159 Q8NHY2 E3 ubiquitin-protein ligase COP1 COP1 170 Q8NHY2 E3 ubiquitin-protein ligase COP1 COP1 370 Q8NHY2 E3 ubiquitin-protein ligase COP1 COP1 395 Q8NHY2 E3 ubiquitin-protein ligase COP1 COP1 632 Q13616 Cullin-1 CUL1 149 Q13616 Cullin-1 CUL1 170 Q13616 Cullin-1 CUL1 291 Q13616 Cullin-1 CUL1 355 Q13616 Cullin-1 CUL1 426 Q13616 Cullin-1 CUL1 496 Q13616 Cullin-1 CUL1 594 Q13616 Cullin-1 CUL1 752 Q13617 Cullin-2 CUL2 103 Q13617 Cullin-2 CUL2 266 Q13617 Cullin-2 CUL2 282 Q13617 Cullin-2 CUL2 385 Q13617 Cullin-2 CUL2 395 Q13617 Cullin-2 CUL2 465 Q13617 Cullin-2 CUL2 721 Q13618 Cullin-3 CUL3 156 Q13618 Cullin-3 CUL3 187 Q13618 Cullin-3 CUL3 251 Q13618 Cullin-3 CUL3 298 Q13618 Cullin-3 CUL3 314 Q13618 Cullin-3 CUL3 316 Q13618 Cullin-3 CUL3 462 Q13618 Cullin-3 CUL3 464 Q13618 Cullin-3 CUL3 522 Q13618 Cullin-3 CUL3 636 Q13619 Cullin-4A CUL4A 94 Q13619 Cullin-4A CUL4A 110 Q13619 Cullin-4A CUL4A 138 Q13619 Cullin-4A CUL4A 241 Q13619 Cullin-4A CUL4A 289 Q13619 Cullin-4A CUL4A 483 Q13619 Cullin-4A CUL4A 633 Q13620 Cullin-4B CUL4B 102 Q13620 Cullin-4B CUL4B 248 Q13620 Cullin-4B CUL4B 264 Q13620 Cullin-4B CUL4B 292 Q13620 Cullin-4B CUL4B 637 Q13620 Cullin-4B CUL4B 787 Q13620 Cullin-4B CUL4B 810 Q93034 Cullin-5 CUL5 51 Q93034 Cullin-5 CUL5 104 Q93034 Cullin-5 CUL5 112 Q93034 Cullin-5 CUL5 188 Q93034 Cullin-5 CUL5 404 Q14999 Cullin-7 CUL7 60 Q14999 Cullin-7 CUL7 562 Q14999 Cullin-7 CUL7 952 Q14999 Cullin-7 CUL7 1106 Q14999 Cullin-7 CUL7 1173 Q14999 Cullin-7 CUL7 1201 Q14999 Cullin-7 CUL7 1405 Q14999 Cullin-7 CUL7 1413 Q14999 Cullin-7 CUL7 1569 Q14999 Cullin-7 CUL7 1601 Q14999 Cullin-7 CUL7 1616 Q14999 Cullin-7 CUL7 1688 Q8IWT3 Cullin-9 CUL9 47 Q8IWT3 Cullin-9 CUL9 1281 Q8IWT3 Cullin-9 CUL9 1340 Q8IWT3 Cullin-9 CUL9 1426 Q8IWT3 Cullin-9 CUL9 1960 Q8IWT3 Cullin-9 CUL9 1969 Q8IWT3 Cullin-9 CUL9 2177 Q8IWT3 Cullin-9 CUL9 2249 Q8IWT3 Cullin-9 CUL9 2257 Q8IWT3 Cullin-9 CUL9 2262 Q8IWT3 Cullin-9 CUL9 2404 Q9Y4B6 DDB1- and CUL4-associated factor 1 DCAF1 69 Q9Y4B6 DDB1- and CUL4-associated factor 1 DCAF1 106 Q9Y4B6 DDB1- and CUL4-associated factor 1 DCAF1 521 Q9Y4B6 DDB1- and CUL4-associated factor 1 DCAF1 784 Q9Y4B6 DDB1- and CUL4-associated factor 1 DCAF1 967 Q9Y4B6 DDB1- and CUL4-associated factor 1 DCAF1 1019 Q9Y4B6 DDB1- and CUL4-associated factor 1 DCAF1 1026 Q9Y4B6 DDB1- and CUL4-associated factor 1 DCAF1 1037 Q9Y4B6 DDB1- and CUL4-associated factor 1 DCAF1 1070 Q9Y4B6 DDB1- and CUL4-associated factor 1 DCAF1 1113 Q5QP82 DDB1- and CUL4-associated factor 10 DCAF10 102 Q5QP82 DDB1- and CUL4-associated factor 10 DCAF10 213 Q5QP82 DDB1- and CUL4-associated factor 10 DCAF10 228 Q5QP82 DDB1- and CUL4-associated factor 10 DCAF10 247 Q5QP82 DDB1- and CUL4-associated factor 10 DCAF10 290 Q5QP82 DDB1- and CUL4-associated factor 10 DCAF10 310 Q5QP82 DDB1- and CUL4-associated factor 10 DCAF10 369 Q5QP82 DDB1- and CUL4-associated factor 10 DCAF10 412 Q5QP82 DDB1- and CUL4-associated factor 10 DCAF10 479 Q5QP82 DDB1- and CUL4-associated factor 10 DCAF10 504 Q5QP82 DDB1- and CUL4-associated factor 10 DCAF10 510 Q5QP82 DDB1- and CUL4-associated factor 10 DCAF10 541 Q5QP82 DDB1- and CUL4-associated factor 10 DCAF10 547 Q8TEB1 DDB1- and CUL4-associated factor 11 DCAF11 143 Q8TEB1 DDB1- and CUL4-associated factor 11 DCAF11 177 Q8TEB1 DDB1- and CUL4-associated factor 11 DCAF11 191 Q8TEB1 DDB1- and CUL4-associated factor 11 DCAF11 288 Q8TEB1 DDB1- and CUL4-associated factor 11 DCAF11 460 Q5T6F0 DDB1- and CUL4-associated factor 12 DCAF12 109 Q5T6F0 DDB1- and CUL4-associated factor 12 DCAF12 141 Q5T6F0 DDB1- and CUL4-associated factor 12 DCAF12 296 Q5T6F0 DDB1- and CUL4-associated factor 12 DCAF12 380 Q5T6F0 DDB1- and CUL4-associated factor 12 DCAF12 425 Q5VU92 DDB1- and CUL4-associated factor 12-like protein 1 DCAF12L1 270 Q5VU92 DDB1- and CUL4-associated factor 12-like protein 1 DCAF12L1 345 Q9NV06 DDB1- and CUL4-associated factor 13 DCAF13 71 Q9NV06 DDB1- and CUL4-associated factor 13 DCAF13 87 Q9NV06 DDB1- and CUL4-associated factor 13 DCAF13 120 Q9NV06 DDB1- and CUL4-associated factor 13 DCAF13 174 Q9NV06 DDB1- and CUL4-associated factor 13 DCAF13 190 Q9NV06 DDB1- and CUL4-associated factor 13 DCAF13 215 Q9NV06 DDB1- and CUL4-associated factor 13 DCAF13 330 Q9NV06 DDB1- and CUL4-associated factor 13 DCAF13 342 Q66K64 DDB1- and CUL4-associated factor 15 DCAF15 62 Q66K64 DDB1- and CUL4-associated factor 15 DCAF15 193 Q66K64 DDB1- and CUL4-associated factor 15 DCAF15 211 Q66K64 DDB1- and CUL4-associated factor 15 DCAF15 347 Q66K64 DDB1- and CUL4-associated factor 15 DCAF15 365 Q9NXF7 DDB1- and CUL4-associated factor 16 DCAF16 100 Q9NXF7 DDB1- and CUL4-associated factor 16 DCAF16 103 Q9NXF7 DDB1- and CUL4-associated factor 16 DCAF16 119 Q9NXF7 DDB1- and CUL4-associated factor 16 DCAF16 173 Q9NXF7 DDB1- and CUL4-associated factor 16 DCAF16 178 Q9NXF7 DDB1- and CUL4-associated factor 16 DCAF16 179 Q5H9S7 DDB1- and CUL4-associated factor 17 DCAF17 20 Q5H9S7 DDB1- and CUL4-associated factor 17 DCAF17 74 Q5H9S7 DDB1- and CUL4-associated factor 17 DCAF17 456 Q8WV16 DDB1- and CUL4-associated factor 4 DCAF4 88 Q8WV16 DDB1- and CUL4-associated factor 4 DCAF4 355 Q96JK2 DDB1- and CUL4-associated factor 5 DCAF5 182 Q96JK2 DDB1- and CUL4-associated factor 5 DCAF5 280 Q96JK2 DDB1- and CUL4-associated factor 5 DCAF5 349 Q96JK2 DDB1- and CUL4-associated factor 5 DCAF5 368 Q96JK2 DDB1- and CUL4-associated factor 5 DCAF5 503 Q96JK2 DDB1- and CUL4-associated factor 5 DCAF5 711 Q96JK2 DDB1- and CUL4-associated factor 5 DCAF5 728 Q96JK2 DDB1- and CUL4-associated factor 5 DCAF5 812 Q96JK2 DDB1- and CUL4-associated factor 5 DCAF5 829 Q96JK2 DDB1- and CUL4-associated factor 5 DCAF5 883 Q58WW2 DDB1- and CUL4-associated factor 6 DCAF6 105 Q58WW2 DDB1- and CUL4-associated factor 6 DCAF6 177 Q58WW2 DDB1- and CUL4-associated factor 6 DCAF6 190 Q58WW2 DDB1- and CUL4-associated factor 6 DCAF6 211 Q58WW2 DDB1- and CUL4-associated factor 6 DCAF6 513 Q58WW2 DDB1- and CUL4-associated factor 6 DCAF6 593 P61962 DDB1- and CUL4-associated factor 7 DCAF7 61 P61962 DDB1- and CUL4-associated factor 7 DCAF7 109 P61962 DDB1- and CUL4-associated factor 7 DCAF7 256 P61962 DDB1- and CUL4-associated factor 7 DCAF7 268 P61962 DDB1- and CUL4-associated factor 7 DCAF7 280 A6NGE4 DDB1- and CUL4-associated factor 8-like protein 1 DCAF8L1 177 P0C7V8 DDB1- and CUL4-associated factor 8-like protein 2 DCAF8L2 209 Q96GG9 DCN1-like protein 1 DCUN1D1 29 Q96GG9 DCN1-like protein 1 DCUN1D1 115 Q16531 DNA damage-binding protein 1 DDB1 87 Q16531 DNA damage-binding protein 1 DDB1 128 Q16531 DNA damage-binding protein 1 DDB1 173 Q16531 DNA damage-binding protein 1 DDB1 260 Q16531 DNA damage-binding protein 1 DDB1 378 Q16531 DNA damage-binding protein 1 DDB1 652 Q16531 DNA damage-binding protein 1 DDB1 725 Q16531 DNA damage-binding protein 1 DDB1 732 Q16531 DNA damage-binding protein 1 DDB1 903 Q92466 DNA damage-binding protein 2 DDB2 48 Q92466 DNA damage-binding protein 2 DDB2 52 Q92466 DNA damage-binding protein 2 DDB2 66 Q92466 DNA damage-binding protein 2 DDB2 253 Q92466 DNA damage-binding protein 2 DDB2 254 Q92466 DNA damage-binding protein 2 DDB2 322 Q92466 DNA damage-binding protein 2 DDB2 364 Q92782 Zinc finger protein neuro-d4 DPF1 50 Q92782 Zinc finger protein neuro-d4 DPF1 122 Q92782 Zinc finger protein neuro-d4 DPF1 128 Q92782 Zinc finger protein neuro-d4 DPF1 149 Q92782 Zinc finger protein neuro-d4 DPF1 168 Q92782 Zinc finger protein neuro-d4 DPF1 260 Q92782 Zinc finger protein neuro-d4 DPF1 269 Q92782 Zinc finger protein neuro-d4 DPF1 305 Q92782 Zinc finger protein neuro-d4 DPF1 308 Q9NZJ0 Denticleless protein homolog DTL 136 Q9NZJ0 Denticleless protein homolog DTL 141 Q9NZJ0 Denticleless protein homolog DTL 157 Q9NZJ0 Denticleless protein homolog DTL 367 Q9NZJ0 Denticleless protein homolog DTL 369 Q9NZJ0 Denticleless protein homolog DTL 379 Q9NZJ0 Denticleless protein homolog DTL 438 Q9NZJ0 Denticleless protein homolog DTL 450 Q9NZJ0 Denticleless protein homolog DTL 454 Q9NZJ0 Denticleless protein homolog DTL 544 Q9NZJ0 Denticleless protein homolog DTL 559 Q9NZJ0 Denticleless protein homolog DTL 573 Q9NZJ0 Denticleless protein homolog DTL 589 Q9NZJ0 Denticleless protein homolog DTL 590 Q9NZJ0 Denticleless protein homolog DTL 633 Q9NZJ0 Denticleless protein homolog DTL 643 Q9NZJ0 Denticleless protein homolog DTL 710 Q9NZJ0 Denticleless protein homolog DTL 722 Q86Y01 E3 ubiquitin-protein ligase DTX1 DTX1 349 Q86Y01 E3 ubiquitin-protein ligase DTX1 DTX1 378 Q86Y01 E3 ubiquitin-protein ligase DTX1 DTX1 468 Q86Y01 E3 ubiquitin-protein ligase DTX1 DTX1 471 Q86Y01 E3 ubiquitin-protein ligase DTX1 DTX1 536 Q86UW9 Probable E3 ubiquitin-protein ligase DTX2 DTX2 169 Q86UW9 Probable E3 ubiquitin-protein ligase DTX2 DTX2 196 Q86UW9 Probable E3 ubiquitin-protein ligase DTX2 DTX2 198 Q86UW9 Probable E3 ubiquitin-protein ligase DTX2 DTX2 201 Q86UW9 Probable E3 ubiquitin-protein ligase DTX2 DTX2 351 Q86UW9 Probable E3 ubiquitin-protein ligase DTX2 DTX2 537 Q8N9I9 Probable E3 ubiquitin-protein ligase DTX3 DTX3 15 Q8N9I9 Probable E3 ubiquitin-protein ligase DTX3 DTX3 105 Q8N9I9 Probable E3 ubiquitin-protein ligase DTX3 DTX3 164 Q8N9I9 Probable E3 ubiquitin-protein ligase DTX3 DTX3 167 Q8N9I9 Probable E3 ubiquitin-protein ligase DTX3 DTX3 185 Q8N9I9 Probable E3 ubiquitin-protein ligase DTX3 DTX3 188 Q8N9I9 Probable E3 ubiquitin-protein ligase DTX3 DTX3 199 Q8N9I9 Probable E3 ubiquitin-protein ligase DTX3 DTX3 202 Q8N9I9 Probable E3 ubiquitin-protein ligase DTX3 DTX3 272 Q8N9I9 Probable E3 ubiquitin-protein ligase DTX3 DTX3 317 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 130 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 144 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 159 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 175 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 219 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 250 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 309 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 406 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 417 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 561 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 564 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 577 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 582 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 585 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 596 Q8TDB6 E3 ubiquitin-protein ligase DTX3L DTX3L 599 Q86Y13 E3 ubiquitin-protein ligase DZIP3 DZIP3 261 Q86Y13 E3 ubiquitin-protein ligase DZIP3 DZIP3 468 Q86Y13 E3 ubiquitin-protein ligase DZIP3 DZIP3 1078 Q66K89 Transcription factor E4F1 E4F1 273 Q66K89 Transcription factor E4F1 E4F1 361 Q66K89 Transcription factor E4F1 E4F1 496 P11161 E3 SUMO-protein ligase EGR2 EGR2 251 P11161 E3 SUMO-protein ligase EGR2 EGR2 443 P11161 E3 SUMO-protein ligase EGR2 EGR2 469 Q14241 Elongin-A ELOA 209 Q14241 Elongin-A ELOA 339 Q14241 Elongin-A ELOA 568 Q14241 Elongin-A ELOA 581 Q14241 Elongin-A ELOA 610 Q15370 Elongin-B ELOB 60 Q15370 Elongin-B ELOB 89 Q15369 Elongin-C ELOC 11 Q15369 Elongin-C ELOC 74 O14682 Ectoderm-neural cortex protein 1 ENC1 59 O14682 Ectoderm-neural cortex protein 1 ENC1 227 O14682 Ectoderm-neural cortex protein 1 ENC1 287 O14682 Ectoderm-neural cortex protein 1 ENC1 307 O14682 Ectoderm-neural cortex protein 1 ENC1 340 O14682 Ectoderm-neural cortex protein 1 ENC1 464 O14682 Ectoderm-neural cortex protein 1 ENC1 468 O14682 Ectoderm-neural cortex protein 1 ENC1 478 O14682 Ectoderm-neural cortex protein 1 ENC1 506 O14682 Ectoderm-neural cortex protein 1 ENC1 531 Q13216 DNA excision repair protein ERCC-8 ERCC8 84 Q13216 DNA excision repair protein ERCC-8 ERCC8 88 Q13216 DNA excision repair protein ERCC-8 ERCC8 157 Q13216 DNA excision repair protein ERCC-8 ERCC8 171 Q13216 DNA excision repair protein ERCC-8 ERCC8 178 Q13216 DNA excision repair protein ERCC-8 ERCC8 222 Q13216 DNA excision repair protein ERCC-8 ERCC8 252 Q13216 DNA excision repair protein ERCC-8 ERCC8 288 Q13216 DNA excision repair protein ERCC-8 ERCC8 340 Q13216 DNA excision repair protein ERCC-8 ERCC8 356 Q9NW38 E3 ubiquitin-protein ligase FANCL FANCL 12 Q9NW38 E3 ubiquitin-protein ligase FANCL FANCL 251 Q8NFZ0 F-box DNA helicase 1 FBH1 156 Q8NFZ0 F-box DNA helicase 1 FBH1 289 Q8NFZ0 F-box DNA helicase 1 FBH1 302 Q8NFZ0 F-box DNA helicase 1 FBH1 508 Q8NFZ0 F-box DNA helicase 1 FBH1 615 Q8NFZ0 F-box DNA helicase 1 FBH1 894 Q8NFZ0 F-box DNA helicase 1 FBH1 999 Q8NFZ0 F-box DNA helicase 1 FBH1 1002 Q9NXK8 F-box/LRR-repeat protein 12 FBXL12 101 Q9NXK8 F-box/LRR-repeat protein 12 FBXL12 108 Q9NXK8 F-box/LRR-repeat protein 12 FBXL12 134 Q9NXK8 F-box/LRR-repeat protein 12 FBXL12 212 Q9NXK8 F-box/LRR-repeat protein 12 FBXL12 304 Q9NXK8 F-box/LRR-repeat protein 12 FBXL12 310 Q8N1E6 F-box/LRR-repeat protein 14 FBXL14 313 Q8N1E6 F-box/LRR-repeat protein 14 FBXL14 382 Q9H469 F-box/LRR-repeat protein 15 FBXL15 124 Q9H469 F-box/LRR-repeat protein 15 FBXL15 139 Q9H469 F-box/LRR-repeat protein 15 FBXL15 150 Q9H469 F-box/LRR-repeat protein 15 FBXL15 218 Q9H469 F-box/LRR-repeat protein 15 FBXL15 244 Q8N461 F-box/LRR-repeat protein 16 FBXL16 74 Q9UF56 F-box/LRR-repeat protein 17 FBXL17 207 Q9UF56 F-box/LRR-repeat protein 17 FBXL17 210 Q9UF56 F-box/LRR-repeat protein 17 FBXL17 295 Q9UF56 F-box/LRR-repeat protein 17 FBXL17 437 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 63 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 104 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 129 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 166 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 190 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 324 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 353 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 356 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 382 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 383 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 406 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 423 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 459 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 468 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 513 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 557 Q96ME1 F-box/LRR-repeat protein 18 FBXL18 620 Q6PCT2 F-box/LRR-repeat protein 19 FBXL19 56 Q6PCT2 F-box/LRR-repeat protein 19 FBXL19 72 Q6PCT2 F-box/LRR-repeat protein 19 FBXL19 142 Q6PCT2 F-box/LRR-repeat protein 19 FBXL19 145 Q6PCT2 F-box/LRR-repeat protein 19 FBXL19 246 Q6PCT2 F-box/LRR-repeat protein 19 FBXL19 273 Q6PCT2 F-box/LRR-repeat protein 19 FBXL19 314 Q6PCT2 F-box/LRR-repeat protein 19 FBXL19 637 Q6PCT2 F-box/LRR-repeat protein 19 FBXL19 644 Q6PCT2 F-box/LRR-repeat protein 19 FBXL19 670 Q9UKC9 F-box/LRR-repeat protein 2 FBXL2 192 Q96IG2 F-box/LRR-repeat protein 20 FBXL20 101 Q96IG2 F-box/LRR-repeat protein 20 FBXL20 127 Q96IG2 F-box/LRR-repeat protein 20 FBXL20 135 Q96IG2 F-box/LRR-repeat protein 20 FBXL20 205 Q96IG2 F-box/LRR-repeat protein 20 FBXL20 389 Q9UKT7 F-box/LRR-repeat protein 3 FBXL3 63 Q9UKT7 F-box/LRR-repeat protein 3 FBXL3 78 Q9UKT7 F-box/LRR-repeat protein 3 FBXL3 137 Q9UKT7 F-box/LRR-repeat protein 3 FBXL3 208 Q9UKT7 F-box/LRR-repeat protein 3 FBXL3 331 Q9UKT7 F-box/LRR-repeat protein 3 FBXL3 340 Q9UKA2 F-box/LRR-repeat protein 4 FBXL4 107 Q9UKA2 F-box/LRR-repeat protein 4 FBXL4 194 Q9UKA2 F-box/LRR-repeat protein 4 FBXL4 307 Q9UKA1 F-box/LRR-repeat protein 5 FBXL5 159 Q8N531 F-box/LRR-repeat protein 6 FBXL6 219 Q8N531 F-box/LRR-repeat protein 6 FBXL6 327 Q8N531 F-box/LRR-repeat protein 6 FBXL6 368 Q8N531 F-box/LRR-repeat protein 6 FBXL6 407 Q8N531 F-box/LRR-repeat protein 6 FBXL6 439 Q96CD0 F-box/LRR-repeat protein 8 FBXL8 41 Q96CD0 F-box/LRR-repeat protein 8 FBXL8 190 Q96CD0 F-box/LRR-repeat protein 8 FBXL8 228 Q9UK96 F-box only protein 10 FBXO10 52 Q9UK96 F-box only protein 10 FBXO10 97 Q9UK96 F-box only protein 10 FBXO10 309 Q9UK96 F-box only protein 10 FBXO10 447 Q9UK96 F-box only protein 10 FBXO10 778 Q86XK2 F-box only protein 11 FBXO11 113 Q86XK2 F-box only protein 11 FBXO11 581 Q96EF6 F-box only protein 17 FBXO17 94 Q96EF6 F-box only protein 17 FBXO17 114 Q96EF6 F-box only protein 17 FBXO17 193 Q9UK22 F-box only protein 2 FBXO2 71 Q9UK22 F-box only protein 2 FBXO2 92 Q9UK22 F-box only protein 2 FBXO2 137 Q9UK22 F-box only protein 2 FBXO2 176 Q9UK22 F-box only protein 2 FBXO2 215 O94952 F-box only protein 21 FBXO21 66 O94952 F-box only protein 21 FBXO21 560 Q8NEZ5 F-box only protein 22 FBXO22 47 Q8NEZ5 F-box only protein 22 FBXO22 117 Q8NEZ5 F-box only protein 22 FBXO22 227 Q8NEZ5 F-box only protein 22 FBXO22 228 Q8NEZ5 F-box only protein 22 FBXO22 378 Q8NI29 F-box only protein 27 FBXO27 99 Q8NI29 F-box only protein 27 FBXO27 162 Q9UK99 F-box only protein 3 FBXO3 37 Q9UK99 F-box only protein 3 FBXO3 74 Q8TB52 F-box only protein 30 FBXO30 18 Q8TB52 F-box only protein 30 FBXO30 28 Q8TB52 F-box only protein 30 FBXO30 44 Q8TB52 F-box only protein 30 FBXO30 53 Q8TB52 F-box only protein 30 FBXO30 67 Q8TB52 F-box only protein 30 FBXO30 317 Q8TB52 F-box only protein 30 FBXO30 366 Q8TB52 F-box only protein 30 FBXO30 396 Q8TB52 F-box only protein 30 FBXO30 523 Q8TB52 F-box only protein 30 FBXO30 555 Q8TB52 F-box only protein 30 FBXO30 562 Q8TB52 F-box only protein 30 FBXO30 570 Q8TB52 F-box only protein 30 FBXO30 592 Q8TB52 F-box only protein 30 FBXO30 687 Q8TB52 F-box only protein 30 FBXO30 707 Q8TB52 F-box only protein 30 FBXO30 723 Q8TB52 F-box only protein 30 FBXO30 725 Q5XUX0 F-box only protein 31 FBXO31 8 Q5XUX0 F-box only protein 31 FBXO31 118 Q5XUX0 F-box only protein 31 FBXO31 131 Q5XUX0 F-box only protein 31 FBXO31 230 Q5XUX0 F-box only protein 31 FBXO31 440 Q969P5 F-box only protein 32 FBXO32 231 Q7Z6M2 F-box only protein 33 FBXO33 95 Q9NWN3 F-box only protein 34 FBXO34 128 Q9NWN3 F-box only protein 34 FBXO34 225 Q9NWN3 F-box only protein 34 FBXO34 229 Q9NWN3 F-box only protein 34 FBXO34 647 Q9NWN3 F-box only protein 34 FBXO34 691 Q6PIJ6 F-box only protein 38 FBXO38 11 Q6PIJ6 F-box only protein 38 FBXO38 206 Q6PIJ6 F-box only protein 38 FBXO38 242 Q6PIJ6 F-box only protein 38 FBXO38 303 Q6PIJ6 F-box only protein 38 FBXO38 401 Q6PIJ6 F-box only protein 38 FBXO38 410 Q6PIJ6 F-box only protein 38 FBXO38 670 Q6PIJ6 F-box only protein 38 FBXO38 674 Q6PIJ6 F-box only protein 38 FBXO38 704 Q6PIJ6 F-box only protein 38 FBXO38 776 Q6PIJ6 F-box only protein 38 FBXO38 777 Q6PIJ6 F-box only protein 38 FBXO38 778 Q6PIJ6 F-box only protein 38 FBXO38 791 Q6PIJ6 F-box only protein 38 FBXO38 803 Q6PIJ6 F-box only protein 38 FBXO38 855 Q6PIJ6 F-box only protein 38 FBXO38 978 Q9UKT5 F-box only protein 4 FBXO4 146 Q9UKT5 F-box only protein 4 FBXO4 147 Q9UKT5 F-box only protein 4 FBXO4 283 Q6P3S6 F-box only protein 42 FBXO42 89 Q6P3S6 F-box only protein 42 FBXO42 302 Q6P3S6 F-box only protein 42 FBXO42 403 Q9H4M3 F-box only protein 44 FBXO44 30 Q9H4M3 F-box only protein 44 FBXO44 170 P0C2W1 F-box/SPRY domain-containing protein 1 FBXO45 69 P0C2W1 F-box/SPRY domain-containing protein 1 FBXO45 98 P0C2W1 F-box/SPRY domain-containing protein 1 FBXO45 119 P0C2W1 F-box/SPRY domain-containing protein 1 FBXO45 218 Q6PJ61 F-box only protein 46 FBXO46 109 Q6PJ61 F-box only protein 46 FBXO46 224 Q6PJ61 F-box only protein 46 FBXO46 288 Q6PJ61 F-box only protein 46 FBXO46 306 Q6PJ61 F-box only protein 46 FBXO46 394 Q6PJ61 F-box only protein 46 FBXO46 545 Q6PJ61 F-box only protein 46 FBXO46 576 Q6PJ61 F-box only protein 46 FBXO46 589 Q9UKT4 F-box only protein 5 FBXO5 6 Q9UKT4 F-box only protein 5 FBXO5 8 Q9UKT4 F-box only protein 5 FBXO5 15 Q9UKT4 F-box only protein 5 FBXO5 17 Q9UKT4 F-box only protein 5 FBXO5 36 Q9UKT4 F-box only protein 5 FBXO5 49 Q9UKT4 F-box only protein 5 FBXO5 53 Q9UKT4 F-box only protein 5 FBXO5 83 Q9UKT4 F-box only protein 5 FBXO5 86 Q9UKT4 F-box only protein 5 FBXO5 95 Q9UKT4 F-box only protein 5 FBXO5 202 Q9UKT4 F-box only protein 5 FBXO5 381 Q9UKT4 F-box only protein 5 FBXO5 389 Q9UKT4 F-box only protein 5 FBXO5 396 Q9UKT4 F-box only protein 5 FBXO5 401 Q9UKT4 F-box only protein 5 FBXO5 406 Q9UKT4 F-box only protein 5 FBXO5 409 Q9UKT4 F-box only protein 5 FBXO5 411 Q9UKT4 F-box only protein 5 FBXO5 419 Q9NRD1 F-box only protein 6 FBXO6 37 Q9Y3I1 F-box only protein 7 FBXO7 36 Q9Y3I1 F-box only protein 7 FBXO7 286 Q9UK97 F-box only protein 9 FBXO9 68 Q9UKB1 F-box/WD repeat-containing protein 11 FBXW11 76 Q9UKB1 F-box/WD repeat-containing protein 11 FBXW11 145 Q9UKB1 F-box/WD repeat-containing protein 11 FBXW11 245 Q9UKB1 F-box/WD repeat-containing protein 11 FBXW11 272 Q9UKB1 F-box/WD repeat-containing protein 11 FBXW11 408 Q9UKB1 F-box/WD repeat-containing protein 11 FBXW11 432 Q9UKB1 F-box/WD repeat-containing protein 11 FBXW11 435 Q9UKB1 F-box/WD repeat-containing protein 11 FBXW11 484 Q9UKT8 F-box/WD repeat-containing protein 2 FBXW2 327 P57775 F-box/WD repeat-containing protein 4 FBXW4 64 P57775 F-box/WD repeat-containing protein 4 FBXW4 108 Q969U6 F-box/WD repeat-containing protein 5 FBXW5 277 Q969U6 F-box/WD repeat-containing protein 5 FBXW5 503 Q969H0 F-box/WD repeat-containing protein 7 FBXW7 202 Q969H0 F-box/WD repeat-containing protein 7 FBXW7 390 Q8N3Y1 F-box/WD repeat-containing protein 8 FBXW8 139 Q8N3Y1 F-box/WD repeat-containing protein 8 FBXW8 176 Q8N3Y1 F-box/WD repeat-containing protein 8 FBXW8 575 Q8N3Y1 F-box/WD repeat-containing protein 8 FBXW8 579 Q5XUX1 F-box/WD repeat-containing protein 9 FBXW9 107 Q5XUX1 F-box/WD repeat-containing protein 9 FBXW9 146 Q5XUX1 F-box/WD repeat-containing protein 9 FBXW9 240 Q5XUX1 F-box/WD repeat-containing protein 9 FBXW9 271 Q5XUX1 F-box/WD repeat-containing protein 9 FBXW9 407 Q9BSK4 Protein fem-1 homolog A FEM1A 641 Q9UK73 Protein fem-1 homolog B FEM1B 186 Q9UK73 Protein fem-1 homolog B FEM1B 244 Q9UK73 Protein fem-1 homolog B FEM1B 363 Q7L622 G2/M phase-specific E3 ubiquitin-protein ligase G2E3 106 Q7L622 G2/M phase-specific E3 ubiquitin-protein ligase G2E3 285 Q7L622 G2/M phase-specific E3 ubiquitin-protein ligase G2E3 580 Q9H2C0 Gigaxonin GAN 30 Q9H2C0 Gigaxonin GAN 248 Q9H2C0 Gigaxonin GAN 294 Q9H2C0 Gigaxonin GAN 296 Q96IK5 Germ cell-less protein-like 1 GMCL1 44 Q96IK5 Germ cell-less protein-like 1 GMCL1 46 Q13888 General transcription factor IIH subunit 2 GTF2H2 83 Q13888 General transcription factor IIH subunit 2 GTF2H2 139 Q13888 General transcription factor IIH subunit 2 GTF2H2 208 Q13888 General transcription factor IIH subunit 2 GTF2H2 247 Q13888 General transcription factor IIH subunit 2 GTF2H2 299 Q13888 General transcription factor IIH subunit 2 GTF2H2 305 Q13888 General transcription factor IIH subunit 2 GTF2H2 308 Q13888 General transcription factor IIH subunit 2 GTF2H2 348 Q9H116 GDNF-inducible zinc finger protein 1 GZF1 319 Q9H116 GDNF-inducible zinc finger protein 1 GZF1 322 Q9H116 GDNF-inducible zinc finger protein 1 GZF1 379 Q9H116 GDNF-inducible zinc finger protein 1 GZF1 382 Q9H116 GDNF-inducible zinc finger protein 1 GZF1 548 Q8IYU2 E3 ubiquitin-protein ligase HACE1 HACE1 99 Q8IYU2 E3 ubiquitin-protein ligase HACE1 HACE1 481 Q8IYU2 E3 ubiquitin-protein ligase HACE1 HACE1 489 Q8IYU2 E3 ubiquitin-protein ligase HACE1 HACE1 508 Q8IYU2 E3 ubiquitin-protein ligase HACE1 HACE1 567 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 44 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 48 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 58 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 88 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 209 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 254 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 316 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 369 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 436 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 487 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 507 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 878 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 936 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 1368 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 1389 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 1811 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 1855 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 1893 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 1944 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 1995 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 2071 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 2086 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 2224 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 2415 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 2545 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 HECTD1 2579 Q5T447 E3 ubiquitin-protein ligase HECTD3 HECTD3 112 Q5T447 E3 ubiquitin-protein ligase HECTD3 HECTD3 133 Q5T447 E3 ubiquitin-protein ligase HECTD3 HECTD3 143 Q5T447 E3 ubiquitin-protein ligase HECTD3 HECTD3 459 Q5T447 E3 ubiquitin-protein ligase HECTD3 HECTD3 487 Q5T447 E3 ubiquitin-protein ligase HECTD3 HECTD3 494 Q5T447 E3 ubiquitin-protein ligase HECTD3 HECTD3 823 Q5T447 E3 ubiquitin-protein ligase HECTD3 HECTD3 838 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 330 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 586 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 1084 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 1488 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 1580 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 1636 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 1783 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 2036 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 2786 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 3504 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 3607 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 3659 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 3787 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 3964 Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 HECTD4 3985 Q76N89 E3 ubiquitin-protein ligase HECW1 HECW1 1200 Q76N89 E3 ubiquitin-protein ligase HECW1 HECW1 1574 Q9P2P5 E3 ubiquitin-protein ligase HECW2 HECW2 224 Q9P2P5 E3 ubiquitin-protein ligase HECW2 HECW2 436 Q9P2P5 E3 ubiquitin-protein ligase HECW2 HECW2 660 Q9P2P5 E3 ubiquitin-protein ligase HECW2 HECW2 949 Q9P2P5 E3 ubiquitin-protein ligase HECW2 HECW2 1540 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 56 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 750 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 1192 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 1195 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 1228 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 1282 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 1388 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 1570 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 1941 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 1968 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 2525 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 2547 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 3002 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 3262 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 3272 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 3849 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 4486 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 4728 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 4811 Q15751 Probable E3 ubiquitin-protein ligase HERC1 HERC1 4837 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 33 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 349 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 412 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 521 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 914 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 998 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 1005 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 1037 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 1201 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 1378 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 1410 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 1419 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 1525 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 1825 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 2025 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 2095 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 2111 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 2726 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 2760 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 2770 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 2808 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 2902 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 3558 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 3723 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 3864 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 3865 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 4762 O95714 E3 ubiquitin-protein ligase HERC2 HERC2 4788 Q15034 Probable E3 ubiquitin-protein ligase HERC3 HERC3 321 Q15034 Probable E3 ubiquitin-protein ligase HERC3 HERC3 333 Q15034 Probable E3 ubiquitin-protein ligase HERC3 HERC3 552 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 41 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 58 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 60 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 160 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 175 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 248 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 249 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 301 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 352 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 384 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 392 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 513 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 708 Q5GLZ8 Probable E3 ubiquitin-protein ligase HERC4 HERC4 1025 Q9UII4 E3 ISG15--protein ligase HERC5 HERC5 58 Q9UII4 E3 ISG15--protein ligase HERC5 HERC5 90 Q9UII4 E3 ISG15--protein ligase HERC5 HERC5 424 Q9UII4 E3 ISG15--protein ligase HERC5 HERC5 979 Q9UII4 E3 ISG15--protein ligase HERC5 HERC5 994 Q8IVU3 Probable E3 ubiquitin-protein ligase HERC6 HERC6 91 Q8IVU3 Probable E3 ubiquitin-protein ligase HERC6 HERC6 135 Q8IVU3 Probable E3 ubiquitin-protein ligase HERC6 HERC6 557 Q8IVU3 Probable E3 ubiquitin-protein ligase HERC6 HERC6 985 P49773 Histidine triad nucleotide-binding protein 1 HINT1 38 P49773 Histidine triad nucleotide-binding protein 1 HINT1 84 Q14527 Helicase-like transcription factor HLTF 360 Q14527 Helicase-like transcription factor HLTF 442 Q14527 Helicase-like transcription factor HLTF 461 Q14527 Helicase-like transcription factor HLTF 763 Q14527 Helicase-like transcription factor HLTF 775 Q14527 Helicase-like transcription factor HLTF 780 Q14527 Helicase-like transcription factor HLTF 812 Q14527 Helicase-like transcription factor HLTF 896 Q14527 Helicase-like transcription factor HLTF 942 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 19 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 29 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 182 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 183 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 349 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 471 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 612 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 624 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 689 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 699 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 790 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 821 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 1074 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 1133 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 1159 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 1252 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 1278 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 1401 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 1421 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 1462 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 1628 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 1832 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 1879 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 1891 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 1892 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 2181 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 2190 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 2655 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 2666 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 2721 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 3213 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 3239 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 3259 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 3296 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 3333 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 3361 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 3372 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 3375 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 3385 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 3635 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 3658 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 4099 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 4126 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 4211 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 4341 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 HUWE1 4367 Q9P2D0 Inhibitor of Bruton tyrosine kinase IBTK 41 Q9P2D0 Inhibitor of Bruton tyrosine kinase IBTK 62 Q9P2D0 Inhibitor of Bruton tyrosine kinase IBTK 201 Q9P2D0 Inhibitor of Bruton tyrosine kinase IBTK 217 Q9P2D0 Inhibitor of Bruton tyrosine kinase IBTK 231 Q9P2D0 Inhibitor of Bruton tyrosine kinase IBTK 325 Q9P2D0 Inhibitor of Bruton tyrosine kinase IBTK 522 Q9P2D0 Inhibitor of Bruton tyrosine kinase IBTK 764 Q9P2D0 Inhibitor of Bruton tyrosine kinase IBTK 1135 Q9Y573 Actin-binding protein IPP IPP 260 Q9Y573 Actin-binding protein IPP IPP 272 Q9Y573 Actin-binding protein IPP IPP 312 Q8IU81 Interferon regulatory factor 2-binding protein 1 IRF2BP1 12 Q8IU81 Interferon regulatory factor 2-binding protein 1 IRF2BP1 15 Q8IU81 Interferon regulatory factor 2-binding protein 1 IRF2BP1 36 Q8IU81 Interferon regulatory factor 2-binding protein 1 IRF2BP1 207 Q8IU81 Interferon regulatory factor 2-binding protein 1 IRF2BP1 239 Q8IU81 Interferon regulatory factor 2-binding protein 1 IRF2BP1 280 Q8IU81 Interferon regulatory factor 2-binding protein 1 IRF2BP1 363 Q8IU81 Interferon regulatory factor 2-binding protein 1 IRF2BP1 503 Q8IU81 Interferon regulatory factor 2-binding protein 1 IRF2BP1 518 Q8IU81 Interferon regulatory factor 2-binding protein 1 IRF2BP1 527 Q8IU81 Interferon regulatory factor 2-binding protein 1 IRF2BP1 530 Q7Z5L9 Interferon regulatory factor 2-binding protein 2 IRF2BP2 16 Q7Z5L9 Interferon regulatory factor 2-binding protein 2 IRF2BP2 19 Q7Z5L9 Interferon regulatory factor 2-binding protein 2 IRF2BP2 37 Q7Z5L9 Interferon regulatory factor 2-binding protein 2 IRF2BP2 40 Q7Z5L9 Interferon regulatory factor 2-binding protein 2 IRF2BP2 65 Q7Z5L9 Interferon regulatory factor 2-binding protein 2 IRF2BP2 509 Q7Z5L9 Interferon regulatory factor 2-binding protein 2 IRF2BP2 521 Q7Z5L9 Interferon regulatory factor 2-binding protein 2 IRF2BP2 530 Q7Z5L9 Interferon regulatory factor 2-binding protein 2 IRF2BP2 533 Q7Z5L9 Interferon regulatory factor 2-binding protein 2 IRF2BP2 555 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL 14 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL 17 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL 35 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL 38 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL 63 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL 298 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL 445 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL 504 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL 718 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL 730 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL 739 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL 742 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL 758 Q9H1B7 Interferon regulatory factor 2-binding protein-like IRF2BPL 764 Q96J02 E3 ubiquitin-protein ligase Itchy homolog ITCH 57 Q96J02 E3 ubiquitin-protein ligase Itchy homolog ITCH 835 Q96J02 E3 ubiquitin-protein ligase Itchy homolog ITCH 871 Q9Y6Y0 Influenza virus NS1A-binding protein IVNS1ABP 32 Q9Y6Y0 Influenza virus NS1A-binding protein IVNS1ABP 39 Q9Y6Y0 Influenza virus NS1A-binding protein IVNS1ABP 52 Q9Y6Y0 Influenza virus NS1A-binding protein IVNS1ABP 53 Q9Y6Y0 Influenza virus NS1A-binding protein IVNS1ABP 121 Q9Y6Y0 Influenza virus NS1A-binding protein IVNS1ABP 134 Q9Y6Y0 Influenza virus NS1A-binding protein IVNS1ABP 143 Q9Y6Y0 Influenza virus NS1A-binding protein IVNS1ABP 187 Q9Y6Y0 Influenza virus NS1A-binding protein IVNS1ABP 274 Q9Y6Y0 Influenza virus NS1A-binding protein IVNS1ABP 381 Q9Y6Y0 Influenza virus NS1A-binding protein IVNS1ABP 454 Q9Y6Y0 Influenza virus NS1A-binding protein IVNS1ABP 564 Q9Y6Y0 Influenza virus NS1A-binding protein IVNS1ABP 575 O94819 Kelch repeat and BTB domain-containing protein 11 KBTBD11 99 O94819 Kelch repeat and BTB domain-containing protein 11 KBTBD11 257 O94819 Kelch repeat and BTB domain-containing protein 11 KBTBD11 421 O94819 Kelch repeat and BTB domain-containing protein 11 KBTBD11 485 O94819 Kelch repeat and BTB domain-containing protein 11 KBTBD11 529 O94819 Kelch repeat and BTB domain-containing protein 11 KBTBD11 537 O94819 Kelch repeat and BTB domain-containing protein 11 KBTBD11 555 Q8IY47 Kelch repeat and BTB domain-containing protein 2 KBTBD2 145 Q8IY47 Kelch repeat and BTB domain-containing protein 2 KBTBD2 299 Q8IY47 Kelch repeat and BTB domain-containing protein 2 KBTBD2 349 Q8IY47 Kelch repeat and BTB domain-containing protein 2 KBTBD2 524 Q8NAB2 Kelch repeat and BTB domain-containing protein 3 KBTBD3 137 Q9NVX7 Kelch repeat and BTB domain-containing protein 4 KBTBD4 68 Q9NVX7 Kelch repeat and BTB domain-containing protein 4 KBTBD4 201 Q9NVX7 Kelch repeat and BTB domain-containing protein 4 KBTBD4 274 Q9NVX7 Kelch repeat and BTB domain-containing protein 4 KBTBD4 301 Q9NVX7 Kelch repeat and BTB domain-containing protein 4 KBTBD4 455 Q9NVX7 Kelch repeat and BTB domain-containing protein 4 KBTBD4 472 Q86V97 Kelch repeat and BTB domain-containing protein 6 KBTBD6 84 Q86V97 Kelch repeat and BTB domain-containing protein 6 KBTBD6 93 Q86V97 Kelch repeat and BTB domain-containing protein 6 KBTBD6 341 Q86V97 Kelch repeat and BTB domain-containing protein 6 KBTBD6 375 Q86V97 Kelch repeat and BTB domain-containing protein 6 KBTBD6 456 Q8WVZ9 Kelch repeat and BTB domain-containing protein 7 KBTBD7 84 Q8WVZ9 Kelch repeat and BTB domain-containing protein 7 KBTBD7 93 Q8WVZ9 Kelch repeat and BTB domain-containing protein 7 KBTBD7 341 Q8NFY9 Kelch repeat and BTB domain-containing protein 8 KBTBD8 181 Q8NFY9 Kelch repeat and BTB domain-containing protein 8 KBTBD8 265 Q8NFY9 Kelch repeat and BTB domain-containing protein 8 KBTBD8 276 Q8NFY9 Kelch repeat and BTB domain-containing protein 8 KBTBD8 306 Q8NFY9 Kelch repeat and BTB domain-containing protein 8 KBTBD8 318 Q8NFY9 Kelch repeat and BTB domain-containing protein 8 KBTBD8 389 Q8NFY9 Kelch repeat and BTB domain-containing protein 8 KBTBD8 413 Q8NFY9 Kelch repeat and BTB domain-containing protein 8 KBTBD8 490 Q8NFY9 Kelch repeat and BTB domain-containing protein 8 KBTBD8 587 Q8NFY9 Kelch repeat and BTB domain-containing protein 8 KBTBD8 596 Q9P0J7 E3 ubiquitin-protein ligase KCMF1 KCMF1 12 Q9P0J7 E3 ubiquitin-protein ligase KCMF1 KCMF1 33 Q9P0J7 E3 ubiquitin-protein ligase KCMF1 KCMF1 54 Q719H9 BTB/POZ domain-containing protein KCTD1 KCTD1 140 Q719H9 BTB/POZ domain-containing protein KCTD1 KCTD1 142 Q9H3F6 BTB/POZ domain-containing adapter for CUL3-mediated KCTD10 80 RhoA degradation protein 3 Q9H3F6 BTB/POZ domain-containing adapter for CUL3-mediated KCTD10 138 RhoA degradation protein 3 Q9H3F6 BTB/POZ domain-containing adapter for CUL3-mediated KCTD10 227 RhoA degradation protein 3 Q9H3F6 BTB/POZ domain-containing adapter for CUL3-mediated KCTD10 228 RhoA degradation protein 3 Q96CX2 BTB/POZ domain-containing protein KCTD12 KCTD12 50 Q96CX2 BTB/POZ domain-containing protein KCTD12 KCTD12 239 Q8WZ19 BTB/POZ domain-containing adapter for CUL3-mediated KCTD13 237 RhoA degradation protein 1 Q8WZ19 BTB/POZ domain-containing adapter for CUL3-mediated KCTD13 238 RhoA degradation protein 1 Q96SI1 BTB/POZ domain-containing protein KCTD15 KCTD15 166 Q96SI1 BTB/POZ domain-containing protein KCTD15 KCTD15 168 Q96SI1 BTB/POZ domain-containing protein KCTD15 KCTD15 202 Q7Z5Y7 BTB/POZ domain-containing protein KCTD20 KCTD20 19 Q7Z5Y7 BTB/POZ domain-containing protein KCTD20 KCTD20 82 Q7Z5Y7 BTB/POZ domain-containing protein KCTD20 KCTD20 327 Q7Z5Y7 BTB/POZ domain-containing protein KCTD20 KCTD20 369 Q4G0X4 BTB/POZ domain-containing protein KCTD21 KCTD21 237 Q9Y597 BTB/POZ domain-containing protein KCTD3 KCTD3 112 Q9Y597 BTB/POZ domain-containing protein KCTD3 KCTD3 530 Q9Y597 BTB/POZ domain-containing protein KCTD3 KCTD3 541 Q9Y597 BTB/POZ domain-containing protein KCTD3 KCTD3 599 Q9Y597 BTB/POZ domain-containing protein KCTD3 KCTD3 606 Q9Y597 BTB/POZ domain-containing protein KCTD3 KCTD3 704 Q8WVF5 BTB/POZ domain-containing protein KCTD4 KCTD4 30 Q9NXV2 BTB/POZ domain-containing protein KCTD5 KCTD5 25 Q9NXV2 BTB/POZ domain-containing protein KCTD5 KCTD5 28 Q9NXV2 BTB/POZ domain-containing protein KCTD5 KCTD5 63 Q8NC69 BTB/POZ domain-containing protein KCTD6 KCTD6 182 Q96MP8 BTB/POZ domain-containing protein KCTD7 KCTD7 204 Q6ZWB6 BTB/POZ domain-containing protein KCTD8 KCTD8 238 Q6ZWB6 BTB/POZ domain-containing protein KCTD8 KCTD8 431 Q7L273 BTB/POZ domain-containing protein KCTD9 KCTD9 220 Q7L273 BTB/POZ domain-containing protein KCTD9 KCTD9 256 Q7L273 BTB/POZ domain-containing protein KCTD9 KCTD9 257 Q7L273 BTB/POZ domain-containing protein KCTD9 KCTD9 272 Q7L273 BTB/POZ domain-containing protein KCTD9 KCTD9 282 Q7L273 BTB/POZ domain-containing protein KCTD9 KCTD9 293 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 200 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 429 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 443 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 463 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 477 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 577 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 582 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 585 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 588 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 604 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 609 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 620 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 623 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 672 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 675 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 708 Q9Y2K7 Lysine-specific demethylase 2A KDM2A 840 Q8NHM5 Lysine-specific demethylase 2B KDM2B 533 Q8NHM5 Lysine-specific demethylase 2B KDM2B 630 Q8NHM5 Lysine-specific demethylase 2B KDM2B 646 Q8NHM5 Lysine-specific demethylase 2B KDM2B 719 Q8NHM5 Lysine-specific demethylase 2B KDM2B 722 Q8NHM5 Lysine-specific demethylase 2B KDM2B 770 Q8NHM5 Lysine-specific demethylase 2B KDM2B 1035 Q8NHM5 Lysine-specific demethylase 2B KDM2B 1110 Q8NHM5 Lysine-specific demethylase 2B KDM2B 1292 Q8NHM5 Lysine-specific demethylase 2B KDM2B 1296 Q14145 Kelch-like ECH-associated protein 1 KEAP1 23 Q14145 Kelch-like ECH-associated protein 1 KEAP1 38 Q14145 Kelch-like ECH-associated protein 1 KEAP1 151 Q14145 Kelch-like ECH-associated protein 1 KEAP1 226 Q14145 Kelch-like ECH-associated protein 1 KEAP1 241 Q14145 Kelch-like ECH-associated protein 1 KEAP1 257 Q14145 Kelch-like ECH-associated protein 1 KEAP1 288 Q14145 Kelch-like ECH-associated protein 1 KEAP1 297 Q14145 Kelch-like ECH-associated protein 1 KEAP1 319 Q14145 Kelch-like ECH-associated protein 1 KEAP1 434 Q14145 Kelch-like ECH-associated protein 1 KEAP1 613 Q14145 Kelch-like ECH-associated protein 1 KEAP1 622 Q14145 Kelch-like ECH-associated protein 1 KEAP1 624 Q9HCI6 E3 SUMO-protein ligase KIAA1586 KIAA1586 98 Q9HCI6 E3 SUMO-protein ligase KIAA1586 KIAA1586 281 Q9HCI6 E3 SUMO-protein ligase KIAA1586 KIAA1586 758 Q6PID8 Kelch domain-containing protein 10 KLHDC10 73 Q6PID8 Kelch domain-containing protein 10 KLHDC10 254 Q6PID8 Kelch domain-containing protein 10 KLHDC10 318 Q9Y2U9 Kelch domain-containing protein 2 KLHDC2 137 Q9Y2U9 Kelch domain-containing protein 2 KLHDC2 223 Q9Y2U9 Kelch domain-containing protein 2 KLHDC2 374 Q9Y2U9 Kelch domain-containing protein 2 KLHDC2 385 Q9BQ90 Kelch domain-containing protein 3 KLHDC3 33 Q9BQ90 Kelch domain-containing protein 3 KLHDC3 102 Q9BQ90 Kelch domain-containing protein 3 KLHDC3 134 Q9BQ90 Kelch domain-containing protein 3 KLHDC3 213 Q9BQ90 Kelch domain-containing protein 3 KLHDC3 229 Q9BQ90 Kelch domain-containing protein 3 KLHDC3 289 Q9NR64 Kelch-like protein 1 KLHL1 525 Q9NR64 Kelch-like protein 1 KLHL1 634 Q9NVR0 Kelch-like protein 11 KLHL11 99 Q9NVR0 Kelch-like protein 11 KLHL11 318 Q9NVR0 Kelch-like protein 11 KLHL11 341 Q9NVR0 Kelch-like protein 11 KLHL11 570 Q9NVR0 Kelch-like protein 11 KLHL11 635 Q9NVR0 Kelch-like protein 11 KLHL11 657 Q9NVR0 Kelch-like protein 11 KLHL11 708 Q53G59 Kelch-like protein 12 KLHL12 244 Q53G59 Kelch-like protein 12 KLHL12 248 Q53G59 Kelch-like protein 12 KLHL12 511 Q9P2N7 Kelch-like protein 13 KLHL13 134 Q9P2N7 Kelch-like protein 13 KLHL13 601 Q9P2G3 Kelch-like protein 14 KLHL14 33 Q9P2G3 Kelch-like protein 14 KLHL14 46 Q9P2G3 Kelch-like protein 14 KLHL14 593 Q9P2G3 Kelch-like protein 14 KLHL14 623 O94889 Kelch-like protein 18 KLHL18 38 O94889 Kelch-like protein 18 KLHL18 523 Q9Y2M5 Kelch-like protein 20 KLHL20 25 Q9Y2M5 Kelch-like protein 20 KLHL20 356 Q53GT1 Kelch-like protein 22 KLHL22 22 Q8NBE8 Kelch-like protein 23 KLHL23 245 Q8NBE8 Kelch-like protein 23 KLHL23 431 Q6TFL4 Kelch-like protein 24 KLHL24 281 Q6TFL4 Kelch-like protein 24 KLHL24 321 Q6TFL4 Kelch-like protein 24 KLHL24 468 Q6TFL4 Kelch-like protein 24 KLHL24 542 Q9H0H3 Kelch-like protein 25 KLHL25 31 Q9H0H3 Kelch-like protein 25 KLHL25 287 Q9H0H3 Kelch-like protein 25 KLHL25 307 Q9H0H3 Kelch-like protein 25 KLHL25 340 Q9H0H3 Kelch-like protein 25 KLHL25 531 Q53HC5 Kelch-like protein 26 KLHL26 221 Q53HC5 Kelch-like protein 26 KLHL26 249 Q53HC5 Kelch-like protein 26 KLHL26 480 Q53HC5 Kelch-like protein 26 KLHL26 554 Q53HC5 Kelch-like protein 26 KLHL26 555 Q53HC5 Kelch-like protein 26 KLHL26 603 Q0D2K2 Kelch-like protein 30 KLHL30 432 Q8N4N3 Kelch-like protein 36 KLHL36 254 Q8N4N3 Kelch-like protein 36 KLHL36 263 Q8N4N3 Kelch-like protein 36 KLHL36 308 Q8N4N3 Kelch-like protein 36 KLHL36 523 Q9C0H6 Kelch-like protein 4 KLHL4 35 Q9C0H6 Kelch-like protein 4 KLHL4 182 Q9C0H6 Kelch-like protein 4 KLHL4 284 Q9C0H6 Kelch-like protein 4 KLHL4 296 Q9C0H6 Kelch-like protein 4 KLHL4 633 Q9C0H6 Kelch-like protein 4 KLHL4 639 Q9P2K6 Kelch-like protein 42 KLHL42 15 Q96PQ7 Kelch-like protein 5 KLHL5 322 Q96PQ7 Kelch-like protein 5 KLHL5 334 Q96PQ7 Kelch-like protein 5 KLHL5 533 Q96PQ7 Kelch-like protein 5 KLHL5 677 Q8WZ60 Kelch-like protein 6 KLHL6 252 Q8WZ60 Kelch-like protein 6 KLHL6 284 Q8WZ60 Kelch-like protein 6 KLHL6 339 Q8WZ60 Kelch-like protein 6 KLHL6 488 Q8WZ60 Kelch-like protein 6 KLHL6 508 Q8WZ60 Kelch-like protein 6 KLHL6 539 Q8WZ60 Kelch-like protein 6 KLHL6 551 Q8WZ60 Kelch-like protein 6 KLHL6 556 Q8IXQ5 Kelch-like protein 7 KLHL7 158 Q8IXQ5 Kelch-like protein 7 KLHL7 259 Q9P2G9 Kelch-like protein 8 KLHL8 282 Q9P2G9 Kelch-like protein 8 KLHL8 590 Q9P2J3 Kelch-like protein 9 KLHL9 19 Q9P2J3 Kelch-like protein 9 KLHL9 92 Q9P2J3 Kelch-like protein 9 KLHL9 559 Q08380 Galectin-3-binding protein LGALS3BP 93 Q08380 Galectin-3-binding protein LGALS3BP 279 Q08380 Galectin-3-binding protein LGALS3BP 526 Q08380 Galectin-3-binding protein LGALS3BP 561 Q8TBB1 E3 ubiquitin-protein ligase LNX LNX1 632 Q8TBB1 E3 ubiquitin-protein ligase LNX LNX1 704 Q8N448 Ligand of Numb protein X 2 LNX2 120 Q8N448 Ligand of Numb protein X 2 LNX2 127 Q8N448 Ligand of Numb protein X 2 LNX2 137 Q8N448 Ligand of Numb protein X 2 LNX2 307 Q8N448 Ligand of Numb protein X 2 LNX2 506 Q1L5Z9 LON peptidase N-terminal domain and RING finger protein 2 LONRF2 143 Q1L5Z9 LON peptidase N-terminal domain and RING finger protein 2 LONRF2 158 Q1L5Z9 LON peptidase N-terminal domain and RING finger protein 2 LONRF2 163 Q1L5Z9 LON peptidase N-terminal domain and RING finger protein 2 LONRF2 166 Q1L5Z9 LON peptidase N-terminal domain and RING finger protein 2 LONRF2 190 Q1L5Z9 LON peptidase N-terminal domain and RING finger protein 2 LONRF2 195 Q1L5Z9 LON peptidase N-terminal domain and RING finger protein 2 LONRF2 298 Q1L5Z9 LON peptidase N-terminal domain and RING finger protein 2 LONRF2 464 Q1L5Z9 LON peptidase N-terminal domain and RING finger protein 2 LONRF2 469 Q1L5Z9 LON peptidase N-terminal domain and RING finger protein 2 LONRF2 543 Q1L5Z9 LON peptidase N-terminal domain and RING finger protein 2 LONRF2 568 Q496Y0 LON peptidase N-terminal domain and RING finger protein 3 LONRF3 178 Q496Y0 LON peptidase N-terminal domain and RING finger protein 3 LONRF3 181 Q496Y0 LON peptidase N-terminal domain and RING finger protein 3 LONRF3 424 Q96L50 Leucine-rich repeat protein 1 LRR1 33 Q96L50 Leucine-rich repeat protein 1 LRR1 91 Q96L50 Leucine-rich repeat protein 1 LRR1 114 Q96L50 Leucine-rich repeat protein 1 LRR1 246 Q96L50 Leucine-rich repeat protein 1 LRR1 266 Q96L50 Leucine-rich repeat protein 1 LRR1 359 Q15345 Leucine-rich repeat-containing protein 41 LRRC41 123 Q15345 Leucine-rich repeat-containing protein 41 LRRC41 170 Q15345 Leucine-rich repeat-containing protein 41 LRRC41 266 Q15345 Leucine-rich repeat-containing protein 41 LRRC41 297 Q15345 Leucine-rich repeat-containing protein 41 LRRC41 481 Q15345 Leucine-rich repeat-containing protein 41 LRRC41 520 Q15345 Leucine-rich repeat-containing protein 41 LRRC41 607 Q15345 Leucine-rich repeat-containing protein 41 LRRC41 735 Q15345 Leucine-rich repeat-containing protein 41 LRRC41 743 Q6UWE0 E3 ubiquitin-protein ligase LRSAM1 LRSAM1 23 Q6UWE0 E3 ubiquitin-protein ligase LRSAM1 LRSAM1 39 Q6UWE0 E3 ubiquitin-protein ligase LRSAM1 LRSAM1 75 Q6UWE0 E3 ubiquitin-protein ligase LRSAM1 LRSAM1 193 Q6UWE0 E3 ubiquitin-protein ligase LRSAM1 LRSAM1 205 Q6UWE0 E3 ubiquitin-protein ligase LRSAM1 LRSAM1 397 Q6UWE0 E3 ubiquitin-protein ligase LRSAM1 LRSAM1 418 Q6UWE0 E3 ubiquitin-protein ligase LRSAM1 LRSAM1 699 Q6UWE0 E3 ubiquitin-protein ligase LRSAM1 LRSAM1 700 Q6UWE0 E3 ubiquitin-protein ligase LRSAM1 LRSAM1 706 Q6UWE0 E3 ubiquitin-protein ligase LRSAM1 LRSAM1 709 O94822 E3 ubiquitin-protein ligase listerin LTN1 91 O94822 E3 ubiquitin-protein ligase listerin LTN1 186 O94822 E3 ubiquitin-protein ligase listerin LTN1 227 O94822 E3 ubiquitin-protein ligase listerin LTN1 237 O94822 E3 ubiquitin-protein ligase listerin LTN1 498 O94822 E3 ubiquitin-protein ligase listerin LTN1 555 O94822 E3 ubiquitin-protein ligase listerin LTN1 595 O94822 E3 ubiquitin-protein ligase listerin LTN1 723 O94822 E3 ubiquitin-protein ligase listerin LTN1 751 O94822 E3 ubiquitin-protein ligase listerin LTN1 753 O94822 E3 ubiquitin-protein ligase listerin LTN1 869 O94822 E3 ubiquitin-protein ligase listerin LTN1 981 O94822 E3 ubiquitin-protein ligase listerin LTN1 999 O94822 E3 ubiquitin-protein ligase listerin LTN1 1131 O94822 E3 ubiquitin-protein ligase listerin LTN1 1146 O94822 E3 ubiquitin-protein ligase listerin LTN1 1159 O94822 E3 ubiquitin-protein ligase listerin LTN1 1174 O94822 E3 ubiquitin-protein ligase listerin LTN1 1565 O94822 E3 ubiquitin-protein ligase listerin LTN1 1745 O94822 E3 ubiquitin-protein ligase listerin LTN1 1758 O94822 E3 ubiquitin-protein ligase listerin LTN1 1761 Q8N653 Leucine-zipper-like transcriptional regulator 1 LZTR1 34 Q8N653 Leucine-zipper-like transcriptional regulator 1 LZTR1 106 Q8N653 Leucine-zipper-like transcriptional regulator 1 LZTR1 228 Q8N653 Leucine-zipper-like transcriptional regulator 1 LZTR1 229 Q8N653 Leucine-zipper-like transcriptional regulator 1 LZTR1 236 Q8N653 Leucine-zipper-like transcriptional regulator 1 LZTR1 342 Q8N653 Leucine-zipper-like transcriptional regulator 1 LZTR1 423 Q8N653 Leucine-zipper-like transcriptional regulator 1 LZTR1 427 Q8N653 Leucine-zipper-like transcriptional regulator 1 LZTR1 760 Q13233 Mitogen-activated protein kinase kinase kinase 1 MAP3K1 193 Q13233 Mitogen-activated protein kinase kinase kinase 1 MAP3K1 491 Q13233 Mitogen-activated protein kinase kinase kinase 1 MAP3K1 691 Q13233 Mitogen-activated protein kinase kinase kinase 1 MAP3K1 916 Q13233 Mitogen-activated protein kinase kinase kinase 1 MAP3K1 1012 Q13233 Mitogen-activated protein kinase kinase kinase 1 MAP3K1 1033 Q13233 Mitogen-activated protein kinase kinase kinase 1 MAP3K1 1257 Q13233 Mitogen-activated protein kinase kinase kinase 1 MAP3K1 1314 Q13233 Mitogen-activated protein kinase kinase kinase 1 MAP3K1 1488 Q8TCQ1 E3 ubiquitin-protein ligase MARCH1 MARCH1 73 Q8TCQ1 E3 ubiquitin-protein ligase MARCH1 MARCH1 85 Q8TCQ1 E3 ubiquitin-protein ligase MARCH1 MARCH1 97 Q8TCQ1 E3 ubiquitin-protein ligase MARCH1 MARCH1 99 Q8TCQ1 E3 ubiquitin-protein ligase MARCH1 MARCH1 241 Q8TCQ1 E3 ubiquitin-protein ligase MARCH1 MARCH1 254 Q86UD3 E3 ubiquitin-protein ligase MARCH3 MARCH3 6 Q9NX47 E3 ubiquitin-protein ligase MARCH5 MARCH5 17 Q9NX47 E3 ubiquitin-protein ligase MARCH5 MARCH5 33 Q9NX47 E3 ubiquitin-protein ligase MARCH5 MARCH5 46 Q9NX47 E3 ubiquitin-protein ligase MARCH5 MARCH5 65 Q9NX47 E3 ubiquitin-protein ligase MARCH5 MARCH5 68 Q9NX47 E3 ubiquitin-protein ligase MARCH5 MARCH5 188 O60337 E3 ubiquitin-protein ligase MARCH6 MARCH6 26 O60337 E3 ubiquitin-protein ligase MARCH6 MARCH6 28 O60337 E3 ubiquitin-protein ligase MARCH6 MARCH6 39 O60337 E3 ubiquitin-protein ligase MARCH6 MARCH6 52 Q9H992 E3 ubiquitin-protein ligase MARCH7 MARCH7 96 Q9H992 E3 ubiquitin-protein ligase MARCH7 MARCH7 99 Q9H992 E3 ubiquitin-protein ligase MARCH7 MARCH7 394 Q9H992 E3 ubiquitin-protein ligase MARCH7 MARCH7 552 Q9H992 E3 ubiquitin-protein ligase MARCH7 MARCH7 555 Q9H992 E3 ubiquitin-protein ligase MARCH7 MARCH7 570 Q9H992 E3 ubiquitin-protein ligase MARCH7 MARCH7 572 Q9H992 E3 ubiquitin-protein ligase MARCH7 MARCH7 583 Q9H992 E3 ubiquitin-protein ligase MARCH7 MARCH7 604 Q9H992 E3 ubiquitin-protein ligase MARCH7 MARCH7 607 Q00987 E3 ubiquitin-protein ligase Mdm2 MDM2 77 Q00987 E3 ubiquitin-protein ligase Mdm2 MDM2 206 Q00987 E3 ubiquitin-protein ligase Mdm2 MDM2 207 Q00987 E3 ubiquitin-protein ligase Mdm2 MDM2 362 Q00987 E3 ubiquitin-protein ligase Mdm2 MDM2 449 Q00987 E3 ubiquitin-protein ligase Mdm2 MDM2 464 Q00987 E3 ubiquitin-protein ligase Mdm2 MDM2 475 Q00987 E3 ubiquitin-protein ligase Mdm2 MDM2 478 O15151 Protein Mdm4 MDM4 165 O15151 Protein Mdm4 MDM4 362 O15151 Protein Mdm4 MDM4 463 Q96G25 Mediator of RNA polymerase II transcription subunit 8 MED8 31 Q96G25 Mediator of RNA polymerase II transcription subunit 8 MED8 147 A1L020 RNA-binding protein MEX3A MEX3A 21 A1L020 RNA-binding protein MEX3A MEX3A 116 A1L020 RNA-binding protein MEX3A MEX3A 135 A1L020 RNA-binding protein MEX3A MEX3A 328 A1L020 RNA-binding protein MEX3A MEX3A 341 A1L020 RNA-binding protein MEX3A MEX3A 505 A1L020 RNA-binding protein MEX3A MEX3A 508 Q6ZN04 RNA-binding protein MEX3B MEX3B 438 Q5U5Q3 RNA-binding E3 ubiquitin-protein ligase MEX3C MEX3C 235 Q5U5Q3 RNA-binding E3 ubiquitin-protein ligase MEX3C MEX3C 319 Q5U5Q3 RNA-binding E3 ubiquitin-protein ligase MEX3C MEX3C 647 Q86XN8 RNA-binding protein MEX3D MEX3D 362 Q86XN8 RNA-binding protein MEX3D MEX3D 488 Q86XN8 RNA-binding protein MEX3D MEX3D 636 Q86XN8 RNA-binding protein MEX3D MEX3D 639 O60291 E3 ubiquitin-protein ligase MGRN1 MGRN1 293 O60291 E3 ubiquitin-protein ligase MGRN1 MGRN1 299 O60291 E3 ubiquitin-protein ligase MGRN1 MGRN1 302 O60291 E3 ubiquitin-protein ligase MGRN1 MGRN1 313 O60291 E3 ubiquitin-protein ligase MGRN1 MGRN1 316 O60291 E3 ubiquitin-protein ligase MGRN1 MGRN1 356 O60291 E3 ubiquitin-protein ligase MGRN1 MGRN1 428 O60291 E3 ubiquitin-protein ligase MGRN1 MGRN1 528 Q86YT6 E3 ubiquitin-protein ligase MIB1 MIB1 85 Q86YT6 E3 ubiquitin-protein ligase MIB1 MIB1 88 Q86YT6 E3 ubiquitin-protein ligase MIB1 MIB1 112 Q86YT6 E3 ubiquitin-protein ligase MIB1 MIB1 217 Q86YT6 E3 ubiquitin-protein ligase MIB1 MIB1 342 Q86YT6 E3 ubiquitin-protein ligase MIB1 MIB1 757 Q86YT6 E3 ubiquitin-protein ligase MIB1 MIB1 786 Q86YT6 E3 ubiquitin-protein ligase MIB1 MIB1 843 Q86YT6 E3 ubiquitin-protein ligase MIB1 MIB1 869 Q86YT6 E3 ubiquitin-protein ligase MIB1 MIB1 913 Q86YT6 E3 ubiquitin-protein ligase MIB1 MIB1 963 Q86YT6 E3 ubiquitin-protein ligase MIB1 MIB1 966 Q86YT6 E3 ubiquitin-protein ligase MIB1 MIB1 985 Q86YT6 E3 ubiquitin-protein ligase MIB1 MIB1 995 Q96AX9 E3 ubiquitin-protein ligase MIB2 MIB2 152 Q96AX9 E3 ubiquitin-protein ligase MIB2 MIB2 323 Q96AX9 E3 ubiquitin-protein ligase MIB2 MIB2 905 Q96AX9 E3 ubiquitin-protein ligase MIB2 MIB2 911 Q96AX9 E3 ubiquitin-protein ligase MIB2 MIB2 924 Q96AX9 E3 ubiquitin-protein ligase MIB2 MIB2 969 Q96AX9 E3 ubiquitin-protein ligase MIB2 MIB2 972 Q96AX9 E3 ubiquitin-protein ligase MIB2 MIB2 988 Q96AX9 E3 ubiquitin-protein ligase MIB2 MIB2 991 O15344 E3 ubiquitin-protein ligase Midline-1 MID1 42 O15344 E3 ubiquitin-protein ligase Midline-1 MID1 119 O15344 E3 ubiquitin-protein ligase Midline-1 MID1 122 O15344 E3 ubiquitin-protein ligase Midline-1 MID1 134 O15344 E3 ubiquitin-protein ligase Midline-1 MID1 137 O15344 E3 ubiquitin-protein ligase Midline-1 MID1 142 O15344 E3 ubiquitin-protein ligase Midline-1 MID1 145 O15344 E3 ubiquitin-protein ligase Midline-1 MID1 248 O15344 E3 ubiquitin-protein ligase Midline-1 MID1 302 O15344 E3 ubiquitin-protein ligase Midline-1 MID1 578 O15344 E3 ubiquitin-protein ligase Midline-1 MID1 580 O15344 E3 ubiquitin-protein ligase Midline-1 MID1 647 O15344 E3 ubiquitin-protein ligase Midline-1 MID1 662 Q9UJV3 Probable E3 ubiquitin-protein ligase MID2 MID2 630 Q9UJV3 Probable E3 ubiquitin-protein ligase MID2 MID2 718 Q9UHC7 E3 ubiquitin-protein ligase makorin-1 MKRN1 69 Q9UHC7 E3 ubiquitin-protein ligase makorin-1 MKRN1 75 Q9UHC7 E3 ubiquitin-protein ligase makorin-1 MKRN1 98 Q9UHC7 E3 ubiquitin-protein ligase makorin-1 MKRN1 186 Q9UHC7 E3 ubiquitin-protein ligase makorin-1 MKRN1 214 Q9UHC7 E3 ubiquitin-protein ligase makorin-1 MKRN1 222 Q9UHC7 E3 ubiquitin-protein ligase makorin-1 MKRN1 259 Q9UHC7 E3 ubiquitin-protein ligase makorin-1 MKRN1 281 Q9UHC7 E3 ubiquitin-protein ligase makorin-1 MKRN1 284 Q9UHC7 E3 ubiquitin-protein ligase makorin-1 MKRN1 305 Q9UHC7 E3 ubiquitin-protein ligase makorin-1 MKRN1 310 Q9UHC7 E3 ubiquitin-protein ligase makorin-1 MKRN1 331 Q9UHC7 E3 ubiquitin-protein ligase makorin-1 MKRN1 334 Q9UHC7 E3 ubiquitin-protein ligase makorin-1 MKRN1 380 Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 16 Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 45 Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 133 Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 171 Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 185 Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 193 Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 216 Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 241 Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 262 Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 267 Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 270 Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 288 Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 291 Q9H000 Probable E3 ubiquitin-protein ligase makorin-2 MKRN2 337 Q13064 Probable E3 ubiquitin-protein ligase makorin-3 MKRN3 35 Q13064 Probable E3 ubiquitin-protein ligase makorin-3 MKRN3 244 P51948 CDK-activating kinase assembly factor MAT1 MNAT1 46 P51948 CDK-activating kinase assembly factor MAT1 MNAT1 49 P51948 CDK-activating kinase assembly factor MAT1 MNAT1 293 Q68DK7 Male-specific lethal 1 homolog MSL1 74 Q68DK7 Male-specific lethal 1 homolog MSL1 104 Q68DK7 Male-specific lethal 1 homolog MSL1 125 Q68DK7 Male-specific lethal 1 homolog MSL1 221 Q68DK7 Male-specific lethal 1 homolog MSL1 322 Q68DK7 Male-specific lethal 1 homolog MSL1 369 Q68DK7 Male-specific lethal 1 homolog MSL1 377 Q68DK7 Male-specific lethal 1 homolog MSL1 434 Q68DK7 Male-specific lethal 1 homolog MSL1 460 Q68DK7 Male-specific lethal 1 homolog MSL1 598 Q9HCI7 E3 ubiquitin-protein ligase MSL2 MSL2 62 Q9HCI7 E3 ubiquitin-protein ligase MSL2 MSL2 67 Q9HCI7 E3 ubiquitin-protein ligase MSL2 MSL2 107 Q9HCI7 E3 ubiquitin-protein ligase MSL2 MSL2 476 Q9HCI7 E3 ubiquitin-protein ligase MSL2 MSL2 483 Q9HCI7 E3 ubiquitin-protein ligase MSL2 MSL2 498 Q969V5 Mitochondrial ubiquitin ligase activator of NFKB 1 MUL1 113 Q969V5 Mitochondrial ubiquitin ligase activator of NFKB 1 MUL1 302 Q969V5 Mitochondrial ubiquitin ligase activator of NFKB 1 MUL1 305 Q969V5 Mitochondrial ubiquitin ligase activator of NFKB 1 MUL1 326 Q969V5 Mitochondrial ubiquitin ligase activator of NFKB 1 MUL1 336 Q969V5 Mitochondrial ubiquitin ligase activator of NFKB 1 MUL1 339 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 114 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 119 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 167 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 184 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 607 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 760 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 767 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 772 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 773 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 900 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 1064 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 1074 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 1111 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 1131 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 1427 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 1437 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 1459 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 1478 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 1868 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 1976 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 1995 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 2006 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 2131 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 2243 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 2531 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 2532 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 2568 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 2662 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 2898 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 2913 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 3152 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 3160 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 3225 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 3326 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 3354 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 3594 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 3786 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 3856 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 3932 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4074 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4181 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4318 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4355 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4375 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4390 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4408 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4437 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4440 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4506 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4520 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4537 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4540 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4549 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4600 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4614 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4631 O75592 E3 ubiquitin-protein ligase MYCBP2 MYCBP2 4634 Q9NPC7 Myoneurin MYNN 267 Q9NPC7 Myoneurin MYNN 342 Q9NPC7 Myoneurin MYNN 371 Q96RE7 Nucleus accumbens-associated protein 1 NACC1 30 Q96RE7 Nucleus accumbens-associated protein 1 NACC1 128 Q96RE7 Nucleus accumbens-associated protein 1 NACC1 178 Q96RE7 Nucleus accumbens-associated protein 1 NACC1 301 Q96RE7 Nucleus accumbens-associated protein 1 NACC1 387 Q96RE7 Nucleus accumbens-associated protein 1 NACC1 416 Q96RE7 Nucleus accumbens-associated protein 1 NACC1 444 Q96RE7 Nucleus accumbens-associated protein 1 NACC1 464 Q96BF6 Nucleus accumbens-associated protein 2 NACC2 310 Q96BF6 Nucleus accumbens-associated protein 2 NACC2 367 Q96BF6 Nucleus accumbens-associated protein 2 NACC2 393 P46934 E3 ubiquitin-protein ligase NEDD4 NEDD4 601 P46934 E3 ubiquitin-protein ligase NEDD4 NEDD4 1286 Q96PU5 E3 ubiquitin-protein ligase NEDD4-like NEDD4L 341 Q96PU5 E3 ubiquitin-protein ligase NEDD4-like NEDD4L 874 Q96PU5 E3 ubiquitin-protein ligase NEDD4-like NEDD4L 942 A8MQ27 E3 ubiquitin-protein ligase NEURL1B NEURL1B 119 A8MQ27 E3 ubiquitin-protein ligase NEURL1B NEURL1B 213 A8MQ27 E3 ubiquitin-protein ligase NEURL1B NEURL1B 300 A8MQ27 E3 ubiquitin-protein ligase NEURL1B NEURL1B 538 Q9BR09 Neuralized-like protein 2 NEURL2 78 Q96EH8 E3 ubiquitin-protein ligase NEURL3 NEURL3 141 Q96EH8 E3 ubiquitin-protein ligase NEURL3 NEURL3 202 Q96EH8 E3 ubiquitin-protein ligase NEURL3 NEURL3 223 Q12986 Transcriptional repressor NF-X1 NFX1 32 Q12986 Transcriptional repressor NF-X1 NFX1 54 Q12986 Transcriptional repressor NF-X1 NFX1 92 Q12986 Transcriptional repressor NF-X1 NFX1 190 Q12986 Transcriptional repressor NF-X1 NFX1 295 Q12986 Transcriptional repressor NF-X1 NFX1 315 Q12986 Transcriptional repressor NF-X1 NFX1 444 Q12986 Transcriptional repressor NF-X1 NFX1 477 Q12986 Transcriptional repressor NF-X1 NFX1 479 Q12986 Transcriptional repressor NF-X1 NFX1 542 Q12986 Transcriptional repressor NF-X1 NFX1 567 Q12986 Transcriptional repressor NF-X1 NFX1 572 Q12986 Transcriptional repressor NF-X1 NFX1 576 Q12986 Transcriptional repressor NF-X1 NFX1 581 Q12986 Transcriptional repressor NF-X1 NFX1 593 Q12986 Transcriptional repressor NF-X1 NFX1 596 Q12986 Transcriptional repressor NF-X1 NFX1 615 Q12986 Transcriptional repressor NF-X1 NFX1 622 Q12986 Transcriptional repressor NF-X1 NFX1 626 Q12986 Transcriptional repressor NF-X1 NFX1 632 Q12986 Transcriptional repressor NF-X1 NFX1 641 Q12986 Transcriptional repressor NF-X1 NFX1 645 Q12986 Transcriptional repressor NF-X1 NFX1 653 Q12986 Transcriptional repressor NF-X1 NFX1 661 Q12986 Transcriptional repressor NF-X1 NFX1 672 Q12986 Transcriptional repressor NF-X1 NFX1 684 Q12986 Transcriptional repressor NF-X1 NFX1 699 Q12986 Transcriptional repressor NF-X1 NFX1 703 Q12986 Transcriptional repressor NF-X1 NFX1 704 Q12986 Transcriptional repressor NF-X1 NFX1 711 Q12986 Transcriptional repressor NF-X1 NFX1 715 Q12986 Transcriptional repressor NF-X1 NFX1 730 Q12986 Transcriptional repressor NF-X1 NFX1 778 Q12986 Transcriptional repressor NF-X1 NFX1 795 Q12986 Transcriptional repressor NF-X1 NFX1 803 Q12986 Transcriptional repressor NF-X1 NFX1 815 Q12986 Transcriptional repressor NF-X1 NFX1 822 Q12986 Transcriptional repressor NF-X1 NFX1 826 Q12986 Transcriptional repressor NF-X1 NFX1 832 Q12986 Transcriptional repressor NF-X1 NFX1 841 Q12986 Transcriptional repressor NF-X1 NFX1 846 Q12986 Transcriptional repressor NF-X1 NFX1 852 Q12986 Transcriptional repressor NF-X1 NFX1 856 Q12986 Transcriptional repressor NF-X1 NFX1 867 Q12986 Transcriptional repressor NF-X1 NFX1 871 Q12986 Transcriptional repressor NF-X1 NFX1 877 Q12986 Transcriptional repressor NF-X1 NFX1 882 Q12986 Transcriptional repressor NF-X1 NFX1 890 Q12986 Transcriptional repressor NF-X1 NFX1 892 Q12986 Transcriptional repressor NF-X1 NFX1 901 Q12986 Transcriptional repressor NF-X1 NFX1 947 Q12986 Transcriptional repressor NF-X1 NFX1 1067 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 163 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 176 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 187 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 212 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 219 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 236 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 265 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 269 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 273 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 278 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 281 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 289 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 291 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 308 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 312 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 318 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 327 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 335 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 343 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 345 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 354 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 361 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 365 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 371 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 376 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 388 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 396 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 398 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 407 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 414 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 418 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 424 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 438 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 441 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 449 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 460 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 476 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 493 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 508 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 512 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 517 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 520 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 528 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 530 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 539 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 550 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 554 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 560 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 570 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 578 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 582 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 589 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 593 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 597 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 652 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 660 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 670 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 675 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 679 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 688 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 698 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 701 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 705 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 713 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 717 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 721 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 729 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 748 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 764 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 765 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 775 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 779 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 783 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 788 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 792 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 800 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 802 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 811 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 823 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 NFXL1 827 Q6VVB1 E3 ubiquitin-protein ligase NHLRC1 NHLRC1 262 Q9Y314 Nitric oxide synthase-interacting protein NOSIP 8 Q9Y314 Nitric oxide synthase-interacting protein NOSIP 45 Q9Y314 Nitric oxide synthase-interacting protein NOSIP 46 Q9Y314 Nitric oxide synthase-interacting protein NOSIP 47 Q9Y314 Nitric oxide synthase-interacting protein NOSIP 185 Q9Y314 Nitric oxide synthase-interacting protein NOSIP 223 Q9Y314 Nitric oxide synthase-interacting protein NOSIP 236 Q9Y314 Nitric oxide synthase-interacting protein NOSIP 250 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 38 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 44 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 144 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 207 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 238 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 294 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 394 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 406 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 464 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 594 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 682 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 686 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 687 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 707 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 710 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 717 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 720 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 730 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 735 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 743 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 759 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 764 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 788 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 813 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 846 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 849 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 899 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1016 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1018 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1026 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1032 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1046 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1052 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1056 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1102 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1144 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1148 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1167 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1183 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1193 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1198 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1242 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1245 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1254 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1267 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1296 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1315 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1323 O96028 Histone-lysine N-methyltransferase NSD2 NSD2 1324 Q8WV22 Non-structural maintenance of chromosomes element 1 NSMCE1 40 homolog Q8WV22 Non-structural maintenance of chromosomes element 1 NSMCE1 215 homolog Q8WV22 Non-structural maintenance of chromosomes element 1 NSMCE1 228 homolog Q96MF7 E3 SUMO-protein ligase NSE2 NSMCE2 140 Q96MF7 E3 SUMO-protein ligase NSE2 NSMCE2 169 Q96MF7 E3 SUMO-protein ligase NSE2 NSMCE2 185 Q96MF7 E3 SUMO-protein ligase NSE2 NSMCE2 210 Q96MF7 E3 SUMO-protein ligase NSE2 NSMCE2 215 Q86WC4 Osteopetrosis-associated transmembrane protein 1 OSTM1 112 Q8TE49 OTU domain-containing protein 7A OTUD7A 210 Q6GQQ9 OTU domain-containing protein 7B OTUD7B 133 Q6GQQ9 OTU domain-containing protein 7B OTUD7B 194 Q6GQQ9 OTU domain-containing protein 7B OTUD7B 345 Q6GQQ9 OTU domain-containing protein 7B OTUD7B 708 Q6GQQ9 OTU domain-containing protein 7B OTUD7B 720 Q6GQQ9 OTU domain-containing protein 7B OTUD7B 734 Q6GQQ9 OTU domain-containing protein 7B OTUD7B 807 Q6GQQ9 OTU domain-containing protein 7B OTUD7B 819 Q6GQQ9 OTU domain-containing protein 7B OTUD7B 821 Q6GQQ9 OTU domain-containing protein 7B OTUD7B 822 Q9HBE1 POZ-, AT hook-, and zinc finger-containing protein 1 PATZ1 9 Q9HBE1 POZ-, AT hook-, and zinc finger-containing protein 1 PATZ1 41 Q9HBE1 POZ-, AT hook-, and zinc finger-containing protein 1 PATZ1 497 Q9HBE1 POZ-, AT hook-, and zinc finger-containing protein 1 PATZ1 500 Q9HBE1 POZ-, AT hook-, and zinc finger-containing protein 1 PATZ1 541 Q9HBE1 POZ-, AT hook-, and zinc finger-containing protein 1 PATZ1 588 Q15366 Poly(rC)-binding protein 2 PCBP2 54 Q15366 Poly(rC)-binding protein 2 PCBP2 109 Q15366 Poly(rC)-binding protein 2 PCBP2 118 Q15366 Poly(rC)-binding protein 2 PCBP2 158 Q15366 Poly(rC)-binding protein 2 PCBP2 163 Q15366 Poly(rC)-binding protein 2 PCBP2 217 Q15366 Poly(rC)-binding protein 2 PCBP2 301 P35227 Polycomb group RING finger protein 2 PCGF2 53 P35227 Polycomb group RING finger protein 2 PCGF2 56 P35227 Polycomb group RING finger protein 2 PCGF2 168 P35227 Polycomb group RING finger protein 2 PCGF2 233 Q3KNV8 Polycomb group RING finger protein 3 PCGF3 20 Q3KNV8 Polycomb group RING finger protein 3 PCGF3 113 Q86SE9 Polycomb group RING finger protein 5 PCGF5 21 Q86SE9 Polycomb group RING finger protein 5 PCGF5 39 Q86SE9 Polycomb group RING finger protein 5 PCGF5 42 Q86SE9 Polycomb group RING finger protein 5 PCGF5 53 Q86SE9 Polycomb group RING finger protein 5 PCGF5 145 Q9BYE7 Polycomb group RING finger protein 6 PCGF6 56 Q9BYE7 Polycomb group RING finger protein 6 PCGF6 137 Q9BYE7 Polycomb group RING finger protein 6 PCGF6 155 Q96JY6 PDZ and LIM domain protein 2 PDLIM2 160 Q96JY6 PDZ and LIM domain protein 2 PDLIM2 286 Q96JY6 PDZ and LIM domain protein 2 PDLIM2 289 Q96JY6 PDZ and LIM domain protein 2 PDLIM2 310 Q96JY6 PDZ and LIM domain protein 2 PDLIM2 313 Q96JY6 PDZ and LIM domain protein 2 PDLIM2 334 Q9UPQ7 E3 ubiquitin-protein ligase PDZRN3 PDZRN3 105 Q9UPQ7 E3 ubiquitin-protein ligase PDZRN3 PDZRN3 117 Q9UPQ7 E3 ubiquitin-protein ligase PDZRN3 PDZRN3 142 Q9UPQ7 E3 ubiquitin-protein ligase PDZRN3 PDZRN3 161 Q9UPQ7 E3 ubiquitin-protein ligase PDZRN3 PDZRN3 162 Q9UPQ7 E3 ubiquitin-protein ligase PDZRN3 PDZRN3 233 Q6ZMN7 PDZ domain-containing RING finger protein 4 PDZRN4 802 Q96FA3 E3 ubiquitin-protein ligase pellino homolog 1 PELI1 61 Q96FA3 E3 ubiquitin-protein ligase pellino homolog 1 PELI1 212 Q96FA3 E3 ubiquitin-protein ligase pellino homolog 1 PELI1 282 Q9HAT8 E3 ubiquitin-protein ligase pellino homolog 2 PELI2 284 Q9HAT8 E3 ubiquitin-protein ligase pellino homolog 2 PELI2 351 Q9HAT8 E3 ubiquitin-protein ligase pellino homolog 2 PELI2 373 O60683 Peroxisome biogenesis factor 10 PEX10 138 O60683 Peroxisome biogenesis factor 10 PEX10 276 O60683 Peroxisome biogenesis factor 10 PEX10 307 O00623 Peroxisome assembly protein 12 PEX12 307 O00623 Peroxisome assembly protein 12 PEX12 339 Q9BUL5 PHD finger protein 23 PHF23 359 Q9BUL5 PHD finger protein 23 PHF23 367 Q9BUL5 PHD finger protein 23 PHF23 381 Q9BUL5 PHD finger protein 23 PHF23 384 Q9P1Y6 PHD and RING finger domain-containing protein 1 PHRF1 126 Q9P1Y6 PHD and RING finger domain-containing protein 1 PHRF1 131 Q9P1Y6 PHD and RING finger domain-containing protein 1 PHRF1 145 Q9P1Y6 PHD and RING finger domain-containing protein 1 PHRF1 407 Q9P1Y6 PHD and RING finger domain-containing protein 1 PHRF1 558 Q9P1Y6 PHD and RING finger domain-containing protein 1 PHRF1 585 Q9P1Y6 PHD and RING finger domain-containing protein 1 PHRF1 658 Q9P1Y6 PHD and RING finger domain-containing protein 1 PHRF1 710 Q9P1Y6 PHD and RING finger domain-containing protein 1 PHRF1 797 Q9P1Y6 PHD and RING finger domain-containing protein 1 PHRF1 878 Q9P1Y6 PHD and RING finger domain-containing protein 1 PHRF1 949 Q9P1Y6 PHD and RING finger domain-containing protein 1 PHRF1 962 Q9P1Y6 PHD and RING finger domain-containing protein 1 PHRF1 1123 O75925 E3 SUMO-protein ligase PIAS1 PIAS1 49 O75925 E3 SUMO-protein ligase PIAS1 PIAS1 220 O75925 E3 SUMO-protein ligase PIAS1 PIAS1 228 O75925 E3 SUMO-protein ligase PIAS1 PIAS1 335 O75925 E3 SUMO-protein ligase PIAS1 PIAS1 346 O75925 E3 SUMO-protein ligase PIAS1 PIAS1 374 O75925 E3 SUMO-protein ligase PIAS1 PIAS1 377 O75925 E3 SUMO-protein ligase PIAS1 PIAS1 399 O75925 E3 SUMO-protein ligase PIAS1 PIAS1 402 O75925 E3 SUMO-protein ligase PIAS1 PIAS1 435 O75925 E3 SUMO-protein ligase PIAS1 PIAS1 481 O75928 E3 SUMO-protein ligase PIAS2 PIAS2 49 O75928 E3 SUMO-protein ligase PIAS2 PIAS2 192 O75928 E3 SUMO-protein ligase PIAS2 PIAS2 220 O75928 E3 SUMO-protein ligase PIAS2 PIAS2 231 O75928 E3 SUMO-protein ligase PIAS2 PIAS2 346 O75928 E3 SUMO-protein ligase PIAS2 PIAS2 357 O75928 E3 SUMO-protein ligase PIAS2 PIAS2 362 O75928 E3 SUMO-protein ligase PIAS2 PIAS2 385 O75928 E3 SUMO-protein ligase PIAS2 PIAS2 388 O75928 E3 SUMO-protein ligase PIAS2 PIAS2 441 O75928 E3 SUMO-protein ligase PIAS2 PIAS2 454 O75928 E3 SUMO-protein ligase PIAS2 PIAS2 490 Q9Y6X2 E3 SUMO-protein ligase PIAS3 PIAS3 49 Q9Y6X2 E3 SUMO-protein ligase PIAS3 PIAS3 184 Q9Y6X2 E3 SUMO-protein ligase PIAS3 PIAS3 327 Q9Y6X2 E3 SUMO-protein ligase PIAS3 PIAS3 338 Q9Y6X2 E3 SUMO-protein ligase PIAS3 PIAS3 418 Q9Y6X2 E3 SUMO-protein ligase PIAS3 PIAS3 468 Q9Y6X2 E3 SUMO-protein ligase PIAS3 PIAS3 582 Q9Y6X2 E3 SUMO-protein ligase PIAS3 PIAS3 620 Q8N2W9 E3 SUMO-protein ligase PIAS4 PIAS4 50 Q8N2W9 E3 SUMO-protein ligase PIAS4 PIAS4 164 Q8N2W9 E3 SUMO-protein ligase PIAS4 PIAS4 221 Q8N2W9 E3 SUMO-protein ligase PIAS4 PIAS4 299 Q8N2W9 E3 SUMO-protein ligase PIAS4 PIAS4 326 Q8N2W9 E3 SUMO-protein ligase PIAS4 PIAS4 337 Q8N2W9 E3 SUMO-protein ligase PIAS4 PIAS4 365 Q8N2W9 E3 SUMO-protein ligase PIAS4 PIAS4 368 Q8N2W9 E3 SUMO-protein ligase PIAS4 PIAS4 500 Q8NG27 E3 ubiquitin-protein ligase Praja-1 PJA1 241 Q8NG27 E3 ubiquitin-protein ligase Praja-1 PJA1 268 Q8NG27 E3 ubiquitin-protein ligase Praja-1 PJA1 361 Q8NG27 E3 ubiquitin-protein ligase Praja-1 PJA1 632 Q8NG27 E3 ubiquitin-protein ligase Praja-1 PJA1 635 O43164 E3 ubiquitin-protein ligase Praja-2 PJA2 48 O43164 E3 ubiquitin-protein ligase Praja-2 PJA2 224 O43164 E3 ubiquitin-protein ligase Praja-2 PJA2 288 O43164 E3 ubiquitin-protein ligase Praja-2 PJA2 294 O43164 E3 ubiquitin-protein ligase Praja-2 PJA2 671 O43164 E3 ubiquitin-protein ligase Praja-2 PJA2 674 P29590 Protein PML PML 57 P29590 Protein PML PML 60 P29590 Protein PML PML 72 P29590 Protein PML PML 77 P29590 Protein PML PML 80 P29590 Protein PML PML 129 P29590 Protein PML PML 132 P29590 Protein PML PML 140 P29590 Protein PML PML 143 P29590 Protein PML PML 148 P29590 Protein PML PML 151 P29590 Protein PML PML 189 P29590 Protein PML PML 204 P29590 Protein PML PML 207 P29590 Protein PML PML 212 P29590 Protein PML PML 213 P29590 Protein PML PML 215 P29590 Protein PML PML 227 P29590 Protein PML PML 338 P29590 Protein PML PML 389 P29590 Protein PML PML 479 P29590 Protein PML PML 484 P29590 Protein PML PML 676 Q13356 RING-type E3 ubiquitin-protein ligase PPIL2 PPIL2 15 Q13356 RING-type E3 ubiquitin-protein ligase PPIL2 PPIL2 103 Q13356 RING-type E3 ubiquitin-protein ligase PPIL2 PPIL2 304 Q13356 RING-type E3 ubiquitin-protein ligase PPIL2 PPIL2 387 O60260 E3 ubiquitin-protein ligase parkin PRKN 293 Q9UMS4 Pre-mRNA-processing factor 19 PRPF19 114 Q9UMS4 Pre-mRNA-processing factor 19 PRPF19 230 Q9UMS4 Pre-mRNA-processing factor 19 PRPF19 298 Q9UMS4 Pre-mRNA-processing factor 19 PRPF19 351 Q9UMS4 Pre-mRNA-processing factor 19 PRPF19 355 Q9UJ41 Rab5 GDP/GTP exchange factor RABGEF1 157 Q9UJ41 Rab5 GDP/GTP exchange factor RABGEF1 161 Q9UJ41 Rab5 GDP/GTP exchange factor RABGEF1 173 Q9UJ41 Rab5 GDP/GTP exchange factor RABGEF1 176 Q9UJ41 Rab5 GDP/GTP exchange factor RABGEF1 359 Q9UJ41 Rab5 GDP/GTP exchange factor RABGEF1 442 Q9UJ41 Rab5 GDP/GTP exchange factor RABGEF1 471 Q9UJ41 Rab5 GDP/GTP exchange factor RABGEF1 507 Q9UJ41 Rab5 GDP/GTP exchange factor RABGEF1 559 Q9UJ41 Rab5 GDP/GTP exchange factor RABGEF1 621 Q9NS91 E3 ubiquitin-protein ligase RAD18 RAD18 63 Q9NS91 E3 ubiquitin-protein ligase RAD18 RAD18 64 Q9NS91 E3 ubiquitin-protein ligase RAD18 RAD18 207 Q9NS91 E3 ubiquitin-protein ligase RAD18 RAD18 223 Q9NS91 E3 ubiquitin-protein ligase RAD18 RAD18 289 Q9NS91 E3 ubiquitin-protein ligase RAD18 RAD18 388 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 50 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 82 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 105 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 141 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 188 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 206 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 220 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 348 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 503 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 514 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 520 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 524 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 536 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 581 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 707 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 815 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1196 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1243 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1296 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1335 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1358 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1361 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1372 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1375 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1421 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1424 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1435 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1438 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1485 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1488 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1499 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1502 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1549 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1552 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1563 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1566 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1612 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1615 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1626 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1629 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1744 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1747 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1749 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1787 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1790 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1791 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1801 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 1804 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 2084 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 2142 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 2381 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 2407 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 2464 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 2577 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 2659 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 2696 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 2710 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 2737 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 2740 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 2791 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 2982 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 3032 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 3040 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 3071 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 3100 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 3122 P49792 E3 SUMO-protein ligase RanBP2 RANBP2 3221 Q7Z6E9 E3 ubiquitin-protein ligase RBBP6 RBBP6 27 Q7Z6E9 E3 ubiquitin-protein ligase RBBP6 RBBP6 44 Q7Z6E9 E3 ubiquitin-protein ligase RBBP6 RBBP6 161 Q7Z6E9 E3 ubiquitin-protein ligase RBBP6 RBBP6 164 Q7Z6E9 E3 ubiquitin-protein ligase RBBP6 RBBP6 174 Q7Z6E9 E3 ubiquitin-protein ligase RBBP6 RBBP6 296 Q7Z6E9 E3 ubiquitin-protein ligase RBBP6 RBBP6 299 Q7Z6E9 E3 ubiquitin-protein ligase RBBP6 RBBP6 1566 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 30 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 199 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 216 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 217 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 285 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 300 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 305 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 308 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 323 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 371 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 394 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 411 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 447 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 450 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 460 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1 502 P62877 E3 ubiquitin-protein ligase RBX1 RBX1 42 P62877 E3 ubiquitin-protein ligase RBX1 RBX1 94 Q5TC82 Roquin-1 RC3H1 87 Q5TC82 Roquin-1 RC3H1 102 Q5TC82 Roquin-1 RC3H1 434 Q5TC82 Roquin-1 RC3H1 815 Q5TC82 Roquin-1 RC3H1 1049 Q9HBD1 Roquin-2 RC3H2 425 Q9HBD1 Roquin-2 RC3H2 747 Q9HBD1 Roquin-2 RC3H2 764 Q9HBD1 Roquin-2 RC3H2 771 Q8NDN9 RCC1 and BTB domain-containing protein 1 RCBTB1 72 Q8NDN9 RCC1 and BTB domain-containing protein 1 RCBTB1 177 Q8NDN9 RCC1 and BTB domain-containing protein 1 RCBTB1 392 O95199 RCC1 and BTB domain-containing protein 2 RCBTB2 201 O95199 RCC1 and BTB domain-containing protein 2 RCBTB2 416 O95199 RCC1 and BTB domain-containing protein 2 RCBTB2 488 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 20 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 27 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 33 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 43 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 65 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 102 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 105 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 108 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 119 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 125 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 136 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 145 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 148 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 164 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 172 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 183 Q96PM5 RING finger and CHY zinc finger domain-containing protein 1 RCHY1 186 Q8WZ73 E3 ubiquitin-protein ligase rififylin RFFL 47 Q8WZ73 E3 ubiquitin-protein ligase rififylin RFFL 50 Q8WZ73 E3 ubiquitin-protein ligase rififylin RFFL 66 Q8WZ73 E3 ubiquitin-protein ligase rififylin RFFL 71 Q8WZ73 E3 ubiquitin-protein ligase rififylin RFFL 74 Q8WZ73 E3 ubiquitin-protein ligase rififylin RFFL 85 Q8WZ73 E3 ubiquitin-protein ligase rififylin RFFL 123 Q8WZ73 E3 ubiquitin-protein ligase rififylin RFFL 272 Q8WZ73 E3 ubiquitin-protein ligase rififylin RFFL 273 Q8WZ73 E3 ubiquitin-protein ligase rififylin RFFL 319 Q8WZ73 E3 ubiquitin-protein ligase rififylin RFFL 337 Q6PCD5 E3 ubiquitin-protein ligase RFWD3 RFWD3 307 Q6PCD5 E3 ubiquitin-protein ligase RFWD3 RFWD3 315 Q6PCD5 E3 ubiquitin-protein ligase RFWD3 RFWD3 327 Q6PCD5 E3 ubiquitin-protein ligase RFWD3 RFWD3 330 Q6PCD5 E3 ubiquitin-protein ligase RFWD3 RFWD3 379 Q6PCD5 E3 ubiquitin-protein ligase RFWD3 RFWD3 424 Q6PCD5 E3 ubiquitin-protein ligase RFWD3 RFWD3 450 Q6PCD5 E3 ubiquitin-protein ligase RFWD3 RFWD3 586 Q6PCD5 E3 ubiquitin-protein ligase RFWD3 RFWD3 696 Q06587 E3 ubiquitin-protein ligase RING1 RING1 48 Q06587 E3 ubiquitin-protein ligase RING1 RING1 51 Q06587 E3 ubiquitin-protein ligase RING1 RING1 69 Q06587 E3 ubiquitin-protein ligase RING1 RING1 72 Q06587 E3 ubiquitin-protein ligase RING1 RING1 84 Q06587 E3 ubiquitin-protein ligase RING1 RING1 87 Q06587 E3 ubiquitin-protein ligase RING1 RING1 279 Q06587 E3 ubiquitin-protein ligase RING1 RING1 332 Q06587 E3 ubiquitin-protein ligase RING1 RING1 398 Q9NVW2 E3 ubiquitin-protein ligase RLIM RLIM 570 Q9NVW2 E3 ubiquitin-protein ligase RLIM RLIM 573 Q9NVW2 E3 ubiquitin-protein ligase RLIM RLIM 588 Q9NVW2 E3 ubiquitin-protein ligase RLIM RLIM 596 Q8N5U6 RING finger protein 10 RNF10 218 Q8N5U6 RING finger protein 10 RNF10 225 Q8N5U6 RING finger protein 10 RNF10 228 Q8N5U6 RING finger protein 10 RNF10 366 Q8N5U6 RING finger protein 10 RNF10 483 Q8N5U6 RING finger protein 10 RNF10 650 Q6ZNA4 E3 ubiquitin-protein ligase Arkadia RNF111 68 Q6ZNA4 E3 ubiquitin-protein ligase Arkadia RNF111 108 Q6ZNA4 E3 ubiquitin-protein ligase Arkadia RNF111 201 Q6ZNA4 E3 ubiquitin-protein ligase Arkadia RNF111 592 Q6ZNA4 E3 ubiquitin-protein ligase Arkadia RNF111 905 Q6ZNA4 E3 ubiquitin-protein ligase Arkadia RNF111 979 Q6ZNA4 E3 ubiquitin-protein ligase Arkadia RNF111 982 Q9ULX5 RING finger protein 112 RNF112 77 O15541 RING finger protein 113A RNF113A 15 O15541 RING finger protein 113A RNF113A 36 O15541 RING finger protein 113A RNF113A 51 O15541 RING finger protein 113A RNF113A 202 O15541 RING finger protein 113A RNF113A 282 O15541 RING finger protein 113A RNF113A 285 O15541 RING finger protein 113A RNF113A 296 O15541 RING finger protein 113A RNF113A 299 Q8IZP6 RING finger protein 113B RNF113B 196 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 8 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 29 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 32 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 44 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 49 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 52 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 56 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 64 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 67 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 91 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 94 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 110 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 143 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 146 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 160 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 173 Q9Y508 E3 ubiquitin-protein ligase RNF114 RNF114 176 Q9H920 RING finger protein 121 RNF121 251 Q9H920 RING finger protein 121 RNF121 264 Q9H920 RING finger protein 121 RNF121 272 Q9H920 RING finger protein 121 RNF121 275 Q5XPI4 E3 ubiquitin-protein ligase RNF123 RNF123 461 Q5XPI4 E3 ubiquitin-protein ligase RNF123 RNF123 977 Q5XPI4 E3 ubiquitin-protein ligase RNF123 RNF123 1180 Q5XPI4 E3 ubiquitin-protein ligase RNF123 RNF123 1277 Q9BV68 E3 ubiquitin-protein ligase RNF126 RNF126 13 Q9BV68 E3 ubiquitin-protein ligase RNF126 RNF126 15 Q9BV68 E3 ubiquitin-protein ligase RNF126 RNF126 16 Q9BV68 E3 ubiquitin-protein ligase RNF126 RNF126 29 Q9BV68 E3 ubiquitin-protein ligase RNF126 RNF126 32 Q9BV68 E3 ubiquitin-protein ligase RNF126 RNF126 229 Q9BV68 E3 ubiquitin-protein ligase RNF126 RNF126 232 Q9BV68 E3 ubiquitin-protein ligase RNF126 RNF126 266 Q8TEB7 E3 ubiquitin-protein ligase RNF128 RNF128 295 Q8TEB7 E3 ubiquitin-protein ligase RNF128 RNF128 303 Q8TEB7 E3 ubiquitin-protein ligase RNF128 RNF128 314 Q8TEB7 E3 ubiquitin-protein ligase RNF128 RNF128 317 O43567 E3 ubiquitin-protein ligase RNF13 RNF13 258 O43567 E3 ubiquitin-protein ligase RNF13 RNF13 264 O43567 E3 ubiquitin-protein ligase RNF13 RNF13 266 O43567 E3 ubiquitin-protein ligase RNF13 RNF13 278 O43567 E3 ubiquitin-protein ligase RNF13 RNF13 281 Q86XS8 E3 ubiquitin-protein ligase RNF130 RNF130 320 Q8IUD6 E3 ubiquitin-protein ligase RNF135 RNF135 44 Q8IUD6 E3 ubiquitin-protein ligase RNF135 RNF135 59 Q8IUD6 E3 ubiquitin-protein ligase RNF135 RNF135 62 Q8IUD6 E3 ubiquitin-protein ligase RNF135 RNF135 101 Q8IUD6 E3 ubiquitin-protein ligase RNF135 RNF135 103 Q8IUD6 E3 ubiquitin-protein ligase RNF135 RNF135 238 Q8IUD6 E3 ubiquitin-protein ligase RNF135 RNF135 270 Q8WVD3 E3 ubiquitin-protein ligase RNF138 RNF138 39 Q8WVD3 E3 ubiquitin-protein ligase RNF138 RNF138 42 Q8WVD3 E3 ubiquitin-protein ligase RNF138 RNF138 54 Q8WVD3 E3 ubiquitin-protein ligase RNF138 RNF138 57 Q8WVD3 E3 ubiquitin-protein ligase RNF138 RNF138 68 Q8WVD3 E3 ubiquitin-protein ligase RNF138 RNF138 86 Q8WVD3 E3 ubiquitin-protein ligase RNF138 RNF138 159 Q8WVD3 E3 ubiquitin-protein ligase RNF138 RNF138 162 Q9UBS8 E3 ubiquitin-protein ligase RNF14 RNF14 57 Q9UBS8 E3 ubiquitin-protein ligase RNF14 RNF14 68 Q9UBS8 E3 ubiquitin-protein ligase RNF14 RNF14 223 Q9UBS8 E3 ubiquitin-protein ligase RNF14 RNF14 225 Q9UBS8 E3 ubiquitin-protein ligase RNF14 RNF14 246 Q9UBS8 E3 ubiquitin-protein ligase RNF14 RNF14 262 Q9UBS8 E3 ubiquitin-protein ligase RNF14 RNF14 270 Q9UBS8 E3 ubiquitin-protein ligase RNF14 RNF14 350 Q9UBS8 E3 ubiquitin-protein ligase RNF14 RNF14 404 Q9UBS8 E3 ubiquitin-protein ligase RNF14 RNF14 406 Q9UBS8 E3 ubiquitin-protein ligase RNF14 RNF14 407 Q9UBS8 E3 ubiquitin-protein ligase RNF14 RNF14 417 Q9UBS8 E3 ubiquitin-protein ligase RNF14 RNF14 453 Q8WVD5 RING finger protein 141 RNF141 169 Q8WVD5 RING finger protein 141 RNF141 174 Q8WVD5 RING finger protein 141 RNF141 177 Q8WVD5 RING finger protein 141 RNF141 191 Q7Z419 E3 ubiquitin-protein ligase RNF144B RNF144B 33 Q7Z419 E3 ubiquitin-protein ligase RNF144B RNF144B 35 Q7Z419 E3 ubiquitin-protein ligase RNF144B RNF144B 53 Q7Z419 E3 ubiquitin-protein ligase RNF144B RNF144B 56 Q7Z419 E3 ubiquitin-protein ligase RNF144B RNF144B 153 Q7Z419 E3 ubiquitin-protein ligase RNF144B RNF144B 155 Q7Z419 E3 ubiquitin-protein ligase RNF144B RNF144B 156 Q7Z419 E3 ubiquitin-protein ligase RNF144B RNF144B 166 Q7Z419 E3 ubiquitin-protein ligase RNF144B RNF144B 193 Q7Z419 E3 ubiquitin-protein ligase RNF144B RNF144B 196 Q7Z419 E3 ubiquitin-protein ligase RNF144B RNF144B 206 Q7Z419 E3 ubiquitin-protein ligase RNF144B RNF144B 240 Q9NTX7 E3 ubiquitin-protein ligase RNF146 RNF146 25 Q9NTX7 E3 ubiquitin-protein ligase RNF146 RNF146 37 Q9NTX7 E3 ubiquitin-protein ligase RNF146 RNF146 40 Q9NTX7 E3 ubiquitin-protein ligase RNF146 RNF146 57 Q9NTX7 E3 ubiquitin-protein ligase RNF146 RNF146 60 Q9NTX7 E3 ubiquitin-protein ligase RNF146 RNF146 185 Q9NTX7 E3 ubiquitin-protein ligase RNF146 RNF146 354 Q8N7C7 RING finger protein 148 RNF148 295 Q8N7C7 RING finger protein 148 RNF148 298 Q8NC42 E3 ubiquitin-protein ligase RNF149 RNF149 90 Q8NC42 E3 ubiquitin-protein ligase RNF149 RNF149 295 Q8NC42 E3 ubiquitin-protein ligase RNF149 RNF149 306 Q8NC42 E3 ubiquitin-protein ligase RNF149 RNF149 309 Q9ULK6 RING finger protein 150 RNF150 315 Q9ULK6 RING finger protein 150 RNF150 318 Q96PX1 E3 ubiquitin ligase RNF157 RNF157 100 Q96PX1 E3 ubiquitin ligase RNF157 RNF157 292 Q96PX1 E3 ubiquitin ligase RNF157 RNF157 312 Q96PX1 E3 ubiquitin ligase RNF157 RNF157 315 Q6ZSG1 E3 ubiquitin-protein ligase RNF165 RNF165 331 Q6ZSG1 E3 ubiquitin-protein ligase RNF165 RNF165 334 Q96A37 RING finger protein 166 RNF166 117 Q96A37 RING finger protein 166 RNF166 127 Q9H6Y7 E3 ubiquitin-protein ligase RNF167 RNF167 248 Q9H6Y7 E3 ubiquitin-protein ligase RNF167 RNF167 256 Q9H6Y7 E3 ubiquitin-protein ligase RNF167 RNF167 268 Q9H6Y7 E3 ubiquitin-protein ligase RNF167 RNF167 271 Q8IYW5 E3 ubiquitin-protein ligase RNF168 RNF168 50 Q8IYW5 E3 ubiquitin-protein ligase RNF168 RNF168 54 Q8IYW5 E3 ubiquitin-protein ligase RNF168 RNF168 190 Q8IYW5 E3 ubiquitin-protein ligase RNF168 RNF168 326 Q8IYW5 E3 ubiquitin-protein ligase RNF168 RNF168 348 Q8IYW5 E3 ubiquitin-protein ligase RNF168 RNF168 355 Q8IYW5 E3 ubiquitin-protein ligase RNF168 RNF168 402 Q8NCN4 E3 ubiquitin-protein ligase RNF169 RNF169 28 Q8NCN4 E3 ubiquitin-protein ligase RNF169 RNF169 103 Q8NCN4 E3 ubiquitin-protein ligase RNF169 RNF169 132 Q8NCN4 E3 ubiquitin-protein ligase RNF169 RNF169 293 Q8NCN4 E3 ubiquitin-protein ligase RNF169 RNF169 337 Q8NCN4 E3 ubiquitin-protein ligase RNF169 RNF169 387 Q8NCN4 E3 ubiquitin-protein ligase RNF169 RNF169 390 Q8NCN4 E3 ubiquitin-protein ligase RNF169 RNF169 529 Q8NCN4 E3 ubiquitin-protein ligase RNF169 RNF169 530 Q8NCN4 E3 ubiquitin-protein ligase RNF169 RNF169 563 Q9BXT8 RING finger protein 17 RNF17 1356 Q9BXT8 RING finger protein 17 RNF17 1530 Q8N4F7 RING finger protein 175 RNF175 265 Q8N4F7 RING finger protein 175 RNF175 273 Q8N4F7 RING finger protein 175 RNF175 276 Q9P0P0 E3 ubiquitin-protein ligase RNF181 RNF181 94 Q96GF1 E3 ubiquitin-protein ligase RNF185 RNF185 76 Q96GF1 E3 ubiquitin-protein ligase RNF185 RNF185 79 Q9NXI6 RING finger protein 186 RNF186 97 Q5TA31 E3 ubiquitin-protein ligase RNF187 RNF187 27 Q5TA31 E3 ubiquitin-protein ligase RNF187 RNF187 97 Q5TA31 E3 ubiquitin-protein ligase RNF187 RNF187 105 Q5TA31 E3 ubiquitin-protein ligase RNF187 RNF187 108 Q9NV58 E3 ubiquitin-protein ligase RNF19A RNF19A 179 Q9NV58 E3 ubiquitin-protein ligase RNF19A RNF19A 246 Q9NV58 E3 ubiquitin-protein ligase RNF19A RNF19A 264 Q9NV58 E3 ubiquitin-protein ligase RNF19A RNF19A 301 Q9NV58 E3 ubiquitin-protein ligase RNF19A RNF19A 460 Q9NV58 E3 ubiquitin-protein ligase RNF19A RNF19A 743 Q6ZMZ0 E3 ubiquitin-protein ligase RNF19B RNF19B 137 Q6ZMZ0 E3 ubiquitin-protein ligase RNF19B RNF19B 251 Q6ZMZ0 E3 ubiquitin-protein ligase RNF19B RNF19B 290 Q6ZMZ0 E3 ubiquitin-protein ligase RNF19B RNF19B 446 Q6ZMZ0 E3 ubiquitin-protein ligase RNF19B RNF19B 695 Q99496 E3 ubiquitin-protein ligase RING2 RNF2 51 Q99496 E3 ubiquitin-protein ligase RING2 RNF2 54 Q99496 E3 ubiquitin-protein ligase RING2 RNF2 72 Q99496 E3 ubiquitin-protein ligase RING2 RNF2 75 Q99496 E3 ubiquitin-protein ligase RING2 RNF2 87 Q99496 E3 ubiquitin-protein ligase RING2 RNF2 90 Q99496 E3 ubiquitin-protein ligase RING2 RNF2 179 Q5VTR2 E3 ubiquitin-protein ligase BRE1A RNF20 344 Q5VTR2 E3 ubiquitin-protein ligase BRE1A RNF20 383 Q5VTR2 E3 ubiquitin-protein ligase BRE1A RNF20 905 Q5VTR2 E3 ubiquitin-protein ligase BRE1A RNF20 922 Q5VTR2 E3 ubiquitin-protein ligase BRE1A RNF20 924 Q5VTR2 E3 ubiquitin-protein ligase BRE1A RNF20 925 Q5VTR2 E3 ubiquitin-protein ligase BRE1A RNF20 942 Q5VTR2 E3 ubiquitin-protein ligase BRE1A RNF20 945 Q5VTR2 E3 ubiquitin-protein ligase BRE1A RNF20 960 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 18 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 21 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 310 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 418 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 438 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 614 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 680 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 700 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 701 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 856 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 876 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 978 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 981 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 1064 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 1134 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 1156 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 1164 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 1325 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 1429 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 1510 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 1614 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 1736 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 1748 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 1916 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 1985 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 2092 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 2132 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 2378 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 2412 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 2424 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 2524 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 2536 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 2620 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 2633 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 2809 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 2868 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 2918 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 2943 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3008 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3084 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3261 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3330 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3365 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3539 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3554 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3574 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3609 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3794 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3854 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3958 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3979 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3981 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 3997 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4000 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4009 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4012 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4017 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4032 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4035 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4111 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4177 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4235 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4258 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4348 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4397 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4407 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4456 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4570 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4737 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4856 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4879 Q63HN8 E3 ubiquitin-protein ligase RNF213 RNF213 4937 Q8ND24 RING finger protein 214 RNF214 99 Q8ND24 RING finger protein 214 RNF214 139 Q8ND24 RING finger protein 214 RNF214 149 Q8ND24 RING finger protein 214 RNF214 315 Q8ND24 RING finger protein 214 RNF214 569 Q8ND24 RING finger protein 214 RNF214 655 Q8ND24 RING finger protein 214 RNF214 661 Q8ND24 RING finger protein 214 RNF214 675 Q8ND24 RING finger protein 214 RNF214 683 Q8ND24 RING finger protein 214 RNF214 696 Q8ND24 RING finger protein 214 RNF214 699 Q9NWF9 E3 ubiquitin-protein ligase RNF216 RNF216 370 Q9NWF9 E3 ubiquitin-protein ligase RNF216 RNF216 518 Q9NWF9 E3 ubiquitin-protein ligase RNF216 RNF216 605 Q9NWF9 E3 ubiquitin-protein ligase RNF216 RNF216 623 Q9NWF9 E3 ubiquitin-protein ligase RNF216 RNF216 628 Q9NWF9 E3 ubiquitin-protein ligase RNF216 RNF216 636 Q9NWF9 E3 ubiquitin-protein ligase RNF216 RNF216 648 Q9NWF9 E3 ubiquitin-protein ligase RNF216 RNF216 678 Q9NWF9 E3 ubiquitin-protein ligase RNF216 RNF216 688 Q8TC41 Probable E3 ubiquitin-protein ligase RNF217 RNF217 278 Q5W0B1 RING finger protein 219 RNF219 52 Q5W0B1 RING finger protein 219 RNF219 55 Q5W0B1 RING finger protein 219 RNF219 65 Q5W0B1 RING finger protein 219 RNF219 105 Q5W0B1 RING finger protein 219 RNF219 271 Q5W0B1 RING finger protein 219 RNF219 321 Q5W0B1 RING finger protein 219 RNF219 338 Q5W0B1 RING finger protein 219 RNF219 375 Q5W0B1 RING finger protein 219 RNF219 390 Q5W0B1 RING finger protein 219 RNF219 397 Q5W0B1 RING finger protein 219 RNF219 432 Q5W0B1 RING finger protein 219 RNF219 458 Q5W0B1 RING finger protein 219 RNF219 506 Q5W0B1 RING finger protein 219 RNF219 555 Q5VTB9 E3 ubiquitin-protein ligase RNF220 RNF220 336 Q5VTB9 E3 ubiquitin-protein ligase RNF220 RNF220 359 Q5VTB9 E3 ubiquitin-protein ligase RNF220 RNF220 382 Q5VTB9 E3 ubiquitin-protein ligase RNF220 RNF220 417 Q5VTB9 E3 ubiquitin-protein ligase RNF220 RNF220 517 Q5VTB9 E3 ubiquitin-protein ligase RNF220 RNF220 530 Q5VTB9 E3 ubiquitin-protein ligase RNF220 RNF220 549 Q5VTB9 E3 ubiquitin-protein ligase RNF220 RNF220 552 E7ERA6 RING finger protein 223 RNF223 54 E7ERA6 RING finger protein 223 RNF223 75 E7ERA6 RING finger protein 223 RNF223 116 P0DH78 RING finger protein 224 RNF224 124 P0DH78 RING finger protein 224 RNF224 140 P0DH78 RING finger protein 224 RNF224 143 Q96BH1 E3 ubiquitin-protein ligase RNF25 RNF25 138 Q96BH1 E3 ubiquitin-protein ligase RNF25 RNF25 153 Q96BH1 E3 ubiquitin-protein ligase RNF25 RNF25 159 Q96BH1 E3 ubiquitin-protein ligase RNF25 RNF25 161 Q96BH1 E3 ubiquitin-protein ligase RNF25 RNF25 198 Q96BH1 E3 ubiquitin-protein ligase RNF25 RNF25 201 Q96BH1 E3 ubiquitin-protein ligase RNF25 RNF25 316 Q96BH1 E3 ubiquitin-protein ligase RNF25 RNF25 360 Q96BH1 E3 ubiquitin-protein ligase RNF25 RNF25 417 Q9BY78 E3 ubiquitin-protein ligase RNF26 RNF26 421 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 59 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 217 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 220 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 229 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 232 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 237 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 473 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 504 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 551 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 572 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 699 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 702 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 717 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 722 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 725 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 817 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 820 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 825 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 841 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 885 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 890 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 898 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 911 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 916 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 930 Q96EP0 E3 ubiquitin-protein ligase RNF31 RNF31 969 Q9H0A6 RING finger protein 32 RNF32 165 Q9H0A6 RING finger protein 32 RNF32 168 Q969K3 E3 ubiquitin-protein ligase RNF34 RNF34 62 Q969K3 E3 ubiquitin-protein ligase RNF34 RNF34 65 Q969K3 E3 ubiquitin-protein ligase RNF34 RNF34 79 Q969K3 E3 ubiquitin-protein ligase RNF34 RNF34 86 Q969K3 E3 ubiquitin-protein ligase RNF34 RNF34 102 Q969K3 E3 ubiquitin-protein ligase RNF34 RNF34 137 Q969K3 E3 ubiquitin-protein ligase RNF34 RNF34 149 Q969K3 E3 ubiquitin-protein ligase RNF34 RNF34 286 Q969K3 E3 ubiquitin-protein ligase RNF34 RNF34 287 Q969K3 E3 ubiquitin-protein ligase RNF34 RNF34 359 Q9H0F5 E3 ubiquitin-protein ligase RNF38 RNF38 110 Q9H0F5 E3 ubiquitin-protein ligase RNF38 RNF38 500 Q9H0F5 E3 ubiquitin-protein ligase RNF38 RNF38 503 P78317 E3 ubiquitin-protein ligase RNF4 RNF4 91 P78317 E3 ubiquitin-protein ligase RNF4 RNF4 154 P78317 E3 ubiquitin-protein ligase RNF4 RNF4 159 P78317 E3 ubiquitin-protein ligase RNF4 RNF4 162 O75150 E3 ubiquitin-protein ligase BRE1B RNF40 69 O75150 E3 ubiquitin-protein ligase BRE1B RNF40 210 O75150 E3 ubiquitin-protein ligase BRE1B RNF40 890 O75150 E3 ubiquitin-protein ligase BRE1B RNF40 948 O75150 E3 ubiquitin-protein ligase BRE1B RNF40 950 O75150 E3 ubiquitin-protein ligase BRE1B RNF40 951 O75150 E3 ubiquitin-protein ligase BRE1B RNF40 971 O75150 E3 ubiquitin-protein ligase BRE1B RNF40 986 Q9H4P4 E3 ubiquitin-protein ligase NRDP1 RNF41 90 Q9H4P4 E3 ubiquitin-protein ligase NRDP1 RNF41 106 Q9H4P4 E3 ubiquitin-protein ligase NRDP1 RNF41 120 Q68DV7 E3 ubiquitin-protein ligase RNF43 RNF43 252 Q68DV7 E3 ubiquitin-protein ligase RNF43 RNF43 451 Q68DV7 E3 ubiquitin-protein ligase RNF43 RNF43 615 Q68DV7 E3 ubiquitin-protein ligase RNF43 RNF43 633 Q7L0R7 RING finger protein 44 RNF44 398 Q7L0R7 RING finger protein 44 RNF44 417 Q7L0R7 RING finger protein 44 RNF44 420 Q99942 E3 ubiquitin-protein ligase RNF5 RNF5 30 Q99942 E3 ubiquitin-protein ligase RNF5 RNF5 42 Q99942 E3 ubiquitin-protein ligase RNF5 RNF5 47 Q99942 E3 ubiquitin-protein ligase RNF5 RNF5 50 Q99942 E3 ubiquitin-protein ligase RNF5 RNF5 64 Q99942 E3 ubiquitin-protein ligase RNF5 RNF5 67 Q9Y252 E3 ubiquitin-protein ligase RNF6 RNF6 667 Q9UBF6 RING-box protein 2 RNF7 47 Q9UBF6 RING-box protein 2 RNF7 61 Q9UBF6 RING-box protein 2 RNF7 64 Q9UBF6 RING-box protein 2 RNF7 73 Q9UBF6 RING-box protein 2 RNF7 80 Q9UBF6 RING-box protein 2 RNF7 87 Q9UBF6 RING-box protein 2 RNF7 88 Q9UBF6 RING-box protein 2 RNF7 99 Q9UBF6 RING-box protein 2 RNF7 102 O76064 E3 ubiquitin-protein ligase RNF8 RNF8 55 O76064 E3 ubiquitin-protein ligase RNF8 RNF8 181 O76064 E3 ubiquitin-protein ligase RNF8 RNF8 300 O76064 E3 ubiquitin-protein ligase RNF8 RNF8 456 Q5M7Z0 E3 ubiquitin-protein ligase RNFT1 RNFT1 62 Q5M7Z0 E3 ubiquitin-protein ligase RNFT1 RNFT1 73 Q5M7Z0 E3 ubiquitin-protein ligase RNFT1 RNFT1 90 Q5M7Z0 E3 ubiquitin-protein ligase RNFT1 RNFT1 106 Q5M7Z0 E3 ubiquitin-protein ligase RNFT1 RNFT1 110 Q5M7Z0 E3 ubiquitin-protein ligase RNFT1 RNFT1 409 Q5M7Z0 E3 ubiquitin-protein ligase RNFT1 RNFT1 412 Q96EX2 RING finger and transmembrane domain-containing protein 2 RNFT2 418 Q96EX2 RING finger and transmembrane domain-containing protein 2 RNFT2 421 Q96DX4 RING finger and SPRY domain-containing protein 1 RSPRY1 190 Q96DX4 RING finger and SPRY domain-containing protein 1 RSPRY1 208 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 8 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 81 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 107 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 155 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 184 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 320 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 351 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 544 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 648 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 651 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 664 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 667 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 672 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 675 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 692 Q96T51 RUN and FYVE domain-containing protein 1 RUFY1 703 Q7Z6J0 E3 ubiquitin-protein ligase SH3RF1 SH3RF1 33 Q7Z6J0 E3 ubiquitin-protein ligase SH3RF1 SH3RF1 36 Q7Z6J0 E3 ubiquitin-protein ligase SH3RF1 SH3RF1 93 Q7Z6J0 E3 ubiquitin-protein ligase SH3RF1 SH3RF1 107 Q7Z6J0 E3 ubiquitin-protein ligase SH3RF1 SH3RF1 279 Q7Z6J0 E3 ubiquitin-protein ligase SH3RF1 SH3RF1 478 Q7Z6J0 E3 ubiquitin-protein ligase SH3RF1 SH3RF1 658 Q7Z6J0 E3 ubiquitin-protein ligase SH3RF1 SH3RF1 700 Q7Z6J0 E3 ubiquitin-protein ligase SH3RF1 SH3RF1 773 Q7Z6J0 E3 ubiquitin-protein ligase SH3RF1 SH3RF1 816 Q7Z6J0 E3 ubiquitin-protein ligase SH3RF1 SH3RF1 831 Q8TEC5 E3 ubiquitin-protein ligase SH3RF2 SH3RF2 28 Q8TEC5 E3 ubiquitin-protein ligase SH3RF2 SH3RF2 36 Q8TEC5 E3 ubiquitin-protein ligase SH3RF2 SH3RF2 134 Q8TEC5 E3 ubiquitin-protein ligase SH3RF2 SH3RF2 413 Q8TEC5 E3 ubiquitin-protein ligase SH3RF2 SH3RF2 695 Q8TEJ3 E3 ubiquitin-protein ligase SH3RF3 SH3RF3 78 Q8TEJ3 E3 ubiquitin-protein ligase SH3RF3 SH3RF3 194 Q8TEJ3 E3 ubiquitin-protein ligase SH3RF3 SH3RF3 428 Q8TEJ3 E3 ubiquitin-protein ligase SH3RF3 SH3RF3 497 Q8TEJ3 E3 ubiquitin-protein ligase SH3RF3 SH3RF3 776 Q9H0F6 Sharpin SHARPIN 140 Q9H0F6 Sharpin SHARPIN 213 Q9H0F6 Sharpin SHARPIN 248 Q9H0F6 Sharpin SHARPIN 275 Q9H0F6 Sharpin SHARPIN 277 Q8TBC3 SH3KBP1-binding protein 1 SHKBP1 121 Q8TBC3 SH3KBP1-binding protein 1 SHKBP1 447 Q8TBC3 SH3KBP1-binding protein 1 SHKBP1 491 Q8TBC3 SH3KBP1-binding protein 1 SHKBP1 550 Q8TBC3 SH3KBP1-binding protein 1 SHKBP1 667 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 171 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 320 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 354 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 439 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 489 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 601 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 680 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 688 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 703 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 706 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 826 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 845 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 885 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 942 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 981 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 982 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 1025 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 1240 Q149N8 E3 ubiquitin-protein ligase SHPRH SHPRH 1435 Q8IUQ4 E3 ubiquitin-protein ligase SIAH1 SIAH1 16 Q8IUQ4 E3 ubiquitin-protein ligase SIAH1 SIAH1 71 Q8IUQ4 E3 ubiquitin-protein ligase SIAH1 SIAH1 72 O43255 E3 ubiquitin-protein ligase SIAH2 SIAH2 110 O43255 E3 ubiquitin-protein ligase SIAH2 SIAH2 111 O43255 E3 ubiquitin-protein ligase SIAH2 SIAH2 114 O43255 E3 ubiquitin-protein ligase SIAH2 SIAH2 138 P63208 S-phase kinase-associated protein 1 SKP1 62 P63208 S-phase kinase-associated protein 1 SKP1 120 P63208 S-phase kinase-associated protein 1 SKP1 160 Q13309 S-phase kinase-associated protein 2 SKP2 111 Q13309 S-phase kinase-associated protein 2 SKP2 113 Q13309 S-phase kinase-associated protein 2 SKP2 124 Q13309 S-phase kinase-associated protein 2 SKP2 345 Q13309 S-phase kinase-associated protein 2 SKP2 390 Q13309 S-phase kinase-associated protein 2 SKP2 423 Q8IY92 Structure-specific endonuclease subunit SLX4 SLX4 192 Q8IY92 Structure-specific endonuclease subunit SLX4 SLX4 296 Q8IY92 Structure-specific endonuclease subunit SLX4 SLX4 318 Q8IY92 Structure-specific endonuclease subunit SLX4 SLX4 519 Q8IY92 Structure-specific endonuclease subunit SLX4 SLX4 926 Q8IY92 Structure-specific endonuclease subunit SLX4 SLX4 1033 Q8IY92 Structure-specific endonuclease subunit SLX4 SLX4 1109 Q8IY92 Structure-specific endonuclease subunit SLX4 SLX4 1239 Q8IY92 Structure-specific endonuclease subunit SLX4 SLX4 1269 Q8IY92 Structure-specific endonuclease subunit SLX4 SLX4 1324 Q8IY92 Structure-specific endonuclease subunit SLX4 SLX4 1482 Q9HCE7 E3 ubiquitin-protein ligase SMURF1 SMURF1 21 Q9HCE7 E3 ubiquitin-protein ligase SMURF1 SMURF1 48 Q9HCE7 E3 ubiquitin-protein ligase SMURF1 SMURF1 152 Q9HCE7 E3 ubiquitin-protein ligase SMURF1 SMURF1 652 Q9HCE7 E3 ubiquitin-protein ligase SMURF1 SMURF1 725 Q9HAU4 E3 ubiquitin-protein ligase SMURF2 SMURF2 20 Q9HAU4 E3 ubiquitin-protein ligase SMURF2 SMURF2 151 Q9HAU4 E3 ubiquitin-protein ligase SMURF2 SMURF2 293 Q9HAU4 E3 ubiquitin-protein ligase SMURF2 SMURF2 356 Q9HAU4 E3 ubiquitin-protein ligase SMURF2 SMURF2 362 Q9HAU4 E3 ubiquitin-protein ligase SMURF2 SMURF2 706 Q9HAU4 E3 ubiquitin-protein ligase SMURF2 SMURF2 716 Q9HAU4 E3 ubiquitin-protein ligase SMURF2 SMURF2 743 O15524 Suppressor of cytokine signaling 1 SOCS1 178 O14508 Suppressor of cytokine signaling 2 SOCS2 5 O14508 Suppressor of cytokine signaling 2 SOCS2 111 O14508 Suppressor of cytokine signaling 2 SOCS2 133 O14508 Suppressor of cytokine signaling 2 SOCS2 174 O14543 Suppressor of cytokine signaling 3 SOCS3 97 O14543 Suppressor of cytokine signaling 3 SOCS3 119 O14543 Suppressor of cytokine signaling 3 SOCS3 193 O14544 Suppressor of cytokine signaling 6 SOCS6 184 O14544 Suppressor of cytokine signaling 6 SOCS6 241 O14544 Suppressor of cytokine signaling 6 SOCS6 342 O14512 Suppressor of cytokine signaling 7 SOCS7 378 O14512 Suppressor of cytokine signaling 7 SOCS7 522 O43791 Speckle-type POZ protein SPOP 68 O43791 Speckle-type POZ protein SPOP 93 O43791 Speckle-type POZ protein SPOP 205 O43791 Speckle-type POZ protein SPOP 361 Q6IQ16 Speckle-type POZ protein-like SPOPL 202 Q6IQ16 Speckle-type POZ protein-like SPOPL 379 Q6PJ21 SPRY domain-containing SOCS box protein 3 SPSB3 321 Q6PJ21 SPRY domain-containing SOCS box protein 3 SPSB3 347 Q9UNE7 E3 ubiquitin-protein ligase CHIP STUB1 48 Q9UNE7 E3 ubiquitin-protein ligase CHIP STUB1 69 Q9UNE7 E3 ubiquitin-protein ligase CHIP STUB1 83 Q9UNE7 E3 ubiquitin-protein ligase CHIP STUB1 180 Q9UNE7 E3 ubiquitin-protein ligase CHIP STUB1 199 Q9UNE7 E3 ubiquitin-protein ligase CHIP STUB1 232 Q9UNE7 E3 ubiquitin-protein ligase CHIP STUB1 244 Q9Y2Z0 Protein SGT1 homolog SUGT1 49 Q9Y2Z0 Protein SGT1 homolog SUGT1 54 Q9Y2Z0 Protein SGT1 homolog SUGT1 62 Q9Y2Z0 Protein SGT1 homolog SUGT1 88 Q9Y2Z0 Protein SGT1 homolog SUGT1 154 Q86TM6 E3 ubiquitin-protein ligase synoviolin SYVN1 307 Q86TM6 E3 ubiquitin-protein ligase synoviolin SYVN1 315 Q86TM6 E3 ubiquitin-protein ligase synoviolin SYVN1 326 Q86TM6 E3 ubiquitin-protein ligase synoviolin SYVN1 329 A0AVI4 E3 ubiquitin-protein ligase TM129 TMEM129 354 Q13829 BTB/POZ domain-containing adapter for CUL3-mediated TNFAIP1 76 RhoA degradation protein 2 Q13829 BTB/POZ domain-containing adapter for CUL3-mediated TNFAIP1 224 RhoA degradation protein 2 Q13829 BTB/POZ domain-containing adapter for CUL3-mediated TNFAIP1 225 RhoA degradation protein 2 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 54 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 57 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 103 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 158 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 243 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 392 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 404 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 407 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 478 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 483 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 521 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 524 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 536 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 539 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 559 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 579 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 590 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 612 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 624 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 627 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 657 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 662 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 674 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 677 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 727 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 733 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 736 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 762 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 767 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 775 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 779 P21580 Tumor necrosis factor alpha-induced protein 3 TNFAIP3 782 Q15025 TNFAIP3-interacting protein 1 TNIP1 171 Q15025 TNFAIP3-interacting protein 1 TNIP1 212 Q15025 TNFAIP3-interacting protein 1 TNIP1 602 Q9NS56 E3 ubiquitin-protein ligase Topors TOPORS 49 Q9NS56 E3 ubiquitin-protein ligase Topors TOPORS 127 Q9NS56 E3 ubiquitin-protein ligase Topors TOPORS 138 Q9NS56 E3 ubiquitin-protein ligase Topors TOPORS 292 Q9NS56 E3 ubiquitin-protein ligase Topors TOPORS 550 Q9NS56 E3 ubiquitin-protein ligase Topors TOPORS 1037 Q13077 TNF receptor-associated factor 1 TRAF1 37 Q13077 TNF receptor-associated factor 1 TRAF1 38 Q13077 TNF receptor-associated factor 1 TRAF1 41 Q13077 TNF receptor-associated factor 1 TRAF1 54 Q13077 TNF receptor-associated factor 1 TRAF1 57 Q13077 TNF receptor-associated factor 1 TRAF1 88 Q13077 TNF receptor-associated factor 1 TRAF1 95 Q13077 TNF receptor-associated factor 1 TRAF1 169 Q13077 TNF receptor-associated factor 1 TRAF1 280 Q13077 TNF receptor-associated factor 1 TRAF1 285 Q13077 TNF receptor-associated factor 1 TRAF1 384 Q12933 TNF receptor-associated factor 2 TRAF2 34 Q12933 TNF receptor-associated factor 2 TRAF2 37 Q12933 TNF receptor-associated factor 2 TRAF2 49 Q12933 TNF receptor-associated factor 2 TRAF2 112 Q12933 TNF receptor-associated factor 2 TRAF2 124 Q12933 TNF receptor-associated factor 2 TRAF2 129 Q12933 TNF receptor-associated factor 2 TRAF2 136 Q12933 TNF receptor-associated factor 2 TRAF2 156 Q12933 TNF receptor-associated factor 2 TRAF2 170 Q12933 TNF receptor-associated factor 2 TRAF2 171 Q12933 TNF receptor-associated factor 2 TRAF2 189 Q12933 TNF receptor-associated factor 2 TRAF2 192 Q12933 TNF receptor-associated factor 2 TRAF2 212 Q12933 TNF receptor-associated factor 2 TRAF2 216 Q12933 TNF receptor-associated factor 2 TRAF2 223 Q12933 TNF receptor-associated factor 2 TRAF2 287 Q12933 TNF receptor-associated factor 2 TRAF2 303 Q12933 TNF receptor-associated factor 2 TRAF2 469 Q13114 TNF receptor-associated factor 3 TRAF3 61 Q13114 TNF receptor-associated factor 3 TRAF3 68 Q13114 TNF receptor-associated factor 3 TRAF3 105 Q13114 TNF receptor-associated factor 3 TRAF3 106 Q13114 TNF receptor-associated factor 3 TRAF3 180 Q13114 TNF receptor-associated factor 3 TRAF3 208 Q9BUZ4 TNF receptor-associated factor 4 TRAF4 90 Q9BUZ4 TNF receptor-associated factor 4 TRAF4 134 Q9BUZ4 TNF receptor-associated factor 4 TRAF4 188 Q9BUZ4 TNF receptor-associated factor 4 TRAF4 195 Q9BUZ4 TNF receptor-associated factor 4 TRAF4 198 Q9BUZ4 TNF receptor-associated factor 4 TRAF4 214 Q9BUZ4 TNF receptor-associated factor 4 TRAF4 221 Q9BUZ4 TNF receptor-associated factor 4 TRAF4 250 Q9BUZ4 TNF receptor-associated factor 4 TRAF4 282 Q9BUZ4 TNF receptor-associated factor 4 TRAF4 332 O00463 TNF receptor-associated factor 5 TRAF5 12 O00463 TNF receptor-associated factor 5 TRAF5 65 O00463 TNF receptor-associated factor 5 TRAF5 68 O00463 TNF receptor-associated factor 5 TRAF5 81 O00463 TNF receptor-associated factor 5 TRAF5 98 O00463 TNF receptor-associated factor 5 TRAF5 116 O00463 TNF receptor-associated factor 5 TRAF5 132 O00463 TNF receptor-associated factor 5 TRAF5 139 O00463 TNF receptor-associated factor 5 TRAF5 144 O00463 TNF receptor-associated factor 5 TRAF5 161 O00463 TNF receptor-associated factor 5 TRAF5 188 O00463 TNF receptor-associated factor 5 TRAF5 195 O00463 TNF receptor-associated factor 5 TRAF5 401 O00463 TNF receptor-associated factor 5 TRAF5 521 Q9Y4K3 TNF receptor-associated factor 6 TRAF6 85 Q9Y4K3 TNF receptor-associated factor 6 TRAF6 105 Q9Y4K3 TNF receptor-associated factor 6 TRAF6 134 Q9Y4K3 TNF receptor-associated factor 6 TRAF6 139 Q9Y4K3 TNF receptor-associated factor 6 TRAF6 182 Q9Y4K3 TNF receptor-associated factor 6 TRAF6 235 Q9Y4K3 TNF receptor-associated factor 6 TRAF6 349 Q9Y4K3 TNF receptor-associated factor 6 TRAF6 366 Q6Q0C0 E3 ubiquitin-protein ligase TRAF7 TRAF7 57 Q6Q0C0 E3 ubiquitin-protein ligase TRAF7 TRAF7 134 Q6Q0C0 E3 ubiquitin-protein ligase TRAF7 TRAF7 151 Q6Q0C0 E3 ubiquitin-protein ligase TRAF7 TRAF7 161 Q6Q0C0 E3 ubiquitin-protein ligase TRAF7 TRAF7 210 Q6Q0C0 E3 ubiquitin-protein ligase TRAF7 TRAF7 226 Q6Q0C0 E3 ubiquitin-protein ligase TRAF7 TRAF7 233 Q6Q0C0 E3 ubiquitin-protein ligase TRAF7 TRAF7 254 Q6Q0C0 E3 ubiquitin-protein ligase TRAF7 TRAF7 259 Q6Q0C0 E3 ubiquitin-protein ligase TRAF7 TRAF7 266 Q6Q0C0 E3 ubiquitin-protein ligase TRAF7 TRAF7 426 Q6Q0C0 E3 ubiquitin-protein ligase TRAF7 TRAF7 450 Q9BWF2 E3 ubiquitin-protein ligase TRAIP TRAIP 373 Q9BWF2 E3 ubiquitin-protein ligase TRAIP TRAIP 408 Q96F44 E3 ubiquitin-protein ligase TRIM11 TRIM11 92 Q96F44 E3 ubiquitin-protein ligase TRIM11 TRIM11 103 Q96F44 E3 ubiquitin-protein ligase TRIM11 TRIM11 111 Q96F44 E3 ubiquitin-protein ligase TRIM11 TRIM11 114 Q96F44 E3 ubiquitin-protein ligase TRIM11 TRIM11 164 Q96F44 E3 ubiquitin-protein ligase TRIM11 TRIM11 236 Q96F44 E3 ubiquitin-protein ligase TRIM11 TRIM11 330 Q96F44 E3 ubiquitin-protein ligase TRIM11 TRIM11 359 O60858 E3 ubiquitin-protein ligase TRIM13 TRIM13 25 O60858 E3 ubiquitin-protein ligase TRIM13 TRIM13 30 O60858 E3 ubiquitin-protein ligase TRIM13 TRIM13 33 Q9C019 Tripartite motif-containing protein 15 TRIM15 36 Q9C019 Tripartite motif-containing protein 15 TRIM15 39 Q9C019 Tripartite motif-containing protein 15 TRIM15 185 Q9C019 Tripartite motif-containing protein 15 TRIM15 227 Q9C019 Tripartite motif-containing protein 15 TRIM15 460 Q9C040 Tripartite motif-containing protein 2 TRIM2 26 Q9C040 Tripartite motif-containing protein 2 TRIM2 38 Q9C040 Tripartite motif-containing protein 2 TRIM2 43 Q9C040 Tripartite motif-containing protein 2 TRIM2 46 Q9C040 Tripartite motif-containing protein 2 TRIM2 254 P19474 E3 ubiquitin-protein ligase TRIM21 TRIM21 51 P19474 E3 ubiquitin-protein ligase TRIM21 TRIM21 54 P19474 E3 ubiquitin-protein ligase TRIM21 TRIM21 92 P19474 E3 ubiquitin-protein ligase TRIM21 TRIM21 103 P19474 E3 ubiquitin-protein ligase TRIM21 TRIM21 111 P19474 E3 ubiquitin-protein ligase TRIM21 TRIM21 114 P19474 E3 ubiquitin-protein ligase TRIM21 TRIM21 273 P19474 E3 ubiquitin-protein ligase TRIM21 TRIM21 359 P19474 E3 ubiquitin-protein ligase TRIM21 TRIM21 463 Q8IYM9 E3 ubiquitin-protein ligase TRIM22 TRIM22 15 Q8IYM9 E3 ubiquitin-protein ligase TRIM22 TRIM22 18 Q8IYM9 E3 ubiquitin-protein ligase TRIM22 TRIM22 35 Q8IYM9 E3 ubiquitin-protein ligase TRIM22 TRIM22 56 Q8IYM9 E3 ubiquitin-protein ligase TRIM22 TRIM22 59 Q8IYM9 E3 ubiquitin-protein ligase TRIM22 TRIM22 97 Q8IYM9 E3 ubiquitin-protein ligase TRIM22 TRIM22 108 Q8IYM9 E3 ubiquitin-protein ligase TRIM22 TRIM22 140 Q8IYM9 E3 ubiquitin-protein ligase TRIM22 TRIM22 416 Q8IYM9 E3 ubiquitin-protein ligase TRIM22 TRIM22 441 P36406 E3 ubiquitin-protein ligase TRIM23 TRIM23 56 P36406 E3 ubiquitin-protein ligase TRIM23 TRIM23 236 O15164 Transcription intermediary factor 1-alpha TRIM24 56 O15164 Transcription intermediary factor 1-alpha TRIM24 59 O15164 Transcription intermediary factor 1-alpha TRIM24 73 O15164 Transcription intermediary factor 1-alpha TRIM24 78 O15164 Transcription intermediary factor 1-alpha TRIM24 81 O15164 Transcription intermediary factor 1-alpha TRIM24 127 O15164 Transcription intermediary factor 1-alpha TRIM24 134 O15164 Transcription intermediary factor 1-alpha TRIM24 223 O15164 Transcription intermediary factor 1-alpha TRIM24 235 O15164 Transcription intermediary factor 1-alpha TRIM24 238 O15164 Transcription intermediary factor 1-alpha TRIM24 243 O15164 Transcription intermediary factor 1-alpha TRIM24 246 O15164 Transcription intermediary factor 1-alpha TRIM24 394 O15164 Transcription intermediary factor 1-alpha TRIM24 629 O15164 Transcription intermediary factor 1-alpha TRIM24 867 O15164 Transcription intermediary factor 1-alpha TRIM24 870 O15164 Transcription intermediary factor 1-alpha TRIM24 882 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 70 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 107 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 110 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 157 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 168 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 174 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 176 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 179 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 186 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 351 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 475 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 498 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 506 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 529 Q12899 Tripartite motif-containing protein 26 TRIM26 19 Q12899 Tripartite motif-containing protein 26 TRIM26 36 Q12899 Tripartite motif-containing protein 26 TRIM26 39 Q12899 Tripartite motif-containing protein 26 TRIM26 53 Q12899 Tripartite motif-containing protein 26 TRIM26 56 Q12899 Tripartite motif-containing protein 26 TRIM26 102 Q12899 Tripartite motif-containing protein 26 TRIM26 113 Q12899 Tripartite motif-containing protein 26 TRIM26 121 Q12899 Tripartite motif-containing protein 26 TRIM26 334 Q12899 Tripartite motif-containing protein 26 TRIM26 353 P14373 Zinc finger protein RFP TRIM27 284 P14373 Zinc finger protein RFP TRIM27 359 P14373 Zinc finger protein RFP TRIM27 365 P14373 Zinc finger protein RFP TRIM27 393 P14373 Zinc finger protein RFP TRIM27 490 Q13263 Transcription intermediary factor 1-beta TRIM28 65 Q13263 Transcription intermediary factor 1-beta TRIM28 68 Q13263 Transcription intermediary factor 1-beta TRIM28 83 Q13263 Transcription intermediary factor 1-beta TRIM28 88 Q13263 Transcription intermediary factor 1-beta TRIM28 91 Q13263 Transcription intermediary factor 1-beta TRIM28 117 Q13263 Transcription intermediary factor 1-beta TRIM28 120 Q13263 Transcription intermediary factor 1-beta TRIM28 124 Q13263 Transcription intermediary factor 1-beta TRIM28 153 Q13263 Transcription intermediary factor 1-beta TRIM28 156 Q13263 Transcription intermediary factor 1-beta TRIM28 166 Q13263 Transcription intermediary factor 1-beta TRIM28 174 Q13263 Transcription intermediary factor 1-beta TRIM28 177 Q13263 Transcription intermediary factor 1-beta TRIM28 209 Q13263 Transcription intermediary factor 1-beta TRIM28 221 Q13263 Transcription intermediary factor 1-beta TRIM28 224 Q13263 Transcription intermediary factor 1-beta TRIM28 229 Q13263 Transcription intermediary factor 1-beta TRIM28 232 Q13263 Transcription intermediary factor 1-beta TRIM28 628 Q13263 Transcription intermediary factor 1-beta TRIM28 713 Q13263 Transcription intermediary factor 1-beta TRIM28 717 O75382 Tripartite motif-containing protein 3 TRIM3 25 O75382 Tripartite motif-containing protein 3 TRIM3 37 O75382 Tripartite motif-containing protein 3 TRIM3 42 O75382 Tripartite motif-containing protein 3 TRIM3 45 O75382 Tripartite motif-containing protein 3 TRIM3 227 O75382 Tripartite motif-containing protein 3 TRIM3 252 O75382 Tripartite motif-containing protein 3 TRIM3 509 O75382 Tripartite motif-containing protein 3 TRIM3 597 O75382 Tripartite motif-containing protein 3 TRIM3 598 Q9BZY9 E3 ubiquitin-protein ligase TRIM31 TRIM31 48 Q13049 E3 ubiquitin-protein ligase TRIM32 TRIM32 39 Q13049 E3 ubiquitin-protein ligase TRIM32 TRIM32 123 Q13049 E3 ubiquitin-protein ligase TRIM32 TRIM32 134 Q13049 E3 ubiquitin-protein ligase TRIM32 TRIM32 239 Q13049 E3 ubiquitin-protein ligase TRIM32 TRIM32 355 Q13049 E3 ubiquitin-protein ligase TRIM32 TRIM32 464 Q13049 E3 ubiquitin-protein ligase TRIM32 TRIM32 509 Q13049 E3 ubiquitin-protein ligase TRIM32 TRIM32 511 Q13049 E3 ubiquitin-protein ligase TRIM32 TRIM32 577 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 145 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 150 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 153 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 241 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 276 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 288 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 291 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 296 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 299 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 447 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 461 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 582 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 754 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 786 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 805 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 849 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 943 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 TRIM33 1035 Q9UPQ4 Tripartite motif-containing protein 35 TRIM35 121 Q9NQ86 E3 ubiquitin-protein ligase TRIM36 TRIM36 33 Q9NQ86 E3 ubiquitin-protein ligase TRIM36 TRIM36 36 Q9NQ86 E3 ubiquitin-protein ligase TRIM36 TRIM36 48 Q9NQ86 E3 ubiquitin-protein ligase TRIM36 TRIM36 53 Q9NQ86 E3 ubiquitin-protein ligase TRIM36 TRIM36 115 Q9NQ86 E3 ubiquitin-protein ligase TRIM36 TRIM36 118 Q9NQ86 E3 ubiquitin-protein ligase TRIM36 TRIM36 157 Q9NQ86 E3 ubiquitin-protein ligase TRIM36 TRIM36 160 Q9NQ86 E3 ubiquitin-protein ligase TRIM36 TRIM36 171 Q9NQ86 E3 ubiquitin-protein ligase TRIM36 TRIM36 224 Q9NQ86 E3 ubiquitin-protein ligase TRIM36 TRIM36 227 Q9NQ86 E3 ubiquitin-protein ligase TRIM36 TRIM36 235 O94972 E3 ubiquitin-protein ligase TRIM37 TRIM37 15 O94972 E3 ubiquitin-protein ligase TRIM37 TRIM37 31 O94972 E3 ubiquitin-protein ligase TRIM37 TRIM37 39 O94972 E3 ubiquitin-protein ligase TRIM37 TRIM37 51 O94972 E3 ubiquitin-protein ligase TRIM37 TRIM37 54 O94972 E3 ubiquitin-protein ligase TRIM37 TRIM37 66 O94972 E3 ubiquitin-protein ligase TRIM37 TRIM37 352 O94972 E3 ubiquitin-protein ligase TRIM37 TRIM37 477 O94972 E3 ubiquitin-protein ligase TRIM37 TRIM37 748 O94972 E3 ubiquitin-protein ligase TRIM37 TRIM37 790 O00635 E3 ubiquitin-protein ligase TRIM38 TRIM38 58 O00635 E3 ubiquitin-protein ligase TRIM38 TRIM38 59 O00635 E3 ubiquitin-protein ligase TRIM38 TRIM38 62 O00635 E3 ubiquitin-protein ligase TRIM38 TRIM38 133 O00635 E3 ubiquitin-protein ligase TRIM38 TRIM38 188 O00635 E3 ubiquitin-protein ligase TRIM38 TRIM38 237 O00635 E3 ubiquitin-protein ligase TRIM38 TRIM38 274 O00635 E3 ubiquitin-protein ligase TRIM38 TRIM38 335 O00635 E3 ubiquitin-protein ligase TRIM38 TRIM38 339 Q9C037 E3 ubiquitin-protein ligase TRIM4 TRIM4 49 Q9C037 E3 ubiquitin-protein ligase TRIM4 TRIM4 52 Q9C037 E3 ubiquitin-protein ligase TRIM4 TRIM4 87 Q9C037 E3 ubiquitin-protein ligase TRIM4 TRIM4 98 Q9C037 E3 ubiquitin-protein ligase TRIM4 TRIM4 106 Q9C037 E3 ubiquitin-protein ligase TRIM4 TRIM4 293 Q9C037 E3 ubiquitin-protein ligase TRIM4 TRIM4 368 Q8WV44 E3 ubiquitin-protein ligase TRIM41 TRIM41 180 Q8WV44 E3 ubiquitin-protein ligase TRIM41 TRIM41 183 Q8WV44 E3 ubiquitin-protein ligase TRIM41 TRIM41 186 Q8WV44 E3 ubiquitin-protein ligase TRIM41 TRIM41 227 Q8WV44 E3 ubiquitin-protein ligase TRIM41 TRIM41 405 Q8WV44 E3 ubiquitin-protein ligase TRIM41 TRIM41 426 Q7Z4K8 Tripartite motif-containing protein 46 TRIM46 48 Q7Z4K8 Tripartite motif-containing protein 46 TRIM46 53 Q7Z4K8 Tripartite motif-containing protein 46 TRIM46 175 Q7Z4K8 Tripartite motif-containing protein 46 TRIM46 189 Q7Z4K8 Tripartite motif-containing protein 46 TRIM46 338 Q7Z4K8 Tripartite motif-containing protein 46 TRIM46 377 Q96LD4 Tripartite motif-containing protein 47 TRIM47 54 Q96LD4 Tripartite motif-containing protein 47 TRIM47 57 Q96LD4 Tripartite motif-containing protein 47 TRIM47 182 Q96LD4 Tripartite motif-containing protein 47 TRIM47 199 Q96LD4 Tripartite motif-containing protein 47 TRIM47 201 Q96LD4 Tripartite motif-containing protein 47 TRIM47 204 Q96LD4 Tripartite motif-containing protein 47 TRIM47 347 Q96LD4 Tripartite motif-containing protein 47 TRIM47 454 Q96LD4 Tripartite motif-containing protein 47 TRIM47 468 Q96LD4 Tripartite motif-containing protein 47 TRIM47 520 Q96LD4 Tripartite motif-containing protein 47 TRIM47 521 Q96LD4 Tripartite motif-containing protein 47 TRIM47 631 Q9C035 Tripartite motif-containing protein 5 TRIM5 55 Q9C035 Tripartite motif-containing protein 5 TRIM5 58 Q9C035 Tripartite motif-containing protein 5 TRIM5 95 Q9C035 Tripartite motif-containing protein 5 TRIM5 106 Q9C035 Tripartite motif-containing protein 5 TRIM5 310 Q9C035 Tripartite motif-containing protein 5 TRIM5 385 Q9C035 Tripartite motif-containing protein 5 TRIM5 482 Q9C035 Tripartite motif-containing protein 5 TRIM5 489 Q9BYV6 Tripartite motif-containing protein 55 TRIM55 136 Q9BYV6 Tripartite motif-containing protein 55 TRIM55 144 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 24 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 36 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 41 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 44 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 56 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 59 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 101 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 104 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 120 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 123 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 128 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 131 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 169 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 181 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 184 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 189 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 202 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 338 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 347 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 363 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 TRIM56 514 Q8IWR1 Tripartite motif-containing protein 59 TRIM59 25 Q8IWR1 Tripartite motif-containing protein 59 TRIM59 30 Q8IWR1 Tripartite motif-containing protein 59 TRIM59 208 Q9C030 Tripartite motif-containing protein 6 TRIM6 97 Q9C030 Tripartite motif-containing protein 6 TRIM6 335 Q9C030 Tripartite motif-containing protein 6 TRIM6 342 Q495X7 Tripartite motif-containing protein 60 TRIM60 59 Q9BVG3 E3 ubiquitin-protein ligase TRIM62 TRIM62 34 Q9BVG3 E3 ubiquitin-protein ligase TRIM62 TRIM62 50 Q6PJ69 Tripartite motif-containing protein 65 TRIM65 15 Q6PJ69 Tripartite motif-containing protein 65 TRIM65 47 Q6PJ69 Tripartite motif-containing protein 65 TRIM65 50 Q6PJ69 Tripartite motif-containing protein 65 TRIM65 106 Q6PJ69 Tripartite motif-containing protein 65 TRIM65 112 Q6PJ69 Tripartite motif-containing protein 65 TRIM65 114 Q6PJ69 Tripartite motif-containing protein 65 TRIM65 117 Q6PJ69 Tripartite motif-containing protein 65 TRIM65 174 Q6PJ69 Tripartite motif-containing protein 65 TRIM65 284 Q6PJ69 Tripartite motif-containing protein 65 TRIM65 320 Q6PJ69 Tripartite motif-containing protein 65 TRIM65 421 Q6PJ69 Tripartite motif-containing protein 65 TRIM65 426 Q6PJ69 Tripartite motif-containing protein 65 TRIM65 500 Q6ZTA4 Tripartite motif-containing protein 67 TRIM67 147 Q6AZZ1 E3 ubiquitin-protein ligase TRIM68 TRIM68 352 Q9C029 E3 ubiquitin-protein ligase TRIM7 TRIM7 56 Q9C029 E3 ubiquitin-protein ligase TRIM7 TRIM7 78 Q9C029 E3 ubiquitin-protein ligase TRIM7 TRIM7 130 Q9C029 E3 ubiquitin-protein ligase TRIM7 TRIM7 141 Q9C029 E3 ubiquitin-protein ligase TRIM7 TRIM7 149 Q9C029 E3 ubiquitin-protein ligase TRIM7 TRIM7 152 Q9C029 E3 ubiquitin-protein ligase TRIM7 TRIM7 378 Q9C029 E3 ubiquitin-protein ligase TRIM7 TRIM7 501 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 19 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 66 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 69 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 94 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 199 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 212 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 215 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 223 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 301 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 380 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 607 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 636 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 661 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 778 Q2Q1W2 E3 ubiquitin-protein ligase TRIM71 TRIM71 829 Q6ZMU5 Tripartite motif-containing protein 72 TRIM72 56 Q6ZMU5 Tripartite motif-containing protein 72 TRIM72 86 Q6ZMU5 Tripartite motif-containing protein 72 TRIM72 97 Q6ZMU5 Tripartite motif-containing protein 72 TRIM72 105 Q6ZMU5 Tripartite motif-containing protein 72 TRIM72 108 Q6ZMU5 Tripartite motif-containing protein 72 TRIM72 144 Q6ZMU5 Tripartite motif-containing protein 72 TRIM72 242 Q9BZR9 E3 ubiquitin-protein ligase TRIM8 TRIM8 8 Q9BZR9 E3 ubiquitin-protein ligase TRIM8 TRIM8 38 Q9BZR9 E3 ubiquitin-protein ligase TRIM8 TRIM8 92 Q9BZR9 E3 ubiquitin-protein ligase TRIM8 TRIM8 95 Q9BZR9 E3 ubiquitin-protein ligase TRIM8 TRIM8 110 Q9BZR9 E3 ubiquitin-protein ligase TRIM8 TRIM8 114 Q9BZR9 E3 ubiquitin-protein ligase TRIM8 TRIM8 145 Q9BZR9 E3 ubiquitin-protein ligase TRIM8 TRIM8 262 Q9BZR9 E3 ubiquitin-protein ligase TRIM8 TRIM8 315 Q9BZR9 E3 ubiquitin-protein ligase TRIM8 TRIM8 367 Q9C026 E3 ubiquitin-protein ligase TRIM9 TRIM9 92 Q9C026 E3 ubiquitin-protein ligase TRIM9 TRIM9 131 Q9C026 E3 ubiquitin-protein ligase TRIM9 TRIM9 168 Q9C026 E3 ubiquitin-protein ligase TRIM9 TRIM9 370 Q9C026 E3 ubiquitin-protein ligase TRIM9 TRIM9 451 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 35 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 156 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 190 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 332 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 502 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 535 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 625 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 703 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 710 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 737 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 947 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 1225 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 1276 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 1411 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 1538 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 1867 Q14669 E3 ubiquitin-protein ligase TRIP12 TRIP12 1959 Q8TEL6 Short transient receptor potential channel 4-associated protein TRPC4AP 448 Q8TEL6 Short transient receptor potential channel 4-associated protein TRPC4AP 508 Q8TEL6 Short transient receptor potential channel 4-associated protein TRPC4AP 749 P53804 E3 ubiquitin-protein ligase TTC3 TTC3 109 P53804 E3 ubiquitin-protein ligase TTC3 TTC3 213 P53804 E3 ubiquitin-protein ligase TTC3 TTC3 422 P53804 E3 ubiquitin-protein ligase TTC3 TTC3 580 P53804 E3 ubiquitin-protein ligase TTC3 TTC3 757 P53804 E3 ubiquitin-protein ligase TTC3 TTC3 823 P53804 E3 ubiquitin-protein ligase TTC3 TTC3 1107 P53804 E3 ubiquitin-protein ligase TTC3 TTC3 1159 P53804 E3 ubiquitin-protein ligase TTC3 TTC3 1168 P53804 E3 ubiquitin-protein ligase TTC3 TTC3 1249 P53804 E3 ubiquitin-protein ligase TTC3 TTC3 1293 P53804 E3 ubiquitin-protein ligase TTC3 TTC3 1318 P53804 E3 ubiquitin-protein ligase TTC3 TTC3 1857 P53804 E3 ubiquitin-protein ligase TTC3 TTC3 2022 Q9NRJ4 Tubby-related protein 4 TULP4 909 Q9NRJ4 Tubby-related protein 4 TULP4 938 Q9NRJ4 Tubby-related protein 4 TULP4 1098 Q9BSL1 Ubiquitin-associated domain-containing protein 1 UBAC1 47 Q9BSL1 Ubiquitin-associated domain-containing protein 1 UBAC1 322 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 101 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 182 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 208 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 230 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 244 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 314 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 341 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 370 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 375 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 400 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 406 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 585 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 598 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 910 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 913 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 1040 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 1099 Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 1288 Q05086 Ubiquitin-protein ligase E3A UBE3A 7 Q05086 Ubiquitin-protein ligase E3A UBE3A 49 Q05086 Ubiquitin-protein ligase E3A UBE3A 57 Q05086 Ubiquitin-protein ligase E3A UBE3A 83 Q05086 Ubiquitin-protein ligase E3A UBE3A 108 Q05086 Ubiquitin-protein ligase E3A UBE3A 140 Q05086 Ubiquitin-protein ligase E3A UBE3A 198 Q05086 Ubiquitin-protein ligase E3A UBE3A 269 Q05086 Ubiquitin-protein ligase E3A UBE3A 310 Q05086 Ubiquitin-protein ligase E3A UBE3A 480 Q05086 Ubiquitin-protein ligase E3A UBE3A 843 Q7Z3V4 Ubiquitin-protein ligase E3B UBE3B 75 Q7Z3V4 Ubiquitin-protein ligase E3B UBE3B 307 Q7Z3V4 Ubiquitin-protein ligase E3B UBE3B 399 Q7Z3V4 Ubiquitin-protein ligase E3B UBE3B 1036 Q15386 Ubiquitin-protein ligase E3C UBE3C 140 Q15386 Ubiquitin-protein ligase E3C UBE3C 152 Q15386 Ubiquitin-protein ligase E3C UBE3C 158 Q15386 Ubiquitin-protein ligase E3C UBE3C 252 Q15386 Ubiquitin-protein ligase E3C UBE3C 395 Q15386 Ubiquitin-protein ligase E3C UBE3C 548 Q15386 Ubiquitin-protein ligase E3C UBE3C 622 Q15386 Ubiquitin-protein ligase E3C UBE3C 1018 Q15386 Ubiquitin-protein ligase E3C UBE3C 1034 Q15386 Ubiquitin-protein ligase E3C UBE3C 1051 Q15386 Ubiquitin-protein ligase E3C UBE3C 1076 Q7Z6J8 E3 ubiquitin-protein ligase E3D UBE3D 52 Q7Z6J8 E3 ubiquitin-protein ligase E3D UBE3D 68 Q7Z6J8 E3 ubiquitin-protein ligase E3D UBE3D 143 Q7Z6J8 E3 ubiquitin-protein ligase E3D UBE3D 144 Q7Z6J8 E3 ubiquitin-protein ligase E3D UBE3D 190 Q7Z6J8 E3 ubiquitin-protein ligase E3D UBE3D 197 Q7Z6J8 E3 ubiquitin-protein ligase E3D UBE3D 330 Q14139 Ubiquitin conjugation factor E4 A UBE4A 79 Q14139 Ubiquitin conjugation factor E4 A UBE4A 175 Q14139 Ubiquitin conjugation factor E4 A UBE4A 202 Q14139 Ubiquitin conjugation factor E4 A UBE4A 398 Q14139 Ubiquitin conjugation factor E4 A UBE4A 450 Q14139 Ubiquitin conjugation factor E4 A UBE4A 465 Q14139 Ubiquitin conjugation factor E4 A UBE4A 490 Q14139 Ubiquitin conjugation factor E4 A UBE4A 710 O95155 Ubiquitin conjugation factor E4 B UBE4B 113 O95155 Ubiquitin conjugation factor E4 B UBE4B 448 O95155 Ubiquitin conjugation factor E4 B UBE4B 464 O95155 Ubiquitin conjugation factor E4 B UBE4B 494 O95155 Ubiquitin conjugation factor E4 B UBE4B 563 O95155 Ubiquitin conjugation factor E4 B UBE4B 581 O95155 Ubiquitin conjugation factor E4 B UBE4B 826 O95155 Ubiquitin conjugation factor E4 B UBE4B 829 O95155 Ubiquitin conjugation factor E4 B UBE4B 1164 O94941 RING finger protein 37 UBOX5 99 O94941 RING finger protein 37 UBOX5 187 O94941 RING finger protein 37 UBOX5 340 O94941 RING finger protein 37 UBOX5 383 O94941 RING finger protein 37 UBOX5 416 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 163 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 180 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 251 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 279 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 350 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 477 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 511 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 872 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 993 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 1197 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 1204 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 1577 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 1603 Q8IWV7 E3 ubiquitin-protein ligase UBR1 UBR1 1685 Q8IWV8 E3 ubiquitin-protein ligase UBR2 UBR2 19 Q8IWV8 E3 ubiquitin-protein ligase UBR2 UBR2 252 Q8IWV8 E3 ubiquitin-protein ligase UBR2 UBR2 280 Q8IWV8 E3 ubiquitin-protein ligase UBR2 UBR2 602 Q8IWV8 E3 ubiquitin-protein ligase UBR2 UBR2 837 Q8IWV8 E3 ubiquitin-protein ligase UBR2 UBR2 1360 Q8IWV8 E3 ubiquitin-protein ligase UBR2 UBR2 1619 Q8IWV8 E3 ubiquitin-protein ligase UBR2 UBR2 1679 Q8IWV8 E3 ubiquitin-protein ligase UBR2 UBR2 1691 Q8IWV8 E3 ubiquitin-protein ligase UBR2 UBR2 1717 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 96 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 141 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 184 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 197 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 216 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 288 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 979 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 1289 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 1373 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 1471 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 1598 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 1629 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 1769 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 1787 Q6ZT12 E3 ubiquitin-protein ligase UBR3 UBR3 1858 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 140 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 260 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 546 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 779 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 934 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 953 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 1080 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 1274 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 1458 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 1662 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 1682 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 1714 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 1724 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 1789 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 1900 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 1962 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 2222 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 2449 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 2489 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 2554 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 2618 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 2619 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 2688 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 2697 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3075 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3279 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3430 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3663 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3677 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3684 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3700 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3703 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3706 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3720 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3721 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3765 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3804 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3807 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3864 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3872 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3875 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 3930 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 4049 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 4146 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 4272 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 4430 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 4487 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 4642 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 4663 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 4838 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 4839 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 4841 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 4890 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 4916 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 4935 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 4946 Q5T4S7 E3 ubiquitin-protein ligase UBR4 UBR4 5121 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 373 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 535 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 572 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 617 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 691 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 730 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 739 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 883 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 1093 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 1215 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 1221 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 1232 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 1291 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 2084 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 2094 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 2267 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 2314 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 2546 O95071 E3 ubiquitin-protein ligase UBR5 UBR5 2768 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 35 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 46 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 61 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 75 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 78 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 82 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 99 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 101 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 111 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 137 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 158 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 185 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 260 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 314 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 316 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 374 Q8N806 Putative E3 ubiquitin-protein ligase UBR7 UBR7 424 O94874 E3 UFM1-protein ligase 1 UFL1 32 O94874 E3 UFM1-protein ligase 1 UFL1 143 O94874 E3 UFM1-protein ligase 1 UFL1 372 O94874 E3 UFM1-protein ligase 1 UFL1 708 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 97 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 98 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 170 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 302 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 305 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 316 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 318 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 321 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 403 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 410 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 497 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 512 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 726 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 727 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 739 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 747 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 759 Q96T88 E3 ubiquitin-protein ligase UHRF1 UHRF1 762 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 14 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 42 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 92 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 171 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 200 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 331 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 334 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 342 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 345 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 347 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 432 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 439 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 541 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 671 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 704 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 768 Q96PU4 E3 ubiquitin-protein ligase UHRF2 UHRF2 771 Q9C0B0 RING finger protein unkempt homolog UNK 45 Q9C0B0 RING finger protein unkempt homolog UNK 53 Q9C0B0 RING finger protein unkempt homolog UNK 106 Q9C0B0 RING finger protein unkempt homolog UNK 130 Q9C0B0 RING finger protein unkempt homolog UNK 140 Q9C0B0 RING finger protein unkempt homolog UNK 147 Q9C0B0 RING finger protein unkempt homolog UNK 221 Q9C0B0 RING finger protein unkempt homolog UNK 383 Q9C0B0 RING finger protein unkempt homolog UNK 675 Q9C0B0 RING finger protein unkempt homolog UNK 696 Q9C0B0 RING finger protein unkempt homolog UNK 772 Q9C0B0 RING finger protein unkempt homolog UNK 782 Q9C0B0 RING finger protein unkempt homolog UNK 788 Q9C0B0 RING finger protein unkempt homolog UNK 791 Q9C0B0 RING finger protein unkempt homolog UNK 797 Q9C0B0 RING finger protein unkempt homolog UNK 800 Q9H9P5 Putative E3 ubiquitin-protein ligase UNKL UNKL 36 Q9H9P5 Putative E3 ubiquitin-protein ligase UNKL UNKL 213 Q9H9P5 Putative E3 ubiquitin-protein ligase UNKL UNKL 226 Q9H9P5 Putative E3 ubiquitin-protein ligase UNKL UNKL 249 Q9H9P5 Putative E3 ubiquitin-protein ligase UNKL UNKL 270 Q9H9P5 Putative E3 ubiquitin-protein ligase UNKL UNKL 297 Q9H9P5 Putative E3 ubiquitin-protein ligase UNKL UNKL 303 Q9H9P5 Putative E3 ubiquitin-protein ligase UNKL UNKL 320 Q9H9P5 Putative E3 ubiquitin-protein ligase UNKL UNKL 595 Q9H9P5 Putative E3 ubiquitin-protein ligase UNKL UNKL 639 Q9H9P5 Putative E3 ubiquitin-protein ligase UNKL UNKL 642 P40337 von Hippel-Lindau disease tumor suppressor VHL 77 P40337 von Hippel-Lindau disease tumor suppressor VHL 162 Q9H270 Vacuolar protein sorting-associated protein 11 homolog VPS11 44 Q9H270 Vacuolar protein sorting-associated protein 11 homolog VPS11 52 Q9H270 Vacuolar protein sorting-associated protein 11 homolog VPS11 128 Q9H270 Vacuolar protein sorting-associated protein 11 homolog VPS11 231 Q9H270 Vacuolar protein sorting-associated protein 11 homolog VPS11 317 Q9H270 Vacuolar protein sorting-associated protein 11 homolog VPS11 460 Q9H270 Vacuolar protein sorting-associated protein 11 homolog VPS11 568 Q9H270 Vacuolar protein sorting-associated protein 11 homolog VPS11 586 Q9H270 Vacuolar protein sorting-associated protein 11 homolog VPS11 660 Q9H270 Vacuolar protein sorting-associated protein 11 homolog VPS11 734 Q9H270 Vacuolar protein sorting-associated protein 11 homolog VPS11 890 Q9P253 Vacuolar protein sorting-associated protein 18 homolog VPS18 22 Q9P253 Vacuolar protein sorting-associated protein 18 homolog VPS18 421 Q9P253 Vacuolar protein sorting-associated protein 18 homolog VPS18 433 Q9P253 Vacuolar protein sorting-associated protein 18 homolog VPS18 445 Q9P253 Vacuolar protein sorting-associated protein 18 homolog VPS18 522 Q9P253 Vacuolar protein sorting-associated protein 18 homolog VPS18 704 Q9P253 Vacuolar protein sorting-associated protein 18 homolog VPS18 713 Q9P253 Vacuolar protein sorting-associated protein 18 homolog VPS18 741 Q9P253 Vacuolar protein sorting-associated protein 18 homolog VPS18 776 Q9P253 Vacuolar protein sorting-associated protein 18 homolog VPS18 780 Q9P253 Vacuolar protein sorting-associated protein 18 homolog VPS18 806 P49754 Vacuolar protein sorting-associated protein 41 homolog VPS41 299 P49754 Vacuolar protein sorting-associated protein 41 homolog VPS41 638 P49754 Vacuolar protein sorting-associated protein 41 homolog VPS41 794 P49754 Vacuolar protein sorting-associated protein 41 homolog VPS41 814 Q8N3P4 Vacuolar protein sorting-associated protein 8 homolog VPS 8 286 Q8N3P4 Vacuolar protein sorting-associated protein 8 homolog VPS8 564 Q8N3P4 Vacuolar protein sorting-associated protein 8 homolog VPS8 974 Q8N3P4 Vacuolar protein sorting-associated protein 8 homolog VPS8 1309 Q8N3P4 Vacuolar protein sorting-associated protein 8 homolog VPS8 1371 Q9H7D7 WD repeat-containing protein 26 WDR26 153 Q9H7D7 WD repeat-containing protein 26 WDR26 238 Q9H7D7 WD repeat-containing protein 26 WDR26 259 Q9H7D7 WD repeat-containing protein 26 WDR26 316 Q9H7D7 WD repeat-containing protein 26 WDR26 338 Q9H7D7 WD repeat-containing protein 26 WDR26 345 Q9H7D7 WD repeat-containing protein 26 WDR26 355 Q9H7D7 WD repeat-containing protein 26 WDR26 473 Q9H7D7 WD repeat-containing protein 26 WDR26 490 Q9H7D7 WD repeat-containing protein 26 WDR26 493 Q9H7D7 WD repeat-containing protein 26 WDR26 656 Q8N9V3 WD repeat, SAM and U-box domain-containing protein 1 WDSUB1 172 Q8N9V3 WD repeat, SAM and U-box domain-containing protein 1 WDSUB1 316 Q8N9V3 WD repeat, SAM and U-box domain-containing protein 1 WDSUB1 410 Q8N5D0 WD and tetratricopeptide repeats protein 1 WDTC1 181 Q8N5D0 WD and tetratricopeptide repeats protein 1 WDTC1 189 Q8N5D0 WD and tetratricopeptide repeats protein 1 WDTC1 199 Q8N5D0 WD and tetratricopeptide repeats protein 1 WDTC1 236 Q8N5D0 WD and tetratricopeptide repeats protein 1 WDTC1 312 Q8N5D0 WD and tetratricopeptide repeats protein 1 WDTC1 375 Q8N5D0 WD and tetratricopeptide repeats protein 1 WDTC1 431 Q8N5D0 WD and tetratricopeptide repeats protein 1 WDTC1 472 Q8N5D0 WD and tetratricopeptide repeats protein 1 WDTC1 531 Q8N5D0 WD and tetratricopeptide repeats protein 1 WDTC1 534 Q8N5D0 WD and tetratricopeptide repeats protein 1 WDTC1 585 Q8N5D0 WD and tetratricopeptide repeats protein 1 WDTC1 593 Q9Y6I7 WD repeat and SOCS box-containing protein 1 WSB1 33 Q9Y6I7 WD repeat and SOCS box-containing protein 1 WSB1 66 Q9Y6I7 WD repeat and SOCS box-containing protein 1 WSB1 126 Q9H0M0 NEDD4-like E3 ubiquitin-protein ligase WWP1 WWP1 335 Q9H0M0 NEDD4-like E3 ubiquitin-protein ligase WWP1 WWP1 854 Q9H0M0 NEDD4-like E3 ubiquitin-protein ligase WWP1 WWP1 890 O00308 NEDD4-like E3 ubiquitin-protein ligase WWP2 WWP2 186 O00308 NEDD4-like E3 ubiquitin-protein ligase WWP2 WWP2 750 O00308 NEDD4-like E3 ubiquitin-protein ligase WWP2 WWP2 802 O00308 NEDD4-like E3 ubiquitin-protein ligase WWP2 WWP2 822 O00308 NEDD4-like E3 ubiquitin-protein ligase WWP2 WWP2 838 P98170 E3 ubiquitin-protein ligase XIAP XIAP 12 P98170 E3 ubiquitin-protein ligase XIAP XIAP 90 P98170 E3 ubiquitin-protein ligase XIAP XIAP 202 P98170 E3 ubiquitin-protein ligase XIAP XIAP 203 P98170 E3 ubiquitin-protein ligase XIAP XIAP 213 P98170 E3 ubiquitin-protein ligase XIAP XIAP 327 P98170 E3 ubiquitin-protein ligase XIAP XIAP 351 P98170 E3 ubiquitin-protein ligase XIAP XIAP 471 P98170 E3 ubiquitin-protein ligase XIAP XIAP 474 P98170 E3 ubiquitin-protein ligase XIAP XIAP 481 P10074 Telomere zinc finger-associated protein ZBTB48 111 P10074 Telomere zinc finger-associated protein ZBTB48 190 P10074 Telomere zinc finger-associated protein ZBTB48 265 P10074 Telomere zinc finger-associated protein ZBTB48 380 Q86WB0 Nuclear-interacting partner of ALK ZC3HC1 102 Q86WB0 Nuclear-interacting partner of ALK ZC3HC1 112 Q86WB0 Nuclear-interacting partner of ALK ZC3HC1 117 Q86WB0 Nuclear-interacting partner of ALK ZC3HC1 120 Q86WB0 Nuclear-interacting partner of ALK ZC3HC1 125 Q86WB0 Nuclear-interacting partner of ALK ZC3HC1 149 Q86WB0 Nuclear-interacting partner of ALK ZC3HC1 156 Q86WB0 Nuclear-interacting partner of ALK ZC3HC1 190 Q86WB0 Nuclear-interacting partner of ALK ZC3HC1 208 Q86WB0 Nuclear-interacting partner of ALK ZC3HC1 406 Q86WB0 Nuclear-interacting partner of ALK ZC3HC1 429 Q86WB0 Nuclear-interacting partner of ALK ZC3HC1 500 Q86WB0 Nuclear-interacting partner of ALK ZC3HC1 502 Q9H8U3 AN1-type zinc finger protein 3 ZFAND3 18 Q9H8U3 AN1-type zinc finger protein 3 ZFAND3 20 Q9H8U3 AN1-type zinc finger protein 3 ZFAND3 32 Q9H8U3 AN1-type zinc finger protein 3 ZFAND3 35 Q9H8U3 AN1-type zinc finger protein 3 ZFAND3 118 Q9H8U3 AN1-type zinc finger protein 3 ZFAND3 157 Q9H8U3 AN1-type zinc finger protein 3 ZFAND3 160 Q9H8U3 AN1-type zinc finger protein 3 ZFAND3 174 Q9H8U3 AN1-type zinc finger protein 3 ZFAND3 192 O76080 AN1-type zinc finger protein 5 ZFAND5 30 O76080 AN1-type zinc finger protein 5 ZFAND5 33 O76080 AN1-type zinc finger protein 5 ZFAND5 76 O76080 AN1-type zinc finger protein 5 ZFAND5 168 O76080 AN1-type zinc finger protein 5 ZFAND5 170 O76080 AN1-type zinc finger protein 5 ZFAND5 186 Q6FIF0 AN1-type zinc finger protein 6 ZFAND6 30 Q6FIF0 AN1-type zinc finger protein 6 ZFAND6 33 Q6FIF0 AN1-type zinc finger protein 6 ZFAND6 163 Q6FIF0 AN1-type zinc finger protein 6 ZFAND6 165 Q6FIF0 AN1-type zinc finger protein 6 ZFAND6 170 Q6FIF0 AN1-type zinc finger protein 6 ZFAND6 181 Q96JP5 E3 ubiquitin-protein ligase ZFP91 ZFP91 115 Q96JP5 E3 ubiquitin-protein ligase ZFP91 ZFP91 182 Q96JP5 E3 ubiquitin-protein ligase ZFP91 ZFP91 313 Q96JP5 E3 ubiquitin-protein ligase ZFP91 ZFP91 318 Q96JP5 E3 ubiquitin-protein ligase ZFP91 ZFP91 344 Q96JP5 E3 ubiquitin-protein ligase ZFP91 ZFP91 349 Q96JP5 E3 ubiquitin-protein ligase ZFP91 ZFP91 409 Q96JP5 E3 ubiquitin-protein ligase ZFP91 ZFP91 520 O95159 Zinc finger protein-like 1 ZFPL1 16 O95159 Zinc finger protein-like 1 ZFPL1 24 O95159 Zinc finger protein-like 1 ZFPL1 27 O95159 Zinc finger protein-like 1 ZFPL1 56 O95159 Zinc finger protein-like 1 ZFPL1 70 O95159 Zinc finger protein-like 1 ZFPL1 78 O95159 Zinc finger protein-like 1 ZFPL1 97 O95159 Zinc finger protein-like 1 ZFPL1 230 Q9ULJ6 Zinc finger MIZ domain-containing protein 1 ZMIZ1 17 Q9ULJ6 Zinc finger MIZ domain-containing protein 1 ZMIZ1 81 Q9ULJ6 Zinc finger MIZ domain-containing protein 1 ZMIZ1 612 Q9ULJ6 Zinc finger MIZ domain-containing protein 1 ZMIZ1 657 Q9ULJ6 Zinc finger MIZ domain-containing protein 1 ZMIZ1 705 Q9ULJ6 Zinc finger MIZ domain-containing protein 1 ZMIZ1 742 Q9ULJ6 Zinc finger MIZ domain-containing protein 1 ZMIZ1 763 Q9ULJ6 Zinc finger MIZ domain-containing protein 1 ZMIZ1 784 Q8NF64 Zinc finger MIZ domain-containing protein 2 ZMIZ2 418 Q8NF64 Zinc finger MIZ domain-containing protein 2 ZMIZ2 471 Q8NF64 Zinc finger MIZ domain-containing protein 2 ZMIZ2 516 Q8NF64 Zinc finger MIZ domain-containing protein 2 ZMIZ2 564 Q8NF64 Zinc finger MIZ domain-containing protein 2 ZMIZ2 600 Q8NF64 Zinc finger MIZ domain-containing protein 2 ZMIZ2 632 Q8NF64 Zinc finger MIZ domain-containing protein 2 ZMIZ2 642 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 133 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 150 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 268 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 317 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 320 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 441 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 461 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 507 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 611 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 638 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 641 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 655 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 730 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 741 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 813 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 940 Q9Y4E5 E3 SUMO-protein ligase ZNF451 ZNF451 959 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 32 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 33 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 44 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 49 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 60 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 65 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 68 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 119 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 122 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 146 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 147 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 189 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 242 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 247 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 269 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 426 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 456 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 610 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 662 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 676 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 725 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 835 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 864 Q86UK7 E3 ubiquitin-protein ligase ZNF598 ZNF598 867 Q8ND25 E3 ubiquitin-protein ligase ZNRF1 ZNRF1 148 Q8ND25 E3 ubiquitin-protein ligase ZNRF1 ZNRF1 164 Q8ND25 E3 ubiquitin-protein ligase ZNRF1 ZNRF1 202 Q8ND25 E3 ubiquitin-protein ligase ZNRF1 ZNRF1 204 Q8ND25 E3 ubiquitin-protein ligase ZNRF1 ZNRF1 210 Q8ND25 E3 ubiquitin-protein ligase ZNRF1 ZNRF1 221 Q8NHG8 E3 ubiquitin-protein ligase ZNRF2 ZNRF2 160 Q8NHG8 E3 ubiquitin-protein ligase ZNRF2 ZNRF2 163 Q8NHG8 E3 ubiquitin-protein ligase ZNRF2 ZNRF2 179 Q8NHG8 E3 ubiquitin-protein ligase ZNRF2 ZNRF2 217 Q8NHG8 E3 ubiquitin-protein ligase ZNRF2 ZNRF2 219 Q8NHG8 E3 ubiquitin-protein ligase ZNRF2 ZNRF2 236 Q9ULT6 E3 ubiquitin-protein ligase ZNRF3 ZNRF3 311 Q9ULT6 E3 ubiquitin-protein ligase ZNRF3 ZNRF3 433 Q9ULT6 E3 ubiquitin-protein ligase ZNRF3 ZNRF3 779 Q9ULT6 E3 ubiquitin-protein ligase ZNRF3 ZNRF3 882 Q8NEG5 E3 ubiquitin-protein ligase ZSWIM2 ZSWIM2 605 Q9C0D3 Protein zyg-11 homolog B ZYG11B 43 Q9C0D3 Protein zyg-11 homolog B ZYG11B 643 Q9C0D3 Protein zyg-11 homolog B ZYG11B 735

TABLE 2B UniProt KB02¹ KB02² KB03³ KB03⁴ KB05⁵ KB05⁶ Q969K4 83 72 53 Q969K4 63 17 34 6 53 Q969K4 53 28 43 18 38 3 Q969K4 39 6 32 65 3 Q969K4 60 62 71 Q8N961 50 51 62 Q8N961 93 52 83 70 89 50 Q8N961 87 60 44 15 42 10 Q8N961 4 7 Q8N961 20 7 25 28 Q8N961 10 Q9C0C7 64 52 64 Q9C0C7 83 71 72 Q9C0C7 54 19 36 Q9C0C7 90 48 88 59 81 23 Q9C0C7 72 49 81 73 79 25 Q9C0C7 37 5 43 Q9UKV5 19 4 48 18 5 Q9H1A4 18 29 22 Q9H1A4 21 5 25 Q9H1A4 74 57 30 76 Q9H1A4 29 24 58 35 Q9H1A4 56 21 46 34 43 29 Q9H1A4 38 16 51 Q9UM13 53 1 37 11 62 18 Q9NYG5 63 41 79 51 37 27 Q9NYG5 38 20 40 Q9NYG5 76 75 77 Q9NYG5 51 49 54 P60006 93 44 65 49 74 24 Q96DE5 85 46 82 52 83 37 Q9UJX6 37 16 56 Q9UJX6 94 40 97 86 76 23 Q9UJX6 67 7 69 46 72 8 Q9UJX6 84 47 73 11 81 35 Q9UJX6 58 14 84 63 59 Q9UJX6 54 73 58 71 24 Q9UJX6 57 37 59 Q9UJX5 7 29 20 6 Q9UJX4 64 35 62 31 74 Q9UJX4 62 16 70 Q9UJX4 71 16 50 73 Q9UJX4 74 42 70 Q9UJX4 41 27 60 Q9UJX4 40 1 45 58 9 Q9UJX4 51 15 53 Q9UJX3 56 24 41 20 86 64 Q9UJX3 87 42 40 Q9UJX3 6 16 47 61 36 Q9UJX3 67 30 39 28 53 58 Q9UJX3 77 62 79 68 77 71 Q9UJX3 73 62 79 Q9UJX3 84 48 75 49 Q9UJX3 79 54 59 Q9UJX3 8 32 9 Q9UJX3 57 50 76 68 60 62 Q9P2R3 68 53 73 Q9P2R3 21 14 50 33 76 26 Q9P2R3 76 51 87 65 75 63 Q9P2R3 63 4 36 54 21 Q9P2R3 44 14 74 55 62 41 Q9P2R3 48 51 64 Q9P2R3 40 41 42 39 41 Q9P2R3 76 12 76 79 38 Q9P2R3 28 34 43 Q9P2R3 44 52 39 37 Q9P2R3 66 48 57 Q9P2R3 27 51 52 Q9P2R3 46 50 57 Q9P2R3 62 32 57 Q9P2R3 68 53 60 Q9P2R3 43 12 73 40 Q9P2R3 52 43 57 Q9P2R3 47 51 61 Q9P2G1 28 16 26 Q9P2G1 20 14 42 Q9P2G1 50 26 38 Q9P2G1 51 40 34 Q9P2G1 39 11 60 29 43 41 Q9P2G1 32 7 58 Q9P2G1 66 39 66 Q9P2G1 52 49 68 Q9P2G1 20 17 36 32 Q9P2G1 80 46 69 55 22 Q92624 100 83 84 56 79 34 Q92624 11 24 16 O15033 96 77 87 57 92 69 Q9Y4X5 82 36 46 23 67 41 Q9Y4X5 46 18 Q9Y4X5 64 45 59 Q9Y4X5 24 22 14 Q9Y4X5 64 36 75 63 55 Q9Y4X5 32 16 24 36 Q9Y4X5 70 46 56 34 51 7 Q9Y4X5 68 33 60 Q9Y4X5 54 8 40 56 Q9Y4X5 67 25 54 Q9Y4X5 51 12 26 51 21 Q9Y4X5 8 Q9Y4X5 18 2 12 31 Q9Y4X5 46 20 51 Q9Y4X5 15 16 22 Q9Y4X5 29 26 32 Q9Y4X5 69 81 83 Q9Y4X5 10 11 41 O95376 59 41 30 42 O95376 77 21 67 4 77 16 O95376 47 16 46 29 43 9 O95376 72 10 63 77 O95376 77 67 79 O95376 89 28 100 87 O95376 100 44 100 87 O95376 88 3 79 80 O95376 89 78 79 O95376 71 22 47 34 63 26 O95376 75 25 39 16 69 13 O95376 65 3 45 67 O95376 64 56 64 O95376 16 14 24 46 9 O95376 7 21 24 28 O95376 26 19 48 26 O95376 23 21 29 38 O95376 28 21 O95376 5 24 O95376 42 5 28 20 37 25 O95376 6 20 30 7 Q96C12 35 34 54 Q96C12 41 33 30 Q96C12 81 73 74 Q96C12 51 27 57 Q96C12 96 62 63 40 65 23 Q9Y576 48 35 33 62 9 Q9Y576 45 14 57 60 Q9Y576 65 31 47 61 14 Q9Y576 60 35 73 51 86 20 Q9Y576 22 16 53 Q9Y576 24 10 19 23 14 Q8WXK3 44 63 40 7 Q8WXK3 30 72 Q8WXK3 36 33 Q8WXK3 6 49 Q8WXK3 11 2 Q96Q27 19 10 21 Q96Q27 96 54 77 88 36 Q96Q27 45 23 Q96Q27 39 16 45 36 Q9NWX5 46 38 75 72 88 51 Q9NWX5 49 8 87 68 55 11 Q9NWX5 82 83 46 Q9NWX5 33 2 44 19 Q9H765 54 19 40 37 Q96DX5 64 30 44 33 37 12 Q96DX5 8 Q96DX5 16 11 32 P46100 31 14 23 P46100 7 10 19 P46100 12 79 P46100 74 36 82 67 49 18 P46100 21 34 29 P46100 22 16 P46100 33 38 40 P46100 13 P46100 47 27 37 13 40 4 P46100 79 29 43 12 40 13 P46100 75 54 49 42 61 44 P46100 42 9 26 29 19 1 P46100 64 42 43 P46100 18 14 21 P46100 23 9 P46100 36 35 5 P46100 33 23 19 P46100 65 17 23 28 P46100 46 P46100 31 16 P46100 67 37 55 33 88 23 P46100 39 36 68 P46100 82 68 78 P46100 80 59 69 P46100 80 52 P46100 74 43 90 74 87 47 P46100 55 12 36 63 P46100 75 60 89 P46100 67 47 85 25 P46100 82 73 57 P46100 57 50 57 P46100 30 11 41 15 54 22 Q9NXR7 50 10 37 26 41 1 Q9NXR7 60 11 64 46 64 Q9NXR7 48 2 46 58 Q9NXR7 63 44 64 53 73 17 Q9NXR7 51 57 29 60 Q9NXR7 54 37 38 51 O14867 64 49 70 O14867 75 17 48 83 O14867 80 54 80 O14867 75 38 76 23 O14867 89 62 92 83 92 36 O14867 60 39 53 O14867 50 14 O14867 19 2 16 O14867 66 51 69 O14867 68 45 84 12 O14867 81 35 70 61 67 29 O14867 66 42 25 O14867 55 32 15 O14867 32 13 35 O14867 54 76 64 62 O14867 97 91 95 92 91 62 O14867 79 36 62 21 45 O14867 39 1 21 Q9BYV9 41 18 48 Q9BYV9 35 3 42 Q9BYV9 61 26 44 35 59 22 Q9BYV9 63 14 43 20 63 Q9BYV9 61 27 65 3 61 10 Q9BYV9 86 47 81 38 75 17 Q9BYV9 56 19 49 44 10 Q9BYV9 49 6 40 19 48 Q9BYV9 50 19 58 54 Q9BYV9 63 24 57 9 70 17 Q9BYV9 56 26 57 3 55 13 Q9BYV9 22 10 48 34 Q9BYV9 83 13 80 100 27 Q9BYV9 87 41 100 Q9BYV9 33 7 23 Q9BYV9 19 11 Q99728 47 22 68 71 Q99728 45 16 59 Q99728 69 29 55 40 Q99728 66 35 52 57 Q99728 37 53 47 31 55 Q99728 66 33 31 38 68 31 P41182 18 25 P41182 55 28 39 19 74 9 P41182 67 9 52 35 65 7 P41182 67 20 53 P41182 58 17 37 20 41 P41182 43 8 49 P41182 48 20 42 P41182 42 13 49 15 41 P41182 17 10 31 31 P41182 28 18 41 P41182 6 2 29 Q13490 99 99 98 91 87 44 Q13490 36 33 33 46 Q13490 37 34 26 40 10 Q13490 57 44 54 Q13490 75 55 63 Q13490 21 19 42 2 Q13490 8 4 10 Q13490 7 6 23 Q13490 16 14 36 Q13490 55 56 58 Q13489 89 44 61 42 48 37 Q13489 36 33 33 46 Q13489 37 34 26 40 10 Q13489 26 17 46 Q13489 91 65 97 88 84 52 Q13489 57 44 54 Q13489 67 57 61 Q13489 21 19 42 2 Q13489 38 13 40 24 Q13489 3 1 28 Q13489 16 14 36 Q13489 55 56 58 Q9NR09 17 4 13 Q9NR09 31 10 16 Q9NR09 90 92 94 Q9NR09 75 11 66 49 Q9NR09 29 24 35 5 55 Q9NR09 37 18 25 Q9NR09 30 29 67 48 36 36 Q9NR09 22 Q9NR09 17 30 33 Q9NR09 32 20 34 19 37 25 Q9NR09 32 35 60 23 Q9NR09 23 16 29 Q9NR09 64 46 54 36 64 38 Q9NR09 38 17 49 Q9NR09 30 18 13 Q9NR09 14 Q9NR09 23 40 54 Q9NR09 58 46 55 26 57 29 Q9NR09 54 46 3 59 7 Q9NR09 30 20 42 Q9NR09 37 2 26 Q9NR09 86 9 89 70 34 4 Q9NR09 86 58 84 Q9NR09 2 19 Q9NR09 27 29 Q9NR09 81 41 78 71 81 35 Q9NR09 50 24 57 35 63 42 Q9NR09 61 18 31 18 47 43 Q9NR09 51 15 57 27 Q9NR09 28 22 57 Q9NR09 84 70 87 83 89 80 Q9NR09 92 69 11 38 Q9NR09 70 24 4 59 13 Q9NR09 73 33 77 44 90 37 Q9NR09 39 3 19 59 Q9NR09 53 12 43 65 Q9NR09 45 22 51 Q9NR09 50 19 38 39 Q96P09 38 21 45 Q7Z569 37 22 16 10 71 33 Q7Z569 26 26 18 32 Q7Z569 6 Q7Z569 30 29 38 Q7Z569 30 36 50 Q7Z569 60 13 43 Q7Z569 35 30 51 Q7Z569 1 Q7Z569 38 33 53 Q7Z569 1 5 16 1 Q7Z569 42 30 30 Q7Z569 26 26 43 30 P38398 62 38 96 78 P38398 75 40 94 68 P38398 71 32 85 70 P38398 55 27 73 65 P38398 80 21 75 14 79 18 P38398 85 37 89 72 P38398 44 7 32 P38398 35 40 36 24 P38398 18 1 P38398 62 35 43 19 66 16 P38398 31 18 31 11 P38398 53 19 34 37 P38398 71 20 31 63 8 P38398 40 8 38 46 P38398 63 30 54 73 P38398 58 22 55 36 P38398 47 5 43 35 45 P38398 69 31 44 5 63 16 P38398 63 28 44 1 70 20 P38398 62 35 48 18 55 14 P38398 19 P38398 44 5 22 39 P38398 65 36 65 47 58 11 P38398 45 20 37 40 P38398 64 19 53 67 P38398 42 12 36 16 38 10 P38398 27 24 38 P38398 45 39 52 P38398 50 28 P38398 72 34 57 Q9H0C5 36 13 56 Q9H0C5 14 9 17 Q9H0C5 42 9 25 36 Q9BSF8 45 8 13 37 Q9BSF8 34 11 13 37 Q9BSF8 56 26 38 29 53 27 A6QL63 39 9 53 62 61 13 A6QL63 50 22 49 A6QL63 7 20 A6QL63 10 A6QL63 17 46 29 79 28 Q9BX70 4 40 Q9P203 12 13 31 Q9P203 17 8 Q5XKL5 31 37 Q5XKL5 67 27 18 55 Q96Q07 54 29 65 Q96Q07 45 12 Q9Y297 69 8 48 66 Q9Y297 69 15 65 Q9Y297 53 28 60 Q9Y297 26 11 35 Q9Y297 62 30 52 Q9Y297 55 36 67 54 63 43 Q9Y297 100 67 85 Q9Y297 70 61 68 Q86VP6 56 47 42 46 43 Q86VP6 4 Q86VP6 11 36 26 4 Q86VP6 65 27 26 31 Q86VP6 59 32 10 7 Q86VP6 9 31 Q86VP6 9 17 49 Q86VP6 35 21 53 28 37 43 Q86VP6 24 27 Q86VP6 44 18 69 53 74 64 Q86VP6 67 38 68 51 78 66 Q86VP6 4 Q86VP6 47 12 43 63 Q86VP6 11 40 Q86VP6 21 39 59 17 41 39 Q86VP6 57 21 51 37 73 18 Q86VP6 62 24 73 57 65 55 Q86VP6 46 10 53 17 75 47 Q86VP6 54 30 79 48 77 60 O75155 34 33 53 O75155 56 67 68 O75155 36 63 65 O75155 34 60 67 O75155 3 39 56 O75155 44 46 64 O75155 76 78 82 O75155 79 83 83 O75155 57 72 86 O75155 73 85 90 O75155 68 87 83 O75155 38 26 59 19 O75155 50 40 61 O75155 29 43 51 O75155 50 62 57 O75155 62 24 43 31 61 5 P22681 14 22 33 P22681 17 41 11 18 P22681 30 3 P22681 4 4 6 P22681 54 22 44 30 48 46 P22681 87 76 59 51 65 14 P22681 88 70 67 54 69 17 P22681 57 27 31 21 38 9 P22681 59 29 36 13 65 29 Q13191 14 22 33 Q13191 5 19 Q13191 30 3 Q13191 67 25 77 Q13191 60 27 76 Q13191 53 41 51 34 63 22 Q13191 65 46 41 27 51 43 Q13191 74 67 69 57 61 12 Q13191 56 65 72 58 Q13191 84 78 87 80 76 21 Q13191 45 28 26 13 42 35 Q13191 72 17 51 Q13191 25 14 9 48 5 Q9ULV8 100 76 100 Q9ULV8 100 31 67 66 Q9ULV8 84 57 77 24 Q9ULV8 85 26 41 18 41 29 Q9ULV8 51 47 12 37 Q75N03 53 18 32 27 37 9 Q75N03 9 5 Q75N03 49 14 53 6 39 Q75N03 26 3 36 25 Q75N03 55 6 62 67 Q75N03 57 6 47 49 Q75N03 40 9 35 42 Q75N03 49 12 47 65 26 O00257 54 23 45 23 45 7 O00257 71 43 70 41 81 20 O00257 71 42 73 39 81 25 O00257 53 16 65 37 51 7 O60826 39 22 46 O60826 71 32 54 63 O60826 38 26 30 7 29 22 P55774 51 5 P55774 51 5 P41002 65 19 49 37 P41002 83 45 66 83 49 P41002 75 21 62 77 Q13042 14 9 43 Q13042 47 8 47 63 Q13042 50 43 62 49 42 52 Q13042 66 10 44 61 Q13042 72 34 68 48 57 27 Q13042 58 51 74 Q13042 44 40 41 49 59 38 Q12834 66 36 83 71 73 9 Q12834 98 91 93 Q12834 83 9 65 16 87 22 Q12834 55 5 52 66 Q9UJX2 28 16 43 Q9UJX2 45 6 24 Q9UJX2 6 16 32 Q9UJX2 78 6 54 78 Q9UJX2 11 9 39 Q9UJX2 82 56 78 Q9UJX2 64 8 44 61 Q9UJX2 76 30 69 18 75 9 Q9UJX2 76 33 79 71 68 12 P30260 49 40 52 P30260 43 34 51 10 P30260 15 P30260 49 57 41 P30260 62 34 69 P30260 39 17 51 45 62 20 P30260 79 59 69 52 82 20 P30260 100 66 79 57 90 35 P30260 90 59 95 87 33 28 P30260 82 5 92 85 76 P30260 35 18 35 P30260 57 6 34 44 P30260 43 17 61 P30260 40 29 53 Q6P1J9 48 18 35 24 42 33 Q6P1J9 13 26 17 13 Q99675 34 19 34 74 Q99675 63 23 83 Q99675 61 34 71 Q99675 63 21 73 29 Q99675 42 24 36 Q99675 30 35 28 Q96EP1 16 Q96EP1 8 34 Q96EP1 54 27 66 66 Q96EP1 38 4 22 26 Q96EP1 45 3 35 12 Q96EP1 63 27 28 Q96EP1 65 35 48 Q96EP1 36 35 35 Q96EP1 84 27 49 29 Q96EP1 32 35 66 Q96EP1 51 65 Q96EP1 9 21 31 Q9NSE2 31 41 44 21 33 31 Q9NSE2 54 13 46 16 77 34 Q9NSE2 18 31 57 Q9NSE2 16 22 P10909 57 32 53 P10909 72 54 75 61 61 15 P10909 45 17 37 P10909 81 69 42 74 17 P10909 70 53 72 58 75 24 O95628 39 31 35 O95628 6 20 O95628 20 6 39 13 97 94 O95628 19 O95628 2 16 Q86X83 83 31 72 35 78 38 Q9UBI1 33 29 39 Q9UBI1 57 29 36 Q9GZQ3 11 24 56 Q7Z4G1 30 22 51 33 32 33 Q7Z4G1 48 25 59 Q9P000 54 25 67 30 64 19 Q9P000 100 83 12 7 Q8NHY2 65 34 54 27 65 43 Q8NHY2 62 28 48 Q8NHY2 58 14 35 Q8NHY2 57 37 59 Q8NHY2 37 11 29 40 Q8NHY2 15 20 58 Q8NHY2 35 35 43 Q8NHY2 64 51 59 Q8NHY2 31 15 31 Q8NHY2 52 15 58 47 Q13616 31 6 22 33 Q13616 54 22 49 51 Q13616 58 34 43 31 58 4 Q13616 34 23 50 Q13616 3 20 Q13616 30 18 41 Q13616 1 17 Q13616 20 9 37 Q13617 58 39 27 46 4 Q13617 45 4 33 59 Q13617 44 1 33 51 Q13617 45 16 49 30 42 37 Q13617 33 2 39 51 Q13617 38 12 22 53 Q13617 16 Q13618 39 38 47 35 53 46 Q13618 48 34 20 Q13618 9 Q13618 29 22 47 11 Q13618 23 16 35 Q13618 4 27 Q13618 51 29 19 5 8 Q13618 55 33 43 39 46 47 Q13618 33 34 57 3 Q13618 37 25 41 18 54 40 Q13619 32 28 52 Q13619 48 33 77 Q13619 72 50 70 Q13619 95 68 71 58 41 Q13619 59 64 62 Q13619 56 13 57 41 61 45 Q13619 45 25 44 36 37 28 Q13620 49 5 45 19 47 23 Q13620 38 23 56 Q13620 16 4 36 56 Q13620 47 27 49 Q13620 56 13 57 41 61 45 Q13620 45 25 44 36 37 28 Q13620 27 24 52 Q93034 41 47 41 Q93034 73 27 60 13 70 12 Q93034 62 31 89 67 63 47 Q93034 24 14 38 Q93034 11 59 61 Q14999 45 6 54 Q14999 24 10 Q14999 12 Q14999 53 25 49 Q14999 60 57 75 Q14999 33 27 40 Q14999 27 5 38 12 Q14999 30 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52 56 50 55 25 Q16531 12 25 34 12 Q16531 18 4 26 27 Q16531 27 21 38 Q16531 61 50 56 55 46 23 Q92466 88 43 78 63 72 53 Q92466 90 36 51 30 59 12 Q92466 80 47 42 57 29 Q92466 31 37 24 33 22 Q92466 32 16 47 25 31 Q92466 63 58 80 74 73 47 Q92466 54 30 50 32 52 7 Q92782 19 26 Q92782 77 48 63 44 66 8 Q92782 32 27 27 14 Q92782 43 20 40 32 32 Q92782 28 23 Q92782 40 14 32 Q92782 40 17 24 3 Q92782 37 17 41 18 30 Q92782 24 20 31 22 33 7 Q9NZJ0 78 51 69 38 80 42 Q9NZJ0 100 96 96 88 87 59 Q9NZJ0 77 30 56 45 66 8 Q9NZJ0 73 65 74 Q9NZJ0 70 64 66 Q9NZJ0 54 11 68 53 68 17 Q9NZJ0 71 5 54 67 Q9NZJ0 71 64 3 65 9 Q9NZJ0 61 14 67 57 65 Q9NZJ0 60 49 69 32 56 25 Q9NZJ0 71 78 68 39 61 27 Q9NZJ0 66 10 55 Q9NZJ0 58 27 82 Q9NZJ0 67 24 88 Q9NZJ0 39 27 Q9NZJ0 62 59 Q9NZJ0 85 66 81 56 85 34 Q9NZJ0 27 20 48 Q86Y01 80 24 81 48 55 17 Q86Y01 56 21 26 3 18 Q86Y01 73 43 Q86Y01 73 43 Q86Y01 74 35 59 Q86UW9 16 Q86UW9 38 23 48 Q86UW9 42 15 41 3 Q86UW9 34 28 30 8 27 16 Q86UW9 61 43 87 Q86UW9 39 49 58 Q8N9I9 76 29 75 Q8N9I9 39 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1 33 22 P0C2W1 4 23 P0C2W1 80 33 57 42 43 16 Q6PJ61 59 8 32 49 Q6PJ61 40 3 27 48 Q6PJ61 47 18 32 Q6PJ61 54 31 37 Q6PJ61 2 Q6PJ61 8 21 Q6PJ61 13 8 Q6PJ61 65 25 56 38 47 4 Q9UKT4 68 28 62 53 45 37 Q9UKT4 39 17 57 36 7 Q9UKT4 83 26 80 58 77 14 Q9UKT4 78 25 71 38 Q9UKT4 80 21 65 56 Q9UKT4 80 34 56 Q9UKT4 61 26 56 Q9UKT4 68 12 33 58 Q9UKT4 71 54 74 Q9UKT4 43 46 68 34 65 45 Q9UKT4 64 27 68 62 33 Q9UKT4 41 8 59 56 42 Q9UKT4 51 16 44 41 Q9UKT4 55 17 Q9UKT4 41 43 54 Q9UKT4 49 17 68 Q9UKT4 48 17 Q9UKT4 28 19 31 Q9UKT4 26 24 Q9NRD1 62 52 61 Q9Y3I1 71 11 77 18 81 Q9Y3I1 52 18 49 38 65 59 Q9UK97 78 23 37 57 11 Q9UKB1 51 53 63 Q9UKB1 76 39 92 Q9UKB1 57 34 67 Q9UKB1 50 49 63 Q9UKB1 62 30 52 Q9UKB1 55 36 67 54 63 43 Q9UKB1 100 67 85 Q9UKB1 83 50 66 Q9UKT8 34 15 48 13 44 9 P57775 83 39 57 73 13 P57775 33 26 49 Q969U6 37 19 33 Q969U6 4 6 34 Q969H0 73 45 27 Q969H0 42 18 24 Q8N3Y1 45 29 51 Q8N3Y1 4 17 Q8N3Y1 70 33 73 68 46 16 Q8N3Y1 93 49 60 27 89 30 Q5XUX1 61 28 79 45 Q5XUX1 65 65 64 Q5XUX1 82 36 73 44 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28 O95714 86 49 29 55 O95714 55 37 62 4 O95714 86 25 70 57 98 47 O95714 77 47 81 67 63 40 O95714 77 55 84 75 88 70 O95714 74 61 94 91 100 76 O95714 10 15 26 O95714 57 31 39 O95714 81 24 52 50 O95714 67 34 75 44 76 29 O95714 40 54 1 53 O95714 94 48 95 85 79 16 O95714 15 3 36 O95714 9 O95714 75 38 97 85 O95714 74 57 95 93 93 83 O95714 8 O95714 27 22 O95714 66 67 72 73 66 29 O95714 68 49 81 8 O95714 18 O95714 28 23 33 O95714 60 13 45 58 O95714 79 35 58 8 75 19 O95714 55 18 49 11 44 O95714 100 60 100 76 49 14 O95714 5 22 45 47 27 Q15034 55 40 48 Q15034 33 58 6 53 Q15034 87 53 78 48 Q5GLZ8 31 5 36 41 15 Q5GLZ8 63 22 76 49 63 48 Q5GLZ8 82 55 78 69 49 55 Q5GLZ8 63 51 57 Q5GLZ8 22 22 40 29 47 53 Q5GLZ8 47 41 48 Q5GLZ8 61 56 64 Q5GLZ8 40 15 34 Q5GLZ8 64 33 59 50 47 Q5GLZ8 84 24 63 34 24 Q5GLZ8 18 29 38 21 38 26 Q5GLZ8 53 21 56 31 50 34 Q5GLZ8 8 4 27 7 Q5GLZ8 12 26 48 35 43 30 Q9UII4 62 6 30 Q9UII4 15 Q9UII4 69 54 59 Q9UII4 19 51 54 Q9UII4 85 41 97 92 72 50 Q8IVU3 56 20 Q8IVU3 33 43 Q8IVU3 45 20 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24 Q9Y2K7 45 22 49 36 46 11 Q9Y2K7 29 38 44 Q9Y2K7 34 63 44 Q9Y2K7 64 44 56 Q9Y2K7 18 2 34 8 26 7 Q9Y2K7 45 27 43 48 42 Q9Y2K7 62 37 48 26 58 57 Q8NHM5 31 8 38 51 Q8NHM5 42 40 32 Q8NHM5 35 29 34 Q8NHM5 21 17 39 3 25 Q8NHM5 53 15 21 70 Q8NHM5 46 18 56 38 52 18 Q8NHM5 61 8 36 Q8NHM5 52 15 52 62 22 Q8NHM5 58 51 73 Q8NHM5 5 20 Q14145 81 19 88 68 Q14145 89 7 80 81 Q14145 98 97 98 98 96 97 Q14145 72 58 57 Q14145 94 84 93 Q14145 88 57 89 Q14145 98 87 99 99 99 85 Q14145 88 76 93 89 92 79 Q14145 78 56 91 77 100 53 Q14145 50 14 54 24 50 36 Q14145 95 90 78 73 97 78 Q14145 12 26 Q14145 37 92 82 69 Q9HCI6 60 25 62 Q9HCI6 33 26 Q9HCI6 31 1 12 Q6PID8 79 32 78 59 Q6PID8 13 1 18 17 Q6PID8 55 10 Q9Y2U9 60 29 45 Q9Y2U9 40 30 52 Q9Y2U9 12 24 35 Q9Y2U9 22 4 30 45 Q9BQ90 52 36 47 33 Q9BQ90 67 35 67 46 37 36 Q9BQ90 17 31 Q9BQ90 92 56 76 51 49 47 Q9BQ90 1 17 32 Q9BQ90 30 6 37 39 25 8 Q9NR64 35 31 27 Q9NR64 44 11 31 Q9NVR0 46 32 33 Q9NVR0 46 3 42 37 Q9NVR0 48 38 59 40 59 32 Q9NVR0 28 34 18 37 7 Q9NVR0 53 29 51 36 Q9NVR0 11 27 Q9NVR0 20 Q53G59 6 Q53G59 64 38 43 Q53G59 7 11 Q9P2N7 21 3 Q9P2N7 44 34 25 23 35 15 Q9P2G3 34 35 Q9P2G3 34 35 Q9P2G3 32 14 28 Q9P2G3 30 35 O94889 17 17 36 O94889 30 24 12 Q9Y2M5 56 22 48 30 53 Q9Y2M5 92 42 25 6 82 7 Q53GT1 61 29 42 29 45 Q8NBE8 32 28 48 Q8NBE8 42 15 21 Q6TFL4 56 22 32 Q6TFL4 26 21 35 Q6TFL4 73 48 70 4 Q6TFL4 79 64 72 Q9H0H3 32 22 38 Q9H0H3 37 13 17 53 Q9H0H3 25 13 Q9H0H3 5 Q9H0H3 40 29 55 Q53HC5 58 11 86 49 Q53HC5 39 60 64 Q53HC5 31 15 38 57 Q53HC5 92 53 91 91 91 40 Q53HC5 89 85 100 Q53HC5 44 24 59 Q0D2K2 70 18 21 Q8N4N3 7 8 37 19 18 Q8N4N3 1 5 4 18 7 Q8N4N3 35 17 36 3 36 Q8N4N3 83 79 36 Q9C0H6 55 5 43 Q9C0H6 44 41 45 Q9C0H6 48 41 55 Q9C0H6 47 46 57 Q9C0H6 44 1 34 13 Q9C0H6 22 17 37 17 Q9P2K6 7 60 4 Q96PQ7 48 41 55 Q96PQ7 32 26 39 Q96PQ7 35 31 27 Q96PQ7 22 17 37 17 Q8WZ60 55 62 53 50 57 10 Q8WZ60 31 5 40 36 Q8WZ60 28 17 54 Q8WZ60 2 33 Q8WZ60 25 41 Q8WZ60 23 9 16 37 1 5 Q8WZ60 35 13 44 Q8WZ60 21 22 70 Q8IXQ5 66 13 49 18 Q8IXQ5 18 Q9P2G9 29 29 60 Q9P2G9 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21 50 39 O00463 35 13 52 O00463 59 9 60 70 O00463 22 4 23 45 O00463 16 29 54 17 O00463 9 51 O00463 40 23 62 13 45 O00463 10 10 27 14 O00463 1 13 Q9Y4K3 39 12 61 15 31 6 Q9Y4K3 21 33 8 30 Q9Y4K3 5 Q9Y4K3 29 12 22 3 32 Q9Y4K3 11 Q9Y4K3 18 18 27 Q9Y4K3 45 24 24 14 34 58 Q9Y4K3 11 Q6Q0C0 42 27 68 Q6Q0C0 62 55 71 Q6Q0C0 57 55 72 Q6Q0C0 62 58 60 5 Q6Q0C0 69 70 61 Q6Q0C0 56 29 45 Q6Q0C0 68 1 39 55 20 Q6Q0C0 9 Q6Q0C0 30 10 Q6Q0C0 47 38 50 Q6Q0C0 30 3 22 9 Q6Q0C0 29 30 Q9BWF2 36 71 22 Q9BWF2 52 10 42 29 Q96F44 49 25 41 Q96F44 63 62 71 Q96F44 33 30 57 Q96F44 53 51 83 61 Q96F44 83 66 69 Q96F44 54 59 53 Q96F44 53 4 39 41 Q96F44 9 O60858 62 58 48 O60858 45 32 46 O60858 4 6 8 Q9C019 1 7 3 Q9C019 35 33 40 Q9C019 26 33 18 34 Q9C019 16 13 19 Q9C019 23 8 24 Q9C040 32 33 23 Q9C040 49 44 40 Q9C040 44 20 33 36 Q9C040 5 24 Q9C040 49 19 61 P19474 32 12 24 33 P19474 25 5 58 39 8 P19474 14 11 20 P19474 66 50 60 P19474 61 23 22 2 22 P19474 40 5 P19474 56 34 55 25 57 39 P19474 1 34 P19474 41 16 18 Q8IYM9 62 25 Q8IYM9 39 47 34 Q8IYM9 37 23 29 Q8IYM9 45 59 65 Q8IYM9 69 77 57 Q8IYM9 47 21 51 17 67 24 Q8IYM9 52 2 38 25 58 20 Q8IYM9 16 9 34 62 Q8IYM9 5 11 39 22 Q8IYM9 28 23 22 20 4 P36406 10 P36406 73 17 61 O15164 40 41 39 O15164 20 17 16 37 O15164 64 17 41 6 50 20 O15164 46 34 58 30 77 58 O15164 43 17 40 O15164 42 8 28 O15164 54 20 32 23 O15164 55 6 55 47 O15164 40 30 46 O15164 67 53 65 O15164 33 26 O15164 43 25 57 29 55 42 O15164 54 29 O15164 21 O15164 46 19 12 O15164 44 27 43 O15164 58 22 19 48 5 Q14258 62 21 58 31 27 41 Q14258 72 18 88 61 62 9 Q14258 72 66 62 47 72 8 Q14258 59 10 43 27 57 21 Q14258 60 50 63 36 62 5 Q14258 51 36 65 35 59 30 Q14258 50 44 55 Q14258 46 51 53 Q14258 42 22 71 41 64 24 Q14258 12 25 Q14258 33 32 32 16 35 5 Q14258 34 25 42 28 44 37 Q14258 52 35 28 7 45 Q14258 82 49 94 85 94 56 Q12899 44 58 31 Q12899 16 17 35 Q12899 24 40 26 Q12899 37 31 46 Q12899 44 35 59 Q12899 7 29 Q12899 74 55 60 Q12899 68 30 55 Q12899 22 Q12899 18 36 18 56 9 28 P14373 25 20 21 P14373 24 60 57 1 P14373 37 5 71 23 P14373 58 25 43 13 52 11 P14373 23 39 28 Q13263 50 29 34 17 71 57 Q13263 58 12 43 21 46 12 Q13263 26 40 19 50 28 Q13263 32 29 53 42 44 35 Q13263 77 26 84 61 62 34 Q13263 23 6 38 10 52 23 Q13263 40 14 50 42 46 6 Q13263 44 25 51 24 68 57 Q13263 26 19 24 45 9 Q13263 33 Q13263 35 6 Q13263 43 1 29 20 Q13263 47 43 Q13263 40 25 47 41 57 38 Q13263 65 24 50 36 79 42 Q13263 50 22 59 41 58 30 Q13263 53 19 87 47 68 7 Q13263 36 37 58 33 52 40 Q13263 18 7 46 19 Q13263 64 23 58 43 62 33 Q13263 44 30 53 40 56 53 O75382 57 66 39 O75382 49 44 40 O75382 44 20 33 36 O75382 18 6 O75382 47 39 70 O75382 82 47 83 45 87 O75382 14 O75382 43 31 26 O75382 2 3 Q9BZY9 68 48 71 Q13049 60 64 61 Q13049 22 20 33 Q13049 36 40 14 40 5 Q13049 55 39 58 Q13049 78 58 79 Q13049 9 31 46 Q13049 25 14 28 Q13049 63 51 43 Q13049 10 11 18 Q9UPN9 53 25 46 24 Q9UPN9 68 28 74 50 47 37 Q9UPN9 72 63 86 87 47 35 Q9UPN9 45 21 30 46 17 Q9UPN9 26 41 23 38 Q9UPN9 53 35 50 51 Q9UPN9 55 23 53 32 55 36 Q9UPN9 45 27 39 Q9UPN9 43 25 57 29 55 42 Q9UPN9 36 16 63 43 79 19 Q9UPN9 64 14 50 5 67 Q9UPN9 85 44 86 64 78 57 Q9UPN9 57 38 40 26 56 40 Q9UPN9 60 42 49 27 30 8 Q9UPN9 51 45 51 26 56 11 Q9UPN9 27 4 13 2 18 3 Q9UPN9 3 5 32 2 34 12 Q9UPN9 35 42 10 63 7 Q9UPQ4 27 10 32 Q9NQ86 16 Q9NQ86 32 33 21 Q9NQ86 56 27 30 35 Q9NQ86 52 14 26 Q9NQ86 73 65 71 Q9NQ86 71 65 67 Q9NQ86 57 39 44 Q9NQ86 49 24 26 1 24 Q9NQ86 89 62 88 Q9NQ86 88 31 Q9NQ86 88 41 Q9NQ86 38 25 11 51 O94972 64 36 O94972 57 57 52 O94972 68 2 89 O94972 69 63 66 O94972 70 25 72 67 O94972 67 28 71 59 O94972 7 28 O94972 43 11 38 34 O94972 49 13 44 72 18 O94972 37 6 28 28 O00635 60 8 39 16 7 O00635 51 7 32 58 O00635 31 50 O00635 68 46 7 70 7 O00635 44 38 43 O00635 45 44 18 50 21 O00635 49 45 63 O00635 35 12 43 O00635 19 27 Q9C037 24 3 44 Q9C037 62 37 38 Q9C037 36 31 33 Q9C037 75 59 70 Q9C037 78 60 80 Q9C037 57 24 42 55 11 Q9C037 79 18 74 77 Q8WV44 40 39 31 50 Q8WV44 30 39 Q8WV44 56 43 55 Q8WV44 47 31 42 Q8WV44 29 Q8WV44 59 15 43 56 Q7Z4K8 60 49 56 Q7Z4K8 63 48 37 Q7Z4K8 22 31 37 Q7Z4K8 75 64 75 Q7Z4K8 44 28 38 Q7Z4K8 63 66 68 Q96LD4 59 18 44 Q96LD4 13 Q96LD4 45 39 21 38 11 Q96LD4 55 48 61 36 45 11 Q96LD4 45 26 66 31 43 17 Q96LD4 58 39 81 47 53 31 Q96LD4 75 22 28 7 41 Q96LD4 52 28 36 14 38 5 Q96LD4 27 44 44 Q96LD4 36 33 39 Q96LD4 44 33 42 Q96LD4 43 27 65 48 45 11 Q9C035 21 22 48 Q9C035 33 34 29 Q9C035 42 13 46 46 Q9C035 67 44 66 Q9C035 32 13 24 34 Q9C035 58 14 69 Q9C035 8 23 18 27 4 Q9C035 53 32 49 Q9BYV6 1 Q9BYV6 1 Q9BRZ2 66 55 61 32 58 39 Q9BRZ2 64 19 78 34 64 16 Q9BRZ2 78 33 93 61 64 47 Q9BRZ2 27 32 4 32 14 Q9BRZ2 34 55 44 Q9BRZ2 39 16 66 Q9BRZ2 66 36 93 57 73 32 Q9BRZ2 58 27 86 70 58 31 Q9BRZ2 28 20 18 Q9BRZ2 62 59 47 Q9BRZ2 54 41 Q9BRZ2 43 26 49 33 27 Q9BRZ2 31 47 29 43 11 Q9BRZ2 80 57 76 Q9BRZ2 77 48 75 62 80 23 Q9BRZ2 35 51 38 5 53 24 Q9BRZ2 39 20 51 51 Q9BRZ2 91 61 85 66 89 67 Q9BRZ2 86 59 82 Q9BRZ2 83 49 89 67 85 35 Q9BRZ2 67 41 80 75 15 Q8IWR1 58 46 49 Q8IWR1 70 27 37 Q8IWR1 66 46 92 90 72 38 Q9C030 46 43 53 Q9C030 73 28 62 Q9C030 54 39 49 Q495X7 44 15 43 27 Q9BVG3 58 59 64 Q9BVG3 13 1 26 Q6PJ69 38 45 16 45 Q6PJ69 16 Q6PJ69 13 14 14 Q6PJ69 76 59 75 56 70 44 Q6PJ69 75 36 89 69 69 35 Q6PJ69 66 34 68 50 75 27 Q6PJ69 52 26 45 5 86 32 Q6PJ69 72 35 69 47 79 26 Q6PJ69 90 57 63 Q6PJ69 89 58 81 56 88 51 Q6PJ69 66 21 42 5 53 27 Q6PJ69 66 67 51 Q6PJ69 1 24 19 Q6ZTA4 44 6 37 Q6AZZ1 44 18 36 Q9C029 66 23 45 54 Q9C029 66 33 37 Q9C029 48 52 58 Q9C029 60 44 55 Q9C029 55 36 52 Q9C029 68 22 39 56 Q9C029 19 Q9C029 92 1 Q2Q1W2 19 23 17 Q2Q1W2 67 41 43 Q2Q1W2 73 38 50 Q2Q1W2 7 14 12 Q2Q1W2 19 3 28 Q2Q1W2 46 20 38 Q2Q1W2 44 38 Q2Q1W2 51 25 45 Q2Q1W2 3 14 Q2Q1W2 34 11 37 Q2Q1W2 10 19 21 Q2Q1W2 87 39 64 17 59 5 Q2Q1W2 53 37 33 Q2Q1W2 20 8 37 Q2Q1W2 8 12 Q6ZMU5 18 6 Q6ZMU5 61 41 Q6ZMU5 46 36 74 55 47 Q6ZMU5 77 64 Q6ZMU5 35 41 54 38 50 Q6ZMU5 27 34 61 22 57 Q6ZMU5 4 24 11 6 31 8 Q9BZR9 34 Q9BZR9 20 11 24 Q9BZR9 73 44 63 67 Q9BZR9 71 58 61 Q9BZR9 86 53 72 Q9BZR9 78 66 74 Q9BZR9 67 64 39 70 10 Q9BZR9 17 7 38 28 Q9BZR9 39 19 47 54 16 Q9BZR9 68 25 48 57 Q9C026 9 57 30 Q9C026 5 13 18 4 Q9C026 21 45 Q9C026 64 3 4 39 Q9C026 69 24 Q14669 24 17 14 46 1 Q14669 47 31 44 10 30 16 Q14669 27 34 9 Q14669 53 34 49 33 51 53 Q14669 63 52 74 Q14669 42 31 92 64 59 61 Q14669 66 4 59 67 Q14669 46 12 46 21 36 1 Q14669 41 26 57 36 44 2 Q14669 43 33 65 33 50 38 Q14669 54 43 49 Q14669 9 37 Q14669 38 11 29 35 Q14669 58 31 42 Q14669 62 56 71 55 72 24 Q14669 63 21 Q14669 80 34 86 52 63 51 Q8TEL6 81 54 77 Q8TEL6 69 1 55 61 Q8TEL6 56 23 61 P53804 91 85 91 P53804 49 9 P53804 44 22 52 P53804 35 82 46 P53804 56 12 52 60 P53804 71 36 54 32 69 26 P53804 50 32 62 P53804 83 59 89 89 86 38 P53804 28 16 39 P53804 28 15 40 P53804 62 25 60 P53804 60 35 65 P53804 40 20 P53804 38 8 45 Q9NRJ4 75 15 45 Q9NRJ4 59 28 37 24 Q9NRJ4 39 17 32 Q9BSL1 17 20 29 36 48 36 Q9BSL1 66 2 38 57 Q9C0C9 27 1 20 Q9C0C9 58 51 50 24 65 19 Q9C0C9 9 15 35 Q9C0C9 36 43 56 Q9C0C9 58 30 66 53 35 17 Q9C0C9 70 40 49 24 80 21 Q9C0C9 43 19 45 37 17 Q9C0C9 96 89 94 84 87 43 Q9C0C9 73 52 70 38 65 49 Q9C0C9 84 79 74 62 79 30 Q9C0C9 56 42 60 37 77 53 Q9C0C9 25 16 29 27 Q9C0C9 35 27 30 24 41 19 Q9C0C9 84 74 59 45 71 31 Q9C0C9 78 54 61 46 76 20 Q9C0C9 32 18 50 29 25 11 Q9C0C9 63 42 57 34 62 51 Q9C0C9 21 10 20 11 Q05086 58 30 35 57 Q05086 66 50 60 42 61 16 Q05086 58 9 39 21 Q05086 78 52 32 36 29 36 Q05086 56 21 51 27 59 41 Q05086 45 11 23 5 Q05086 51 13 43 42 34 34 Q05086 20 34 50 8 Q05086 35 43 55 Q05086 72 2 53 35 51 8 Q05086 57 27 61 43 27 35 Q7Z3V4 86 42 56 33 64 8 Q7Z3V4 50 38 56 Q7Z3V4 13 Q7Z3V4 45 24 36 Q15386 56 9 59 59 10 Q15386 3 2 Q15386 72 50 52 Q15386 79 40 69 9 Q15386 49 11 34 56 Q15386 32 12 7 30 Q15386 38 14 34 Q15386 50 48 68 16 53 8 Q15386 54 41 47 Q15386 28 36 42 Q15386 12 12 Q7Z6J8 19 4 16 19 Q7Z6J8 59 10 41 57 Q7Z6J8 62 43 25 17 Q7Z6J8 80 16 50 82 13 Q7Z6J8 52 25 53 Q7Z6J8 75 54 65 Q7Z6J8 42 16 50 51 Q14139 90 34 63 29 48 66 Q14139 6 31 Q14139 31 32 54 Q14139 58 40 43 17 21 Q14139 51 26 37 58 16 Q14139 56 39 71 57 64 31 Q14139 3 23 15 2 Q14139 25 55 55 42 O95155 25 3 21 28 37 20 O95155 88 86 78 69 62 31 O95155 45 49 71 O95155 56 59 60 O95155 54 58 66 O95155 54 5 48 23 52 2 O95155 96 72 99 57 O95155 61 16 68 70 O95155 39 3 47 15 42 7 O94941 46 24 24 36 O94941 4 23 20 O94941 70 47 72 63 86 40 O94941 21 36 O94941 9 12 Q8IWV7 40 2 13 Q8IWV7 64 44 62 34 55 44 Q8IWV7 37 42 35 Q8IWV7 51 8 13 65 Q8IWV7 61 62 63 Q8IWV7 8 1 Q8IWV7 50 28 50 Q8IWV7 68 65 57 Q8IWV7 33 32 39 22 32 Q8IWV7 5 34 Q8IWV7 12 48 43 Q8IWV7 16 Q8IWV7 89 63 85 64 95 59 Q8IWV7 13 Q8IWV8 17 1 18 33 Q8IWV8 40 3 25 35 Q8IWV8 11 Q8IWV8 31 28 7 Q8IWV8 22 3 20 24 Q8IWV8 65 26 57 39 44 50 Q8IWV8 28 15 64 19 61 8 Q8IWV8 74 72 86 Q8IWV8 88 54 64 Q8IWV8 93 72 83 67 77 49 Q6ZT12 54 48 74 Q6ZT12 35 12 44 Q6ZT12 19 16 36 Q6ZT12 31 24 38 Q6ZT12 54 29 17 Q6ZT12 39 16 23 67 Q6ZT12 62 14 52 21 61 Q6ZT12 45 39 51 Q6ZT12 62 34 46 Q6ZT12 24 7 26 33 Q6ZT12 8 17 Q6ZT12 26 25 37 38 Q6ZT12 82 54 Q6ZT12 89 58 70 Q6ZT12 70 41 59 40 56 41 Q5T4S7 34 34 39 18 39 14 Q5T4S7 69 58 44 Q5T4S7 48 9 44 56 Q5T4S7 8 22 Q5T4S7 64 24 57 31 55 40 Q5T4S7 65 24 53 64 Q5T4S7 63 19 43 73 Q5T4S7 62 17 55 2 54 7 Q5T4S7 22 73 60 71 31 Q5T4S7 33 26 35 Q5T4S7 38 6 33 47 Q5T4S7 12 49 Q5T4S7 63 37 70 Q5T4S7 44 11 32 57 29 Q5T4S7 56 32 37 Q5T4S7 51 18 33 15 Q5T4S7 78 53 80 49 77 56 Q5T4S7 32 10 42 32 Q5T4S7 11 38 30 Q5T4S7 50 16 77 58 97 56 Q5T4S7 50 7 40 8 93 3 Q5T4S7 51 36 76 46 100 64 Q5T4S7 29 25 67 36 52 51 Q5T4S7 68 61 66 Q5T4S7 57 50 49 33 58 30 Q5T4S7 26 4 39 44 Q5T4S7 58 35 58 17 35 36 Q5T4S7 45 36 58 Q5T4S7 35 21 47 Q5T4S7 62 40 42 Q5T4S7 65 4 69 66 Q5T4S7 56 42 63 Q5T4S7 70 4 62 48 60 Q5T4S7 51 30 32 29 78 23 Q5T4S7 29 26 58 38 81 43 Q5T4S7 33 44 56 37 50 25 Q5T4S7 41 14 34 Q5T4S7 37 47 67 Q5T4S7 67 30 61 48 72 45 Q5T4S7 52 21 50 34 52 26 Q5T4S7 49 35 20 36 1 Q5T4S7 78 38 38 34 29 Q5T4S7 82 28 49 24 51 39 Q5T4S7 23 12 35 42 Q5T4S7 33 23 33 19 34 46 Q5T4S7 36 6 43 Q5T4S7 67 33 57 20 66 27 Q5T4S7 51 38 50 Q5T4S7 53 33 54 Q5T4S7 77 69 75 Q5T4S7 62 50 60 Q5T4S7 69 46 63 Q5T4S7 9 14 6 Q5T4S7 59 33 44 27 58 29 Q5T4S7 6 14 Q5T4S7 49 21 38 Q5T4S7 33 46 43 O95071 24 O95071 76 22 49 O95071 34 O95071 34 6 18 44 4 O95071 46 12 30 58 O95071 56 24 52 39 50 52 O95071 34 11 32 14 33 O95071 21 O95071 2 18 47 O95071 2 38 O95071 41 23 48 23 O95071 75 4 48 65 O95071 39 7 33 25 43 4 O95071 78 40 70 23 71 71 O95071 78 34 66 16 73 11 O95071 65 38 57 38 60 51 O95071 76 28 59 34 55 52 O95071 24 29 42 15 O95071 73 51 Q8N806 20 55 34 14 25 Q8N806 51 8 33 6 47 Q8N806 81 67 79 Q8N806 76 61 80 Q8N806 78 60 80 Q8N806 78 58 80 Q8N806 50 33 45 Q8N806 75 67 78 Q8N806 57 17 46 64 4 Q8N806 56 40 91 Q8N806 2 24 12 14 Q8N806 12 Q8N806 24 19 5 2 16 14 Q8N806 4 14 23 21 Q8N806 16 4 6 Q8N806 51 30 77 62 57 18 Q8N806 6 2 10 O94874 62 34 67 32 76 12 O94874 23 9 29 O94874 30 9 29 44 O94874 60 41 70 59 66 45 Q96T88 54 40 Q96T88 52 28 Q96T88 44 26 21 12 21 35 Q96T88 47 33 33 25 42 51 Q96T88 19 53 6 21 28 Q96T88 63 42 61 47 40 18 Q96T88 47 37 36 44 7 Q96T88 30 26 35 26 36 31 Q96T88 57 32 44 30 45 33 Q96T88 51 34 29 12 59 16 Q96T88 39 20 23 20 72 5 Q96T88 57 7 15 40 11 Q96T88 21 5 28 Q96T88 19 Q96T88 30 35 24 Q96T88 17 12 40 Q96T88 58 32 50 28 42 4 Q96T88 35 12 61 64 48 17 Q96PU4 4 1 Q96PU4 33 11 29 8 16 Q96PU4 32 9 Q96PU4 48 15 21 14 43 7 Q96PU4 5 7 Q96PU4 14 4 6 29 Q96PU4 9 Q96PU4 39 32 54 Q96PU4 51 50 46 31 45 Q96PU4 51 27 54 Q96PU4 57 32 44 30 45 33 Q96PU4 23 39 27 14 32 Q96PU4 11 21 Q96PU4 46 42 32 13 32 Q96PU4 19 20 42 48 20 Q96PU4 58 32 50 28 42 4 Q96PU4 35 12 61 64 48 17 Q9C0B0 57 67 70 Q9C0B0 21 10 54 Q9C0B0 50 49 32 Q9C0B0 31 19 30 Q9C0B0 32 28 50 Q9C0B0 31 29 32 Q9C0B0 3 Q9C0B0 34 20 15 34 Q9C0B0 64 34 54 Q9C0B0 78 17 56 21 67 15 Q9C0B0 31 25 35 Q9C0B0 83 43 63 52 53 23 Q9C0B0 76 40 45 Q9C0B0 57 44 41 25 27 Q9C0B0 44 18 33 Q9C0B0 59 76 43 46 Q9H9P5 81 76 63 Q9H9P5 28 14 Q9H9P5 46 22 37 Q9H9P5 3 6 26 11 Q9H9P5 60 20 21 27 Q9H9P5 27 Q9H9P5 6 44 21 Q9H9P5 42 6 37 Q9H9P5 48 30 67 Q9H9P5 45 17 36 Q9H9P5 55 9 31 37 P40337 38 12 32 19 32 15 P40337 23 19 Q9H270 56 42 50 38 26 Q9H270 99 58 92 80 26 1 Q9H270 6 14 Q9H270 44 34 48 Q9H270 21 13 26 9 37 Q9H270 20 17 38 Q9H270 46 36 60 Q9H270 15 14 18 30 Q9H270 28 23 42 34 39 Q9H270 36 34 46 Q9H270 47 24 81 55 52 43 Q9P253 73 30 81 56 74 43 Q9P253 41 10 53 36 51 12 Q9P253 63 34 47 Q9P253 72 30 54 Q9P253 90 55 86 17 Q9P253 39 20 Q9P253 46 15 33 47 Q9P253 24 4 31 17 Q9P253 49 8 67 64 Q9P253 90 30 94 84 Q9P253 89 64 92 85 97 85 P49754 33 17 34 1 39 P49754 76 12 79 10 62 10 P49754 55 P49754 91 34 55 Q8N3P4 8 3 16 16 Q8N3P4 27 1 16 21 Q8N3P4 62 35 87 44 45 55 Q8N3P4 38 19 37 40 Q8N3P4 48 9 48 36 Q9H7D7 79 52 41 Q9H7D7 39 39 43 21 20 Q9H7D7 23 32 41 Q9H7D7 65 54 87 78 74 32 Q9H7D7 72 58 55 42 60 32 Q9H7D7 18 9 29 18 Q9H7D7 73 49 63 33 74 Q9H7D7 18 36 37 Q9H7D7 33 29 51 Q9H7D7 37 29 41 Q9H7D7 28 31 27 30 32 22 Q8N9V3 41 20 41 Q8N9V3 66 30 58 36 65 40 Q8N9V3 44 17 28 2 22 16 Q8N5D0 45 42 46 Q8N5D0 100 58 96 87 95 46 Q8N5D0 74 45 73 Q8N5D0 68 40 61 29 69 31 Q8N5D0 83 49 92 79 85 70 Q8N5D0 89 51 61 Q8N5D0 79 28 68 20 81 20 Q8N5D0 70 72 87 Q8N5D0 80 57 87 Q8N5D0 75 49 72 Q8N5D0 79 76 82 Q8N5D0 79 83 87 Q9Y6I7 61 10 61 Q9Y6I7 56 43 66 Q9Y6I7 29 5 22 36 Q9H0M0 22 7 17 24 Q9H0M0 55 35 81 61 85 36 Q9H0M0 59 22 34 80 25 O00308 55 26 40 32 54 37 O00308 62 9 48 55 O00308 55 35 81 61 85 36 O00308 59 23 54 56 O00308 59 22 34 80 25 P98170 34 20 13 12 30 8 P98170 46 22 25 P98170 55 15 70 58 48 24 P98170 74 27 65 37 37 12 P98170 27 25 21 33 5 P98170 38 21 45 P98170 43 23 50 25 40 21 P98170 42 45 55 P98170 40 38 45 P98170 65 44 62 P10074 50 26 60 74 P10074 59 15 69 P10074 45 31 38 24 40 P10074 47 Q86WB0 69 21 64 45 71 14 Q86WB0 38 20 47 15 52 26 Q86WB0 80 69 80 Q86WB0 69 81 75 Q86WB0 69 27 80 48 81 20 Q86WB0 45 15 61 38 78 33 Q86WB0 67 13 65 76 23 Q86WB0 66 73 85 Q86WB0 49 11 53 40 55 18 Q86WB0 78 50 54 39 64 15 Q86WB0 81 39 77 62 68 26 Q86WB0 33 8 28 Q86WB0 34 28 73 Q9H8U3 44 43 19 35 6 Q9H8U3 72 39 59 42 33 3 Q9H8U3 15 18 Q9H8U3 64 31 26 17 18 24 Q9H8U3 41 41 35 19 35 12 Q9H8U3 54 30 59 Q9H8U3 49 13 40 Q9H8U3 63 37 45 20 Q9H8U3 42 7 28 O76080 29 7 11 18 5 O76080 31 18 11 O76080 37 16 14 14 26 O76080 15 10 24 18 8 O76080 1 17 16 O76080 50 13 48 3 Q6FIF0 29 7 11 18 5 Q6FIF0 31 18 11 Q6FIF0 15 16 32 8 36 23 Q6FIF0 1 6 14 Q6FIF0 1 16 22 Q6FIF0 5 12 Q96JP5 34 22 22 4 42 17 Q96JP5 33 22 16 17 40 36 Q96JP5 67 66 75 70 73 26 Q96JP5 63 44 61 40 55 12 Q96JP5 49 20 33 Q96JP5 57 36 49 10 Q96JP5 28 22 7 5 Q96JP5 65 68 67 43 66 32 O95159 68 20 73 52 4 O95159 59 6 61 59 O95159 62 7 52 58 O95159 43 41 51 50 13 O95159 66 55 57 O95159 65 18 61 66 O95159 100 59 70 O95159 26 40 22 15 54 48 Q9ULJ6 47 11 34 16 42 42 Q9ULJ6 11 3 19 Q9ULJ6 51 4 32 58 7 Q9ULJ6 59 24 54 69 Q9ULJ6 47 22 34 15 80 59 Q9ULJ6 47 37 31 3 23 8 Q9ULJ6 7 62 Q9ULJ6 41 41 40 Q8NF64 46 41 53 20 41 Q8NF64 51 4 32 58 7 Q8NF64 59 24 54 69 Q8NF64 47 22 34 15 80 59 Q8NF64 47 37 31 3 23 8 Q8NF64 41 8 34 Q8NF64 41 41 40 Q9Y4E5 40 7 35 13 56 11 Q9Y4E5 67 35 52 13 66 17 Q9Y4E5 58 34 49 Q9Y4E5 30 15 Q9Y4E5 40 Q9Y4E5 49 11 33 50 Q9Y4E5 54 15 65 64 70 45 Q9Y4E5 27 36 40 Q9Y4E5 18 Q9Y4E5 38 33 58 Q9Y4E5 65 49 60 Q9Y4E5 25 Q9Y4E5 62 24 43 Q9Y4E5 15 5 25 Q9Y4E5 33 24 15 Q9Y4E5 43 22 59 25 50 12 Q9Y4E5 34 29 65 3 Q86UK7 66 51 63 50 67 24 Q86UK7 3 54 21 32 Q86UK7 49 57 57 Q86UK7 47 22 48 45 1 Q86UK7 72 9 73 27 44 22 Q86UK7 17 33 30 Q86UK7 51 47 44 Q86UK7 46 22 47 32 25 Q86UK7 76 37 56 Q86UK7 51 Q86UK7 4 3 53 Q86UK7 6 2 11 Q86UK7 45 9 37 48 Q86UK7 70 43 16 67 Q86UK7 25 8 18 23 Q86UK7 30 13 15 30 Q86UK7 27 15 25 23 32 32 Q86UK7 57 21 36 2 27 Q86UK7 66 39 75 56 66 18 Q86UK7 68 26 75 59 68 15 Q86UK7 63 6 70 42 58 29 Q86UK7 35 61 44 34 Q86UK7 21 1 16 8 Q86UK7 1 3 Q8ND25 42 15 28 Q8ND25 32 2 23 Q8ND25 45 18 56 20 45 9 Q8ND25 43 3 59 48 29 Q8ND25 47 13 Q8ND25 27 28 43 Q8NHG8 11 Q8NHG8 24 Q8NHG8 35 8 Q8NHG8 45 18 56 20 45 9 Q8NHG8 43 3 59 48 29 Q8NHG8 4 13 Q9ULT6 39 16 36 Q9ULT6 53 39 49 Q9ULT6 79 42 55 Q9ULT6 44 29 51 Q8NEG5 35 8 16 Q9C0D3 50 12 44 37 Q9C0D3 46 20 48 Q9C0D3 72 34 58 38 64 48 ¹KB02_500 uM_percent_inhibition ²KB02_100 uM_percent_inhibition ³KB03_500 uM_percent_inhibition ⁴KB03_100 uM_percent_inhibition ⁵KB05_500 uM_percent_inhibition ⁶KB05_100 uM_percent_inhibition

Example 2

The following 96-well sample prep protocol was used for sample preparation.

Cells were resuspended in cold PBS on ice and sonicated with a probe sonicator to achieve lysis. 200 μL of lysate containing 5 mg/ml proteome was treated with 2 μL of 100× compound stock in a 2-mL deep-well plate. The treated lysate was subsequently incubate at 25° C. for 1 hr with shaking at 600 rpm. The treated lysate was further incubated with 2 μL of 10 mM desthiobiotin iodoacetamide probe at 25° C. for 1 hr with shaking at 600 rpm. Next, the lysate was further treat with 20 μL of solution of PBS containing 11 mM MgSO₄ and 2.5% Turbonuclease stock and incubated at 25° C. for 20 minutes with shaking at 600 rpm. 1.7 mL ice-cold acetone was added to each well and incubated at −20° C. for 2 hr, followed by max speed (4200 rpm) spin for 45 min. Acetone was then decanted and the plates were blotted to remove acetone. The plates were then dried in open air for 20 minutes. After drying, the plates were then covered with foil seal and stored at −80° C. overnight.

The next day, samples were re-suspended in 90 μL of solution of 9M urea, 50 mM ammonium bicarbonate and 10 mM DTT by incubating at 65C for 20 min with shaking at 1500 rpm. Next, samples were cooled to 37° C. and then 10 μL of 500 mM iodoacetamide solution (92.48 mg/ml) was added. The samples were then incubated at 37° C. for 30 min with shaking at 600 rpm.

ZEBA desalting plates were equilibrated 4 times using 250 μL of 2M urea, 50 mM ammonium bicarbonate solution followed by centrifugation at 1500 rpm for 2 minutes. After equilibration was complete, samples were applied to ZEBA desalting plate and spin at 1500 rpm for 2 min on top of 1 mL 96-well deep-well collection plate to buffer exchange samples. 4 μL of solution containing 25 mM CaCl₂ and 0.25 mg/mL trypsin was added to the plate and the plate was then incubated at 37° C. for 2 hrs with shaking at 600 rpm. 300 μL of solution containing 5% high-capacity streptavidin agarose slurry in 25 mM Tris-HCl pH 7.5, 150 mM NaCl, and 0.1% NP-40 then added. The plate was incubated at 25° C. for 2 hrs with shaking at 600 rpm. Samples were transferred to 25 μm filter plate and spin at 1000 rpm for 2 min. Samples were then washed 3 times with 0.75 mL of wash buffer (25 mM Tris-HCl pH 7.5, 150 mM NaCl, and 0.1% NP-40) followed by washing 3 times with 0.75 mL PBS, and then 4 times with 0.75 mL water. After the washing step, samples were eluted into polypropylene 96-well plate by addition of 250 L of 50% MeCN/water, 0.1% formic acid and allowed to gravity drip for 10 min, followed by centrifugation at 1000 rpm for 2 min. Speedvac was used to dry the plates at about 45° C. for −5 hrs. Then the plates were covered with foil seal and stored at −20° C.

Samples were resuspended by addition of 20 μl of 12.5% ACN, 0.1% formic acid solution, covered with foil seal, and incubated at 42° C. for 10 minutes with shaking at 600 rpm. Then add 30 μL of 0.1% formic acid solution was added and the plate was covered and incubated at 42° C. for 10 minutes with shaking at 600 rpm. Seal plate was then sealed with a 96-well silicon mat for analysis.

While preferred embodiments of the present disclosure have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the disclosure. It should be understood that various alternatives to the embodiments of the disclosure described herein may be employed in practicing the disclosure. It is intended that the following claims define the scope of the disclosure and that methods and structures within the scope of these claims and their equivalents be covered thereby. 

What is claimed is:
 1. A protein-probe adduct wherein the probe binds to a cysteine residue of a protein illustrated in Table 1A or Table 2A, wherein the probe has a structure represented by Formula (I):

wherein, n is 0-8.
 2. The protein-probe adduct of claim 1, wherein the protein is selected from Ankyrin repeat and BTB/POZ domain-containing protein 1, Ankyrin repeat and BTB/POZ domain-containing protein 2, Activating molecule in BECN1-regulated autophagy protein 1, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 15, Anaphase-promoting complex subunit 16, Anaphase-promoting complex subunit 2, Anaphase-promoting complex subunit 7, Rabankyrin-5, Ankyrin repeat and IBR domain-containing protein 1, Amyloid protein-binding protein 2, Apoptosis-resistant E3 ubiquitin protein ligase 1, E3 ubiquitin-protein ligase ARIH1, E3 ubiquitin-protein ligase ARIH2, Armadillo repeat-containing protein 5, Ankyrin repeat and SOCS box protein 2, Ankyrin repeat and SOCS box protein 6, Transcriptional regulator ATRX, Transcription regulator protein BACH1, Transcription regulator protein BACH2, Baculoviral IAP repeat-containing protein 2, Baculoviral IAP repeat-containing protein 3, Baculoviral IAP repeat-containing protein 6, Breast cancer type 1 susceptibility protein, F-box/WD repeat-containing protein 1A, Cullin-associated NEDD8-dissociated protein 1, Cullin-associated NEDD8-dissociated protein 2, E3 ubiquitin-protein ligase CBL, E3 ubiquitin-protein ligase CBL-B, E3 ubiquitin-protein ligase CBL-C, Cyclin-F, Cell division cycle protein 20 homolog, Cell division cycle protein 23 homolog, Cell division cycle protein 27 homolog, Cell growth regulator with RING finger domain protein 1, E3 ubiquitin-protein ligase CHFR, Clusterin, CCR4-NOT transcription complex subunit 4, COMM domain-containing protein 2, COMM domain-containing protein 9, Cullin-4A, Cullin-5, Cullin-7, Cullin-9, DDB1- and CUL4-associated factor 1, DDB1- and CUL4-associated factor 10, DDB1- and CUL4-associated factor 13, DDB1- and CUL4-associated factor 16, DDB1- and CUL4-associated factor 17, DDB1- and CUL4-associated factor 5, DDB1- and CUL4-associated factor 6, DDB1- and CUL4-associated factor 7, DNA damage-binding protein 2, Zinc finger protein neuro-d4, Denticleless protein homolog, E3 ubiquitin-protein ligase DTX1, Probable E3 ubiquitin-protein ligase DTX3, E3 ubiquitin-protein ligase DTX3L, E3 SUMO-protein ligase EGR2, Ectoderm-neural cortex protein 1, DNA excision repair protein ERCC-8, E3 ubiquitin-protein ligase FANCL, F-box DNA helicase 1, F-box/LRR-repeat protein 12, F-box/LRR-repeat protein 17, F-box/LRR-repeat protein 18, F-box/LRR-repeat protein 20, F-box/LRR-repeat protein 3, F-box/LRR-repeat protein 6, F-box only protein 11, F-box only protein 30, F-box only protein 31, F-box only protein 38, F-box only protein 42, F-box/SPRY domain-containing protein 1, F-box only protein 5, F-box only protein 7, F-box only protein 9, F-box/WD repeat-containing protein 11, F-box/WD repeat-containing protein 4, F-box/WD repeat-containing protein 8, F-box/WD repeat-containing protein 9, Protein fem-1 homolog A, Protein fem-1 homolog B, Gigaxonin, General transcription factor IIH subunit 2, E3 ubiquitin-protein ligase HACE1, E3 ubiquitin-protein ligase HECTD1, Probable E3 ubiquitin-protein ligase HECTD4, E3 ubiquitin-protein ligase HECW1, E3 ubiquitin-protein ligase HECW2, Probable E3 ubiquitin-protein ligase HERC1, E3 ubiquitin-protein ligase HERC2, Probable E3 ubiquitin-protein ligase HERC3, Probable E3 ubiquitin-protein ligase HERC4, E3 ISG15-protein ligase HERC5, Helicase-like transcription factor, E3 ubiquitin-protein ligase HUWE1, Actin-binding protein IPP, Interferon regulatory factor 2-binding protein 1, Interferon regulatory factor 2-binding protein 2, Interferon regulatory factor 2-binding protein-like, E3 ubiquitin-protein ligase Itchy homolog, Influenza virus NS1A-binding protein, Kelch repeat and BTB domain-containing protein 11, Kelch repeat and BTB domain-containing protein 4, Kelch repeat and BTB domain-containing protein 6, Kelch repeat and BTB domain-containing protein 7, Kelch repeat and BTB domain-containing protein 8, E3 ubiquitin-protein ligase KCMF1, BTB/POZ domain-containing protein KCTD3, BTB/POZ domain-containing protein KCTD7, Kelch-like ECH-associated protein 1, Kelch domain-containing protein 10, Kelch domain-containing protein 3, Kelch-like protein 20, Kelch-like protein 24, Kelch-like protein 26, Kelch-like protein 36, E3 ubiquitin-protein ligase LNX, LON peptidase N-terminal domain and RING finger protein 2, Leucine-rich repeat protein 1, Leucine-rich repeat-containing protein 41, E3 ubiquitin-protein ligase LRSAM1, E3 ubiquitin-protein ligase listerin, E3 ubiquitin-protein ligase MARCH1, E3 ubiquitin-protein ligase MARCH3, E3 ubiquitin-protein ligase MARCH5, E3 ubiquitin-protein ligase MARCH6, E3 ubiquitin-protein ligase MARCH7, E3 ubiquitin-protein ligase Mdm2, E3 ubiquitin-protein ligase MGRN1, E3 ubiquitin-protein ligase MIB2, Probable E3 ubiquitin-protein ligase MID2, E3 ubiquitin-protein ligase makorin-1, Probable E3 ubiquitin-protein ligase makorin-2, Male-specific lethal 1 homolog, E3 ubiquitin-protein ligase MYCBP2, E3 ubiquitin-protein ligase NEDD4, E3 ubiquitin-protein ligase NEDD4-like, Transcriptional repressor NF-X1, NF-X1-type zinc finger protein NFXL1, Nitric oxide synthase-interacting protein, Histone-lysine N-methyltransferase NSD2, OTU domain-containing protein 7B, POZ-, AT hook-, and zinc finger-containing protein 1, Polycomb group RING finger protein 2, E3 ubiquitin-protein ligase PDZRN3, E3 ubiquitin-protein ligase pellino homolog 1, E3 ubiquitin-protein ligase pellino homolog 2, Peroxisome biogenesis factor 10, PHD and RING finger domain-containing protein 1, E3 SUMO-protein ligase PIAS2, E3 SUMO-protein ligase PIAS4, E3 ubiquitin-protein ligase Praja-2, Protein PML, RING-type E3 ubiquitin-protein ligase PPIL2, E3 ubiquitin-protein ligase parkin, Pre-mRNA-processing factor 19, E3 SUMO-protein ligase RanBP2, E3 ubiquitin-protein ligase RBX1, RCC1 and BTB domain-containing protein 1, RING finger and CHY zinc finger domain-containing protein 1, E3 ubiquitin-protein ligase RFWD3, E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RLIM, RING finger protein 10, E3 ubiquitin-protein ligase RNF114, E3 ubiquitin-protein ligase RNF126, E3 ubiquitin-protein ligase RNF128, E3 ubiquitin-protein ligase RNF135, E3 ubiquitin-protein ligase RNF14, E3 ubiquitin-protein ligase RNF144B, RING finger protein 148, E3 ubiquitin-protein ligase RNF149, RING finger protein 150, E3 ubiquitin ligase RNF157, E3 ubiquitin-protein ligase RNF168, E3 ubiquitin-protein ligase RNF187, E3 ubiquitin-protein ligase RNF19B, E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase RNF213, RING finger protein 214, E3 ubiquitin-protein ligase RNF216, Probable E3 ubiquitin-protein ligase RNF217, RING finger protein 219, E3 ubiquitin-protein ligase RNF25, E3 ubiquitin-protein ligase RNF31, E3 ubiquitin-protein ligase BRE1B, E3 ubiquitin-protein ligase RNF43, E3 ubiquitin-protein ligase RNF5, RING-box protein 2, E3 ubiquitin-protein ligase RNF8, RUN and FYVE domain-containing protein 1, E3 ubiquitin-protein ligase SH3RF2, SH3KBP1-binding protein 1, Structure-specific endonuclease subunit SLX4, E3 ubiquitin-protein ligase SMURF1, E3 ubiquitin-protein ligase SMURF2, Suppressor of cytokine signaling 2, Suppressor of cytokine signaling 3, Suppressor of cytokine signaling 6, Suppressor of cytokine signaling 7, Speckle-type POZ protein, Tumor necrosis factor alpha-induced protein 3, E3 ubiquitin-protein ligase Topors, TNF receptor-associated factor 1, TNF receptor-associated factor 2, TNF receptor-associated factor 3, E3 ubiquitin-protein ligase TRIM11, E3 ubiquitin-protein ligase TRIM22, E3 ubiquitin/ISG15 ligase TRIM25, Transcription intermediary factor 1-beta, Tripartite motif-containing protein 3, E3 ubiquitin-protein ligase TRIM32, E3 ubiquitin-protein ligase TRIM33, E3 ubiquitin-protein ligase TRIM36, E3 ubiquitin-protein ligase TRIM4, Tripartite motif-containing protein 47, E3 ubiquitin-protein ligase TRIM56, Tripartite motif-containing protein 59, Tripartite motif-containing protein 65, E3 ubiquitin-protein ligase TRIM7, E3 ubiquitin-protein ligase TRIM71, Tripartite motif-containing protein 72, E3 ubiquitin-protein ligase TRIM8, E3 ubiquitin-protein ligase TRIP12, Short transient receptor potential channel 4-associated protein, E3 ubiquitin-protein ligase TTC3, (E3-independent) E2 ubiquitin-conjugating enzyme, Ubiquitin-protein ligase E3A, Ubiquitin-protein ligase E3B, Ubiquitin-protein ligase E3C, E3 ubiquitin-protein ligase E3D, Ubiquitin conjugation factor E4 A, Ubiquitin conjugation factor E4 B, E3 ubiquitin-protein ligase UBR1, E3 ubiquitin-protein ligase UBR2, E3 ubiquitin-protein ligase UBR3, E3 ubiquitin-protein ligase UBR4, E3 ubiquitin-protein ligase UBR5, Putative E3 ubiquitin-protein ligase UBR7, RING finger protein unkempt homolog, Putative E3 ubiquitin-protein ligase UNKL, Vacuolar protein sorting-associated protein 11 homolog, Vacuolar protein sorting-associated protein 18 homolog, Vacuolar protein sorting-associated protein 41 homolog, Vacuolar protein sorting-associated protein 8 homolog, WD repeat-containing protein 26, WD and tetratricopeptide repeats protein 1, NEDD4-like E3 ubiquitin-protein ligase WWP1, NEDD4-like E3 ubiquitin-protein ligase WWP2, Nuclear-interacting partner of ALK, Zinc finger protein-like 1, E3 ubiquitin-protein ligase ZNF598, and E3 ubiquitin-protein ligase ZNRF3.
 3. The protein-probe adduct of claim 1, wherein the protein is B-cell lymphoma 6 protein and the cysteine residue is C121, C175, C232, C254, C296, C339, C348, C354, C414, C548, or C663, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier P41182.
 4. The protein-probe adduct of claim 1, wherein the protein is Polycomb group RING finger protein 6 and the cysteine residue is C56, C137, or C155, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9BYE7.
 5. The protein-probe adduct of claim 1, wherein the protein is E3 ubiquitin-protein ligase CBL-B and the cysteine residue is C60, C345, C376, C435, C436, C470, C523, C535, C594, C607, C686, C741, or C895, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191.
 6. The protein-probe adduct of claim 1, wherein the protein is Elongin-B and the cysteine residue is C60 or C89, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q15370.
 7. The protein-probe adduct of claim 1, wherein the protein is Elongin-C and the cysteine residue is C11 or C74, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q15369.
 8. The protein-probe adduct of claim 1, wherein the protein is F-box only protein 22 and the cysteine residue is C47, C117, C227, C228, or C378, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8NEZ5.
 9. The protein-probe adduct of claim 1, wherein the protein is Kelch repeat and BTB domain-containing protein 4 and the cysteine residue is C68, C201, C274, C301, C455, or C472, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7.
 10. The protein-probe adduct of claim 1, wherein the protein is Kelch-like ECH-associated protein 1 and the cysteine residue is C23, C38, C151, C226, C241, C257, C288, C297, C319, C434, C613, C622, or C624 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145.
 11. The protein-probe adduct of claim 1, wherein the protein is E3 ubiquitin-protein ligase pellino homolog 11 and the cysteine residue is C61, C212, or C282 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96FA3.
 12. The protein-probe adduct of claim 1, wherein the protein is E3 ubiquitin-protein ligase RNF128 and the cysteine residue is C295, C303, C314, or C317 wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8TEB7.
 13. The protein-probe adduct of claim 1, wherein the protein is TNF receptor-associated factor 6 and the cysteine residue is C85, C105, C134, C139, C182, C235, C349, or C366, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9Y4K3.
 14. The protein-probe adduct of claim 1, wherein the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C101, C182, C208, C230, C244, C314, C341, C370, C375, C400, C406, C585, C598, C910, C913, C1040, C1099, or C1288, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9.
 15. The protein-probe adduct of claim 1, wherein the protein is E3 ubiquitin-protein ligase CBL-B and the cysteine residue is C607, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q13191.
 16. The protein-probe adduct of claim 1, wherein the protein is Kelch repeat and BTB domain-containing protein 4 and the cysteine residue is 68, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9NVX7.
 17. The protein-probe adduct of claim 1, wherein the protein is Kelch-like ECH-associated protein 1 and the cysteine residue is C23, C38, C151, C241, C257, C288, C297, C319, C613, or C624, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q14145.
 18. The protein-probe adduct of claim 1, wherein the protein is E3 ubiquitin-protein ligase pellino homolog 1 and the cysteine residue is C282, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q96FA3.
 19. The protein-probe adduct of claim 1, wherein the protein is E3 ubiquitin-protein ligase RNF128 and the cysteine residue is C317, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q8TEB7.
 20. The protein-probe adduct of claim 1, wherein the protein is (E3-independent) E2 ubiquitin-conjugating enzyme and the cysteine residue is C370, C400, C910, or C913, wherein the numbering of the amino acid position corresponds to the amino acid position with the UniProt Identifier Q9C0C9. 